Patents by Inventor Vamsi Krishna Mootha

Vamsi Krishna Mootha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF MODULATING SLC7A11 PRE-MRNA TRANSCRIPTS FOR DISEASES AND CONDITIONS ASSOCIATED WITH EXPRESSION OF SLC7A11
    Publication number: 20220162617
    Abstract: Described are methods for enhancing exon skipping in a pre-mRNA of interest, comprising contacting the pre-mRNA with interfering oligonucleotides such as antisense, siRNA, and miRNA. The exon skipping methods are associated with methods of treating a variety of diseases and conditions, including cancer.
    Type: Application
    Filed: September 22, 2021
    Publication date: May 26, 2022
    Applicants: The Broad Institute, Inc., The General Hospital Corporation
    Inventors: Vamsi Krishna MOOTHA, Alexis André JOURDAIN
  • Methods and compositions for treating metabolic disorders
    Publication number: 20090143279
    Abstract: The present invention provides methods of treating of disorders characterized by defective mitochondrial activity. In particular compounds of the present invention can be used in the treatment metabolic diseases and neurodegenerative diseases. The methods are also useful to increase oxidative phosphorylation or to decrease reactive oxygen species (ROS) production in a subject in need thereof.
    Type: Application
    Filed: June 13, 2008
    Publication date: June 4, 2009
    Inventors: Vamsi Krishna Mootha, Bridget Wagner, Toshimori Kitami