Patents by Inventor Veli-Matti Mukkala

Veli-Matti Mukkala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6127529
    Abstract: Bifuncitonal chelating pyridine compound and its use for conferring chelating properties on organic compounds. The pyridine compound has the structure ##STR1## where (i) n is an integer 1 or 2,(ii) R.sub.1, R.sub.2 and R.sub.3 represent groups that have no electrons capable of significantly delocalizing or resonating with the pyridine ring, such as hydrogen, alkyl or aralkyl having an aliphatic carbon atom next to the pyridine ring; at least two of R.sub.1, R.sub.2 and R.sub.
    Type: Grant
    Filed: September 13, 1991
    Date of Patent: October 3, 2000
    Assignee: Wallac Oy
    Inventors: Marek Kwiatkowski, Christian Sund, Jyrki Ylikoski, Veli-Matti Mukkala, Ilkka Hemmila
  • Patent number: 6080839
    Abstract: The invention relates to a novel labeling reactant, suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The invention further concerns new labeling methods. The novel labeling reactant has the formula (I) ##STR1## wherein -A- is a bivalent aromatic structure capable of absorbing light or energy and transferring the excitation energy to a lanthanide ion after the product made by the said solid-phase synthesis has been released from the used solid support, deprotected and converted to a lanthanide chelate;-G- is a bridge replacing a hydrogen atom in A;R is a protected amino acid residue --CH(NHX)COOH, where X is a transient protecting group, or its active ester, where said ester is e.g. an N-hydroxysuccinimido, p-nitrophenol or pentafluorophenol ester; andR' is --COOR'" where R'" is an alkyl of 1 to 4 carbon atoms, phenyl or benzyl, which phenyl or benzyl can be substituted or unsubstituted.
    Type: Grant
    Filed: June 25, 1998
    Date of Patent: June 27, 2000
    Assignee: Wallac Oy
    Inventors: Harri Takalo, Jari Hovinen, Veli-Matti Mukkala, Paivi Liitti, Heikki Mikola
  • Patent number: 5859215
    Abstract: This invention relates to a detectable molecule comprising a biospecific binding reactant attached to a luminescent lanthanide chelate comprising a lanthanide ion and a chelating ligand of the formula ##STR1## wherein --A-- is a bivalent aromatic structure selected from the group consisting of ##STR2## One of the two groups G.sub.1 or G.sub.2 is used for coupling the chelate to a biospecific binding reactant. The lanthanide ion is europium(III), terbium(III), dysprosium (III) or samarium (III).
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: January 12, 1999
    Assignee: Wallac Oy
    Inventors: Juan Carlos Rodriguez-Ubis, Harri Takalo, Veli-Matti Mukkala
  • Patent number: 5571897
    Abstract: Lanthanide chelates which contain three heterocyclic rings covalently coupled to each other (either one 2,6-pyridylene and two five-membered unsaturated heterocyclic ring moieties or two 2,6-pyridylene and one five-membered unsaturated heterocyclic ring moiety) and two chelating groups so seated that they together chelate the same lanthanide ion even in aqueous solutions. These lanthanide chelates can optionally contain a reactive group for coupling to biologically active molecules. The new chelates are suitable for classical lanthanide chelate applications and are also useful as probes in time-resolved fluorescence microscopy, cytometry, multilabelling techniques and in process controls in industry.
    Type: Grant
    Filed: July 26, 1994
    Date of Patent: November 5, 1996
    Assignee: Wallac Oy
    Inventors: Harri Takalo, Veli-Matti Mukkala
  • Patent number: 5457186
    Abstract: A method of conducting assays for analytes, usually from biological samples, utilizing bioaffinity reagents linked to luminescent lanthanide chelates, which are synthesized so that the non-radiative quenching of the ion luminescence through C--H bond vibrational energy manifolds is avoided using a stable chelate where the CH and CH.sub.2 groups in the vicinity of the emittive ion are substituted with CD and CD.sub.2 groups hence producing improved luminescence quantum yield and higher assay sensitivities.
    Type: Grant
    Filed: October 13, 1993
    Date of Patent: October 10, 1995
    Assignee: Wallac Oy
    Inventors: Veli-Matti Mukkala, Harri Takalo, Ilkka Hemmila, Jouko Kankare
  • Patent number: 5324825
    Abstract: The invention pertains to terpyridine compounds having structure (I). These compounds form fluorescent lanthanide chelates with the appropriate metal ions. The fluorescent metal chelates are useful as probes in time-resolved fluorescence spectroscopy.
    Type: Grant
    Filed: October 28, 1992
    Date of Patent: June 28, 1994
    Assignee: Wallac OY
    Inventors: Jouko Kankare, Harri Takalo, Elina Hanninen, Matti Helenius, Veli-Matti Mukkala
  • Patent number: 5216134
    Abstract: A chelate formed between Eu.sup.3+, Tb.sup.3+, Dy.sup.3+ and Sm.sup.3+ and a compound having the formula ##STR1## where A.sub.1-6 are single carbon or nitrogen atoms; n=1 or 2; R.sub.1-6 is nothing when A is a nitrogen, and hydrogen or an organic group when A is a carbon; Z and Z' are selected among --N(CH.sub.2 CH.sub.2 COO.sup.-).sub.2, --N(CH.sub.2 COO.sup.-).sub.2, --N(CH.sub.2 OPO.sub.3.sup.2-).sub.2 and --N(CH.sub.2 PO.sub.3.sup.2-).sub.2 ;--species that --X--Y is a substituent replacing a hydrogen anywhere in the parent compound; and --X--Y represents an organic group containing no chelating heteroatom closer than four atoms from a chelating heteroatom in the parent compound and X is a stable bridge containing certain groups and Y is selected from (a) specified relative groups allowing coupling to other compounds and (b) residues of compounds participating in biospecific affinity reactions.
    Type: Grant
    Filed: March 6, 1991
    Date of Patent: June 1, 1993
    Assignee: Wallac Oy
    Inventors: Veli-Matti Mukkala, Christian Sund, Marek Kwiatkowski
  • Patent number: 5202423
    Abstract: The invention pertains to terpyridine compounds having structure (I). These compounds form fluorescent lanthanide chelates with the appropriate metal ions. The fluorescent metal chelates are useful as probes in time-resolved fluorescence spectroscopy.
    Type: Grant
    Filed: April 19, 1991
    Date of Patent: April 13, 1993
    Assignee: Wallac Oy
    Inventors: Jouko Kankare, Harri Takalo, Elina Hanninen, Matti Helenius, Veli-Matti Mukkala
  • Patent number: 4808541
    Abstract: Compound having the following structure: ##STR1## R is a direct chain or branched alkylene group comprising 2-8 carbon atoms,n and m are 0 or 1,Y is a carboxylic or phosphonic acid, andX is an active functional group which permits covalent coupling to a bio-organic molecule.
    Type: Grant
    Filed: February 20, 1987
    Date of Patent: February 28, 1989
    Assignees: LKB Produkter AB, Wallac OY
    Inventors: Heikki Mikola, Veli-Matti Mukkala, Ilkka Hemmila