Abstract: A vehicle latch, including: a power release mechanism for transitioning the vehicle latch from a latched state to an unlatched state, the power release mechanism includes a motor that rotates a worm that meshingly engages a power release gear, which is operably coupled to a pawl of the latch; and a spring provided to reduce a speed of the gear as it is back driven into a home position.

Abstract: A device for delivering fluid to a user includes a fluid reservoir for holding the fluid, the fluid reservoir defining an internal volume and a stopper positioned in the internal volume of the fluid reservoir, wherein the stopper is formed with a cavity. The device further includes a piston having a distal end received within the cavity of the stopper and an actuator coupled to the piston for driving the piston into the internal volume of the fluid reservoir. Also, the device includes a coupling device for engaging the piston in the cavity of the stopper at a desired position and a sensor for determining whether the piston is engaged in the cavity of the stopper at the desired position.

Abstract: A device for delivering fluid to a user includes a fluid reservoir for holding the fluid, the fluid reservoir defining an internal volume and a stopper positioned in the internal volume of the fluid reservoir, wherein the stopper is formed with a cavity. The device further includes a piston having a distal end received within the cavity of the stopper and an actuator coupled to the piston for driving the piston into the internal volume of the fluid reservoir. Also, the device includes a coupling device for engaging the piston in the cavity of the stopper at a desired position and a sensor for determining whether the piston is engaged in the cavity of the stopper at the desired position.

Abstract: Dental periscopes having mounting clips configured to couple to mobile devices are disclosed. A patient can mount the dental periscope to a mobile device by coupling the mounting clip of the periscope to the mobile device. The patient can then use the mobile device-mounted dental periscope to capture image and/or video data of one or more dental structures. The captured image/video data can be sent to a remote system to obtain a remote dental diagnosis based on the captured data. The remote diagnosis may be an automated diagnosis generated by a trained machine learning classifier.

Abstract: The present invention provides a new animal model for mucopolysaccharidosis type lVA or Morquio A syndrome and to methods of generating the animal model and uses thereof.

Abstract: Dental periscopes having mounting clips configured to couple to mobile devices are disclosed. A patient can mount the dental periscope to a mobile device by coupling the mounting clip of the periscope to the mobile device. The patient can then use the mobile device-mounted dental periscope to capture image and/or video data of one or more dental structures. The captured image/video data can be sent to a remote system to obtain a remote dental diagnosis based on the captured data. The remote diagnosis may be an automated diagnosis generated by a trained machine learning classifier.

Abstract: The present invention provides new polynucleotide sequences, adeno-associated virus-derived vectors and pharmaceutical compositions containing the same for the treatment of lysosomal storage disorders and specially, for the treatment of mucopolysaccharidosis type IVA or Morquio A syndrome.

Abstract: A device for delivering fluid to a user includes a fluid reservoir for holding the fluid, the fluid reservoir defining an internal volume and a stopper positioned in the internal volume of the fluid reservoir, wherein the stopper is formed with a cavity. The device further includes a piston having a distal end received within the cavity of the stopper and an actuator coupled to the piston for driving the piston into the internal volume of the fluid reservoir. Also, the device includes a coupling device for engaging the piston in the cavity of the stopper at a desired position and a sensor for determining whether the piston is engaged in the cavity of the stopper at the desired position.

Abstract: In some embodiments, an apparatus includes a memory having an instance of a distributed shared memory and a processor operatively coupled to the memory. The processor is configured to instantiate a first instance of a front-end application and receive, at the first instance of the front-end application, and input signal associated with a state of the first instance of the front-end application. The processor is configured to insert a value into a field data structure defined in the instance of the distributed shared memory and associated with an event source configured through a second instance of the distributed shared memory. The processor is configured to generate an event object indicative of the value inserted into the field data structure and send a signal to update the second instance of the front-end application.

Abstract: A system includes a head supporting device, an alignment checker and a scanning device. The head supporting device is disposed on a first surface of an examination table for supporting a patient. The head supporting device includes an adjustable headrest platform for supporting a head of the patient. The adjustable headrest platform is configured to be movable along a direction perpendicular to the first surface of the examination table. The alignment checker is disposed on the examination table. The alignment checker is located corresponding to the head of the patient. The alignment checker is configured to verify a location or an orientation of the head of the patient. The scanning device is configured for capturing a scan image corresponding to a mandible of the patient.

