Patents by Inventor Uday Khire

Uday Khire has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITION OF RAF KINASE USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS
    Publication number: 20080009527
    Abstract: Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se,
    Type: Application
    Filed: June 26, 2007
    Publication date: January 10, 2008
    Inventors: Jacques Dumas, Uday Khire, Timothy Lowinger, Bernard Riedl, William Scott, Roger Smith, Jill Wood, Holia Hatoum-Mokdad, Jeffrey Johnson, Aniko Redman, Robert Sibley
  • INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS
    Publication number: 20070244120
    Abstract: Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
    Type: Application
    Filed: June 25, 2007
    Publication date: October 18, 2007
    Inventors: Jacques Dumas, Uday Khire, Timothy Lowinger, Holger Paulsen, Bernd Riedl, William Scott, Roger Smith, Jill Wood, Holia Hatoum-Mokdad, Jeffrey Johnson, Wendy Lee, Aniko Redman, Robert Sibley, Joel Renick
  • RHO-KINASE INHIBITORS
    Publication number: 20070238741
    Abstract: Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
    Type: Application
    Filed: April 9, 2007
    Publication date: October 11, 2007
    Inventors: Dhanapalan Nagarathnam, Uday Khire, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Chunguang Wang, Barry Hart, Olaf Weber, Mark Lynch, Lei Zhang, Lei Wang
  • Quinolone Carboxylic Acid Derivatives for Treatment of Hyperproliferative Conditions
    Publication number: 20070213339
    Abstract: Quinolone carboxylic acid derivatives of formula (I) wherein Ar is an optionally substituted phenyl, pyridyl, or pyrimidinyl group and the substituent groups R1, R4, R10, R11, R19, and R20 are as defined in the specification, pharmaceutical compositions containing them, and methods of using them in treatment of hyperproliferative diseases such as cancer are disclosed and claimed.
    Type: Application
    Filed: March 31, 2005
    Publication date: September 13, 2007
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Uday Khire, Xiao-Gao Liu, Dhanapalan Nagarathnam, Jill Wood, Lei Wang, Donglei Liu, Jin Zhao, Leatte Guernon, Lei Zhang
  • Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
    Patent number: 7235576
    Abstract: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: June 26, 2007
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Bernd Riedl, Jacques Dumas, Uday Khire, Timothy B. Lowinger, William J. Scott, Roger A. Smith, Jill E. Wood, Mary-Katherine Monahan, Reina Natero, Joel Renick, Robert N. Sibley
  • Rho-kinase inhibitors
    Publication number: 20060142313
    Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
    Type: Application
    Filed: February 16, 2006
    Publication date: June 29, 2006
    Inventors: Dhanaphalan Nagarathnam, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Uday Khire, Chunguang Wang, Barry Hart, Stephen Boyer, Olaf Weber, Mark Lynch
  • Method of treating cancer with quinolone carboxylic acid derivatives
    Publication number: 20060142295
    Abstract: This invention relates to a method of treating a hyper-proliferative disorder comprising the administration of an effective amount of a compound of Formula (I) to a patient in need thereof.
    Type: Application
    Filed: March 5, 2004
    Publication date: June 29, 2006
    Inventors: Jacques Dumas, Uday Khire, Shirley Lasch, Dhanapalan Nagarathnam, William Scott
  • Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
    Publication number: 20060019990
    Abstract: The invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy.
    Type: Application
    Filed: June 22, 2005
    Publication date: January 26, 2006
    Inventors: Jacques Dumas, Bernd Riedl, Uday Khire, Robert Sibley, Holia Hatoum-Mokdad, Mary-Katherine Monahan, David Gunn, Timotthy Lowinger, William Scott, Roger Smith, Jill Wood
  • 2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists
    Publication number: 20050215594
    Abstract: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
    Type: Application
    Filed: April 28, 2005
    Publication date: September 29, 2005
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Stephen O'Connor, Gaetan Ladouceur, William Bullock, Ann-Marie Campbell, Miao Dai, Robert Dally, Jacques Dumas, Holia Hatoum-Mokdad, Uday Khire, Wendy Lee, Qingjie Liu, Derek Lowe, Steven Magnuson, Ning Qi, Tatiana Skelekhin, Quanrong Shen, Roger Smith, Ming Wang
  • 2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists
    Patent number: 6919371
    Abstract: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
    Type: Grant
    Filed: September 17, 2003
    Date of Patent: July 19, 2005
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Stephen J. O'Connor, Gaetan H. Ladouceur, William H. Bullock, Ann-Marie Campbell, Miao Dai, Robert Dally, Jacques Dumas, Holia N. Hatoum-Mokdad, Uday Khire, Wendy Lee, Qingjie Liu, Derek B. Lowe, Steven R. Magnuson, Ning Qi, Tatiana E. Shelekhin, Quanrong Shen, Roger A. Smith, Ming Wang
