Patents by Inventor Vignesh Narayan Hariharan

Vignesh Narayan Hariharan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OLIGONUCLEOTIDES WITH INTERNUCLEOTIDE LINKAGE MODIFICATIONS FOR KIDNEY TARGETING
    Publication number: 20250066780
    Abstract: This disclosure relates to oligonucleotides with internucleotide linkage modifications and used thereof for treating and preventing kidney diseases. In particular, the present disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotide to kidney. The oligonucleotide disclosed herein can be delivered to the kidney upon administration.
    Type: Application
    Filed: June 27, 2024
    Publication date: February 27, 2025
    Inventors: Anastasia Khvorova, Ken Yamada, Vignesh Narayan Hariharan, Julianna Buchwald
  • SGLT-2 TARGETING OLIGONUCLEOTIDES
    Publication number: 20250059539
    Abstract: This disclosure relates to oligonucleotides with internucleotide linkage modifications and used thereof for treating and preventing diseases. Particularly, this disclosure relates to SLC5A2 targeting sequences, and methods for treating and preventing kidney diseases using same.
    Type: Application
    Filed: June 27, 2024
    Publication date: February 20, 2025
    Inventors: Anastasia Khvorova, Ken Yamada, Vignesh Narayan Hariharan, Julianna Buchwald
  • OLIGONUCLEOTIDES FOR SARS-CoV-2 MODULATION
    Publication number: 20240425860
    Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.
    Type: Application
    Filed: May 28, 2024
    Publication date: December 26, 2024
    Inventors: Anastasia Khvorova, Jonathan Watts, Zachary Kennedy, Annabelle Biscans, Bruno Miguel da Cruz Godinho, Chantal Ferguson, Dimas Echeverria Moreno, Ken Yamada, Daniel O'Reilly, Kathryn Monopoli, Vignesh Narayan Hariharan, Qi Tang, Sarah Davis, Samuel Hildebrand, Socheata Ly, Minwook Shin, Pranathi Meda Krishnamurthy, Nicholas McHugh, Jacquelyn Sousa, Jillian Caiazzi, Yann Thillier, Gitali Devi
  • CARBOHYDRATE CONJUGATES FOR THE DELIVERY OF THERAPEUTIC OLIGONUCLEOTIDES
    Publication number: 20240293555
    Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides. The oligonucleotide is conjugated to a functional moiety comprising a carbohydrate. In certain embodiments, the carbohydrate is a glucosamine or a derivative thereof.
    Type: Application
    Filed: December 12, 2023
    Publication date: September 5, 2024
    Inventors: Anastasia Khvorova, Ken Yamada, Vignesh Narayan Hariharan, Ananth Karumanchi
  • Oligonucleotides for SARS-CoV-2 modulation
    Patent number: 12077758
    Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: September 3, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Jonathan Watts, Zachary Kennedy, Annabelle Biscans, Bruno Miguel da Cruz Godinho, Chantal Ferguson, Dimas Echeverria Moreno, Ken Yamada, Daniel O′Reilly, Kathryn Monopoli, Vignesh Narayan Hariharan, Qi Tang, Sarah Davis, Samuel Hildebrand, Socheata Ly, Minwook Shin, Pranathi Meda Krishnamurthy, Nicholas McHugh, Jacquelyn Sousa, Jillian Caiazzi, Yann Thillier, Gitali Devi
  • OPTIMIZED ANTI-FLT1 OLIGONUCLEOTIDE COMPOUNDS FOR TREATMENT OF PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS
    Publication number: 20240067967
    Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
    Type: Application
    Filed: May 23, 2023
    Publication date: February 29, 2024
    Inventors: Anastasia Khvorova, Vignesh Narayan Hariharan, Sarah Davis, Annabelle Biscans, Ananth Karumanchi
  • OPTIMIZED SIRNA SCAFFOLDS
    Publication number: 20230399645
    Abstract: This disclosure relates to novel modified oligonucleotides with increased stability and extended in vivo mRNA silencing activity.
    Type: Application
    Filed: May 16, 2023
    Publication date: December 14, 2023
    Inventors: Anastasia Khvorova, Daniel O'Reilly, Vignesh Narayan Hariharan, Clemens Lochmann, David Cooper
  • OLIGONUCLEOTIDES FOR MECP2 MODULATION
    Publication number: 20230348907
    Abstract: This disclosure relates to novel MECP2 targeting sequences. Novel MECP2 targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: January 9, 2023
    Publication date: November 2, 2023
    Inventors: Anastasia Khvorova, Vignesh Narayan Hariharan
  • Optimized anti-FLT1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
    Patent number: 11702659
    Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
    Type: Grant
    Filed: June 22, 2022
    Date of Patent: July 18, 2023
    Assignees: UNIVERSITY OF MASSACHUSETTS, BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventors: Anastasia Khvorova, Vignesh Narayan Hariharan, Sarah Davis, Annabelle Biscans, Ananth Karumanchi
  • OPTIMIZED ANTI-FLT1 OLIGONUCLEOTIDE COMPOUNDS FOR TREATMENT OF PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS
    Publication number: 20230078622
    Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
    Type: Application
    Filed: June 22, 2022
    Publication date: March 16, 2023
    Inventors: Anastasia Khvorova, Vignesh Narayan Hariharan, Sarah Davis, Annabelle Biscans, Ananth Karumanchi
  • OLIGONUCLEOTIDES FOR SARS-CoV-2 MODULATION
    Publication number: 20230021431
    Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.
    Type: Application
    Filed: May 28, 2021
    Publication date: January 26, 2023
    Inventors: Anastasia Khvorova, Jonathan Watts, Zachary Kennedy, Annabelle Biscans, Bruno Miguel da Cruz Godinho, Chantal Ferguson, Dimas Echeverria Moreno, Ken Yamada, Daniel O'Reilly, Kathryn Monopoli, Vignesh Narayan Hariharan, Qi Tang, Sarah Davis, Samuel Hildebrand, Socheata Ly, Minwook Shin, Pranathi Meda Krishnamurthy, Nicholas McHugh, Jacquelyn Sousa, Jillian Caiazzi, Yann Thillier, Gitali Devi