Patents by Inventor Toshihisa Ito

Toshihisa Ito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7820402
    Abstract: The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the labelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: October 26, 2010
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Yoshiki Sakaino, Hitomi Ito, Toshihiro Mori, Osamu Seshimoto, Toshihisa Ito, Yoshikazu Amano
  • Publication number: 20080279725
    Abstract: The object of the invention is to provide a multilayer analytical element having a non-fibrous porous film with high film strength, which does not produce uneven coloration in the form of a white-out and which has high accuracy of analysis. The present invention provides a dry multilayer analytical element for the analysis of a liquid sample which comprises a water-non-transmitting planar support on one side of which at least one adhesion layer and a porous liquid-sample-developing layer are integrally layered in the mentioned order, wherein the porous liquid-sample-developing layer comprises a non-fibrous porous film whose bending fracture strength is 20 g weight or more and whose elongation ratio when pulled with a 50-g weight is 2% or less, and wherein a adhesion layer polymer binder is caused to become seeped up in the non-fibrous porous film to 2 to 50 ?m.
    Type: Application
    Filed: September 29, 2005
    Publication date: November 13, 2008
    Applicant: FUJI PHOTO FILM CO., LTD.
    Inventors: Mitsuharu Nirasawa, Shigeki Kageyama, Toshihisa Ito
  • Publication number: 20080019869
    Abstract: It is an object of the invention to provide a multilayer analysis element with small intra-lot and lot-to-lot differences that has high measurement accuracy and which is small in size. The present invention provides a multilayer analysis element for liquid sample analysis wherein at least one functional layer and at least one porous liquid sample spreading layer of non-fibrous porous film are integrally laminated in this order on one side of a water-impermeable planar support, and the non-fibrous porous film has a bending rupture strength of 20 gram-weight or more and a tensile percentage of 2% or less when the film is stretched with a tensile force of 50 gram-weight.
    Type: Application
    Filed: February 18, 2005
    Publication date: January 24, 2008
    Applicant: Fuji Photo Film Co., Ltd.
    Inventors: Kentaro Nakamura, Kazuya Kawasaki, Yoshiki Sakaino, Toshihisa Ito, Osamu Seshimoto
  • Publication number: 20060024770
    Abstract: The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the lebelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase.
    Type: Application
    Filed: September 19, 2005
    Publication date: February 2, 2006
    Inventors: Yoshiki Sakaino, Hitomi Ito, Toshihiro Mori, Osamu Seshimoto, Toshihisa Ito, Yoshikazu Amano
  • Publication number: 20060016747
    Abstract: A glass fiber filter for blood filtration, in which a glass fiber is cleaned with an organic acid and then the surface of a glass fiber is coated with a biocompatible polymer such as poly (alkoxy acrylate), a blood filtration device and a dry-type blood analysis element in which the glass fiber filter for blood filtration is used.
    Type: Application
    Filed: July 21, 2005
    Publication date: January 26, 2006
    Inventors: Yoshiki Sakaino, Toshihisa Ito
  • Publication number: 20050186109
    Abstract: An object of the invention to provide a multilayer analysis element with small intra-lot and lot-to-lot differences that has high measurement accuracy and which is small in size. The present invention provides a multilayer analysis element for the analysis of a liquid sample, comprising a water impermeable planar support on one side of which at least one functional layer and at least one porous liquid sample spreading layer of non-fibrous porous film are integrally laminated in the mentioned order, wherein the arithmetic mean deviation of the profile (Ra) of a contact surface of the at least one functional layer that is in contact with said porous liquid sample spreading layer of said non-fibrous porous film is 1 ?m or less and/or the ten-point height of irregularities (Rz) of said contact surface is 8 ?m or less.
    Type: Application
    Filed: February 18, 2005
    Publication date: August 25, 2005
    Applicant: Fuji Photo Film Co., Ltd.
    Inventors: Kentaro Nakamura, Kazuya Kawasaki, Yoshiki Sakaino, Toshihisa Ito, Osamu Seshimoto
  • Publication number: 20050186110
    Abstract: It is an object of the invention to provide a multilayer analysis element with small intra-lot and lot-to-lot differences that has high measurement accuracy and which is small in size. The present invention provides a multilayer analysis element for the analysis of a liquid sample, comprising a water impermeable planar support on one side of which at least one functional layer and at least one porous liquid sample spreading layer of non-fibrous porous film are integrally laminated in the mentioned order, wherein said spreading layer comprises a non-fibrous porous film such that, when a liquid sample containing a target substance to be measured is caused to become attached to the surface of said liquid sample spreading layer, where said liquid sample is spread and dispersed, 30% or more of said target substance to be measured can be transferred to the at least one functional layer below said liquid sample spreading layer.
    Type: Application
    Filed: February 18, 2005
    Publication date: August 25, 2005
    Applicant: Fuji Photo Film Co., Ltd.
