Patents by Inventor Uri Herzberg
Uri Herzberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220348875Abstract: Provided herein are genetically modified (GM) natural killer (NK) cells and methods of producing populations of GM NK cells. Further provided herein are methods of using the GM NK cells described herein, to, e.g., suppress the proliferation of tumor cells, or to inhibit pathogen infection, e.g., viral infection. In certain alternatives, GM NK cells provided herein lack expression of CBLB, NKG2A and/or TGFBR2 and/or function or show reduced expression and/or function of CBLB, NKG2A and/or TGFBR2. In certain alternatives, GM NK cells provided herein comprise modified CD16.Type: ApplicationFiled: December 17, 2021Publication date: November 3, 2022Applicant: Celularity Inc.Inventors: Xiaokui Zhang, Qian Ye, Tianjian Li, Chuan Wang, Mini Bharathan, Uri Herzberg, Robert J. HARIRI
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Patent number: 11180731Abstract: Provided herein are methods of treating acute myeloid leukemia (AML) and multiple myeloma (MM) by administering an effective amount of a cell population comprising natural killer cells, wherein the cell population comprising natural killer cells is produced by a three-stage method comprising culturing a population of hematopoietic stem or progenitor cells in media comprising stem cell mobilizing factors, e.g., three-stage methods of producing NK cells in media comprising stem cell mobilizing factors starting with hematopoietic stem or progenitor cells from cells of the placenta, for example, from placental perfusate (e.g., human placental perfusate) or other tissues, for example, umbilical cord blood or peripheral blood. Further provided herein are methods of using the NK cells produced by the three-stage methods provided herein to suppress the proliferation of acute myeloid leukemia cells.Type: GrantFiled: May 5, 2017Date of Patent: November 23, 2021Assignee: Celularity Inc.Inventors: Steven A. Fischkoff, Uri Herzberg, Lin Kang, Brian Murphy, Andrea Nordberg, Vanessa Voskinarian-Berse, Keith Wilson, Xiaokui Zhang, Han Myint, Mohamad Hussein, Robert J Hariri
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Patent number: 11090339Abstract: Provided herein are methods of treatment of an individual having pain, e.g., neuropathic pain, comprising administering to the individual a therapeutically effective amount of tissue culture plastic adherent placental stem cells (PDAC™).Type: GrantFiled: August 5, 2019Date of Patent: August 17, 2021Assignee: Celularity Inc.Inventors: Uri Herzberg, Jodi P. Gurney, Robert J. Hariri
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Publication number: 20200023015Abstract: Provided herein are methods of treatment of an individual having pain, e.g., neuropathic pain, comprising administering to the individual a therapeutically effective amount of tissue culture plastic adherent placental stem cells (PDAC™).Type: ApplicationFiled: August 5, 2019Publication date: January 23, 2020Applicant: CELULARITY, INC.Inventors: Uri Herzberg, Jodi P. Gurney
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Patent number: 10532069Abstract: Compositions and methods are disclosed for the treatment of osteoarthritis. The compositions comprising combinations of hyaluronic acid, glucosamine, and chondroitin sulfate, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.Type: GrantFiled: June 2, 2017Date of Patent: January 14, 2020Assignee: DEPUY SYNTHES PRODUCTS, INC.Inventors: Brooks J. Story, Scott A. Wadsworth, William R. Parrish, Uri Herzberg, Donna Torres, Benjamin A. Byers, Julia Hwang, Dongling Su
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Publication number: 20190153389Abstract: Provided herein are methods of treating acute myeloid leukemia (AML) and multiple myeloma (MM) by administering an effective amount of a cell population comprising natural killer cells, wherein the cell population comprising natural killer cells is produced by a three-stage method comprising culturing a population of hematopoietic stem or progenitor cells in media comprising stem cell mobilizing factors, e.g., three-stage methods of producing NK cells in media comprising stem cell mobilizing factors starting with hematopoietic stem or progenitor cells from cells of the placenta, for example, from placental perfusate (e.g., human placental perfusate) or other tissues, for example, umbilical cord blood or peripheral blood. Further provided herein are methods of using the NK cells produced by the three-stage methods provided herein to suppress the proliferation of acute myeloid leukemia cells.Type: ApplicationFiled: May 5, 2017Publication date: May 23, 2019Applicant: CELULARITY, INC.Inventors: Steven A. FFISCHKOFF, Uri HERZBERG, Lin KANG, Brian MURPHY, Andrea NORDBERG, Vanessa VOSKINARIAN-BERSE, Keith WILSON, Xiaokui ZHANG, Han MYINT, Mohamed HUSSEIN
