Abstract: A method for evaluating the binding of an evaluation target molecule with respect to a macromolecular compound based on numerical calculations and which detects the binding sites of the evaluation target molecule with respect to the macromolecular compound as a site where electronic states in a predetermined restricted region including the evaluation target molecule and the part of the macromolecular compound, which is adjacent to the evaluation target molecule, are unstable.

Abstract: A method for evaluating the binding of an evaluation target molecule with respect to a macromolecular compound based on numerical calculations and which detects the binding sites of the evaluation target molecule with respect to the macromolecular compound as a site where electronic states in a predetermined restricted region including the evaluation target molecule and the part of the macromolecular compound, which is adjacent to the evaluation target molecule, are unstable.

Abstract: Cooling liquid flowing through cooling-liquid passages cools in heat-transmission manner an inner layer on an inner surface of an impermeable intermediate layer and is directed through a piping to an interface between the intermediate and outer layers, whereby the porous outer layer is cooled by latent heat generated by evaporation of the cooling liquid infiltrated into the porous outer layer.

Abstract: Cooling liquid flowing through cooling-liquid passages cools in heat-transmission manner an inner layer on an inner surface of an impermeable intermediate layer and is directed through a piping to an interface between the intermediate and outer layers, whereby the porous outer layer is cooled by latent heat generated by evaporation of the cooling liquid infiltrated into the porous outer layer.

Abstract: Cooling liquid flowing through cooling-liquid passages cools in heat-transmission manner an inner layer on an inner surface of an impermeable intermediate layer and is directed through a piping to an interface between the intermediate and outer layers, whereby the porous outer layer is cooled by latent heat generated by evaporation of the cooling liquid infiltrated into the porous outer layer.

Abstract: Cooling liquid flowing through cooling-liquid passages cools in heat-transmission manner an inner layer on an inner surface of an impermeable intermediate layer and is directed through a piping to an interface between the intermediate and outer layers, whereby the porous outer layer is cooled by latent heat generated by evaporation of the cooling liquid infiltrated into the porous outer layer.

Abstract: Cooling liquid flowing through cooling-liquid passages cools in heat-transmission manner an inner layer on an inner surface of an impermeable intermediate layer and is directed through a piping to an interface between the intermediate and outer layers, whereby the porous outer layer is cooled by latent heat generated by evaporation of the cooling liquid infiltrated into the porous outer layer.

Abstract: In an apparatus for depicting a pattern with a beam of electrically charged particles, error making appearance upon division of a pattern into a plurality of subpatterns each of a size suited for irradiation with a predetermined resolution is suppressed by adding a first coordinate of one of the adjacent subpatterns which is deviated from the origin serving as a reference point by a given distance with a half value of the predetermined resolution to thereby produce a first sum value whose fractional part smaller than the resolution is rounded off to thereby obtain a first output value representing the origin, whereon the first output value is subtracted from the first coordinate to obtain a second output value which is then added to a length of a side of the one subpattern extending from the first coordinate in the diretion to which the first coordinate belongs to thereby obtain a second sum value.