Patents by Inventor Toshio Shinohara

Toshio Shinohara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10626095
    Abstract: This invention relates to a cyanotriazole compound represented by the formula (1): wherein each symbols are defined in the specification, or a salt thereof. The compound or a salt thereof stimulates the citric acid cycle activity and/or improves hyperglycemia with less side effects, and excellent safety, and therefore, it is useful for treating and/or preventing diseases or disorders on which citric acid cycle activation and/or improvement of hyperglycemia has a prophylactic and/or therapeutic effect, for example, diabetes, impaired glucose tolerance, insulin resistance, diabetic complications, obesity, dyslipidemia, hepatic steatosis, atherosclerosis and/or cardiovascular disease, as well as diseases or disorders that would benefit from stimulating energy expenditure.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: April 21, 2020
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Seiji Sato, Satoshi Matsuda, Chiharu Matsumura, Motohiro Itotani, Toshio Shinohara, Shigekazu Fujita, Yohji Sakurai, Kuninori Tai, Tae Fukushima, Naohide Kanemoto, Takashi Okamoto
  • Patent number: 10464926
    Abstract: It is an object of the present invention to provide a compound having an excellent antibacterial activity against tuberculosis bacteria, multidrug-resistant tuberculosis bacteria and/or non-tuberculous mycobacteria. Disclosed is a compound of the general formula (1): wherein each symbol is defined as described in the attached specification, or a salt thereof.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: November 5, 2019
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Hiroshi Shimizu, Yoshikazu Kawano, Shunpei Ishikawa, Yukitaka Uematsu, Toshio Shinohara, Motohiro Itotani, Yoshikazu Haraguchi, Isao Takemura, Atsunori Kaneshige, Yuya Nakai, Norimitsu Hariguchi, Yohei Hayashi, Makoto Matsumoto
  • Publication number: 20180312488
    Abstract: It is an object of the present invention to provide a compound having an excellent antibacterial activity against tuberculosis bacteria, multidrug-resistant tuberculosis bacteria and/or non-tuberculous mycobacteria. Disclosed is a compound of the general formula (1): wherein each symbol is defined as described in the attached specification, or a salt thereof.
    Type: Application
    Filed: July 9, 2018
    Publication date: November 1, 2018
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Hiroshi SHIMIZU, Yoshikazu KAWANO, Shunpei ISHIKAWA, Yukitaka UEMATSU, Toshio SHINOHARA, Motohiro ITOTANI, Yoshikazu HARAGUCHI, Isao TAKEMURA, Atsunori KANESHIGE, Yuya NAKAI, Norimitsu HARIGUCHI, Yohei HAYASHI, Makoto MATSUMOTO
  • Patent number: 10053446
    Abstract: It is an object of the present invention to provide a compound having an excellent antibacterial activity against tuberculosis bacteria, multidrug-resistant tuberculosis bacteria and/or non-tuberculous mycobacteria. Disclosed is a compound of the general formula (1): wherein each symbol is defined as described in the attached specification, or a salt thereof.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: August 21, 2018
    Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Hiroshi Shimizu, Yoshikazu Kawano, Shunpei Ishikawa, Yukitaka Uematsu, Toshio Shinohara, Motohiro Itotani, Yoshikazu Haraguchi, Isao Takemura, Atsunori Kaneshige, Yuya Nakai, Norimitsu Hariguchi, Yohei Hayashi, Makoto Matsumoto
  • Publication number: 20170253576
    Abstract: It is an object of the present invention to provide a compound having an excellent antibacterial activity against tuberculosis bacteria, multidrug-resistant tuberculosis bacteria and/or non-tuberculous mycobacteria. Disclosed is a compound of the general formula (1): wherein each symbol is defined as described in the attached specification, or a salt thereof.
