Abstract: The present invention relates to a pharmaceutical composition comprising an anti-PD-L1 antibody as an active ingredient, wherein the pharmaceutical composition is used in combination with camptothecin and/or a derivative thereof, or a pharmaceutically acceptable salt thereof.

Abstract: A detection apparatus for detecting abnormal operations at a point of sales (POS) terminal in a POS system that includes the POS terminal and an attendant terminal for monitoring the status of the POS terminal. The detection apparatus includes a camera interface connected to a camera for capturing images of customers operating the POS terminal, a network interface to communicate with a display control apparatus for the attendant terminal, and a processor configured to identify an action performed by a customer using an image thereof, identify an operation performed on the POS terminal by the customer based on changes in monitoring screen data generated by the display control apparatus for the attendant terminal, detect whether an abnormal operation is performed by the customer based on the identified actions and operations, and control the network interface to transmit a notification to the attendant terminal when an abnormal operation is performed.

Abstract: The present invention provides an odor-modulating agent that modulates malodors generated in daily living environments or industries to different odors so that harm caused by the malodors can be easily solved, and an odor-modulating method. Specifically, the present invention provides an odor-modulating agent comprising at least one oxygen-containing cyclic compound selected from the group consisting of furan compounds, pyran compounds, and cyclopentanone derivatives.

Abstract: Provided is a position measurement apparatus in which a measurement error in a target is reduced. A position measurement apparatus measuring a position of a target includes an illumination unit configured to illuminate the target with illumination light including light of a first wavelength and light of a second wavelength different from the first wavelength, a measurement unit configured to measure the position of the target by detecting light from the target illuminated with the illumination light, and a control unit configured to adjust a ratio of a light intensity of the first wavelength to a light intensity of the second wavelength such that a measurement error varying depending on the position of the target in the measurement unit is reduced.

Abstract: An issue is directed to suppressing light interference occurring between a plurality of waveguides and providing waveguides at high densities. Means for solving the issue includes a plurality of cores (104) each configured to allow light to be transmitted therethrough, a clad (106) surrounding the plurality of cores (104) and smaller in refractive index for light than each of the cores (104), and a transmission suppression member (108) located between mutually adjacent two cores out of the plurality of cores (104) and configured to suppress transmission of light leaking from each of the cores.

Abstract: The present invention relates to medicaments, treatment methods, kits, and uses for treating cancer in individuals, characterized in that a VEGF signaling inhibitor and a PD-1/PD-L1 signaling inhibitor are administered in combination, as well as VEGF signaling inhibitors, PD-1/PD-L1 signaling inhibitors, and combinations thereof.

Abstract: A measurement device for measuring a relative position between alignment marks includes an illumination unit capable of illuminating the alignment marks at a plurality of wavelengths, a detection unit that detects light from the alignment marks, a processing unit that obtain the relative position between the alignment marks, and an adjustment unit that adjusts a relative amount between light amounts of the plurality of wavelengths so that a relative value between detection light amounts of light from the alignment marks falls within a predetermined range.

Abstract: A multilayer substrate includes a plurality of plates laminated in a thickness direction of the multilayer substrate, a resin layer provided between the plurality of plates adjacent in the thickness direction, an internal conductive layer provided between the plurality of plates adjacent in the thickness direction, and an external conductive layer provided over an outer surface of each plate of the plurality of plates located at both ends in the thickness direction, wherein a total thickness of the internal conductive layer and the external conductive layer is equal to or less than 25% of a total thickness of the plurality of plates.

Abstract: Provided is a detection apparatus having a high detection accuracy. A detection apparatus comprises an optical element arranged at a position optically conjugate to a target surface, including a first region for forming illumination light that illuminates the target surface with a first angle distribution and a second region for forming illumination light that illuminates the target surface with a second angle distribution, a measurement mark arranged at the target surface; and a detector for detecting a deviation direction and a deviation amount of the optical element based on reflection light from the measurement mark illuminated by the first region and the second region of the optical element.

Abstract: Provided is a position measurement apparatus in which a measurement error in a target is reduced. A position measurement apparatus measuring a position of a target includes an illumination unit configured to illuminate the target with illumination light including light of a first wavelength and light of a second wavelength different from the first wavelength, a measurement unit configured to measure the position of the target by detecting light from the target illuminated with the illumination light, and a control unit configured to adjust a ratio of a light intensity of the first wavelength to a light intensity of the second wavelength such that a measurement error varying depending on the position of the target in the measurement unit is reduced.