    Inventors: Kentaro Nakamura, Kazuya Kawasaki, Toshihisa Ito, Yoshiki Sakaino, Osamu Seshimoto
  • Publication number: 20050084953
    Abstract: The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the lebelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase.
    Type: Application
    Filed: October 7, 2004
    Publication date: April 21, 2005
    Inventors: Yoshiki Sakaino, Hitomi Ito, Toshihiro Mori, Osamu Seshimoto, Toshihisa Ito, Yoshikazu Amano
  • Publication number: 20030207332
    Abstract: The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the lebelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase.
    Type: Application
    Filed: April 10, 2003
    Publication date: November 6, 2003
    Inventors: Yoshiki Sakaino, Hitomi Ito, Toshihiro Mori, Osamu Seshimoto, Toshihisa Ito, Yoshikazu Amano
  • Patent number: 6616822
    Abstract: A silver/silver halide electrode composed of a non-electroconductive support sheet, a silver metal layer and a silver halide layer in order, is improved in its sensitivity by making the silver halide layer almost free from heavy metal element, for instance, by oxidizing the silver metal layer on its surface side with an oxidizing compound containing no heavy metal element or a chelated ferric oxidizing compound in the presence of a halide containing no heavy metal element.
    Type: Grant
    Filed: March 11, 2002
    Date of Patent: September 9, 2003
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Masaaki Terashima, Toshihisa Ito, Osamu Seshimoto
  • Publication number: 20030059821
    Abstract: The present invention provides a biosensor surface comprising a metal surface or metal membrane treated with a linker compound capable of binding to a physiologically active substance, a measurement chip for a biosensor having a physiologically active substance immobilized on the biosensor surface, a method for producing the same, and a method for measurement using the same. The present invention can provide a method for immobilizing a physiologically active substance on a metal surface in simple processes with high reliability while most of the molecules maintain activity and do not become detached.
    Type: Application
    Filed: August 30, 2002
    Publication date: March 27, 2003
    Inventors: Bo Yang, Shigeki Kageyama, Masayoshi Kojima, Toshihisa Ito, Hiroshi Shinoki, Yoshihiko Abe
  • Patent number: 6471868
    Abstract: A method for preparing a plasma or serum sample from a whole blood sample, by contacting a glass fiber filter which contains calcium, sodium or potassium components with an aqueous solution of an organic acid or a mineral acid to elute the calcium, sodium and potassium components in the glass fiber filter into the aqueous solution, separating the aqueous solution from the filter and washing the glass fiber filter with water to remove any residual aqueous solution adhered thereto and then filtering a whole blood sample through the thus treated fiber filter.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: October 29, 2002
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Toshihisa Ito, Takaki Arai, Kenichiro Yazawa, Osamu Seshimoto
  • Publication number: 20020134679
    Abstract: A silver/silver halide electrode composed of a non-electroconductive support sheet, a silver metal layer and a silver halide layer in order, is improved in its sensitivity by making the silver halide layer almost free from heavy metal element, for instance, by oxidizing the silver metal layer on its surface side with an oxidizing compound containing no heavy metal element or a chelated ferric oxidizing compound in the presence of a halide containing no heavy metal element.
    Type: Application
    Filed: March 11, 2002
    Publication date: September 26, 2002
    Inventors: Masaaki Terashima, Toshihisa Ito, Osamu Seshimoto
  • Patent number: 6217540
    Abstract: The invention provides a blood filter cartridge which is made so that the filtrate discharged from the filtrate outlet is not drawn back to the inside of the filtering chamber. The blood filter cartridge includes a blood filtering material, a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, and a filtrate receiver which receives the filtrate discharged from the filtrate outlet. The blood filter catridge is provided with a means for preventing the filtrate in the filtrate receiver from returning to inside of the holder upon finishing filtration. Such means include the following: removing opposite faces around the filtrate outlet, making length of lower end of the filtrate outlet 0.8 mm or more, smoothing surface around the filtrate outlet, and forming surface around the filtrate outlet by a material having a small surface energy.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: April 17, 2001
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Kenichiro Yazawa, Keiichi Ishizaki, Takeshi Igarashi, Masao Kitajima, Shigeru Tezuka, Takaki Arai, Toshihisa Ito, Osamu Seshimoto
  • Patent number: 4587170
    Abstract: A magnetic recording medium comprising a nonmagnetic support having coated thereon a magnetic recording layer comprising a ferromagnetic particles dispersed in a binder, the binder containing polyisocyanate and the molar ratio of (urethane bond+allophanate bond):(urea bond+biuret bond) being 85:15 to 60:40.
    Type: Grant
    Filed: June 28, 1984
    Date of Patent: May 6, 1986
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Kazuko Hanai, Takashi Yoneyama, Toshihisa Ito