Patents by Inventor Tsutomu Katakami
Tsutomu Katakami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 5332739Abstract: Pyrimidinedione derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 is so linked with each other as to make an alkylene chain and thus form a heterocyclic structure, A, R.sup.3, R.sup.4, X.sup.1, X.sup.2 and X.sup.3 are substituents, respectively, and n is 2 or 3 have a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain and a heterocyclic ring having two nitrogen atoms. These compounds are useful for a medical treatment of cardiac arrhythmias.Type: GrantFiled: November 2, 1992Date of Patent: July 26, 1994Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Tsutomu Katakami, Tatsuro Yokoyama, Michihiko Miyamoto, Haruki Mori, Nobuya Kawauchi, Tadahito Nobori, Joji Kamiya, Masaaki Ishii
-
Patent number: 5308848Abstract: A pyrimidinedione derivative compound has a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a linking structure comprising an alkyl chain containing two nitrogen atoms. This linking structure is represented by ##STR1## [wherein A is --(CH.sub.2).sub.n --, --CO-- or --O--(CH.sub.2).sub.m --; each of R.sup.1 and R.sup.2 is independently a hydrogen atom or a lower alkyl group which may be substituted by a hydroxyl group, or R.sup.1 and R.sup.2 may be so linked with each other as to make an alkylene chain and thus form a heterocyclic structure; R.sup.5 is a halogen atom, a hydroxyl group, a lower alkyloxycarbonyl group, a lower alkyloxy group which may be substituted by a lower alkyloxy group, or a lower alkyl group which may be substituted by a hydroxyl group, or R.sup.5 may be so linked with R.sup.1 as to make an alkylene chain and thus form a heterocyclic structure; n is 0, 1, 2 or 3 (when R.sup.5 is the hydroxyl group, n.noteq.Type: GrantFiled: August 12, 1992Date of Patent: May 3, 1994Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Michihiko Miyamoto, Tsutomu Katakami, Nobuya Kawauchi, Tadahito Nobori, Joji Kamiya, Masaaki Ishii
-
Patent number: 5114941Abstract: A pyrimidinedione derivative compound has a basic backbone in which a 4-oxobenzopyran ring group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain containing at least two nitrogen atoms and one oxygen. The pyrimidinedione derivative is useful for a medical treatment of cardiac arrhythmias.Type: GrantFiled: November 27, 1990Date of Patent: May 19, 1992Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Tsutomu Katakami, Tatsuro Yokoyama, Haruki Mori, Nobuya Kawauchi, Joji Kamiya, Masaaki Ishii
-
Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same
Patent number: 5008267Abstract: A pyrimidinedione derivative compound has a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain containing at least two nitrogen atoms. The pyrimidinedione derivative is useful for a medical treatment of cardiac arrhythmias.Type: GrantFiled: October 24, 1989Date of Patent: April 16, 1991Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Tsutomu Katakami, Tatsuro Yokoyama, Michihiko Miyamoto, Haruki Mori, Nobuya Kawauchi, Tadahito Nobori, Kunio Sannohe, Joji Kamiya, Masaaki Ishii, Kanji Yoshihara -
Patent number: 4965263Abstract: This invention relates to pyridazinone derivatives of the general formula: ##STR1## [wherein R.sup.1 stands for a hydrogen atom or a lower alkyl group; R.sup.2 for a hydrogen atom or a lower alkyl group; and A for (i) a ring selected from a benzene ring, a furan ring, a thiophene ring and a pyridine ring (on which ring 1-3 substituents or atoms selected from amino groups, nitro groups, lower alkanoylamino groups, hydroxyl groups, lower alkanoyloxy groups, sulfamoyl groups and halogen atoms may be present), or (ii) a grouping of the formula: ##STR2## (wherein R.sup.3 stands for a hydrogen atom, a lower alkyl group, a phenyl(lower)alkyl, a hydroxyphenyl(lower)alkyl group, a lower alkylmercapto(lower)alkyl group, a benzylmercapto(lower)alkyl group, a guanidino(lower)alkyl group, a nitroguanidino(lower)alkyl group, an indolyl(lower)alkyl group, a carbamoyl(lower)alkyl group or a carboxy(lower)alkyl group, R.sup.4 for a hydrogen atom or a lower alkyl group, R.sup.Type: GrantFiled: February 14, 1989Date of Patent: October 23, 1990Assignee: Mitsui Toatsu Kagaku Kabushiki KaishaInventors: Takashi Nishina, Joji Kamiya, Yasuhito Tanaka, Tsutomu Katakami, Nobuyuki Fukazawa, Hajime Iizuka, Takuo Nakano
-
Patent number: 4639451Abstract: This invention relates to pyridazinone derivatives of the general formula: ##STR1## [wherein R.sup.1 stands for a hydrogen atom or a lower alkyl group; R.sup.2 for a hydrogen atom or a lower alkyl group; and A for (i) a ring selected from a benzene ring, a furan ring, a thiophene ring and a pyridine ring (on which ring 1-3 substituents or atoms selected from amino groups, nitro groups, lower alkanoylamino groups, hydroxyl groups, lower alkanoyloxy groups, sulfamoyl groups and halogen atoms may be present), or (ii) a grouping of the formula: ##STR2## (wherein R.sup.3 stands for a hydrogen atom, a lower alkyl group, a phenyl(lower)alkyl, a hydroxyphenyl(lower)alkyl group, a lower alkylmercapto(lower)alkyl group, a benzylmercapto(lower)alkyl group, a guanidino(lower)alkyl group, a nitroguanidino(lower)alkyl group, an indolyl(lower)alkyl group, a carbamoyl(lower)alkyl group or a carboxy(lower)alkyl group, R.sup.4 for a hydrogen atom or a lower alkyl group, R.sup.Type: GrantFiled: June 3, 1983Date of Patent: January 27, 1987Assignee: Mitsui Toatsu Kagaku-Kabushiki KaishaInventors: Tsutomu Katakami, Nobuyuki Fukazawa, Hajime Iizuka, Takashi Nishina, Joji Kamiya, Yasuhito Tanaka, Takuo Nakano
