Patents by Inventor Ulrich Schlecht

Ulrich Schlecht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human Therapeutic Targets and Modulators Thereof
    Publication number: 20240120023
    Abstract: Methods for identifying biosynthetic gene clusters that include genes for producing compounds that interact with specific target proteins are disclosed. Some methods relate to bioinformatics methods for identifying and/or prioritizing biosynthetic gene clusters. Related systems, components, and tools for the identification and expression of such gene clusters are also disclosed.
    Type: Application
    Filed: July 7, 2023
    Publication date: April 11, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian Thomas Naughton, Colin Harvey, Ulrich Schlecht, Maureen Elizabeth Hillenmeyer, Joe Horecka
  • Inducible Production-Phase Promoters for Coordinated Heterologous Expression in Yeast
    Publication number: 20240102030
    Abstract: Inducible promoters for the coordinated expression of at least one heterologous gene in yeast and methods of using them are disclosed. In particular, the invention relates to sets of inducible promoters derived from S. cerevisiae and related species that can be induced in the presence of nonfermentable carbon sources.
    Type: Application
    Filed: September 6, 2023
    Publication date: March 28, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Colin Harvey, Ulrich Schlecht, Maureen Elizabeth Hillenmeyer
  • DEVICES FOR SAMPLE ANALYSIS USING EPITACHOPHORESIS
    Publication number: 20230356211
    Abstract: The present disclosure generally relates to devices and methods for effecting epitachophoresis. Epitachophoresis may be used to effect sample analysis, such as by selective separation, detection, extraction, and/or pre-concentration of target analytes such as, for example, DNA, RNA, and/or other biological molecules. Said target analytes may be collected following epitachophoresis and used for desired downstream applications and further analysis.
    Type: Application
    Filed: May 15, 2023
    Publication date: November 9, 2023
    Inventors: Yann ASTIER, Jan BERKA, Ulrich SCHLECHT, Frantisek FORET, Vladimira DATINSKA, Ivona VORACOVA
  • Inducible production-phase promoters for coordinated heterologous expression in yeast
    Patent number: 11795464
    Abstract: Inducible promoters for the coordinated expression of at least one heterologous gene in yeast and methods of using them are disclosed. In particular, the invention relates to sets of inducible promoters derived from S. cerevisiae and related species that can be induced in the presence of nonfermentable carbon sources.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: October 24, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Colin Harvey, Ulrich Schlecht, Maureen Elizabeth Hillenmeyer
  • Systems and Methods for Identifying and Expressing Gene Clusters
    Publication number: 20230215512
    Abstract: Methods for identifying biosynthetic gene clusters that include genes for producing compounds that interact with specific target proteins are disclosed. Some methods relate to bioinformatics methods for identifying and/or prioritizing biosynthetic gene clusters. Related systems, components, and tools for the identification and expression of such gene clusters are also disclosed.
    Type: Application
    Filed: March 3, 2023
    Publication date: July 6, 2023
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian Thomas Naughton, Colin Harvey, Ulrich Schlecht, Maureen Elizabeth Hillenmeyer, Joe Horecka
  • Devices for sample analysis using epitachophoresis
    Patent number: 11691141
    Abstract: The present disclosure generally relates to devices for effecting epitachophoresis. Epitachophoresis may be used to effect sample analysis, such as by selective separation, detection, extraction, and/or pre-concentration of target analytes such as, for example, DNA, RNA, and/or other biological molecules. Said target analytes may be collected following epitachophoresis and used for desired downstream applications and further analysis.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: July 4, 2023
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Yann Astier, Jan Berka, Ulrich Schlecht, Frantisek Foret, Vladimira Datinska, Ivona Voracova
  • MICROFLUIDIC BEAD TRAPPING DEVICES AND METHODS FOR NEXT GENERATION SEQUENCING LIBRARY PREPARATION
    Publication number: 20230039014
    Abstract: The present disclosure is directed to automated systems including a microfluidic chip having one or more independently operable processing conduits. In some embodiments, the automated systems are suitable for use in sample cleanup and/or target enrichment processes, such as sample cleanup and/or target enrichment processes conducted prior to sequencing.
    Type: Application
    Filed: January 21, 2021
    Publication date: February 9, 2023
    Inventors: Yann Astier, Daniel Burgess, Ulrich Schlecht, Jaeyoung Yang
  • Scalable method for isolation and sequence-verification of oligonucleotides from complex libraries
    Patent number: 11505794
    Abstract: A novel method for preparing sequence-verified oligonucleotides is disclosed. In particular, the invention relates to a simple, affordable, and scalable method that combines high-throughput mating of yeast clones, a unique selectable system for combining DNA sequences in yeast, and next-generation sequencing. This method allows sequence-verified oligonucleotides to be readily isolated from complex libraries.
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: November 22, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Robert P. St. Onge, Ulrich Schlecht, Sasha F. Levy, Ronald W. Davis, Joseph Horecka
  • METHOD FOR INCREASING THROUGHPUT OF SINGLE MOLECULE SEQUENCING BY CONCATENATING SHORT DNA FRAGMENTS
    Publication number: 20210363570
    Abstract: The invention comprises a method and compositions for sequencing library preparation, which increases the throughput of single-molecule sequencing (SMS) platforms by generating long concatenated templates from pools of short DNA molecules.
