Patents by Inventor Trond Erling Ellingsen
Trond Erling Ellingsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10494375Abstract: The invention provides a new compound, a method to produce it and use of it as an antimicrobial agent, as well as pharmaceutical compositions comprising it. It is also disclosed use of actinomycetes bacteria to produce the compound (Formula III).Type: GrantFiled: April 21, 2017Date of Patent: December 3, 2019Assignee: SINTEF TTO ASInventors: Havard Sletta, Kristin Flogstad Degnes, Trond Erling Ellingsen, Anna Nordborg, Geir Klinkenberg, Sigrid Hakvag
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Publication number: 20190135822Abstract: The invention provides a new compound, a method to produce it and use of it as an antimicrobial agent, as well as pharmaceutical compositions comprising it. It is also disclosed use of actinomycetes bacteria to produce the compound (Formula III).Type: ApplicationFiled: April 21, 2017Publication date: May 9, 2019Inventors: HAVARD SLETTA, KRISTIN FLOGSTAD DEGNES, TROND ERLING ELLINGSEN, ANNA NORDBORG, GEIR KLINKENBERG, SIGRID HAKVAG
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Patent number: 10047363Abstract: A nucleic acid molecule comprises a nucleotide sequence: as shown in SEQ ID No. 1, which is the complement of SEQ ID No. 1, which is degenerate with SEQ ID No. 1, or which has at least 85% sequence identity with SEQ ID No. 1, or which is a part of such a sequence. The nucleic acid molecule encodes or is a complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of a polyketide-based or macrolactam molecule. The nucleic acid molecule may be used to prepare a modified BE-14106 biosynthetic gene cluster for the preparation of a modified BE-14106 molecule.Type: GrantFiled: November 11, 2015Date of Patent: August 14, 2018Assignee: SINTEF TTO ASInventors: Hanne Jørgensen, Havard Sletta, Trond Erling Ellingsen, Espen Fjaervik, Kristin Fløgstad Degnes, Geir Klinkenberg, Per Bruheim, Sergey Zotchev
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Publication number: 20160060636Abstract: A nucleic acid molecule comprises a nucleotide sequence: as shown in SEQ ID No. 1, which is the complement of SEQ ID No. 1, which is degenerate with SEQ ID No. 1, or which has at least 85% sequence identity with SEQ ID No. 1, or which is a part of such a sequence. The nucleic acid molecule encodes or is a complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of a polyketide-based or macrolactam molecule. The nucleic acid molecule may be used to prepare a modified BE-14106 biosynthetic gene cluster for the preparation of a modified BE-14106 molecule.Type: ApplicationFiled: November 11, 2015Publication date: March 3, 2016Inventors: Hanne JØRGENSEN, Havard SLETTA, Trond Erling ELLINGSEN, Espen FJAERVIK, Kristin Fløgstad DEGNES, Geir KLINKENBERG, Per BRUHEIM, Sergey ZOTCHEV
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Patent number: 9217150Abstract: The present invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 1; or (b) a nucleotide sequence which is the complement of SEQ ID No. 1; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 1; or (d) a nucleotide sequence having at least 85% sequence identity (preferably at least 87%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity) with SEQ ID No. 1; or (e) a part of any one of (a) to (d), wherein said nucleic acid molecule encodes or is a complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of a polyketide-based or macrolactam molecule.Type: GrantFiled: March 20, 2009Date of Patent: December 22, 2015Assignee: SINTEF TTO ASInventors: Hanne Jørgensen, Trond Erling Ellingsen, Kristin Fløgstad Degnes, Per Bruheim, Håvard Sletta, Espen Fjærvik, Geir Klinkenberg, Sergey Zotchev
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Publication number: 20140031534Abstract: The present invention provides a compound which is a nystatin derivative having an additional double bond present between C28 and C29 and which is further modified relative to nystatin at one or more of positions C5, C7, C9, C10, C11, C16 or at the amino group of mycosamine.Type: ApplicationFiled: March 8, 2013Publication date: January 30, 2014Applicant: BIOSERGEN ASInventors: Sergey Borisovich ZOTCHEV, Sven Even Finn BORGOS, Trygve BRAUTASET, Trond Erling ELLINGSEN, Evgenia Nikolaevna OLSUFYEVA, Maria Nikolaevna PREOBRAZHENSKAYA, Havard SLETTA
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Patent number: 8415312Abstract: The present invention relates to compounds which are nystatin derivatives and are anti-fungal agents.Type: GrantFiled: June 30, 2008Date of Patent: April 9, 2013Assignee: Biosergen ASInventors: Sergey Borisovich Zotchev, Sven Even Finn Borgos, Trygve Brautaset, Trond Erling Ellingsen, Evgenia Nikolaevna Olsufyeva, Maria Nikolaevna Preobrazhenskaya, Havard Sletta
