Patents by Inventor VARTIKA AGRAWAL

VARTIKA AGRAWAL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10957420
    Abstract: The amount of genomic data as well the sensitivity of the information carried necessitates the need to develop smart and efficient ways to transmit genomic data in a secure way. While encryption schemes exist, there is also the need to first reduce the amount of massive information and then apply an encoding and encryption method that will be effective both in the economic sense as well as for security of genomic data. In this invention, we discuss novel techniques to encode processed variant information and send it across to a remote site ensuring covert transmission. The protocols not only encode and encrypts the information; it condenses the information that needs to be transferred.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: March 23, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Vartika Agrawal, Nevenka Dimitrova, Raymond J. Krasinski
  • Patent number: 10734095
    Abstract: The present disclosure describes systems and methods for generating a priority score for a variant of a gene based on its potential significance to a disease. Priority scores may be calculated for multiple variants, and the variants may be ranked based on the generated priority scores.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: August 4, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Vartika Agrawal, Nevenka Dimitrova
  • Publication number: 20200035332
    Abstract: Methods and corresponding systems for anonymizing genetic data obtained from a patient are described. The ancestry data can be masked by identifying ancestry information marker (AIM) regions in the genetic data. Each AIM region can include including one or more single-nucleotide polymorphism (SNP) alleles associated with a population of patients belonging to a certain ancestry. Once the AIM regions are identified, one or more regions that include clinically relevant data can be identified. The clinically relevant data can be data having one or more gene variants associated with a specific disease or disorder. The genetic data can be anonymized the by masking or removing AIM regions that do not include clinically relevant data.
    Type: Application
    Filed: April 4, 2018
    Publication date: January 30, 2020
    Inventor: Vartika Agrawal
  • Publication number: 20200020421
    Abstract: A clinical genomic data processing device includes at least one microprocessor (10) and a non-transitory storage medium (12) storing instructions to implement functions of the device. A user interface (26, 28) receives requests for execution of genomic workflows and to display output generated by the execution of the genomic workflows. A genomic workflow manager manages an asynchronous messaging queue (24) and manages the execution of the genomic workflows. Service providers (20) performs jobs associated with the genomic workflows. The genomic workflow manager communicates with the service providers by messages exchanged via the asynchronous messaging queue to manage the execution of the genomic workflows via jobs performed by the service providers.
    Type: Application
    Filed: September 29, 2017
    Publication date: January 16, 2020
    Inventors: Nevenka Dimitrova, Ronen Solomon, Keswarpu Payal, Mine Danisman-Tasar, Moran Bentzur, Nadav Sharabi, Sergey Yussim, Alexander Ryan Mankovich, Vartika Agrawal, Julie Gu, Iliya Fridman, Kostyantyn Volyanskyy
  • Patent number: 10528758
    Abstract: Methods and apparatus for a secure framework for storing and analyzing genomic data. Embodiments of the present invention apply persistent governance to sensitive information and to the analytics that operate upon it, managing the interaction between the two.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: January 7, 2020
    Assignees: Koninklijke Philips N.V., Intertrust Technologies Corporation
    Inventors: Nevenka Dimitrova, William Knox Carey, Raymond J. Krasinski, Jarl Nilsson, Bart Grantham, Alexander Ryan Mankovich, Vartika Agrawal
  • Publication number: 20190079938
    Abstract: In patient cohort identification, clustering (30) of patients is performed using a patient comparison metric dependent on a set of features (24). Information is displayed on sample patients who are similar or dissimilar to a query patient according to the clustering. User inputted comparison values are received comparing the sample patients with the query patient. The set of features and/or feature weights are adjusted to generate an adjusted patient comparison metric having improved agreement with the user inputted comparison values. The clustering is repeated using the adjusted patient comparison metric. A patient cohort is identified from a cluster (34) containing the query patient produced by the last clustering repetition. The information on the sample patients may be shown by simultaneously displaying two or more graphical modality representations (70, 72, 74) each plotting the sample patients and the query patient against two or more features of the modality.
