Patents by Inventor Urs Schwitter

Urs Schwitter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10919041
    Abstract: In a method of analyzing solid form properties of a substance, which including the step of solidifying the substance, the solidified substance is obtained in one of a plurality of wells of a multi-well plate. In the multi-well plate the at least one of the plurality of wells has a bottom made of a thermoplastic polyimide. The method further includes analyzing the solidified substance in the well of the multi-well plate by X-ray diffraction. Thereby, the analysis includes providing X-ray through the solidified substance and a bottom of the well and evaluating the X-ray which passed the solidified substance and the bottom of the well. Such method and multi-well plate provide a durable and cost efficient system allowing a high quality analysis of solid form properties of the substance and an efficient and safe processing of the substance.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: February 16, 2021
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Urs Schwitter, Frédéric Ran, André Alker, Tom Kissling, Thomas Zumstein
  • Publication number: 20200024288
    Abstract: The present invention relates to novel solid forms of compound (I) [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate and pharmaceutical compositions comprising the solid forms thereof disclosed herein, which may be used as a TLR7 agonist, or for the treatment or prophylaxis of a viral disease in a patient relating to HBV infection or a disease caused by HBV infection.
    Type: Application
    Filed: January 4, 2018
    Publication date: January 23, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Katja GROSSE-SENDER, Urs SCHWITTER, Frank STOWASSER, Xuemei WANG, Jing XIONG
  • Publication number: 20190293576
    Abstract: A sample holder (1) for containing a substance in a solid form screening process comprises a body (2) with a sidewall portion (21), a bottom portion (22) and a hollow interior limited by the sidewall portion (21) and the bottom portion (22). The bottom portion (22) is made of a thermoplastic polyimide. The sample holder (1) allows for providing a high quality analysis of solid form properties of a substance and an efficient and safe processing of the substance.
    Type: Application
    Filed: October 27, 2017
    Publication date: September 26, 2019
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Urs SCHWITTER, Frédéric RAN, André ALKER, Tom KISSLING, Thomas ZUMSTEIN
  • Publication number: 20190291104
    Abstract: In a method of analyzing solid form properties of a substance, which including the step of solidifying the substance, the solidified substance is obtained in one of a plurality of wells of a multi-well plate. In the multi-well plate the at least one of the plurality of wells has a bottom made of a thermoplastic polyimide. The method further includes analyzing the solidified substance in the well of the multi-well plate by X-ray diffraction. Thereby, the analysis includes providing X-ray through the solidified substance and a bottom of the well and evaluating the X-ray which passed the solidified substance and the bottom of the well. Such method and multi-well plate provide a durable and cost efficient system allowing a high quality analysis of solid form properties of the substance and an efficient and safe processing of the substance.
    Type: Application
    Filed: October 27, 2017
    Publication date: September 26, 2019
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Urs SCHWITTER, Frédéric RAN, André ALKER, Tom KISSLING, Thomas ZUMSTEIN
  • Publication number: 20190194210
    Abstract: The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Application
    Filed: March 4, 2019
    Publication date: June 27, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Benno Rothenhaeusler, Rene Trussardi, Fabienne Hoffmann-Emery, Urs Schwitter, Jean-Michel Adam, Olaf Grassmann, Thomas Hartung, Frederic Ran, Ralph Diodone, Christophe Pfleger, Bjorn Bartels
  • Patent number: 10246460
    Abstract: The present invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: April 2, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Benno Rothenhaeusler, Rene Trussardi, Fabienne Hoffmann-Emery, Urs Schwitter, Jean-Michel Adam, Olaf Grassmann, Thomas Hartung, Frederic Ran, Ralph Diodone, Christophe Pfleger, Bjorn Bartels
  • Patent number: 10227298
    Abstract: The present application discloses solid forms of compound (1) (1), methods for making them, as well as compositions comprising said solid forms.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: March 12, 2019
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Urs Schwitter, Ralph Diodone, Rudolf Benz, Zhongjiang Jia, Choi Duk Soon, Ningxin Yan, Bharat Patel
  • Patent number: 10221125
    Abstract: The instant invention relates to novel solid forms of the compound of formula (I) or salts thereof as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: March 5, 2019
    Assignee: Oryzon Genomics, S.A.
    Inventors: Ralph Diodone, Urs Schwitter, René Trussardi
  • Publication number: 20180086692
    Abstract: The instant invention relates to novel solid forms of the compound of formula (I) or salts thereof as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Application
    Filed: May 2, 2016
    Publication date: March 29, 2018
    Inventors: Ralph DIODONE, Urs SCHWITTER, René TRUSSARDI
  • Publication number: 20170281602
    Abstract: The present invention relates to solid forms of (S)-2-methoxy-3-{442-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxyl-benzo[b]thiophen-7-yl}-propionic acid, and of salts of (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid.
