Abstract: Reprogramming of mammalian stem cells including aged human adult stem cells of all types with young adult stem cell's supernatant-intracellular matrix, bioactive lipids and or microvesicules in a single step or as a secondary two step process using oocyte supernatant, its intracellular matrix and/or cellular components are disclosed to accomplish a gene erasure and reprogramming. This invention focuses on reprogramming and/or reactivating genes that are active and involved in youthful adult stem cell function, within aged adult stem cells that have been previously collected by and/or stored for patients who are 40 years and older. The process is accomplished by using the natural unaltered young adult stem cell fluid and its cellular components.

Abstract: A treatment method for restoring of age related tissue loss in the face or selected areas of the body is disclosed which includes injecting an injectable composition containing a growth factor and hyaluronic acid as a carrier into the dermis, the hypodermis, or both, in various areas of the face, or selected areas of the body of a person to stimulate collagen, elastin, or fat cell production, thereby restoring age related tissue loss in the face and selected areas of the body. Further disclosed is an injectable composition for restoring of age related tissue loss in the face and selected areas of the body, which contains a growth factor and hyaluronic acid as a carrier for providing time release of the growth factor into tissues. The growth factor can be insulin, insulin-like growth factor, thyroid hormone, fibroblast growth factor, estrogen, retinoic acid, or their combinations.

Abstract: A treatment method for restoring of age related tissue loss in the face or selected areas of the body is disclosed which includes injecting an injectable composition containing a growth factor and hyaluronic acid as a carrier into the dermis, the hypodermis, or both, in various areas of the face, or selected areas of the body of a person to stimulate collagen, elastin, or fat cell production, thereby restoring age related tissue loss in the face and selected areas of the body. Further disclosed is an injectable composition for restoring of age related tissue loss in the face and selected areas of the body, which contains a growth factor and hyaluronic acid as a carrier for providing time release of the growth factor into tissues. The growth factor can be insulin, insulin-like growth factor, thyroid hormone, fibroblast growth factor, estrogen, retinoic acid, or their combinations.

Abstract: A topical composition for anti-aging treatment of the skin includes water soluble extract of Uncaria species, Arabidopsis thaliana extract, lipoic acid, dimethylethanolamine, tetrahexyldecyl ascorbate, dimethyl sulfoxide, Glycyrrhiza Glabra(Licorice) root extract, methylsulfonylmethane, phytosterols, D-ribose, tocotrienol, tocopherol, glucosamine hydrochloride, Pisum sativum extract; Bambusa vulgaris extract, and a dermatologically acceptable liposomal delivery medium. Further disclosed is a method using the topical composition for anti-aging skin treatment utilizing DNA repair in both the nucleus and the mitochondria. The topical composition can be applied on the skin of a person daily, and can also be applied in a dermal infusion treatment, with or without micro-dermal abrasion or skin suction. Topical application of the composition achieves effective reduction of pigmentation spots and degree of winkles, and improvement of skin color tone.

Abstract: A treatment method for restoring of age related tissue loss in the face or selected areas of the body is disclosed which includes injecting an injectable composition containing a growth factor and hyaluronic acid as a carrier into the dermis, the hypodermis, or both, in various areas of the face, or selected areas of the body of a person to stimulate collagen, elastin, or fat cell production, thereby restoring age related tissue loss in the face and selected areas of the body. Further disclosed is an injectable composition for restoring of age related tissue loss in the face and selected areas of the body, which contains a growth factor and hyaluronic acid as a carrier for providing time release of the growth factor into tissues. The growth factor can be insulin, insulin-like growth factor, thyroid hormone, fibroblast growth factor, estrogen, retinoic acid, or their combinations.