Abstract: According to one embodiment, a commodity management device includes a first sensor configured to detect a movement of a commodity from a display region and a second sensor configured to detect a removal of a commodity from of the display region to outside of the display region by a person. A controller is configured to notify a designated notification destination when the movement of the commodity from the display region is detected by the first sensor but the removal of the commodity from the display region to outside the display region by a person has not been detected.

Abstract: A transaction processing system including a sensing device, one or more cameras, and a processor. The sensing device is configured to detect displacement of a commodity item from a commodity display section. The one or more cameras are configured to capture images around the commodity display section. The processor is configured to track a location of each of one or more customers who is determined to have entered a first area around the commodity display section based on the captured images, and upon detection of the displacement of the commodity item by the sensing device, perform an operation to determine a purchasing customer of the commodity item based on the tracked location of each of the one or more customers, and cause purchase registration of the commodity item in association with an ID of the purchasing customer.

Abstract: A circuit board includes: a first substrate including a first through hole, a first metal layer formed over an inner wall of the first through hole, and a first conductive composite resin provided on an inner side of the first metal layer of the first through hole; and a second substrate stacked together with the first substrate and including a second through hole that faces the first through hole and has a first open end which is provided on a side of the first through hole and is located on the inner side of the first metal layer, and a second conductive composite resin that is provided in the second through hole and is coupled to the first conductive composite resin.

Abstract: The present invention relates to a pharmaceutical composition comprising an anti-PD-L1 antibody as an active ingredient, wherein the pharmaceutical composition is used in combination with camptothecin and/or a derivative thereof, or a pharmaceutically acceptable salt thereof.

Abstract: A detection device includes an illumination optical system and a detection optical system. The illumination optical system is configured to illuminate a first diffraction grating having a first period in a first direction and a second diffraction grating having a second period different from the first period. The detection optical system is configured to detect light diffracted by the first and second diffraction gratings. The illumination optical system includes an optical member configured to form, on a pupil plane, a first pole and a second pole opposite to the first pole. The illumination optical system causes lights from the first and second poles to obliquely enter the first and second diffraction gratings from the first direction to illuminate the first and second diffraction gratings. The detection optical system detects diffracted light diffracted by one of the first and second diffraction gratings and by an other diffraction grating.

Abstract: A wiring board includes: an insulating layer that includes a first surface over which an electronic component is mounted and a second surface opposite to the first surface; a conductive layer that is disposed on the second surface; a via that is provided inside a first through-hole that penetrates a portion between the first surface and the second surface of the insulating layer; an electrode that is disposed on the first surface and connected to the via; and a glass plate that is not contact with the conductive layer and is disposed on the first surface and includes a second through-hole through which the electrode is disposed.

Abstract: A wiring board includes: an insulating layer that includes a first surface over which an electronic component is mounted and a second surface opposite to the first surface; a conductive layer that is disposed on the second surface; a via that is provided inside a first through-hole that penetrates a portion between the first surface and the second surface of the insulating layer; an electrode that is disposed on the first surface and connected to the via; and a glass plate that is not contact with the conductive layer and is disposed on the first surface and includes a second through-hole through which the electrode is disposed.

Abstract: A substrate includes: a glass layer having a first surface, a second surface opposite to the first surface, and a through hole penetrating between the first surface and the second surface; a metal layer provided in a first portion of the through hole, the first portion extending from the first surface and not reaching the second surface; and a conductive layer provided in a second portion of the through hole, coupled to the metal layer, and containing a resin and a conductive filler mixed with the resin, the second portion extending from the second surface and not reaching the first surface.

Abstract: A multilayer substrate includes a plurality of plates laminated in a thickness direction of the multilayer substrate, a resin layer provided between the plurality of plates adjacent in the thickness direction, an internal conductive layer provided between the plurality of plates adjacent in the thickness direction, and an external conductive layer provided over an outer surface of each plate of the plurality of plates located at both ends in the thickness direction, wherein a total thickness of the internal conductive layer and the external conductive layer is equal to or less than 25% of a total thickness of the plurality of plates.

Abstract: A wiring substrate includes: a first plate member including a first surface and a second surface opposite to the first surface; a first through wiring configured to extend in a tubular shape from the first surface to the second surface along an inner peripheral surface of a first through hole; a conductive member provided at an end of the first through wiring on a first surface side of the first plate member; a second plate member including a third surface and a fourth surface opposite to the third surface, the fourth surface facing the first surface of the first plate member; and a second through wiring configured to extend from the third surface to the fourth surface along an inner peripheral surface of a second through hole and be in contact with the conductive member.