Patents by Inventor Valery Krasnoperov

Valery Krasnoperov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF CANCERS USING sEphB4-HSA FUSION PROTEINS
    Publication number: 20220249621
    Abstract: Compositions and methods are provided for treating cancer in a subject comprising administering to the subject a therapeutically effective amount of a polypeptide agent that inhibits EphB4 or EphrinB2 mediated functions. In various embodiments the methods further provide administration of a therapeutically effective amount of an immune checkpoint inhibitor. The present inventors have demonstrated that the synergistic effect of the combination of an EphB4-EphrinB2 inhibitor and checkpoint inhibitor provides superior progression-free survival (PFS) and objective response rates (ORR) patients with various cancers by activating T cell and promoting T cell and NK cell trafficking into the tumor and via migration of immune cells (e.g., CD3 and CD8) into the tumor.
    Type: Application
    Filed: March 17, 2020
    Publication date: August 11, 2022
    Inventor: Valery Krasnoperov
  • EPHB4-EPHRIN B2 RECEPTOR LIGAND PAIR AS A NOVEL MARKER FOR THE TREATMENT OF PROSTATE CANCER
    Publication number: 20220153791
    Abstract: Compositions and methods are provided for treating prostate cancer (PC) in a subject comprising administering to the subject a therapeutically effective amount of a polypeptide agent that inhibits EphB4 or Ephrin B2 mediated functions. More specifically, methods are provided for use in treating PTEN deficient PC or PC that is refractory to treatment using androgen receptor (AR) targeted therapy. Importantly, a therapeutic agent, soluble EphB4, prevented tumor formation and induced tumor regression in established pre-castration and post-castration tumors. Surprisingly, androgen receptor (AR) levels also declined with therapy. PI3K isoform analysis showed downregulation of only PI3K p110 beta which directly regulates AR levels, such that AR decline was rescued with ectopic expression of PI3K beta. EphB4 is thus a novel target in prostate cancer.
    Type: Application
    Filed: February 13, 2020
    Publication date: May 19, 2022
    Inventor: Valery Krasnoperov
  • Polypeptide compounds for inhibiting angiogenesis and tumor growth
    Patent number: 9533026
    Abstract: In certain embodiments, this present invention provides polypeptide compositions, including compositions containing a modified polypeptide, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: January 3, 2017
    Assignee: VASGENE THERAPEUTICS, INC
    Inventors: Valery Krasnoperov, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill, Sergey Zozulya
  • Polypeptide compounds for inhibiting angiogenesis and tumor growth
    Patent number: 8981062
    Abstract: In certain embodiments, this present invention provides polypeptide compositions (e.g., antibodies and antigen binding portions thereof that bind to EphB4), and methods for inhibiting EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: March 17, 2015
    Assignee: Vasgene Theapeutics, Inc
    Inventors: Valery Krasnoperov, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill, Sergey Zozulya
  • Cancer treatment using humanized antibodies that bind to EphB4
    Patent number: 8975377
    Abstract: In certain embodiments, this application provides humanized antibodies that bind to the EphB4 protein as well as uses of the antibodies for therapeutic purposes.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: March 10, 2015
    Assignee: Vasgene Therapeutics, Inc
    Inventors: Parkash Gill, Valery Krasnoperov, Simon William Keen, Timothy David Jones, Francis Joseph Carr
  • POLYPEPTIDE COMPOUNDS FOR INHIBITING ANGIOGENESIS AND TUMOR GROWTH
    Publication number: 20140107030
    Abstract: In certain embodiments, this present invention provides polypeptide compositions, including compositions containing a modified polypeptide, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
    Type: Application
    Filed: May 6, 2013
    Publication date: April 17, 2014
    Applicant: VasGene Therapeutics, Inc.
    Inventors: Valery Krasnoperov, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill, Sergey Zozulya
  • POLYPEPTIDE COMPOUNDS FOR INHIBITING ANGIOGENESIS AND TUMOR GROWTH
    Publication number: 20130344075
    Abstract: In certain embodiments, this present invention provides polypeptide compositions (e.g., antibodies and antigen binding portions thereof that bind to EphB4), and methods for inhibiting EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
    Type: Application
    Filed: June 6, 2011
    Publication date: December 26, 2013
    Applicant: VASGENE THERAPEUTICS, INC.
    Inventors: Valery Krasnoperov, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill, Sergey Zozulya
  • POLYPEPTIDE COMPOUNDS FOR INHIBITING ANGIOGENESIS AND TUMOR GROWTH
    Publication number: 20120277162
    Abstract: In certain embodiments, this present invention provides polypeptide compositions, including compositions containing a modified polypeptide, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
    Type: Application
    Filed: March 15, 2012
    Publication date: November 1, 2012
    Applicant: VASGENE THERAPEUTICS, INC.
    Inventors: Valery Krasnoperov, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill, Sergey Zozulya
  • Polypeptide compounds for inhibiting angiogenesis and tumor growth
    Patent number: 8273858
    Abstract: In certain embodiments, this present invention provides polypeptide compositions, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: September 25, 2012
    Assignee: VasGene Therapeutics, Inc.