  • Pyrazole derivatives useful in the treatment of hyper-proliferative disorders
    Publication number: 20040180891
    Abstract: This invention relates to pyrazole derivatives of 1
    Type: Application
    Filed: March 15, 2004
    Publication date: September 16, 2004
    Inventors: Uday Khire, Chengzhi Zhang, Harold C E Kluender, Ingo Mugge, Zhengqui Hong, Jianxing Shao, Neil Bifulco, Pamela A Trail, Jacques Dumas, Rico C Lavoie, Xaio-Gao Liu, Veena Agarwal, Sharad K Verma, Lei Wang
  • Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
    Publication number: 20040102636
    Abstract: This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
    Type: Application
    Filed: February 1, 2002
    Publication date: May 27, 2004
    Applicant: BAYER CORPORATION
    Inventors: Scott Miller, Martin Osterhout, Jacques Dumas, Uday Khire, Timothy B. Lowinger, William J. Scott, Roger A. Smith, Jill E. Wood, David E. Gunn, Holia Hatoum-Mokdad, Marell Rodriguez, Robert Sibley, Ming Wang, Tiffany Turner, Catherine Brennan
  • 2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists
    Publication number: 20040072828
    Abstract: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
    Type: Application
    Filed: September 17, 2003
    Publication date: April 15, 2004
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Stephen J. O'Connor, Gaetan H. Ladouceur, William H. Bullock, Ann-Marie Campbell, Miao Dai, Robert Dally, Jacques Dumas, Holia N. Hatoum-Mokdad, Uday Khire, Wendy Lee, Qingjie Liu, Derek B. Lowe, Steven R. Magnuson, Ning Qi, Tatiana E. Shelekhin, Quanrong Shen, Roger A. Smith, Ming Wang
  • Rho-kinase inhibitors
    Publication number: 20040014755
    Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
    Type: Application
    Filed: January 10, 2003
    Publication date: January 22, 2004
    Inventors: Dhanapalan Nagarathnam, Uday Khire, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Chunguang Wang, Barry Hart, Olaf Weber, Mark Lynch, Lei Zhang, Lei Wang
  • 2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists
    Patent number: 6660752
    Abstract: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
    Type: Grant
    Filed: April 22, 2002
    Date of Patent: December 9, 2003
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Stephen J. O'Connor, Gaetan H. Ladouceur, William H. Bullock, Ann-Marie Campbell, Miao Dai, Robert Dally, Jacques Dumas, Holia N. Hatoum-Mokdad, Uday Khire, Wendy Lee, Qingjie Liu, Derek B. Lowe, Steven R. Magnuson, Ning Qi, Tatiana E. Shelekhin, Quanrong Shen, Roger A. Smith, Ming Wang
  • Process for preparing quinazoline Rho-kinase inhibitiors and intermediates thereof
    Publication number: 20030220357
    Abstract: A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.
    Type: Application
    Filed: September 24, 2002
    Publication date: November 27, 2003
    Inventors: Donald Bankston, Dhanaphalan Nagarathnam, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Uday Khire, Chunguang Wang, Barry Hart, Stephen Boyer, Olaf Weber, Mark Lynch
  • INHIBITION OF RAF KINASE USING QUINOLYL, ISOQUINOLYL OR PYRIDYL UREAS
    Publication number: 20030207914
    Abstract: This invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy.
    Type: Application
    Filed: April 19, 2002
    Publication date: November 6, 2003
    Applicant: BAYER CORPORATION
    Inventors: Jacques Dumas, Bernd Riedl, Uday Khire, Robert N. Sibley, Holia Hatoum-Mokdad, Mary-Katherine Monahan, David E. Gunn, Timothy B. Lowinger, William J. Scott, Roger A. Smith, Jill E. Wood
  • OMEGA-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS
    Publication number: 20030207872
    Abstract: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
    Type: Application
    Filed: January 11, 2002
    Publication date: November 6, 2003
    Applicant: BAYER CORPORATION
    Inventors: Bernd Riedl, Jacques Dumas, Uday Khire, Timothy B. Lowinger, William J. Scott, Roger A. Smith, Jill E. Wood, Mary-Katherine Monahan, Reina Natero, Joel Renick, Robert N. Sibley
  • omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
    Publication number: 20030181442
    Abstract: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
    Type: Application
    Filed: November 27, 2001
    Publication date: September 25, 2003
    Applicant: BAYER CORPORATION
    Inventors: Bernd Riedl, Jacques Dumas, Uday Khire, Timothy B. Lowinger, William J. Scott, Roger A. Smith, Jill E. Wood, Mary-Katherine Monahan, Reina Natero, Joel Renick, Robert N. Sibley
  • Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
    Publication number: 20030144278
    Abstract: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
    Type: Application
    Filed: October 30, 2002
    Publication date: July 31, 2003
    Applicant: BAYER CORPORATION
    Inventors: Bernd Riedl, Jacques Dumas, Uday Khire, Timothy B. Lowinger, William J. Scott, Roger A. Smith, Jill E. Wood, Mary-Katherine Monahan, Reina Natero, Joel Renick, Robert N. Sibley