    Type: Application
    Filed: August 28, 2015
    Publication date: September 7, 2017
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Hiroshi SHIMIZU, Yoshikazu KAWANO, Shunpei ISHIKAWA, Yukitaka UEMATSU, Toshio SHINOHARA, Motohiro ITOTANI, Yoshikazu HARAGUCHI, Isao TAKEMURA, Atsunori KANESHIGE, Yuya NAKAI, Norimitsu HARIGUCHI, Yohei HAYASHI, Makoto MATSUMOTO
  • Publication number: 20160229816
    Abstract: This invention relates to a cyanotriazole compound represented by the formula (1): wherein each symbols are defined in the specification, or a salt thereof. The compound or a salt thereof stimulates the citric acid cycle activity and/or improves hyperglycemia with less side effects, and excellent safety, and therefore, it is useful for treating and/or preventing diseases or disorders on which citric acid cycle activation and/or improvement of hyperglycemia has a prophylactic and/or therapeutic effect, for example, diabetes, impaired glucose tolerance, insulin resistance, diabetic complications, obesity, dyslipidemia, hepatic steatosis, atherosclerosis and/or cardiovascular disease, as well as diseases or disorders that would benefit from stimulating energy expenditure.
    Type: Application
    Filed: July 16, 2014
    Publication date: August 11, 2016
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Seiji SATO, Satoshi MATSUDA, Chiharu MATSUMURA, Motohire ITOTANI, Toshio SHINOHARA, Shigekazu FUJITA, Yohji SAKURAI, Kuninori TAI, Tae FUKUSHIMA, Naohide KANEMOTO, Takashi OKAMOTO
  • Patent number: 6984748
    Abstract: In a Rochow process, organohalosilanes are prepared by reacting metallic silicon particles with an organohalide in the presence of a copper catalyst and a co-catalyst. The invention uses as the co-catalyst a powder of co-catalyst active element-copper alloy containing substantial strain energy because this co-catalyst can reduce the activation time taken until a steady state is reached, which has been an outstanding problem in Rochow reaction, maintain the steady state over time and increase the selectivity of desired diorganodihalosilane for eventually increasing the yield based on the starting silicon.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: January 10, 2006
    Assignee: Shin-Etsu Chemical Co., LTD
    Inventors: Mikio Aramata, Hideaki Ozeki, Akio Muraida, Susumu Ueno, Toshio Shinohara, Tetsuya Inukai
  • Patent number: 6894181
    Abstract: In an industrial process for preparing organohalosilanes by reacting metallic silicon particles with an organohalide in the presence of a copper catalyst, a contact mass composed of the metallic silicon and the catalyst further contains an effective amount of a phosphine chalcogenide compound. The invention drastically increases the silane formation rate and the utilization of silicon without lowering the selectivity of useful silane.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: May 17, 2005
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Susumu Ueno, Toshio Shinohara, Mikio Aramata, Yoichi Tanifuji, Tetsuya Inukai, Hajime Ishizaka
  • Patent number: 6727376
    Abstract: In an industrial process for preparing organohalosilanes by reacting metallic silicon particles with an organohalide in the presence of a copper catalyst, a contact mass composed of the metallic silicon and the catalyst further contains an effective amount of a phosphonium compound having on the molecule at least one group of the formula: [R2R3R4P—]+Y− wherein R2, R3 and R4 each are a monovalent hydrocarbon group and Y is a halogen atom or acid group. The invention drastically increases the silane formation rate and the utilization of silicon without lowering the selectivity of useful silane.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: April 27, 2004
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Susumu Ueno, Toshio Shinohara, Mikio Aramata, Yoichi Tanifuji, Tetsuya Inukai, Hajime Ishizaka
  • Patent number: 6686312
    Abstract: In the synthesis of organohalosilanes by the direct process of reacting an organic halogen with metallic silicon powder, a metallic copper catalyst in the form of a thermally active metallic copper powder having large strain energy is used.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: February 3, 2004
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Mikio Aramata, Masaaki Furuya, Yoshihiro Shirota, Akio Muraida, Susumu Ueno, Toshio Shinohara
  • Publication number: 20030199705
    Abstract: In an industrial process for preparing organohalosilanes by reacting metallic silicon particles with an organohalide in the presence of a copper catalyst, a contact mass composed of the metallic silicon and the catalyst further contains an effective amount of a phosphine chalcogenide compound. The invention drastically increases the silane formation rate and the utilization of silicon without lowering the selectivity of useful silane.
