Patents by Inventor Uri Piran

Uri Piran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for forming liposomes
    Patent number: 4933121
    Abstract: The present invention relates to a process for forming stable, uniform unilamellar or oligolamellar liposomes which encapsulate a macromolecule. However, unlike prior processes, the present method maintains a temperature below the phase transition temperature of the lipid used to make the liposome both during the hydration of the lipid and, if used, during an extrusion step. In addition, the liposome is formed and the macromolecule encapsulated in a low ionic strength solution, then they are dialyzed against a high ionic strength solution.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: June 12, 1990
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Say-Jong Law, Uri Piran
  • Assay and product in which binder and liposomes are supported on a solid support
    Patent number: 4874710
    Abstract: In an assay, a conjugate of ligand and sac lysing agent is contacted with analyte and binder to produce bound and unbound portions of conjugate. The unbound portion of the conjugate contacts sacs, containing a detectable marker to release the marker as a measure of analyte. The binder and sacs may be placed on different portions of a solid support to provide a solid phase assay.
    Type: Grant
    Filed: February 20, 1986
    Date of Patent: October 17, 1989
    Assignee: Becton Dickinson and Company
    Inventor: Uri Piran
  • Production of loaded vesicles
    Patent number: 4814270
    Abstract: Vesicles having a material encapsulated therein are produced by placing an "empty" vesicle in a liguid including a material to be encapsulated and perturbing the vesicle, preferable by passage through a porous material.
    Type: Grant
    Filed: September 13, 1984
    Date of Patent: March 21, 1989
    Assignee: Becton Dickinson and Company
    Inventor: Uri Piran
  • Vesicles and use thereof in an assay
    Patent number: 4717676
    Abstract: Sacs comprising a compound having a hydrophilic peptide radical are prepared and are believed to have improved stability as a result of hydrogen bonding. The sacs, including a detectable marker and derivatized with a ligand may be used as a tracer in an assay.
    Type: Grant
    Filed: March 3, 1986
    Date of Patent: January 5, 1988
    Assignee: Becton Dickinson and Company
    Inventors: Daniel B. Wagner, Uri Piran
  • Sac or liposome containing dye (sulforhodamine) for immunoassay
    Patent number: 4695554
    Abstract: A sac, in particular a vesicle, including as a detectable marker an absorbing dye having an extinction coefficient of at least 100,000 and a solubility in water of at least 0.1M; in particular, sulforhodamine B or salt thereof. The sacs have improved stability to leakage and are useful in a variety of assays; in particular, when sensitized with a ligand.
    Type: Grant
    Filed: March 27, 1985
    Date of Patent: September 22, 1987
    Assignee: Becton Dickinson and Company
    Inventors: James P. O'Connell, Uri Piran, Daniel B. Wagner