    Type: Application
    Filed: March 8, 2017
    Publication date: March 14, 2019
    Inventors: Vartika Agrawal, Alexander Ryan Mankovich, Nevenka Dimitrova, Nilanjana Banerjee, Yee Him Cheung, Johanna Maria De Bont, Jozef Hieronymus Maria Raijmakers
  • Publication number: 20190071718
    Abstract: A system for characterizing intercellular communication and heterogeneity in cancer tumors, and more particularly a method for detecting sub-populations and receptor-ligand states for providing predictive information in relation to cancer and cancer treatment is disclosed. The system comprises the steps of obtaining from a NGS sequencer, single-cell RNA-seq for a plurality of cells within a tumor, correlation with a plurality of data sets from a curated gene list of receptor-ligand pairs, normalizing their transcript abundance data, assigning states (e.g. 0,1,2,3) to each curated receptor-ligand pair in each cell (e.g.
    Type: Application
    Filed: April 7, 2017
    Publication date: March 7, 2019
    Inventors: Balaji Srinivasan Santhanam, Yee Him Cheung, Vartika Agrawal, Johanna Maria De Bont, Nevenka Dimitrova
  • Publication number: 20180218116
    Abstract: The present disclosure describes systems and methods for generating a priority score for a variant of a gene based on its potential significance to a disease. Priority scores may be calculated for multiple variants, and the variants may be ranked based on the generated priority scores.
    Type: Application
    Filed: July 26, 2016
    Publication date: August 2, 2018
    Inventors: Vartika Agrawal, Nevenka Dimitrova
  • Publication number: 20170286597
    Abstract: Methods and systems for visualizing gene expression data in a way that permits the comparison of different patient groups to facilitate medical applications, including cancer diagnostics and treatment planning, particularly breast cancer. The method organises gene expression data for at least one patient into a plurality of windows of a specified size, calculates an average RSEM score for all of the genes in each window and presents the average RSEM scores in a two-dimensional array, wherein one axis organises the windows by patient and the other axis organises the windows by sequence.
    Type: Application
    Filed: August 17, 2015
    Publication date: October 5, 2017
    Inventors: ALEXANDER RYAN MANKOVICH, NEVENKA DIMITROVA, VARTIKA AGRAWAL, NILANJANA BANERJEE
  • Publication number: 20170262579
    Abstract: The amount of genomic data as well the sensitivity of the information carried necessitates the need to develop smart and efficient ways to transmit genomic data in a secure way. While encryption schemes exist, there is also the need to first reduce the amount of massive information and then apply an encoding and encryption method that will be effective both in the economic sense as well as for security of genomic data. In this invention, we discuss novel techniques to encode processed variant information and send it across to a remote site ensuring covert transmission. The protocols not only encode and encrypts the information; it condenses the information that needs to be transferred.
    Type: Application
    Filed: November 18, 2015
    Publication date: September 14, 2017
    Inventors: VARTIKA AGRAWAL, NEVENKA DIMITROVA, RAYMOND J. KRASINSKI
  • Publication number: 20170068826
    Abstract: Methods and apparatus for a secure framework for storing and analyzing genomic data. Embodiments of the present invention apply persistent governance to sensitive information and to the analytics that operate upon it, managing the interaction between the two.
    Type: Application
    Filed: April 24, 2015
    Publication date: March 9, 2017
    Inventors: NEVENKA DIMITROVA, WILLIAM KNOX CAREY, RAYMOND J. KRASINSKI, JARL NILSSON, BART GRANTHAM, ALEXANDER RYAN MANKOVICH, VARTIKA AGRAWAL
  • Publication number: 20170032081
    Abstract: The present disclosure describes systems and methods for generating a priority score for a variant of a gene based on its potential significance to a disease. Priority scores may be calculated for multiple variants, and the variants may be ranked based on the generated priority scores.
    Type: Application
    Filed: July 28, 2016
    Publication date: February 2, 2017
    Inventors: VARTIKA AGRAWAL, NEVENKA DIMITROVA