Patents by Inventor Tsuguji Nakahara

Tsuguji Nakahara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Plasminogen activator derivatives
    Patent number: 4640835
    Abstract: Derivatives of a nonimmunogenic plasminogen activator which comprises at least one polyalkylene glycol group chemically bonded with at least one coupling agent to amino acid side chains of said plasminogen activator, wherein said polyalkylene glycol has a molecular weight of about 200-20,000 and is unsubstituted or is substituted with one or more alkyl, alkoxy or alkanoyl groups or a mixture thereof.The plasminogen activator derivatives have an extended circulating life in the mammalian bloodstream and also inhibit the formation of thrombus in the same.
    Type: Grant
    Filed: October 28, 1983
    Date of Patent: February 3, 1987
    Assignee: Nippon Chemiphar Company, Ltd.
    Inventors: Kimihiro Shimizu, Tsuguji Nakahara, Taketoshi Kinoshita, Jun Takatsuka, Michiko Igarashi
  • Plasminogen activator derivatives
    Patent number: 4495285
    Abstract: A derivative of a human-originated non-immunogenic plasminogen activator is disclosed which comprises at least one polyalkylene glycol attached with at least one coupling agent to amino acid side chains of said plasminogen activator, said polyalkylene glycol having a molecular weight of 200-20,000 and optionally containing one or more alkyl and/or alkanoyl groups as substituents. Also disclosed are a process for producing such derivative and a thrombolytic agent containing such derivative.
    Type: Grant
    Filed: October 27, 1982
    Date of Patent: January 22, 1985
    Inventors: Kimihiro Shimizu, Tsuguji Nakahara, Taketoshi Kinoshita