Patents by Inventor Vadim V Yuzhakov

Vadim V Yuzhakov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130218083
    Abstract: Microneedle arrays and drug delivery devices are provided for transdermally delivering a drug formulation to a patient. The microneedle array device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the planar substrate, the microneedles having a base portion integrally connected to the substrate, a tip end portion distal to the base portion, and body portion therebetween, wherein each microneedle has at least one channel extending substantially from the base portion through at least a part of the body portion, the channel being open along at least part of the body portion and in fluid communication with at least one of the apertures in the substrate. In a preferred embodiment, each microneedle has a substantially rectangular cross-sectional shape and the channel is open to two opposing surfaces of the microneedle.
    Type: Application
    Filed: April 5, 2013
    Publication date: August 22, 2013
    Inventor: Vadim V. Yuzhakov
  • Patent number: 8414548
    Abstract: Microneedle arrays and drug delivery devices are provided for transdermally delivering a drug formulation to a patient. The microneedle array device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the planar substrate, the microneedles having a base portion integrally connected to the substrate, a tip end portion distal to the base portion, and body portion therebetween, wherein each microneedle has at least one channel extending substantially from the base portion through at least a part of the body portion, the channel being open along at least part of the body portion and in fluid communication with at least one of the apertures in the substrate. In a preferred embodiment, each microneedle has a substantially rectangular cross-sectional shape and the channel is open to two opposing surfaces of the microneedle.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: April 9, 2013
    Inventor: Vadim V. Yuzhakov
  • Publication number: 20100305473
    Abstract: Microneedle arrays are provided for use on a contoured or flexible tissue surface. In one embodiment, the microneedle array includes a plurality of microneedles, each having a base portion, a tip end portion distal to the base portion, and body portion therebetween; and a flexible substrate which comprises a plurality of apertures, each of which are defined by (i) a plurality of substrate elements which are integral with the base portions of the microneedles, and (ii) at least one spring element connecting at least two of the substrate elements. The spring element may include a curved element, such as a C-shaped, U-shaped, or S-shaped element. Apertures may be defined, for example, by two substrate elements, which connected to three or four spring elements. A skin patch is provided for therapeutic or diagnostic applications, which includes the microneedle array and an adhesive material.
    Type: Application
    Filed: August 10, 2010
    Publication date: December 2, 2010
    Inventor: Vadim V. Yuzhakov
  • Patent number: 7785301
    Abstract: Microneedle arrays are provided for use on a contoured or flexible tissue surface. In one embodiment, the microneedle array includes a plurality of microneedles, each having a base portion, a tip end portion distal to the base portion, and body portion therebetween; and a flexible substrate which comprises a plurality of apertures, each of which are defined by (i) a plurality of substrate elements which are integral with the base portions of the microneedles, and (ii) at least one spring element connecting at least two of the substrate elements. The spring element may include a curved element, such as a C-shaped, U-shaped, or S-shaped element. Apertures may be defined, for example, by two substrate elements, which connected to three or four spring elements. A skin patch is provided for therapeutic or diagnostic applications, which includes the microneedle array and an adhesive material.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: August 31, 2010
    Inventor: Vadim V Yuzhakov
  • Publication number: 20100130940
    Abstract: Microneedle arrays and drug delivery devices are provided for transdermally delivering a drug formulation to a patient. The microneedle array device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the planar substrate, the microneedles having a base portion integrally connected to the substrate, a tip end portion distal to the base portion, and body portion therebetween, wherein each microneedle has at least one channel extending substantially from the base portion through at least a part of the body portion, the channel being open along at least part of the body portion and in fluid communication with at least one of the apertures in the substrate. In a preferred embodiment, each microneedle has a substantially rectangular cross-sectional shape and the channel is open to two opposing surfaces of the microneedle.
    Type: Application
    Filed: January 27, 2010
    Publication date: May 27, 2010
    Inventor: Vadim V. Yuzhakov
  • Patent number: 7658728
    Abstract: Microneedle arrays and drug delivery devices are provided for transdermally delivering a drug formulation to a patient. The microneedle array device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the planar substrate, the microneedles having a base portion integrally connected to the substrate, a tip end portion distal to the base portion, and body portion therebetween, wherein each microneedle has at least one channel extending substantially from the base portion through at least a part of the body portion, the channel being open along at least part of the body portion and in fluid communication with at least one of the apertures in the substrate. In a preferred embodiment, each microneedle has a substantially rectangular cross-sectional shape and the channel is open to two opposing surfaces of the microneedle.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: February 9, 2010
    Inventor: Vadim V. Yuzhakov
  • Publication number: 20080125743
    Abstract: Microneedle arrays are provided for use on a contoured or flexible tissue surface. In one embodiment, the microneedle array includes a plurality of microneedles, each having a base portion, a tip end portion distal to the base portion, and body portion therebetween; and a flexible substrate which comprises a plurality of apertures, each of which are defined by (i) a plurality of substrate elements which are integral with the base portions of the microneedles, and (ii) at least one spring element connecting at least two of the substrate elements. The spring element may include a curved element, such as a C-shaped, U-shaped, or S-shaped element. Apertures may be defined, for example, by two substrate elements, which connected to three or four spring elements. A skin patch is provided for therapeutic or diagnostic applications, which includes the microneedle array and an adhesive material.
