Patents by Inventor Toshihiro Nakanishi
Toshihiro Nakanishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240123435Abstract: A metal removal filtering material having a basis weight of 30 to 120 g/m2 including a polyethylene porous base material and graft chains fixed to the polyethylene porous base material and having a functional group. The graft chains have a graft rate of 40 to 150%. The functional group is selected from a quaternary ammonium group, a primary, secondary, or tertiary amino group, an iminodiacetic acid group, a phosphate group, and an iminodiethanol group.Type: ApplicationFiled: December 14, 2021Publication date: April 18, 2024Inventors: Toshihiro Nakanishi, Chika Naruoka
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Patent number: 11660268Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.Type: GrantFiled: November 29, 2021Date of Patent: May 30, 2023Assignee: HISAMITSU PHARMACEUTICAL CO.. INC.Inventors: Shinya Matsumura, Toshihiro Nakanishi, Yasuhisa Kose
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Publication number: 20220079879Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.Type: ApplicationFiled: November 29, 2021Publication date: March 17, 2022Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Shinya MATSUMURA, Toshihiro NAKANISHI, Yasuhisa KOSE
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Patent number: 11246830Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.Type: GrantFiled: February 19, 2019Date of Patent: February 15, 2022Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Shinya Matsumura, Toshihiro Nakanishi, Yasuhisa Kose
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Patent number: 11219601Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.Type: GrantFiled: February 19, 2019Date of Patent: January 11, 2022Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Shinya Matsumura, Toshihiro Nakanishi, Yasuhisa Kose
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Publication number: 20210077393Abstract: The present invention provides an emulsified gel composition comprising diclofenac sodium, water, a gelling agent, an antioxidant, and a surfactant having an HLB of 14 or more, in which the gelling agent is a nonionic water-soluble polymer.Type: ApplicationFiled: February 19, 2019Publication date: March 18, 2021Inventors: Toshihiro NAKANISHI, Yuko NAGASE, Shinya MATSUMURA, Yasuhisa KOSE
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Publication number: 20200397694Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.Type: ApplicationFiled: February 19, 2019Publication date: December 24, 2020Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Shinya MATSUMURA, Toshihiro NAKANISHI, Yasuhisa KOSE
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Publication number: 20160113877Abstract: An oral cavity patch comprising: a drug layer and an adhesive layer, wherein the drug layer comprises a drug-release-controlling agent consisting of at least one selected from the group consisting of a hydroxyalkyl alkyl cellulose, hydroxypropyl cellulose, a sodium carboxyalkyl cellulose, ethyl cellulose, hydrogenated castor oil, and a sucrose fatty acid ester.Type: ApplicationFiled: May 30, 2014Publication date: April 28, 2016Inventors: Takaaki YOSHINAGA, Yuko NAGASE, Toshihiro NAKANISHI
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Publication number: 20040115196Abstract: There are provided an H chain polypeptide of a recombinant antibody against human TNF&agr; or its fragment, having at least one of the following amino acid sequences:Type: ApplicationFiled: December 18, 2001Publication date: June 17, 2004Inventors: Yoshiaki Fukuda, Kazuhiro Nagahira, Toshihiro Nakanishi
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Patent number: 6659510Abstract: A pipe-end-connecting joint comprisse a nipple 1 inserted in the pipe end, a holder 2 for tightening the outer circumference of the pipe end, and an elastic packing 3 divided into half parts and attached in the holder 2. The nipple 1 includes a tubular portion 11 provided in one longitudinal end side thereof so as to be inserted in the pipe end, a connection portion 12 provided in the other longitudinal end side thereof so as to be connected to another joint, and a flange portion 13 provided in a longitudinal intermediate portion thereof so as to protrude outward.Type: GrantFiled: August 26, 1999Date of Patent: December 9, 2003Assignee: Totaku Industries, Inc.Inventors: Hiroshi Ikegami, Yasuhiro Kikumori, Toshihiro Nakanishi, Susumu Okairi, Nobuo Shindo, Tatsuya Machino
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Patent number: 6659136Abstract: A flexible hose having air-permeability is formed by either: sandwiching an air-permeable tape between tape end edge portions, as leading and trailing in a hose longitudinal direction, of a soft resin tape that is helically wound integrally with the air-permeable tape; or by helically winding only an air-permeable tape. The flexible hose can be properly used as a cleaner hose of a discharge circulation type by using it as an outer tube of a double tube structure. By providing lubricating properties to an inner circumference of the outer tube or an outer circumference of the inner tube, it is possible to prevent wear which might otherwise be caused by rubbing contact between the inner tube and outer tube.Type: GrantFiled: February 22, 2001Date of Patent: December 9, 2003Assignee: Totaku Industries, Inc.Inventors: Kouki Fukui, Hiroyuki Masui, Toshihiro Nakanishi, Isao Kurimoto, Masahiko Ogake
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Publication number: 20010017164Abstract: A flexible hose having an air-permeability and formed either: by sandwiching an air-permeable tape between the tape end edge portions, as leading and trailing in the hose longitudinal direction, of a soft resin tape to be helically wound, and by winding the air-permeable tape integrally with the soft resin tape; or by winding only the air-permeable tape helically. Especially, the air-permeable flexible hose can be properly used as a cleaner hose of the discharge circulation type by using it as an outer tube of a double tube. By giving lubricating properties to the inner circumference of the outer tube or the outer circumference of the inner tube, on the other hand, it is possible to prevent the wear which might otherwise be caused by the rubbing contact.Type: ApplicationFiled: February 22, 2001Publication date: August 30, 2001Inventors: Kouki Fukui, Hiroyuki Masui, Toshihiro Nakanishi, Isao Kurimoto, Masahiko Ogake
