Patents by Inventor Toshihiro Nakanishi

Toshihiro Nakanishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240123435
    Abstract: A metal removal filtering material having a basis weight of 30 to 120 g/m2 including a polyethylene porous base material and graft chains fixed to the polyethylene porous base material and having a functional group. The graft chains have a graft rate of 40 to 150%. The functional group is selected from a quaternary ammonium group, a primary, secondary, or tertiary amino group, an iminodiacetic acid group, a phosphate group, and an iminodiethanol group.
    Type: Application
    Filed: December 14, 2021
    Publication date: April 18, 2024
    Inventors: Toshihiro Nakanishi, Chika Naruoka
  • Patent number: 11660268
    Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.
    Type: Grant
    Filed: November 29, 2021
    Date of Patent: May 30, 2023
    Assignee: HISAMITSU PHARMACEUTICAL CO.. INC.
    Inventors: Shinya Matsumura, Toshihiro Nakanishi, Yasuhisa Kose
  • Publication number: 20220079879
    Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.
    Type: Application
    Filed: November 29, 2021
    Publication date: March 17, 2022
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Shinya MATSUMURA, Toshihiro NAKANISHI, Yasuhisa KOSE
  • Patent number: 11246830
    Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: February 15, 2022
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Shinya Matsumura, Toshihiro Nakanishi, Yasuhisa Kose
  • Patent number: 11219601
    Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: January 11, 2022
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Shinya Matsumura, Toshihiro Nakanishi, Yasuhisa Kose
  • Publication number: 20210077393
    Abstract: The present invention provides an emulsified gel composition comprising diclofenac sodium, water, a gelling agent, an antioxidant, and a surfactant having an HLB of 14 or more, in which the gelling agent is a nonionic water-soluble polymer.
    Type: Application
    Filed: February 19, 2019
    Publication date: March 18, 2021
    Inventors: Toshihiro NAKANISHI, Yuko NAGASE, Shinya MATSUMURA, Yasuhisa KOSE
  • Publication number: 20200397694
    Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.
    Type: Application
    Filed: February 19, 2019
    Publication date: December 24, 2020
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Shinya MATSUMURA, Toshihiro NAKANISHI, Yasuhisa KOSE
  • Publication number: 20160113877
    Abstract: An oral cavity patch comprising: a drug layer and an adhesive layer, wherein the drug layer comprises a drug-release-controlling agent consisting of at least one selected from the group consisting of a hydroxyalkyl alkyl cellulose, hydroxypropyl cellulose, a sodium carboxyalkyl cellulose, ethyl cellulose, hydrogenated castor oil, and a sucrose fatty acid ester.
    Type: Application
    Filed: May 30, 2014
    Publication date: April 28, 2016
    Inventors: Takaaki YOSHINAGA, Yuko NAGASE, Toshihiro NAKANISHI
  • Publication number: 20040115196
    Abstract: There are provided an H chain polypeptide of a recombinant antibody against human TNF&agr; or its fragment, having at least one of the following amino acid sequences:
    Type: Application
    Filed: December 18, 2001
    Publication date: June 17, 2004
    Inventors: Yoshiaki Fukuda, Kazuhiro Nagahira, Toshihiro Nakanishi
  • Patent number: 6659510
    Abstract: A pipe-end-connecting joint comprisse a nipple 1 inserted in the pipe end, a holder 2 for tightening the outer circumference of the pipe end, and an elastic packing 3 divided into half parts and attached in the holder 2. The nipple 1 includes a tubular portion 11 provided in one longitudinal end side thereof so as to be inserted in the pipe end, a connection portion 12 provided in the other longitudinal end side thereof so as to be connected to another joint, and a flange portion 13 provided in a longitudinal intermediate portion thereof so as to protrude outward.
    Type: Grant
    Filed: August 26, 1999
    Date of Patent: December 9, 2003
    Assignee: Totaku Industries, Inc.