    Type: Application
    Filed: November 28, 2006
    Publication date: May 29, 2008
    Inventor: Vadim V. Yuzhakov
  • Patent number: 7144495
    Abstract: Methods and devices for electrochemically detecting a change in the viscosity of a fluid are provided. In the subject methods, a fluid sample (e.g., a whole blood sample) is introduced into an electrochemical test strip's electrochemical cell using a micro-needle integrated into one of oppositely spaced apart working and reference electrodes. An electric potential is applied to the electrochemical cell to first achieve a steady state cell current. A decrease in the steady state cell current is then detected and related to a change in viscosity of the sample. In many embodiments, the sample is blood and the change in viscosity is related to the onset of coagulation in the blood sample, and often the PT of the blood sample. An electrochemical test strip includes an electrochemical cell and an integrated micro-needle. The electrochemical cell includes oppositely spaced apart working and reference electrodes and a reagent mixture (e.g., a redox couple and a coagulation catalyzing agent).
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: December 5, 2006
    Assignee: Lifescan, Inc.
    Inventors: Maria Teodorczyk, Ernest J. Kiser, Lorin P. Olson, Devin McAllister, Vadim V. Yuzhakov, Koon-wah Leong
  • Patent number: 7060192
    Abstract: Methods of fabricating devices for collecting a sample of physiological and for measuring a characteristic, e.g., an analyte concentration, of the sampled physiological sample. The devices are in the form of a test strip which include a biosensor and at least one skin-piercing element which is a planar extension of a portion of the biosensor. The fabrication methods provide various or forming the test strip and the skin-piercing element.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: June 13, 2006
    Assignee: LifeScan, Inc.
    Inventors: Vadim V Yuzhakov, Devin V. McAllister, Lorin Olson, Koon-wah Leong, Maria Teodorczyk, Ernest Kiser
  • Publication number: 20030212346
    Abstract: Methods of fabricating devices for collecting a sample of physiological and for measuring a characteristic, e.g., an analyte concentration, of the sampled physiological sample. The devices are in the form of a test strip which include a biosensor and at least one skin-piercing element which is a planar extension of a portion of the biosensor. The fabrication methods provide various or forming the test strip and the skin-piercing element.
    Type: Application
    Filed: May 9, 2002
    Publication date: November 13, 2003
    Inventors: Vadim V. Yuzhakov, Devin V. McAllister, Lorin Olson, Koon-Wah Leong, Maria Teodorczyk, Ernest Kiser
  • Publication number: 20030150745
    Abstract: Methods and devices for electrochemically detecting a change in the viscosity of a fluid are provided. In the subject methods, a fluid sample (e.g., a whole blood sample) is introduced into an electrochemical test strip's electrochemical cell using a micro-needle integrated into one of oppositely spaced apart working and reference electrodes. An electric potential is applied to the electrochemical cell to first achieve a steady state cell current. A decrease in the steady state cell current is then detected and related to a change in viscosity of the sample. In many embodiments, the sample is blood and the change in viscosity is related to the onset of coagulation in the blood sample, and often the PT of the blood sample. An electrochemical test strip includes an electrochemical cell and an integrated micro-needle. The electrochemical cell includes oppositely spaced apart working and reference electrodes and a reagent mixture (e.g., a redox couple and a coagulation catalyzing agent).
    Type: Application
    Filed: August 23, 2002
    Publication date: August 14, 2003
    Inventors: Maria Teodorczyk, Ernest J. Kiser, Lorin P. Olson, Devin McAllister, Vadim V. Yuzhakov, Koon-wah Leong
  • Publication number: 20030143113
    Abstract: Devices, systems and methods are provided for piercing the skin, accessing and collecting physiological sample therein, and measuring a characteristic, e.g., an analyte concentration, of the sampled physiological sample. The subject devices are in the form of a test strip which include a biosensor and at least one skin-piercing element which is a planar extension of a portion of the biosensor. At least one fluid pathway resides within a portion of the biosensor and within the skin-piercing element. The skin-piercing element has a space-defining configuration therein which acts as a sample fluid pooling area upon penetration into the skin. Systems are provided which include one or more test strip devices and a meter for making analyte concentration measurements. Methods for using the devices and systems are also provided.
    Type: Application
    Filed: May 9, 2002
    Publication date: July 31, 2003
    Applicant: LIFESCAN, INC.
    Inventors: Vadim V. Yuzhakov , Devin V. McAllister , Lorin Olson , Koon-wah Leong , Maria Teodorczyk , Ernest Kiser
  • Publication number: 20030028125
    Abstract: Devices and methods are provided for piercing the skin and accessing and collecting physiological sample therein. The subject devices include at least one fluid pathway, wherein at least a substantial portion of the distal end of the at least one fluid pathway is open to the outside environment. One or more subject devices may be integrated into a test strip for determining the concentration of at least one analyte in the sample. Also provided are methods for using the subject devices. The devices and methods are particularly suited for collecting physiological sample and determining glucose concentrations therein and, more particularly, glucose concentrations in blood, blood fractions or interstitial fluid. Also provided are kits that include the devices for use in practicing the subject methods.
    Type: Application
    Filed: August 6, 2001
    Publication date: February 6, 2003
    Inventors: Vadim V. Yuzhakov, Devin V. McAllister
  • Publication number: 20020168290
    Abstract: Devices, systems and methods are provided for piercing the skin, accessing and collecting physiological sample therein, and measuring a characteristic, e.g., an analyte concentration, of the sampled physiological sample. The subject devices are in the form of a test strip which include a biosensor and at least one skin-piercing element which is a planar extension of a portion of the biosensor. At least one fluid pathway resides within a portion of the biosensor and within the skin-piercing element. The skin-piercing element has a space-defining configuration therein which acts as a sample fluid pooling area upon penetration into the skin. Systems are provided which include one or more test strip devices and a meter for making analyte concentration measurements. Methods for using the devices and systems are also provided.
    Type: Application
    Filed: May 9, 2002
    Publication date: November 14, 2002
    Inventors: Vadim V. Yuzhakov, Devin V. McAllister, Lorin Olson, Koon-Wah Leong, Maria Teodorczyk, Ernest Kiser