    Type: Application
    Filed: April 23, 2003
    Publication date: October 23, 2003
    Inventors: Susumu Ueno, Toshio Shinohara, Mikio Aramata, Yoichi Tanifuji, Tetsuya Inukai, Hajime Ishizaka
  • Publication number: 20030055277
    Abstract: In an industrial process for preparing organohalosilanes by reacting metallic silicon particles with an organohalide in the presence of a copper catalyst, a contact mass composed of the metallic silicon and the catalyst further contains an effective amount of a phosphonium compound having on the molecule at least one group of the formula: [R2R3R4P—]+Y− wherein R2, R3 and R4 each are a monovalent hydrocarbon group and Y is a halogen atom or acid group. The invention drastically increases the silane formation rate and the utilization of silicon without lowering the selectivity of useful silane.
    Type: Application
    Filed: August 29, 2002
    Publication date: March 20, 2003
    Inventors: Susumu Ueno, Toshio Shinohara, Mikio Aramata, Yoichi Tanifuji, Tetsuya Inukai, Hajime Ishizaka
  • Patent number: 6506923
    Abstract: In a process for preparing oganohalosilanes by reacting metallic silicon particles with an organohalide in the presence of a copper catalyst, a contact mass composed of the metallic silicon and the catalyst further contains a minute, but effective amount of a catalytic metal powder which has been produced by an atomizing technique. The process is successful in drastically increasing a formation rate without lowering the selectivity of useful silane.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: January 14, 2003
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Tetsuya Inukai, Susumu Ueno, Toshio Shinohara, Mikio Aramata, Yoichi Tanifuji, Hajime Ishizaka
  • Publication number: 20020183536
    Abstract: In a Rochow process, organohalosilanes are prepared by reacting metallic silicon particles with an organohalide in the presence of a copper catalyst and a co-catalyst. The invention uses as the co-catalyst a powder of co-catalyst active element-copper alloy containing substantial strain energy because this co-catalyst can reduce the activation time taken until a steady state is reached, which has been an outstanding problem in Rochow reaction, maintain the steady state over time and increase the selectivity of desired diorganodihalosilane for eventually increasing the yield based on the starting silicon.
    Type: Application
    Filed: April 10, 2002
    Publication date: December 5, 2002
    Inventors: Mikio Aramata, Hideaki Ozeki, Akio Muraida, Susumu Ueno, Toshio Shinohara, Tetsuya Inukai
  • Publication number: 20020156310
    Abstract: In a process for preparing oganohalosilanes by reacting metallic silicon particles with an organohalide in the presence of a copper catalyst, a contact mass composed of the metallic silicon and the catalyst further contains a minute, but effective amount of a catalytic metal powder which has been produced by an atomizing technique. The process is successful in drastically increasing a formation rate without lowering the selectivity of useful silane.
    Type: Application
    Filed: February 14, 2002
    Publication date: October 24, 2002
    Inventors: Tetsuya Inukai, Susumu Ueno, Toshio Shinohara, Mikio Aramata, Yoichi Tanifuji, Hajime Ishizaka
  • Publication number: 20020082437
    Abstract: When oganohalosilanes are prepared by charging a reactor with a contact mass containing a metallic silicon powder, a copper catalyst and a co-catalyst, and introducing an organohalide-containing gas into the reactor to effect the direct reaction, the catalyst and/or co-catalyst used in the contact mass is obtained by mixing particles of the catalyst and/or co-catalyst with finely divided silica, and applying shear forces to the mixture for mutually rubbing the particles, thereby producing the catalyst and/or co-catalyst having finely divided silica fused to surfaces thereof. The invention is successful in producing organohalosilanes at a significantly improved formation rate without reducing the proportion of diorganodihalosilane.