    Inventors: Valery Krasnoperov, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill, Sergey Zozulya
  • Polypeptide compounds for inhibiting angiogenesis and tumor growth
    Patent number: 8063183
    Abstract: In certain embodiments, this present invention provides polypeptide compositions, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: November 22, 2011
    Assignee: VasGene Therapeutics, Inc.
    Inventors: Valery Krasnoperov, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill, Sergey Zozulya
  • METHODS FOR USING AND IDENTIFYING MODULATORS OF DELTA-LIKE 4
    Publication number: 20110213127
    Abstract: In certain embodiments, this present invention provides antibodies that act as either agonists or antagonists of Delta-like 4 (Dll4) signaling.
    Type: Application
    Filed: February 4, 2011
    Publication date: September 1, 2011
    Applicant: VasGene Therapeutics, Inc.
    Inventors: Parkash Gill, Ren Liu, Valery Krasnoperov
  • Polypeptide compounds for inhibiting angiogenesis and tumor growth
    Patent number: 7977463
    Abstract: In certain embodiments, this present invention provides polypeptide compositions (e.g., antibodies and antigen binding portions thereof that bind to EphB4), and methods for inhibiting EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: July 12, 2011
    Assignee: VasGene Therapeutics, Inc.
    Inventors: Valery Krasnoperov, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill, Sergey Zozulya
  • POLYPEPTIDE COMPOUNDS FOR INHIBITING ANGIOGENESIS AND TUMOR GROWTH
    Publication number: 20110129482
    Abstract: In certain embodiments, this present invention provides polypeptide compositions, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
    Type: Application
    Filed: November 23, 2010
    Publication date: June 2, 2011
    Applicant: VASGENE THERAPEUTICS, INC.
    Inventors: Valery Krasnoperov, Sergey Zozulya, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill
  • Methods for using and identifying modulators of Delta-like 4
    Patent number: 7906116
    Abstract: In certain embodiments, this present invention provides methods of identifying and using antibodies that act as either agonists or antagonists of Delta-like 4 (Dll4) signaling.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: March 15, 2011
    Inventors: Parkash Gill, Ren Liu, Valery Krasnoperov
  • Polypeptide compounds for inhibiting angiogenesis and tumor growth
    Patent number: 7862816
    Abstract: In certain embodiments, this present invention provides polypeptide compositions, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: January 4, 2011
    Assignee: Vasgene Therapeutics, Inc.
    Inventors: Valery Krasnoperov, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill, Sergey Zozulya
  • Polypeptide compounds for inhibiting angiogenesis and tumor growth
    Publication number: 20100261653
    Abstract: In certain embodiments, this present invention provides polypeptide compositions, including compositions containing a modified polypeptide, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
    Type: Application
    Filed: September 14, 2009
    Publication date: October 14, 2010
    Applicant: VasGene Therapeutics, Inc.
    Inventors: Valery Krasnoperov, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill, Sergey Zozulya
  • Cancer treatment using humanized antibodies that bind to EphB4
    Publication number: 20090196880
    Abstract: In certain embodiments, this application provides humanized antibodies that bind to the EphB4 protein as well as uses of the antibodies for therapeutic purposes.
    Type: Application
    Filed: August 11, 2008
    Publication date: August 6, 2009
    Applicant: Vasgene Therapeutics, Inc.
    Inventors: Parkash Gill, Valery Krasnoperov, Simon William Keen, Timothy David Jones, Francis Joseph Carr
  • Polypeptide compounds for inhibiting angiogenesis and tumor growth
    Publication number: 20090155251
    Abstract: In certain embodiments, this present invention provides polypeptide compositions, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
    Type: Application
    Filed: June 2, 2008
    Publication date: June 18, 2009
    Applicant: VasGene Therapeutics, Inc.
    Inventors: Valery Krasnoperov, Sergey Zozulya, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill
  • Methods for using and identifying modulators of Delta-like 4
    Publication number: 20090035308
    Abstract: In certain embodiments, this present invention provides methods of identifying and using agonists and antagonists of Delta-like 4 (Dll4) signaling.
    Type: Application
    Filed: December 20, 2007
    Publication date: February 5, 2009
    Applicant: VasGene Therapeutics, Inc.
    Inventors: Parkash Gill, Ren Liu, Valery Krasnoperov
  • Polypeptide Compounds for Inhibiting Angiogenesis and Tumor Growth
    Publication number: 20080131436
    Abstract: In certain embodiments, this present invention provides polypeptide compositions (e.g., antibodies and antigen binding portions thereof that bind to EphB4), and methods for inhibiting EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases.
    Type: Application
    Filed: March 11, 2005
    Publication date: June 5, 2008
    Applicant: VasGene Therapeutics, Inc.
    Inventors: Valery Krasnoperov, Nathalie Kertesz, Ramachandra Reddy, Parkash Gill, Sergey Zozulya