Abstract: An anti-aging nutritional supplement composition includes vitamins, minerals, an inflammatory process support, a blood sugar/insulin support, a botanical antioxidants, a methylating factor, a DNA repair agent, a fat metabolizer, an absorption enhancer, a brain function support, whole foods, a cellular energizer, a nucleotide precursor, amino acids, a fatty acid complex, and digestive enzymes. The composition supplies nutritional supplements necessary for proper glycation, DNA methylation, anti-oxidation, and control of inflammatory processes. The composition and the method of use provide an effective anti-aging treatment by decreasing DNA damage, increasing DNA repair, and improving immune function of human body.

Abstract: A multi-agent tri-daily comestible of vitamin, mineral, plant extracts, aminos, neurochemical precursors, enzymes, and Ph regulating agents which supply key elements necessary for proper metabolization and function of the human body delivered at specific times of the daily biocycle when the need for such specific agents exists in order to maximize the body's extra- and intra-cellular matrix to cellular and biochemical protective and repair mechanisms utilized to deter the effects of otherwise normal aging.

Abstract: An article for tissue-specific delivery of therapeutic agents constitutes a substrate of a material that is biodegradable in situ in human tissue, which substrate is configured into a projectile and proportioned for insertion into a channel of an endoscope, the substrate having incorporated thereinto selectable therapeutic agents to be delivered, the projectile including, upon an exterior surface, a capacity for tissue affixation to the tissue of interest.

Abstract: A system for tissue-specific delivery of therapeutic agents includes an implantable element. biodegradable in situ within human tissue; a vasoinductive agent integrated into a surface of the element; and having the therapeutic agents incorporated into the implantable element. Upon implantation of the implantable element into tissue, the vasoinductive agent stimulates capillary growth, facilitating delivery of the therapeutic agents to the selected tissue.

Abstract: An implantable multiple-agent biologic delivery system includes a pod proportioned for subcutaneous implantation beneath the dermis of the skin, the pod including a porous surface and having at least one internal chamber which is in fluid communication with the porous surface. The system includes a dome proportioned for selectable detachable securement to the chamber of the pod. The dome includes interior chambers, each in fluid communication with the interior of the pod. Bio-acting agents, such as hormones, enzymes, biologic response modifiers, free radical scavengers, and other genetically altered cell cultures may be provided, within the chambers of the dome, prior to implantation. Such agents within the dome will, through the use of time release micropumps, enter the interior chambers of the pod for transmission, through the porous surfaces into a growth factor stimulated capillary matrix and then to the bloodstream of the user.

Abstract: A facial implant for augmentation of the sub-malar region of the face includes a three dimensional body formed of a flexible tissue-compatible material having a convex front surface and a concave rear surface, such surfaces being substantially symmetrical about a plane of symmetry existing about midway between proximal and distal tips of the body, at which tips the convex and concave surfaces intersect. The body is also characterized by a thin proximal head portion consisting of upper and lower protrusions existing proximally with reducing thickness, a wider central portion, and a tail portion extending distally with reducing height and thickness to the distal tip of the body of the implant.

Abstract: An implantable multiple-agent biologic delivery system includes a pod proportioned for subcutaneous implantation beneath the dermis of the skin, the pod including a porous surface and having at least one internal chamber which is in fluid communication with the porous surface. The system includes a dome proportioned for selectable detachable securement to the chamber of the pod. The dome includes interior chambers, each in fluid communication with the interior of the pod. Bio-acting agents, such as hormones, enzymes, biologic response modifiers, free radical scavengers, and genetically altered cell cultures, may be provided, within the chambers of the dome, prior to implantation. Such agents within the dome will, through the use of time release micropumps, enter the interior of the pod for transmission through the porous surfaces into a vascular growth factor stimulated capillary matrix and then to the bloodstream of the user.

Abstract: The method of tissue-specific delivery of therapeutic agents via a bio-oncotic pump which includes the steps of furnishing an implantable element which is biodegradable in situ within human tissue. Such an element defines a series of respective concentric shells having different therapeutic agents disposed upon each of the shells such that the outermost shell and associated agents will be delivered earliest, while the innermost shell and its agents will be delivered last. The material of the biodegradable element is selected from the group of materials including processed sheep dermal collagen, Hench's bioglass, fibrinogen, polyimino-carbonate, and polylactic acid. A vaso-inductive agent is integrated into the surface of the element. Selected groups of therapeutic agents are incorporated into the element, which is followed by the subcutaneous implantation and securing of said element into the human tissue at the site of interest.

