Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Abstract: Methods, systems, and media are disclosed for providing career motivation, career inspiration and career guidance to a user through one or more journeys. Metrics concerning attention and fact retention of the user after having been presented with one or more career videos on a user device and after the user having responded to career- and skill-specific situational learning exercises and questioning may be recorded in a student record. A career code, such as a Holland Code, may be determined for the user using the responses provided by the user during a career tendency assessment. Metrics of the user's selection of one or more careers may be recorded in the student record. Mentor interaction may be provided for the selected one or more careers and results of the mentor interaction may be stored in the student record. One or more virtual field trips may be provided to the user and results of the one or more virtual field trips may be stored in the student record.

Abstract: Methods, systems, and media are disclosed for providing career motivation, career inspiration and career guidance to a user through one or more journeys. Metrics concerning attention and fact retention of the user after having been presented with one or more career videos on a user device and after the user having responded to career- and skill-specific situational learning exercises and questioning may be recorded in a student record. A career code, such as a Holland Code, may be determined for the user using the responses provided by the user during a career tendency assessment. Metrics of the user's selection of one or more careers may be recorded in the student record. Mentor interaction may be provided for the selected one or more careers and results of the mentor interaction may be stored in the student record. One or more virtual field trips may be provided to the user and results of the one or more virtual field trips may be stored in the student record.

Abstract: Methods, systems, and media are disclosed for providing career motivation, career inspiration and career guidance to a user through one or more journeys. Metrics concerning attention and fact retention of the user after having been presented with one or more career videos on a user device and after the user having responded to career- and skill-specific situational learning exercises and questioning may be recorded in a student record. A career code, such as a Holland Code, may be determined for the user using the responses provided by the user during a career tendency assessment. Metrics of the user's selection of one or more careers may be recorded in the student record. Mentor interaction may be provided for the selected one or more careers and results of the mentor interaction may be stored in the student record. One or more virtual field trips may be provided to the user and results of the one or more virtual field trips may be stored in the student record.

Abstract: A downhole tool for use in a well has a mandrel with an expandable sealing element disposed thereabout. The mandrel has a head portion threadedly connected thereto. A shoulder in the head portion and an upper end of the mandrel define an annular space. A sleeve with a bore therethrough may be positioned in the annular space. The head portion may be removed and a solid plug installed so that it fits within the annular space and so that the downhole tool will act as a bridge plug. The downhole tool has slip rings made up of a plurality of individual slip segments that are adhesively bonded to one another at the sides thereof.

Abstract: Herein disclosed is a frac ball comprising three orthogonal axes x, y, and z; wherein the frac ball has approximately equal strength in each direction of the three axes x, y, and z. In an embodiment, the frac ball comprises a resin. In an embodiment, the frac ball comprises glass fibers or carbon fibers or both. In an embodiment, the frac ball comprises an equal amount of glass fibers in each direction of the x, y, and z axes. In an embodiment, the frac ball comprises glass fibers in the x and y axes and carbon fibers in the z axis. In an embodiment, the frac ball comprises no interlaminar layers. In an embodiment, the frac ball has different diameters. Also disclosed herein are methods of making and using such frac balls.

Abstract: A downhole tool for use in a well has a mandrel with an expandable sealing element disposed thereabout. The mandrel has a head portion threadedly connected thereto. A shoulder in the head portion and an upper end of the mandrel define an annular space. A sleeve with a bore therethrough may be positioned in the annular space. The head portion may be removed and a solid plug installed so that it fits within the annular space and so that the downhole tool will act as a bridge plug. The downhole tool has slip rings made up of a plurality of individual slip segments that are adhesively bonded to one another at the sides thereof.

Abstract: A bridge plug having a segmented backup shoe, and at least one split cone extrusion limiter, the extrusion limiter comprising a two part conical retainer positioned between packer elements and the segmented backup shoe to block packer element extrusion though spaces between backup shoe segments. In one embodiment, two split cone extrusion limiters are used together and positioned so that each split cone extrusion limiter covers gaps in the other extrusion limiter and together the two split cone extrusion limiters block packer element extrusion though gaps between backup shoe segments regardless of their orientation relative to the segmented backup shoe. In one embodiment, a solid retaining ring is positioned between a split retaining cone extrusion limiter and a packer element and resists extrusion of packer elements into spaces in the split cone extrusion limiter or limiters.

Abstract: A bridge plug having a segmented backup shoe, and at least one split cone extrusion limiter, the extrusion limiter comprising a two part conical retainer positioned between packer elements and the segmented backup shoe to block packer element extrusion though spaces between backup shoe segments. In one embodiment, two split cone extrusion limiters are used together and positioned so that each split cone extrusion limiter covers gaps in the other extrusion limiter and together the two split cone extrusion limiters block packer element extrusion though gaps between backup shoe segments regardless of their orientation relative to the segmented backup shoe. In one embodiment, a solid retaining ring is positioned between a split retaining cone extrusion limiter and a packer element and resists extrusion of packer elements into spaces in the split cone extrusion limiter or limiters.

Abstract: The invention provides methods and compositions relating to the Tax-response Complex-1 (TRC-1) a transcription complex associated with disease, particularly HTLV infection. TRC-1 is composed of novel forms of JunB and a member of a novel protein family called small nuclear factors or SNFs. The expression of these compounds are shown to correlate with cell lineage, activation and infection. SNFs and T-cell specific forms of JunB, find particular use in screening assays for agents or lead compounds for agents useful in the diagnosis, prognosis or treatment of disease, particularly HTLV infection. Nucleic acids encoding SNFs, and SNF-specific binding agents find use in diagnosis and as commercial reagents for the biopharmaceutical industry.

Abstract: The invention provides methods and compositions relating to the Tax-response Complex-1 (TRC-1) a transcription complex associated with disease, particularly HTLV infection. TRC-1 is composed of novel forms of JunB and a member of a novel protein family called small nuclear factors or SNFs. The expression of these compounds are shown to correlate with cell lineage, activation and infection. SNFs and T-cell specific forms of JunB, find particular use in screening assays for agents or lead compounds for agents useful in the diagnosis, prognosis or treatment of disease, particularly HTLV infection. Nucleic acids encoding SNFs, and SNF-specific binding agents find use in diagnosis and as commercial reagents for the biopharmaceutical industry.