    Type: Application
    Filed: June 14, 2017
    Publication date: October 5, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lukas Dreier, Andre Egli, Karsten Faehnrich, Olaf Grassmann, Peter Mohr, Urs Schwitter, Helmut Stahr, Nicole Wyttenbach
  • Patent number: 9676793
    Abstract: Co-crystals of Formula I compounds and their pharmaceutical compositions are novel therapeutics for the treatment of diseases, such as human immunodeficiency virus (HIV) infection, hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection and cancer. The co-crystal are more stable to oxidation and aqueous degradation, have a better pharmacokinetic profile and superior biological activity than the corresponding tosylate salt form of Formula I compound.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: June 13, 2017
    Assignee: Hoffmann-LaRoche Inc.
    Inventors: Urs Schwitter, Fritz Bliss, Michael Kammerer, Florence Tixeront
  • Publication number: 20170037005
    Abstract: The present application discloses solid forms of compound (1) (1), methods for making them, as well as compositions comprising said solid forms.
    Type: Application
    Filed: April 13, 2015
    Publication date: February 9, 2017
    Inventors: Urs Schwitter, Ralph Diodone, Rudolf Benz, Zhongjiang Jia, Choi Duk Soon, Ningxin Yan, Bharat Patel
  • Patent number: 9562009
    Abstract: The present invention provides processes to manufacture crystalline N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-pyrrolidin-3-yl]acetamide. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: February 7, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Olaf Grassmann, Stefan Hildbrand, Roland Meier, Michelangelo Scalone, Urs Schwitter, Beat Wirz, Ulrich Zutter
  • Publication number: 20160280712
    Abstract: The present invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Application
    Filed: June 3, 2016
    Publication date: September 29, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Benno Rothenhaeusler, Rene Trussardi, Fabienne Hoffmann-Emery, Urs Schwitter, Jean-Michel Adam, Olaf Grassmann, Thomas Hartung, Frederic Ran, Ralph Diodone, Christophe Pfleger, Bjorn Bartels
  • Publication number: 20160237032
    Abstract: The present invention provides processes to manufacture crystalline N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-pyrrolidin-3-yl]acetamide. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Application
    Filed: April 27, 2016
    Publication date: August 18, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Olaf Grassmann, Stefan Hildbrand, Roland Meier, Michelangelo Scalone, Urs Schwitter, Beat Wirz, Ulrich Zutter
  • Publication number: 20160176899
    Abstract: Co-crystals of Formula I compounds and their pharmaceutical compositions are novel therapeutics for the treatment of diseases, such as human immunodeficiency virus (HIV) infection, hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection and cancer. The co-crystal are more stable to oxidation and aqueous degradation, have a better pharmacokinetic profile and superior biological activity than the corresponding tosylate salt form of Formula I compound.
    Type: Application
    Filed: December 21, 2015
    Publication date: June 23, 2016
    Inventors: Urs Schwitter, Fritz Bliss, Michael Kammerer, Florence Tixeront
  • Publication number: 20150182505
    Abstract: The present invention relates to solid forms of (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid, and of salts of (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid.
    Type: Application
    Filed: March 11, 2015
    Publication date: July 2, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lukas Dreier, Andre Egli, Karsten Faehnrich, Olaf Grassman, Peter Mohr, Urs Schwitter, Helmut Stahr, Nicole Wyttenbach
  • Patent number: 8975397
    Abstract: The instant invention relates to novel solid forms of the compound of formula (I) as well as solvates, inclusion complexes with other suitable compounds, processes for their manufacture, pharmaceutical compositions containing these solid forms, and their use as pharmaceuticals.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: March 10, 2015
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pascal Dott, Olaf Grassmann, Michael Kammerer, Joachim Manns, Urs Schwitter, Andrew Thomas, Nicole Wyttenbach
  • Publication number: 20140329806
    Abstract: The instant invention relates to novel solid forms of the compound of formula (I) as well as solvates, inclusion complexes with other suitable compounds, processes for their manufacture, pharmaceutical compositions containing these solid forms, and their use as pharmaceuticals.
    Type: Application
    Filed: June 4, 2014
    Publication date: November 6, 2014
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Pascal Dott, Olaf Grassmann, Michael Kammerer, Joachim Manns, Urs Schwitter, Andrew Thomas, Nicole Wyttenbach
  • Patent number: 8865735
    Abstract: The present invention provides solid forms of the compound of formula 1 and pharmaceutical uses thereof.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: October 21, 2014
    Assignees: Hoffman-La Roche Inc., Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Gary Conard Visor, Shan-Ming Kuang, Baoshu Zhao, Ralph Diodone, Karsten Fähnrich, Urs Schwitter