    Type: Application
    Filed: October 19, 2001
    Publication date: June 27, 2002
    Inventors: Hajime Ishizaka, Susumu Ueno, Toshio Shinohara, Yoichi Tanifuji, Tetsuya Inukai, Mikio Aramata
  • Patent number: 6395917
    Abstract: When oganohalosilanes are prepared by charging a reactor with a contact mass containing a metallic silicon powder, a copper catalyst and a co-catalyst, and introducing an organohalide-containing gas into the reactor to effect the direct reaction, the catalyst and/or co-catalyst used in the contact mass is obtained by mixing particles of the catalyst and/or co-catalyst with finely divided silica, and applying shear forces to the mixture for mutually rubbing the particles, thereby producing the catalyst and/or co-catalyst having finely divided silica fused to surfaces thereof. The invention is successful in producing organohalosilanes at a significantly improved formation rate without reducing the proportion of diorganodihalosilane.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: May 28, 2002
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Hajime Ishizaka, Susumu Ueno, Toshio Shinohara, Yoichi Tanifuji, Tetsuya Inukai, Mikio Aramata
  • Patent number: 6365766
    Abstract: Organohalosilanes are prepared by reacting an organic halide with metallic silicon particles in the presence of a metallic copper catalyst which is a metallic copper powder in flake form having a bulk specific gravity of 1-3 g/cm3 and a mean particle size of 10 &mgr;m to 1 mm as measured by laser diffraction particle size distribution analysis.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: April 2, 2002
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Mikio Aramata, Masaaki Furuya, Yoshihiro Shirota, Akio Muraida, Susumu Ueno, Toshio Shinohara
  • Patent number: 6353274
    Abstract: The present invention provides a mounting structure of a rotary shaft of rotary electric machinery in which it is possible to cope with vibration of the rotary shaft in an axial direction with a low parts count. A fitting groove into which a portion of a rear side stopper is fitted is formed at a rear end portion of the rotary shaft. A rear side stopper has three projecting chips fitted into the fitting groove and three leaf spring chips in contact with an inner ring of a rolling bearing forming a bearing structure. The rear side stopper has a structure in which the rear side stopper generates spring force for restoring an original shape thereof when the rear side stopper is compressed in an axial direction of the rotary shaft. The rear side stopper is disposed in a compressed state between a wall face surrounding the fitting groove and the inner ring of the rolling bearing.
    Type: Grant
    Filed: May 23, 2000
    Date of Patent: March 5, 2002
    Assignee: Sanyo Denki Co., Ltd.
    Inventors: Toshiki Ogawara, Toshio Shinohara, Michihiro Suzuki
  • Patent number: 6250952
    Abstract: The igniter connector comprises an insulating housing having a bead-receiving cavity open at one end, a partition in a center of a bottom wall of the cavity, a ferrite bead disposed in the bead-receiving cavity, and holes in the bottom wall of the bead-receiving cavity for insertion of pin terminals, the ferrite bead that is inserted in the bead-receiving cavity and secured in the insulating housing with the ferrite bead having a central opening through which the partition is passed when the ferrite bead is inserted in the bead-receiving cavity, a pair of electrical contacts having receptacle sections for electrical connection with the pin terminals are arranged in contact-receiving cavities disposed between the partition and the ferrite bead inserted in the bead-receiving cavity and wire-connecting sections for connection to electrical wires, and a cover member enclosing the bead-receiving cavity of the insulating housing is latched to the housing and has posts coaxially aligning the receptacle sections of t
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: June 26, 2001
    Assignee: The Whitaker Corporation
    Inventors: Katsumi Shiga, Hiroshi Kitamura, Toshio Shinohara, Hidehisa Yamagami