    Type: Application
    Filed: April 29, 2021
    Publication date: November 25, 2021
    Inventors: Janine Mok, Ulrich Schlecht, Austin So
  • Circularization methods for single molecule sequencing sample preparation
    Patent number: 11168360
    Abstract: The invention is a novel method of making and using a library such as a sequencing library of single stranded circular nucleic acid templates via splint ligation.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: November 9, 2021
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Michael George, Jenny A. Johnson, Duylinh Nguyen, Ulrich Schlecht
  • METHOD FOR GENERATING SINGLE-STRANDED CIRCULAR DNA LIBRARIES FOR SINGLE MOLECULE SEQUENCING
    Publication number: 20210310048
    Abstract: The invention comprises circular single-stranded templates for nucleic acid sequencing, methods of making and using the same.
    Type: Application
    Filed: June 16, 2021
    Publication date: October 7, 2021
    Inventors: Janine Mok, Ulrich Schlecht
  • SCALABLE METHOD FOR ISOLATION AND SEQUENCE-VERIFICATION OF OLIGONUCLEOTIDES FROM COMPLEX LIBRARIES
    Publication number: 20210246440
    Abstract: A novel method for preparing sequence-verified oligonucleotides is disclosed. In particular, the invention relates to a simple, affordable, and scalable method that combines high-throughput mating of yeast clones, a unique selectable system for combining DNA sequences in yeast, and next-generation sequencing. This method allows sequence-verified oligonucleotides to be readily isolated from complex libraries.
    Type: Application
    Filed: August 19, 2020
    Publication date: August 12, 2021
    Inventors: Robert P. St. Onge, Ulrich Schlecht, Sasha F. Levy, Ronald W. Davis, Joseph Horecka
  • Method for generating single-stranded circular DNA libraries for single molecule sequencing
    Patent number: 11085068
    Abstract: The invention comprises circular single-stranded templates for nucleic acid sequencing, methods of making and using the same.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 10, 2021
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Janine Mok, Ulrich Schlecht
  • Systems and Methods for Identifying and Expressing Gene Clusters
    Publication number: 20210230611
    Abstract: Methods for identifying biosynthetic gene clusters that include genes for producing compounds that interact with specific target proteins are disclosed. Some methods relate to bioinformatics methods for identifying and/or prioritizing biosynthetic gene clusters. Related systems, components, and tools for the identification and expression of such gene clusters are also disclosed.
    Type: Application
    Filed: January 26, 2021
    Publication date: July 29, 2021
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian Thomas Naughton, Colin Harvey, Ulrich Schlecht, Maureen Elizabeth Hillenmeyer, Joe Horecka
  • Scalable method for isolation and sequence-verification of oligonucleotides from complex libraries
    Patent number: 10787661
    Abstract: A novel method for preparing sequence-verified oligonucleotides is disclosed. In particular, the invention relates to a simple, affordable, and scalable method that combines high-throughput mating of yeast clones, a unique selectable system for combining DNA sequences in yeast, and next-generation sequencing. This method allows sequence-verified oligonucleotides to be readily isolated from complex libraries.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: September 29, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Robert P. St. Onge, Ulrich Schlecht, Sasha F. Levy, Ronald W. Davis, Joseph Horecka
  • Inducible Production-Phase Promoters for Coordinated Heterologous Expression in Yeast
    Publication number: 20200291411
    Abstract: Inducible promoters for the coordinated expression of at least one heterologous gene in yeast and methods of using them are disclosed. In particular, the invention relates to sets of inducible promoters derived from S. cerevisiae and related species that can be induced in the presence of nonfermentable carbon sources.
    Type: Application
    Filed: February 20, 2020
    Publication date: September 17, 2020
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Colin Harvey, Ulrich Schlecht, Maureen Elizabeth Hillenmeyer
  • DEVICES FOR SAMPLE ANALYSIS USING EPITACHOPHORESIS
    Publication number: 20200282392
    Abstract: The present disclosure generally relates to devices for effecting epitachophoresis. Epitachophoresis may be used to effect sample analysis, such as by selective separation, detection, extraction, and/or pre-concentration of target analytes such as, for example, DNA, RNA, and/or other biological molecules. Said target analytes may be collected following epitachophoresis and used for desired downstream applications and further analysis.
    Type: Application
    Filed: November 13, 2018
    Publication date: September 10, 2020
    Inventors: Yann ASTIER, Jan BERKA, Ulrich SCHLECHT, Frantisek FORET, Vladimira DATINSKA, Ivona VORACOVA
  • CIRCULARIZATION METHODS FOR SINGLE MOLECULE SEQUENCING SAMPLE PREPARATION
    Publication number: 20200208208
    Abstract: The invention is a novel method of making and using a library such as a sequencing library of single stranded circular nucleic acid templates via splint ligation.
    Type: Application
    Filed: March 9, 2020
    Publication date: July 2, 2020
    Inventors: Michael George, Jenny A. Johnson, Duylinh Nguyen, Ulrich Schlecht
  • Inducible production-phase promoters for coordinated heterologous expression in yeast
    Patent number: 10612032
    Abstract: Inducible promoters for the coordinated expression of at least one heterologous gene in yeast and methods of using them are disclosed. In particular, the invention relates to sets of inducible promoters derived from S. cerevisiae and related species that can be induced in the presence of nonfermentable carbon sources.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: April 7, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Colin Harvey, Ulrich Schlecht, Maureen Elizabeth Hillenmeyer
  • Systems and Methods for Identifying and Expressing Gene Clusters
    Publication number: 20200040347
    Abstract: Methods for identifying biosynthetic gene clusters that include genes for producing compounds that interact with specific target proteins are disclosed. Some methods relate to bioinformatics methods for identifying and/or prioritizing biosynthetic gene clusters. Related systems, components, and tools for the identification and expression of such gene clusters are also disclosed.
    Type: Application
    Filed: November 16, 2017
    Publication date: February 6, 2020
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian Thomas Naughton, Colin Harvey, Ulrich Schlecht, Maureen Elizabeth Hillenmeyer, Joe Horecka