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Patent number: 6216742Abstract: There is provided a heat insulating hose which comprises a seamless cylindrical inner tube formed of a synthetic resin, and a cylindrical heat insulating layer formed of a foamed synthetic resin for covering an outer peripheral face of the inner tube, characterized in that the inner tube is provided at its one end with a cylindrical part for connection with a drain outlet of an air conditioning appliance and formed with a number of ring-shaped protrusion stripes which project toward its outer circumference over an entire length thereof in its axial direction except the cylindrical part spacing a distance W which is wider than an axial width w of each of the ring-shaped protrusion stripes, and that an area b of a desired range spaced by a determined length a from the cylindrical part is an area wherein a number of ring-shaped protrusion stripes are formed at a smaller distance s.Type: GrantFiled: February 18, 2000Date of Patent: April 17, 2001Assignee: Totaku Industries, Inc.Inventors: Hiroyuki Masui, Toshihiro Nakanishi, Masaru Sato
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Patent number: 6103971Abstract: Two hard steel wire-made reinforcing wires and two synthetic resin wires which are harder than a soft synthetic resin pipe wall are alternately wound spirally on an inner side of the synthetic resin pipe wall while keeping predetermined intervals.Type: GrantFiled: July 6, 1998Date of Patent: August 15, 2000Assignee: Totaku Industries, Inc.Inventors: Masaru Sato, Toshihiro Nakanishi, Hikaru Mizukoshi, Hiroyuki Masui
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Patent number: 5704401Abstract: With a desired intermediate portion as a boundary, in a hose, a corrugated wall is formed on one side of the boundary while a scalene-triangularly corrugated wall is formed on the other side of the boundary, the whole of a hose is formed of a soft synthetic resin material and a hard synthetic resin material in the form of a double-layered wall. The soft synthetic resin material is made thicker than the hard synthetic resin material in a portion on a connection cylindrical portion side while the hard synthetic resin material is made thicker than the soft synthetic resin material in a portion on a drainage cylindrical portion side.Type: GrantFiled: April 10, 1996Date of Patent: January 6, 1998Assignee: Totaku Industries, Inc.Inventors: Kouki Fukui, Hiroyuki Masui, Toshihiro Nakanishi
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Patent number: 5648078Abstract: The metastasis of cells, which express a glycoprotein of human carcinoembryonic antigen on the cells surfaces, is inhibited in a living organ by administering, in advance, to a subject, a monoclonal antibody which binds a peptide which comprises at least the peptide sequence of domain N in the glycoprotein of human carcinoembryonic antigen.Type: GrantFiled: May 11, 1994Date of Patent: July 15, 1997Assignee: Suntory LimitedInventors: Junko Hashino, Shinzo Oikawa, Hiroshi Nakazato, Toshihiro Nakanishi
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Patent number: 5126253Abstract: A novel cell line for use as a parent for hybridoma preparation is provided. This cell line is derived from tumor cells, in particular human tumor cells, other than those originating from bone marrow cells. A method for establishing this cell line is also provided. By fusing this cell line with cells producing useful physiologically active substances, such as B cells immunized with an antigen, a hybridoma capable of active growth can be prepared. This hybridoma can be cultivated for the production of useful physiologically active substances.Type: GrantFiled: September 25, 1986Date of Patent: June 30, 1992Assignee: Suntory LimitedInventors: Toshihiro Nakanishi, Masashi Matsui, Kenju Miura, Yoshiaki Fukuda, Teruhisa Noguchi
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Patent number: 4820641Abstract: The specification discloses a monoclonal antibody capable of distinguishing human hepato-carcinoma cells, a hybridoma producing said monoclonal antibody and a process for preparing the monoclonal antibody using said hybridoma. The monoclonal antibody of the invention specifically attackes hepato-carcinoma cells in vivo.Type: GrantFiled: June 27, 1985Date of Patent: April 11, 1989Assignee: Suntory LimitedInventors: Toshihiro Nakanishi, Yoshiaki Fukuda, Kenju Miura, Hiroshi Nakazato
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Patent number: 4774342Abstract: An ailanthone derivative having the general formula: ##STR1## wherein R is a p-alkyl benzoic acid residue having 8 to 21 carbon atoms, a 2-methyl saturated fatty acid residue having 6 to 19 carbon atoms, a 2-methyl-2-unsaturated fatty acid residue having 4 to 19 carbon atoms, a 3,4-dimethyl-4-acyloxy-2-pentenoic acid residue having 9 to 19 carbon atoms, a 3,4,4-trimethyl-2-unsaturated fatty acid residue having 8 to 21 carbon atoms, a group having the formula ##STR2## wherein n is an integer of 1 to 13, a group having the general formula ##STR3## wherein n is an integer of 1 to 13, a trans-cinnamic acid residue, a linear saturated fatty acid residue having 3 to 22 carbon atoms, a 3-methyl-2-unsaturated fatty acid residue having 6 to 19 carbon atoms, a 3,4-dimethyl-2-unsaturated fatty acid residue having 7 to 20 carbon atoms, a terpenic acid residue, a 2-amino saturated fatty acid residue having 2 to 18 carbon atoms or a salt thereof, a 2-hydroxy saturated fatty acid residue having 3 to 18 carbon atoms, or a 3,Type: GrantFiled: November 4, 1985Date of Patent: September 27, 1988Assignee: Suntory LimitedInventors: Tadashi Honda, Toshio Tatsuoka, Toshihiro Nakanishi
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Patent number: 4698423Abstract: An ellipticine derivative having the structure: ##STR1## as well as process for the preparation of such ellipticine derivatives. The ellipticine derivatives have antineoplastic or antitumor activity.Type: GrantFiled: July 25, 1985Date of Patent: October 6, 1987Assignee: Suntory LimitedInventors: Tadashi Honda, Toshihiro Nakanishi