Abstract: The present invention relates to novel compounds comprising a steroid hormone linked to a DNA-interacting molecule that target nucleic acids to the cell nucleus. Further, the invention relates to a method for introducing nucleic acids into the nucleus of cells with the help of such compounds. Pharmaceutical preparations containing such compounds and the use of such compounds for gene therapy are also provided.

Abstract: With the invention is shown an artificial knee joint, in which the rear cruciate ligament and the collateral ligaments are assumed as being retained. A metal platform is attached to the tibia and perpendicular to the tibia axis has a plane surface, on which three slide members are slidably disposed so as to guide the metal platform relative to the femur condyles made of metal within the limits of the degree of freedom remaining to them under the tension of the ligaments. A central slide member forms an eminentia rotatable around a pin, which guides the femur condyles directly or indirectly with respect to rotation around the tibia axis and which along its median line, which extends in the sagittal direction in the non-rotated central position, forms a direct or indirect longitudinal guiding device for the femur condyles, while the flexion movement is guided at doubly curved femur condyles by the two outer slide members.