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Publication number: 20190105351Abstract: Methods for treating chronic pain, neuropathic pain or spasticity are provided. Some embodiments are to methods for treatment comprising administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of nerves in the patient to decrease chronic pain, neuropathic pain or spasticity. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.Type: ApplicationFiled: December 19, 2009Publication date: April 11, 2019Applicant: Ethicon, IncorporatedInventors: Brian C. Kramer, Uri Herzberg
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Publication number: 20180273903Abstract: Provided herein are genetically modified (GM) natural killer (NK) cells and methods of producing populations of GM NK cells. Further provided herein are methods of using the GM NK cells described herein, to, e.g., suppress the proliferation of tumor cells, or to inhibit pathogen infection, e.g., viral infection. In certain alternatives, GM NK cells provided herein lack expression of CBLB, NKG2A and/or TGFBR2 and/or function or show reduced expression and/or function of CBLB, NKG2A and/or TGFBR2. In certain alternatives, GM NK cells provided herein comprise modified CD16.Type: ApplicationFiled: December 28, 2017Publication date: September 27, 2018Applicant: Celularity, Inc.Inventors: Xiaokui Zhang, Qian Ye, Tianjian Li, Chuan Wang, Mini Bharathan, Uri Herzberg
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Publication number: 20180133261Abstract: Provided herein are methods of treatment of an individual having pain, e.g., neuropathic pain, comprising administering to the individual a therapeutically effective amount of tissue culture plastic adherent placental stem cells (PDAC™).Type: ApplicationFiled: November 1, 2017Publication date: May 17, 2018Applicant: Anthrogenesis CorporationInventors: Uri Herzberg, Jodi P. Gurney
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Publication number: 20170360481Abstract: Mechanical modifications to a spinal rod that will enable the rod to accept various coating technologies in such a way that the spinal construct's biomechanical performance is not compromised. These modifications preserve construct biomechanics in the presence of a coating and increase the bactericidal payload of an anti-infective spinal rod coating.Type: ApplicationFiled: August 31, 2017Publication date: December 21, 2017Applicant: DePuy Synthes Products, Inc.Inventors: Michael A. Fisher, Paul Birkmeyer, Jeffrey Sutton, Uri Herzberg, Ikshoo Chun, Raymond S. Shissias
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Publication number: 20170290861Abstract: Provided herein are methods of using tissue culture plastic-adherent placental cells, e.g. placental stem cells, in the treatment of diabetic foot ulcer (DFU).Type: ApplicationFiled: September 25, 2015Publication date: October 12, 2017Applicant: Anthrogenesis CorporationInventors: Steven A. FISCHKOFF, Denesh CHITKARA, Uri HERZBERG, Vladimir JANKOVIC
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Publication number: 20170266221Abstract: Compositions and methods are disclosed for the treatment of osteoarthritis. The compositions comprising combinations of hyaluronic acid, glucosamine, and chondroitin sulfate, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.Type: ApplicationFiled: June 2, 2017Publication date: September 21, 2017Inventors: Brooks J. Story, Scott A. Wadsworth, William R. Parrish, Uri Herzberg, Donna Torres, Benjamin A. Byers, Julia Hwang, Dongling Su
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Patent number: 9763697Abstract: Mechanical modifications to a spinal rod that will enable the rod to accept various coating technologies in such a way that the spinal construct's biomechanical performance is not compromised. These modifications preserve construct biomechanics in the presence of a coating and increase the bactericidal payload of an anti-infective spinal rod coating.Type: GrantFiled: December 16, 2008Date of Patent: September 19, 2017Inventors: Michael A. Fisher, Paul Birkmeyer, Hassan Serhan, Jeffrey Sutton, Uri Herzberg, Iksoo Chun, Raymond S. Shissias
