Patents by Inventor Toshio Heike

Toshio Heike has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9921212
    Abstract: A method of screening for a therapeutic and/or preventive drug for cartilaginous hyperplasia and a therapeutic and/or preventive drug for cartilaginous hyperplasia are provided. The following are provided: a method of screening for a therapeutic and/or preventive drug for cartilaginous hyperplasia, comprising a step of culturing chondroprogenitor cells under conditions in which the cells are brought into contact with a test substance and conditions in which the cells are not brought into contact with the test substance and a step of determining the SOX9 promoter activity, cAMP level, or degree of phosphorylation of CREB in the cells or the extracellular matrix volume in a culture; and a therapeutic and/or preventive drug for cartilaginous hyperplasia, comprising as an active ingredient an adenylate cyclase inhibitor.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: March 20, 2018
    Assignee: Kyoto University
    Inventors: Junya Toguchida, Ryuta Nishikomori, Koji Yokoyama, Makoto Ikeya, Toshio Heike
  • Publication number: 20160177406
    Abstract: A method of screening for a therapeutic and/or preventive drug for cartilaginous hyperplasia and a therapeutic and/or preventive drug for cartilaginous hyperplasia are provided. The following are provided: a method of screening for a therapeutic and/or preventive drug for cartilaginous hyperplasia, comprising a step of culturing chondroprogenitor cells under conditions in which the cells are brought into contact with a test substance and conditions in which the cells are not brought into contact with the test substance and a step of determining the SOX9 promoter activity, cAMP level, or degree of phosphorylation of CREB in the cells or the extracellular matrix volume in a culture; and a therapeutic and/or preventive drug for cartilaginous hyperplasia, comprising as an active ingredient an adenylate cyclase inhibitor.
    Type: Application
    Filed: October 9, 2015
    Publication date: June 23, 2016
    Applicant: KYOTO UNIVERSITY
    Inventors: Junya Toguchida, Ryuta Nishikomori, Koji Yokoyama, Makoto Ikeya, Toshio Heike
  • Patent number: 8883498
    Abstract: A method for inducing the differentiation of pluripotent stem cells into skeletal muscle or skeletal muscle progenitor cells is provided. Specifically, a method for producing artificial skeletal muscle or skeletal muscle progenitor cells from human pluripotent stem cells is provided, comprising the following steps of: (1) culturing human pluripotent stem cells by suspension culture; (2) culturing a cell population after suspension culture by adhesion culture; (3) dissociating cells after adhesion culture; and (4) culturing the dissociated cells by adhesion culture. Artificial skeletal muscle or induced skeletal muscle progenitor cells prepared by the method are also provided.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: November 11, 2014
    Assignee: Kyoto University
    Inventors: Toshio Heike, Tatsutoshi Nakahata, Tomonari Awaya
  • Patent number: 8652845
    Abstract: The present invention provides a method for inducing differentiation of pluripotent stem cells into mesodermal cells, comprising the step of culturing pluripotent stem cells in a serum-free medium without forming an embryoid body and without coculturing with cells from a different species.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: February 18, 2014
    Assignee: Kyoto University
    Inventors: Akira Niwa, Tatsutoshi Nakahata, Toshio Heike
  • Publication number: 20130040387
    Abstract: A method for inducing the differentiation of pluripotent stem cells into skeletal muscle or skeletal muscle progenitor cells is provided. Specifically, a method for producing artificial skeletal muscle or skeletal muscle progenitor cells from human pluripotent stem cells is provided, comprising the following steps of: (1) culturing human pluripotent stem cells by suspension culture; (2) culturing a cell population after suspension culture by adhesion culture; (3) dissociating cells after adhesion culture; and (4) culturing the dissociated cells by adhesion culture. Artificial skeletal muscle or induced skeletal muscle progenitor cells prepared by the method are also provided.
    Type: Application
    Filed: April 21, 2011
    Publication date: February 14, 2013
    Applicant: Kyoto University
    Inventors: Toshio Heike, Tatsutoshi Nakahata, Tomonari Awaya
  • Publication number: 20130011924
    Abstract: The present invention provides a method for inducing differentiation of pluripotent stem cells into mesodermal cells, comprising the step of culturing pluripotent stem cells in a serum-free medium without forming an embryoid body and without coculturing with cells from a different species.
    Type: Application
    Filed: March 18, 2011
    Publication date: January 10, 2013
    Applicant: KYOTO UNIVERSITY
    Inventors: Akira Niwa, Tatsutoshi Nakahata, Toshio Heike