Abstract: In some embodiments, an apparatus includes a memory having an instance of a distributed shared memory and a processor operatively coupled to the memory. The processor is configured to instantiate a first instance of a front-end application and receive, at the first instance of the front-end application, and input signal associated with a state of the first instance of the front-end application. The processor is configured to insert a value into a field data structure defined in the instance of the distributed shared memory and associated with an event source configured through a second instance of the distributed shared memory. The processor is configured to generate an event object indicative of the value inserted into the field data structure and send a signal to update the second instance of the front-end application.

Abstract: An illuminated baby bottle device including a cap, a nipple, a body configured to retain a liquid, and a base. The body includes an inner-wall and an outer-wall. The nipple is affixable and sealed to the cap, and the protective-cover is also affixable to the cap to protect the nipple and maintain sanitary conditions of the nipple, where the cap is affixable to one end of the body. The base is affixable to the body on the opposing end from the cap. Base is affixable to the body, with the base including a power-supply and an audio-source configured to provide an audio-track. The body includes a light-source arranged between the inner-wall and the outer-wall configured to illuminate the baby bottle device. The light-source includes multiple colors and is illuminated by at least one light-emitting-diode.

Abstract: An open air thermowell system includes a measurement protection device, a temperature measurement device, a torque mechanism, and a torque transfer mechanism.

Abstract: A system includes a head supporting device, an alignment checker and a scanning device. The head supporting device is disposed on a first surface of an examination table for supporting a patient. The head supporting device includes an adjustable headrest platform for supporting a head of the patient. The adjustable headrest platform is configured to be movable along a direction perpendicular to the first surface of the examination table. The alignment checker is disposed on the examination table. The alignment checker is located corresponding to the head of the patient. The alignment checker is configured to verify a location or an orientation of the head of the patient. The scanning device is configured for capturing a scan image corresponding to a mandible of the patient.

Abstract: The invention relates to a method for rapid immunogen selection (RIS) based on the binding a library of recombinant viruses containing randomized HIV gp120 variants of a surface polypeptide displayed to said neutralizing antibodies. The invention relates as well to the use of the HIV gp120 immunogens isolated according to the RIS method of the invention in medicine for the treatment of diseases caused by a virus and in diagnosis for the identification of neutralizing antibodies in a patient.

Abstract: A leak identification system includes a boundary containment system and a leak indicator system that enables quick identification of leaks within various systems.

Abstract: It comprises applying a mould release agent on a compaction tool (1), carrying out its curing and applying a layer with adhesive properties (2) on the mould release agent. It is characterized in that it also comprises extending an aerator blanket (4) along the layer (2) with dimensions larger than the adhesive layer (2), extending a membrane with resilient properties (5) on the entire surface of the tool (1) by applying vacuum to the membrane (5) for compacting the adhesive layer. This method reduces the number of stages required to perform the compaction and avoids the generation of waste materials thus reducing the cost of the process.

Abstract: The invention relates to a method for rapid immunogen selection (RIS) based on the binding a library of recombinant viruses containing randomized HIV gp120 variants of a surface polypeptide displayed to said neutralizing antibodies. The invention relates as well to the use of the HIV gp120 immunogens isolated according to the RIS method of the invention in medicine for the treatment of diseases caused by a virus and in diagnosis for the identification of neutralizing antibodies in a patient.

Abstract: It comprises applying a mould release agent on a compaction tool (1), carrying out its curing and applying a layer with adhesive properties (2) on the mould release agent. It is characterized in that it also comprises extending an aerator blanket (4) along the layer (2) with dimensions larger than the adhesive layer (2), extending a membrane with resilient properties (5) on the entire surface of the tool (1) by applying vacuum to the membrane (5) for compacting the adhesive layer. This method reduces the number of stages required to perform the compaction and avoids the generation of waste materials thus reducing the cost of the process.