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Patent number: 9682099Abstract: Compositions and methods are disclosed for the treatment of osteoarthritis. The compositions comprising combinations of hyaluronic acid, glucosamine, and chondroitin sulfate, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.Type: GrantFiled: January 20, 2015Date of Patent: June 20, 2017Assignee: DEPUY SYNTHES PRODUCTS, INC.Inventors: Brooks J. Story, Scott A. Wadsworth, William R. Parrish, Uri Herzberg, Donna Torres, Benjamin A. Byers, Julia Hwang, Dongling Su
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Publication number: 20170056479Abstract: Provided herein are placental extracellular matrix (ECM) compositions and methods of making the same. Also provided herein are uses of the placental ECM compositions provided herein.Type: ApplicationFiled: November 1, 2016Publication date: March 2, 2017Inventors: Mohit B. BHATIA, Uri HERZBERG, Aleksandr KAPLUNOVSKY, Raihana ZAKA, Qian Ye
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Publication number: 20160206649Abstract: Compositions and methods are disclosed for the treatment of osteoarthritis. The compositions comprising combinations of hyaluronic acid, glucosamine, and chondroitin sulfate, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.Type: ApplicationFiled: January 20, 2015Publication date: July 21, 2016Applicant: DEPUY SYNTHES PRODUCTS, INC.Inventors: Brooks J. Story, Scott A. Wadsworth, William R. Parrish, Uri Herzberg, Donna Torres, Benjamin A. Byers, Julia Hwang, Dongling Su
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Publication number: 20160166618Abstract: Provided herein are methods of treatment of an individual having pain, e.g., neuropathic pain, comprising administering to the individual a therapeutically effective amount of tissue culture plastic adherent amnion-derived cells (AMDACs). Because mammalian placentas are plentiful and are normally discarded as medical waste, they represent a unique source of medically-useful stem cells.Type: ApplicationFiled: October 18, 2013Publication date: June 16, 2016Applicant: ANTHROGENESIS CORPROATIONInventors: Uri Herzberg, Robert J. Hariri, Jodi P Gurney
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Patent number: 9295538Abstract: A method of repairing a hernia using a hernia mesh support device includes providing a hernia mesh support device, reducing a hernia within a patient's abdomen, inserting the hernia mesh support device into the abdomen and positioning the device in alignment with the hernia, ensuring that no abdominal organs are present between the device and the abdominal wall, whereby the step of ensuring that no abdominal organ is between the device and the abdominal wall includes the step of digitally sweeping the space between the abdominal wall and the device, removing a protective cover, and pulling on a pull strap joined to an inner ring to place the device tightly against the abdominal wall and to anchor barbed pins and hollow needles into the abdominal wall.Type: GrantFiled: March 9, 2013Date of Patent: March 29, 2016Assignee: Ethicon, Inc.Inventors: Ilya S. Koyfman, Uri Herzberg
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Publication number: 20160074439Abstract: Provided herein are methods of treatment of an individual having pain, e.g., neuropathic pain, comprising administering to the individual a therapeutically effective amount of tissue culture plastic adherent placental stem cells (PDAC™).Type: ApplicationFiled: November 25, 2015Publication date: March 17, 2016Applicant: ANTHROGENESIS CORPORATIONInventors: Uri Herzberg, Jodi P. Gurney
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Publication number: 20150224148Abstract: Provided herein are methods of treatment of an individual having pain, e.g., neuropathic pain, comprising administering to the individual a therapeutically effective amount of tissue culture plastic adherent placental stem cells (PDAC™).Type: ApplicationFiled: April 21, 2015Publication date: August 13, 2015Applicant: ANTHROGENESIS CORPORATIONInventors: Uri Herzberg, Jodi P. Gurney