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Publication number: 20110117606Abstract: The present invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 1; or (b) a nucleotide sequence which is the complement of SEQ ID No. 1; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 1; or (d) a nucleotide sequence having at least 85% sequence identity (preferably at least 87%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity) with SEQ ID No. 1; or (e) a part of any one of (a) to (d), wherein said nucleic acid molecule encodes or is a complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of a polyketide-based or macrolactam molecule.Type: ApplicationFiled: March 20, 2009Publication date: May 19, 2011Inventors: Hanne Jørgensen, Trond Erling Ellingsen, Kristin Fløgstad Degnes, Per Bruheim, Håvard Sletta, Espen Fjaervik, Geir Klinkenberg, Sergey Zotchev
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Patent number: 7851183Abstract: The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof.Type: GrantFiled: March 29, 2010Date of Patent: December 14, 2010Assignee: Sinvent ASInventors: Sergey Borisovich Zotchev, Olga Nikolayivna Sekurova, Espen Fjærvik, Trygve Brautaset, Arne Reidar Strøm, Svein Valla, Trond Erling Ellingsen, Håvard Sletta, Ole-Martin Gulliksen
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Publication number: 20100286077Abstract: The present invention provides a compound of formula (I?) which is a nystatin derivative having an additional double bond present between C28 and C29 and which is further modified relative to nystatin at one or more of positions C5, C7, C9, C10, C11, C16 or at the amino group of mycosamine. These compounds are used as anti-fungal agents.Type: ApplicationFiled: June 30, 2008Publication date: November 11, 2010Inventors: Sergey Borisovich Zotchev, Sven Even Finn Borgos, Trygve Brautaset, Trond Erling Ellingsen, Evgenia Nikolaevna Olsufyeva, Maria Nikolaevna Preobrazhenskaya, Havard Sletta
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Publication number: 20100227779Abstract: The present invention relates to a cloning vector for cloning of DNA in a broad host range of bacteria, the vector being an autonomously replicating artificial chromosome comprising: (i) the RK2 origin of replication oriV; (ii) the RK2 origin of conjugate transfer oriT; (iii) par DE from RK2; (iv) a cloning region; (v) a further origin of replication which permits replication of said vector at a copy number of no more than 1 or 2; wherein the vector is no more than 15 kb in size, does not contain trfA of RK2, and is capable of cloning inserts of at least 12 kb and wherein the content of RK2 DNA in the vector is no more than 10% of RK2. The invention also relates to host cells and a vector system having the cloning vector. Methods of cloning DNA and preparing a library and uses of the vector and the RK2 replicon in metagenomic cloning are provided.Type: ApplicationFiled: June 8, 2007Publication date: September 9, 2010Applicant: SINVENT ASInventors: Trine Aakvik, Kristin Fløgstad Degnes, Trond Erling Ellingsen, Rannveig Dahlsrud, Svein Valla
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Publication number: 20100216870Abstract: The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof.Type: ApplicationFiled: March 29, 2010Publication date: August 26, 2010Applicant: SINVENT ASInventors: Sergey Borisovich Zotchev, Olga Nikolayivna Sekurova, Espen Fjaervik, Trygve Brautaset, Arne Reidar Strom, Svein Valla, Trond Erling Ellingsen, Håvard Sletta, Ole-Martin Gulliksen
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Patent number: 7709231Abstract: The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof.Type: GrantFiled: September 11, 2006Date of Patent: May 4, 2010Assignee: Sinvent ASInventors: Sergey Borisovich Zotchev, Olga Nikolayivna Sekurova, Espen Fjærvik, Trygve Brautaset, Arne Reidar Strøm, Svein Valla, Trond Erling Ellingsen, Håvard Sletta, Ole-Martin Gulliksen
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Publication number: 20080119541Abstract: The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof.Type: ApplicationFiled: September 11, 2006Publication date: May 22, 2008Applicant: Sinvent ASInventors: Sergey Borisovich Zotchev, Olga Nikolayivna Sekurova, Espen Fjaervik, Trygve Brautaset, Arne Reidar Strom, Svein Valla, Trond Erling Ellingsen, Havard Sletta, Ole-Martin Gulliksen
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Patent number: 7141660Abstract: The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof.Type: GrantFiled: February 8, 2001Date of Patent: November 28, 2006Assignee: Sinvent ASInventors: Sergey Borisovich Zotchev, Olga Nikolayivna Sekurova, Espen Fjaervik, Trygve Brautaset, Arne Reidar Strøm, Svein Valla, Trond Erling Ellingsen, Hävard Sletta, Ole-Martin Gulliksen
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Publication number: 20040115762Abstract: The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof.Type: ApplicationFiled: February 7, 2003Publication date: June 17, 2004Inventors: Sergey Borisovich Zotchev, Olga Nikolayivna Sekurova, Espen Fjaervik, Trygve Brautaset, Arne Reidar Strom, Svein Valla, Trond Erling Ellingsen, Havard Sletta, Ole-Martin Gulliksen