    Inventors: Hiroshi Ikegami, Yasuhiro Kikumori, Toshihiro Nakanishi, Susumu Okairi, Nobuo Shindo, Tatsuya Machino
  • Patent number: 6659136
    Abstract: A flexible hose having air-permeability is formed by either: sandwiching an air-permeable tape between tape end edge portions, as leading and trailing in a hose longitudinal direction, of a soft resin tape that is helically wound integrally with the air-permeable tape; or by helically winding only an air-permeable tape. The flexible hose can be properly used as a cleaner hose of a discharge circulation type by using it as an outer tube of a double tube structure. By providing lubricating properties to an inner circumference of the outer tube or an outer circumference of the inner tube, it is possible to prevent wear which might otherwise be caused by rubbing contact between the inner tube and outer tube.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: December 9, 2003
    Assignee: Totaku Industries, Inc.
    Inventors: Kouki Fukui, Hiroyuki Masui, Toshihiro Nakanishi, Isao Kurimoto, Masahiko Ogake
  • Publication number: 20010017164
    Abstract: A flexible hose having an air-permeability and formed either: by sandwiching an air-permeable tape between the tape end edge portions, as leading and trailing in the hose longitudinal direction, of a soft resin tape to be helically wound, and by winding the air-permeable tape integrally with the soft resin tape; or by winding only the air-permeable tape helically. Especially, the air-permeable flexible hose can be properly used as a cleaner hose of the discharge circulation type by using it as an outer tube of a double tube. By giving lubricating properties to the inner circumference of the outer tube or the outer circumference of the inner tube, on the other hand, it is possible to prevent the wear which might otherwise be caused by the rubbing contact.
    Type: Application
    Filed: February 22, 2001
    Publication date: August 30, 2001
    Inventors: Kouki Fukui, Hiroyuki Masui, Toshihiro Nakanishi, Isao Kurimoto, Masahiko Ogake
  • Patent number: 6216742
    Abstract: There is provided a heat insulating hose which comprises a seamless cylindrical inner tube formed of a synthetic resin, and a cylindrical heat insulating layer formed of a foamed synthetic resin for covering an outer peripheral face of the inner tube, characterized in that the inner tube is provided at its one end with a cylindrical part for connection with a drain outlet of an air conditioning appliance and formed with a number of ring-shaped protrusion stripes which project toward its outer circumference over an entire length thereof in its axial direction except the cylindrical part spacing a distance W which is wider than an axial width w of each of the ring-shaped protrusion stripes, and that an area b of a desired range spaced by a determined length a from the cylindrical part is an area wherein a number of ring-shaped protrusion stripes are formed at a smaller distance s.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: April 17, 2001
    Assignee: Totaku Industries, Inc.
    Inventors: Hiroyuki Masui, Toshihiro Nakanishi, Masaru Sato
  • Patent number: 6103971
    Abstract: Two hard steel wire-made reinforcing wires and two synthetic resin wires which are harder than a soft synthetic resin pipe wall are alternately wound spirally on an inner side of the synthetic resin pipe wall while keeping predetermined intervals.
    Type: Grant
    Filed: July 6, 1998
    Date of Patent: August 15, 2000
    Assignee: Totaku Industries, Inc.
    Inventors: Masaru Sato, Toshihiro Nakanishi, Hikaru Mizukoshi, Hiroyuki Masui
  • Patent number: 5704401
    Abstract: With a desired intermediate portion as a boundary, in a hose, a corrugated wall is formed on one side of the boundary while a scalene-triangularly corrugated wall is formed on the other side of the boundary, the whole of a hose is formed of a soft synthetic resin material and a hard synthetic resin material in the form of a double-layered wall. The soft synthetic resin material is made thicker than the hard synthetic resin material in a portion on a connection cylindrical portion side while the hard synthetic resin material is made thicker than the soft synthetic resin material in a portion on a drainage cylindrical portion side.
    Type: Grant
    Filed: April 10, 1996
    Date of Patent: January 6, 1998
    Assignee: Totaku Industries, Inc.