Abstract: A sensory input discrimination system for use with a prosthetic limb such as the prosthetic lower arm includes touch pressure transducers such that information regarding pressure upon portions of the prosthesis, temperature therein, and changes in position of joints thereof will result in a sonic frequencies of characteristic pattern. Such characteristic sonic frequency patterns are communicated to the sonic proximity vibratory receptors existent upon a bone stump of an amputation site correspondent to the connection of the prosthetic limb. Such receptors will resulting generate neural impulses having a signal pattern correlating to the sonic output patterns of a system power unit that will travel from the stump to the posterior columns of the spinal cord and, therefrom, to the brain. Discrimination of such impulses will be accomplished to enable recognition of pressure, upon the prosthesis.

Abstract: There is provided an implantable multiple-agent delivery system which includes a pod proportioned for subcutaneous implantation beneath the dermis of the skin, the pod including a porous surface having at least one internal chamber there within which is in fluid communication with the porous surface. The system further includes a dome proportioned for complemental, selectable detachable securement upon the pod. The dome includes a plurality of interior chambers, each in fluid communication with the internal chambers of the pod. Bio-acting agents, such as hormones, biologic response modifiers, free radical scavengers, and other therapeutic agents may be provided, within the chambers of the dome, prior to implantation. Such agents with the chambers of the dome will, through the use of time release microelectronics, enter at least one of the interior chambers of the pod for transmission, through the porous surfaces thereof, into a growth factor stimulated capillary matrix and then to the bloodstream of the user.

Abstract: The implant for the chin is defined by a solid crescent formed by the intersection of an interior radius of curvature with an exterior radius of curvature in which the interior radius is slightly smaller than the exterior radius, the resulting crescent having a total included angle of approximately forty-five degrees. An outer portion of the implant is provided with a softer, lower durometer material than is the rest of the implant to simulate the fat pad at the point of the chin.

Abstract: A structure for implantation below the surface of the epidermis of the scalp includes a group of human hair shafts embedded within a non-hydrophilic core. The core is surrounded by a cylindrical annulus of hydrophilic material which possesses a property of volumetric expansion of at least two fold after fixation within the human scalp. Through such expansion an artificial arch or within the scalp is obtained.

Abstract: A method of applying a chin implant to a human, the method including the steps of positioning a resilient preformed chin implant against an area of the chin to be enhanced, the implant having an interior radius having a curvature slightly smaller than the opposing radius of the curvature of the area of the chin which is to receive the implant. As a second step, a mounting pin bore is drilled through the implant and into the periostium of the area of the chin at an outward angulation of about thirty degrees relative to a front-to-rear vertical medial plane of the face and, concurrently, at a downward angulation of about thirty degrees relative to a front-to-horizontal plane of the face taken through the area of the chin to be enhanced. A third step is defined by drilling through the implant and into the periostium a mounting pin bore having, about the front-to-rear vertical median plane, a mirror symmetry to the drilled hole described above.

Abstract: A sensory input discrimination system for use with a prosthetic limb such as a prosthetic hand having five digits. The discrimination system includes pairs of sonic frequency generators in electrical communication with pressure transducers which are disposed proximally to each other and within the extremity of corresponding digits of the prosthetic hand, the frequency generators having discrete sonic frequencies. The electrical communication between each frequency generator and the pressure sensor is open in the absence of contact pressure, and closed in the presence of contact pressure. Such closure generates a discrete sonic frequency output from the digit to which the contact pressure has been applied. In the prosthesis, a power unit amplifies the frequency outputs and provides power for the operation of the frequency generators and pressure transducers. The power unit exhibits an output including a voltage and a sonic frequency.