Patents by Inventor Ute Schellenberger

Ute Schellenberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10667524
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: June 2, 2020
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Scott Diehn, James English, Lu Liu, Azalea Ong, Jarred Oral, Barbara Rosen, Ute Schellenberger, Ingrid Udranszky, Jun-Zhi Wei, Weiping Xie, Genhai Zhu
  • Publication number: 20200158739
    Abstract: Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.
    Type: Application
    Filed: January 24, 2020
    Publication date: May 21, 2020
    Inventors: Ute Schellenberger, Eric E. Niederkofier, Urban A. Kiernan, Jessica O'Rear, Randall W. Nelson
  • Patent number: 10655143
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: May 19, 2020
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: David C. Cerf, James J. English, Carol A. Hendrick, Lu Liu, Jarred K. Oral, Phillip A. Patten, Barbara A. Rosen, Ute Schellenberger, Ingrid Udranszky, Jun-Zhi Wei, Genhai Zhu
  • Patent number: 10641781
    Abstract: Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: May 5, 2020
    Assignee: CRIMSON U.S. ASSETS LLC
    Inventors: Ute Schellenberger, Eric E. Niederkofier, Urban A. Kiernan, Jessica O'Rear, Randall W. Nelson
  • Publication number: 20200055906
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: September 14, 2017
    Publication date: February 20, 2020
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: DANIEL J ALTIER, JENNIFER KARA BARRY, RYAN MICHAEL GERBER, STEVEN D GRUVER, LU LIU, UTE SCHELLENBERGER, JUN-ZHI WEI, WEIPING XIE, NASSER YALPANI, GENHAI ZHU
  • Patent number: 10563221
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: February 18, 2020
    Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Lu Liu, Jessica O'Rear, Young-Jun Park, Barbara Rosen, Ute Schellenberger, Eric Schepers, Jun-Zhi Wei, Weiping Xie, Nasser Yalpani, Xiaohong Zhong, Genhai Zhu
  • Publication number: 20190387749
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: September 11, 2019
    Publication date: December 26, 2019
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: STEVEN D. GRUVER, HEATHER KOZY, JESSICA O'REAR, BARBARA ROSEN, UTE SCHELLENBERGER, JUN-ZHI WEI, WEIPING XIE, XIAOHONG ZHONG, GENHAI ZHU
  • Patent number: 10457957
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are isolated insecticidal proteins and nucleic acids. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: October 29, 2019
    Assignee: PIONEER HI-BRED IINTERNATIONAL, INC.
    Inventors: Andre R Abad, Zhenglin Hou, Lu Liu, Brad Poland, Ute Schellenberger, Ingrid Udranszky, Jimei Wang, Jun-Zhi Wei, Thomas C Wolfe, Weiping Xie, Lan Zhou, Genhai Zhu
  • Patent number: 10448648
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: October 22, 2019
    Assignee: PIONEER HI-BRED INTERANTIONAL, INC.
    Inventors: Steven Gruver, Heather Kozy, Jessica O'Rear, Barbara Rosen, Ute Schellenberger, Jun-Zhi Wei, Weiping Xie, Xiaohong Zhong, Genhai Zhu
  • Publication number: 20190142013
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: January 28, 2019
    Publication date: May 16, 2019
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: STEVEN GRUVER, HEATHER KOZY, JESSICA O'REAR, BARBARA ROSEN, UTE SCHELLENBERGER, JUN-ZHI WEI, WEIPING XIE, XIAOHONG ZHONG, GENHAI ZHU
  • Publication number: 20190119334
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: May 13, 2016
    Publication date: April 25, 2019
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: HEATHER KOZY, JARRED ORAL, UTE SCHELLENBERGER, JUN-ZHI WEI, WEIPING XIE, XIAOHONG ZHONG, GENHAI ZHU
  • Patent number: 10231460
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: March 19, 2019
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Steven Gruver, Heather Kozy, Jessica O'Rear, Barbara Rosen, Ute Schellenberger, Jun-Zhi Wei, Weiping Xie, Xiaohong Zhong, Genhai Zhu
  • Publication number: 20180325119
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: December 8, 2016
    Publication date: November 15, 2018
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: LU LIU, AMY LUM, JARRED KENNETH ORAL, CLAUDIA PEREZ-ORTEGA, BARBARA ANN MARIE ROSEN, UTE SCHELLENBERGER, JUN-ZHI WEI, WEIPING XIE, XIAOHONG ZHONG, GENHAI ZHU
  • Publication number: 20180273974
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: June 6, 2018
    Publication date: September 27, 2018
    Applicants: E. I. DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: LU LIU, JESSICA O'REAR, YOUNG-JUN PARK, BARBARA ROSEN, UTE SCHELLENBERGER, ERIC SCHEPERS, JUN-ZHI WEI, WEIPING XIE, NASSER YALPANI, XIAOHONG ZHONG, GENHAI ZHU
  • Patent number: 10006045
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: June 26, 2018
    Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Lu Liu, Jessica O'Rear, Young Jun Park, Barbara Rosen, Ute Schellenberger, Eric Schepers, Jun-Zhi Wei, Weiping Xie, Nasser Yalpani, Xiaohong Zhong, Genhai Zhu
  • Publication number: 20180111967
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: March 3, 2016
    Publication date: April 26, 2018
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: LU LIU, JARRED KENNETH ORAL, BRAD POLAND, UTE SCHELLENBERGER
  • Publication number: 20180094278
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are isolated insecticidal proteins and nucleic acids. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: December 13, 2017
    Publication date: April 5, 2018
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Andre R Abad, Zhenglin Hou, Lu Liu, Brad Poland, Ute Schellenberger, Ingrid Udranszky, Jimei Wang, Jun-Zhi Wei, Thomas C Wolfe, Weiping Xie, Lan Zhou, Genhai Zhu
  • Publication number: 20180042242
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with one or more nucleic acid sequence encoding insecticidal protein(s) and one or more silencing element(s). In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The molecular and breeding stacks find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: March 3, 2016
    Publication date: February 15, 2018
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: SCOTT HENRY DIEHN, XU HU, ALBERT L. LU, LU LIU, JAMES KEVIN PRESNAIL, GARY A. SANDAHL, UTE SCHELLENBERGER, GUSUI WU
  • Patent number: 9879277
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are isolated insecticidal proteins and nucleic acids. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 30, 2018
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Andre R. Abad, Zhenglin Hou, Lu Liu, Brad Poland, Ute Schellenberger, Ingrid Udranszky, Jimei Wang, Jun-Zhi Wei, Thomas C. Wolfe, Weiping Xie, Lan Zhou, Genhai Zhu
  • Publication number: 20170367349
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: January 7, 2016
    Publication date: December 28, 2017
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: STEVEN GRUVER, HEATHER KOZY, JESSICA O'REAR, BARBARA ROSEN, UTE SCHELLENBERGER, JUN-ZHI WEI, WEIPING XIE, XIAOHONG ZHONG, GENHAI ZHU