    Inventors: Kouki Fukui, Hiroyuki Masui, Toshihiro Nakanishi
  • Patent number: 5648078
    Abstract: The metastasis of cells, which express a glycoprotein of human carcinoembryonic antigen on the cells surfaces, is inhibited in a living organ by administering, in advance, to a subject, a monoclonal antibody which binds a peptide which comprises at least the peptide sequence of domain N in the glycoprotein of human carcinoembryonic antigen.
    Type: Grant
    Filed: May 11, 1994
    Date of Patent: July 15, 1997
    Assignee: Suntory Limited
    Inventors: Junko Hashino, Shinzo Oikawa, Hiroshi Nakazato, Toshihiro Nakanishi
  • Patent number: 5126253
    Abstract: A novel cell line for use as a parent for hybridoma preparation is provided. This cell line is derived from tumor cells, in particular human tumor cells, other than those originating from bone marrow cells. A method for establishing this cell line is also provided. By fusing this cell line with cells producing useful physiologically active substances, such as B cells immunized with an antigen, a hybridoma capable of active growth can be prepared. This hybridoma can be cultivated for the production of useful physiologically active substances.
    Type: Grant
    Filed: September 25, 1986
    Date of Patent: June 30, 1992
    Assignee: Suntory Limited
    Inventors: Toshihiro Nakanishi, Masashi Matsui, Kenju Miura, Yoshiaki Fukuda, Teruhisa Noguchi
  • Patent number: 4820641
    Abstract: The specification discloses a monoclonal antibody capable of distinguishing human hepato-carcinoma cells, a hybridoma producing said monoclonal antibody and a process for preparing the monoclonal antibody using said hybridoma. The monoclonal antibody of the invention specifically attackes hepato-carcinoma cells in vivo.
    Type: Grant
    Filed: June 27, 1985
    Date of Patent: April 11, 1989
    Assignee: Suntory Limited
    Inventors: Toshihiro Nakanishi, Yoshiaki Fukuda, Kenju Miura, Hiroshi Nakazato
  • Patent number: 4774342
    Abstract: An ailanthone derivative having the general formula: ##STR1## wherein R is a p-alkyl benzoic acid residue having 8 to 21 carbon atoms, a 2-methyl saturated fatty acid residue having 6 to 19 carbon atoms, a 2-methyl-2-unsaturated fatty acid residue having 4 to 19 carbon atoms, a 3,4-dimethyl-4-acyloxy-2-pentenoic acid residue having 9 to 19 carbon atoms, a 3,4,4-trimethyl-2-unsaturated fatty acid residue having 8 to 21 carbon atoms, a group having the formula ##STR2## wherein n is an integer of 1 to 13, a group having the general formula ##STR3## wherein n is an integer of 1 to 13, a trans-cinnamic acid residue, a linear saturated fatty acid residue having 3 to 22 carbon atoms, a 3-methyl-2-unsaturated fatty acid residue having 6 to 19 carbon atoms, a 3,4-dimethyl-2-unsaturated fatty acid residue having 7 to 20 carbon atoms, a terpenic acid residue, a 2-amino saturated fatty acid residue having 2 to 18 carbon atoms or a salt thereof, a 2-hydroxy saturated fatty acid residue having 3 to 18 carbon atoms, or a 3,
    Type: Grant
    Filed: November 4, 1985
    Date of Patent: September 27, 1988
    Assignee: Suntory Limited
    Inventors: Tadashi Honda, Toshio Tatsuoka, Toshihiro Nakanishi
  • Patent number: 4698423
    Abstract: An ellipticine derivative having the structure: ##STR1## as well as process for the preparation of such ellipticine derivatives. The ellipticine derivatives have antineoplastic or antitumor activity.
    Type: Grant
    Filed: July 25, 1985
    Date of Patent: October 6, 1987
    Assignee: Suntory Limited
    Inventors: Tadashi Honda, Toshihiro Nakanishi