-
Patent number: 4539151Abstract: This invention relates to benzothiazepine derivatives of the general formula ##STR1## where Y is hydrogen, a CHR.sub.3 --COOR.sub.1 group, an alkanoyl group or a --COO(CH.sub.2).sub.n R.sub.4 group where R.sub.1 is hydrogen or a lower alkyl group, R.sub.3 is hydrogen, an alkyl group, an alkylphenyl group or an aryl-lower alkyl group, R.sub.4 is an aryl group and n is a whole number of 1 to 10, and to their method of preparation.The benzothiazepine derivatives of this invention, including their salts, have an inhibitory effect on the angiotensin converting enzyme and are useful as raw materials or intermediates for the synthesis of antihypertensive agents and as intermediates for the manufacture of other drugs, agricultural chemicals and industrial chemicals.Type: GrantFiled: June 28, 1984Date of Patent: September 3, 1985Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Tsutomu Katakami, Nobuyuki Fukazawa, Hajime Iizuka
-
Patent number: 4539150Abstract: This invention relates to benzothiazepine derivatives of the general formula ##STR1## where K is hydrogen or a --CH.sub.2 COOR.sub.2 group where R.sub.2 is hydrogen or a lower alkyl group, Z is hydrogen or phenyl except when both K and Z are hydrogen, and Y is hydrogen, a --CHR.sub.3 --COOR.sub.1 group, an alkanoyl group or a --COO(CH.sub.2).sub.n R.sub.4 group where R.sub.1 is hydrogen or a lower alkyl group, R.sub.3 is hydrogen, an alkyl group, an alkylphenyl group or an aryl-lower alkyl group, R.sub.4 is an aryl group and n is a whole number of 1 to 10, and to their methods of preparation.The benzothiazepine derivatives of this invention, including their salts, have a powerful inhibitory effect on the angiotensin converting enzyme and exert a marked depressor effect in such models of hypertension as spontaneously occurring hypertensive rats and the like, so that they are useful as drugs for the treatment of hypertension and other cardiovascular diseases.Type: GrantFiled: June 28, 1984Date of Patent: September 3, 1985Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Tsutomu Katakami, Nobuyuki Fukazawa, Hajime Iizuka, Takashi Nishina, Isao Shirakawa
-
Patent number: 4523011Abstract: 6-(Substituted phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds possessing strong platelet aggregation inhibiting activity and blood pressure depressing activity, having the general formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2 is hydrogen, lower alkyl, lower alkylthio or the grouping R.sup.5 --NH-- where R.sup.5 is lower alkyl; R.sup.3 is phenyl, pyridyl, benzyl, lower alkyl or a substituted phenyl group carrying at any desired position on the benzene ring thereof the grouping: ##STR2## where R.sup.1 has the same meaning as given above; R.sup.4 is hydrogen or halogen; n is 0 or 1; and when both R.sup.2 and R.sup.3 are lower alkyl groups, R.sup.2 and R.sup.3 may be combined together with the bridging member ##STR3## between them to form the structure: ##STR4## where m is 2 or 3, as well as physiologically acceptable acid-addition salts thereof, and processes for preparing them.Type: GrantFiled: March 28, 1984Date of Patent: June 11, 1985Assignee: Mitsui Toatsu Kagaku Kabushiki KaishaInventors: Tsutomu Katakami, Nobuyuki Fukazawa, Hajime Iizuka, Takashi Nishina, Joji Kamiya, Yasuhito Tanaka, Takuo Nakano
-
Patent number: 4521415Abstract: 6-(Substituted phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds possessing strong platelet aggregation inhibiting activity and blood pressure depressing activity, having the general formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2 is hydrogen, lower alkyl, lower alkylthio or the grouping R.sup.5 --NH-- where R.sup.5 is lower alkyl; R.sup.3 is phenyl, pyridyl, benzyl, lower alkyl or a substituted phenyl group carrying at any desired position on the benzene ring thereof the grouping: ##STR2## where R.sup.1 has the same meaning as given above; R.sup.4 is hydrogen or halogen; n is 0 or 1; and when both R.sup.2 and R.sup.3 are lower alkyl groups, R.sup.2 and R.sup.3 may be combined together with the bridging member ##STR3## where m is 2 or 3, as well as physiologically acceptable acid-addition salts thereof, and processes for preparing them.Type: GrantFiled: December 28, 1982Date of Patent: June 4, 1985Assignee: Mitsui Toatsu Kagaku Kabushiki KaishaInventors: Tsutomu Katakami, Nobuyuki Fukazawa, Hajime Iizuka, Takashi Nishina, Joji Kamiya, Yasuhito Tanaka, Takuo Nakano