Patents by Inventor Vinod P. Balachandran

Vinod P. Balachandran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200232040
    Abstract: Systems and methods for determining the likely responsiveness of a human cancer subject to a checkpoint blockade immunotherapy regimen are provided. Sequencing reads are obtained from samples from the subject representative of the cancer. A human leukocyte antigen type and a plurality of clones is determined from the sequencing reads. For each clone, an initial frequency X? in the one or more samples is determined and a corresponding clone fitness score of the clone is computed, thereby computing clone fitness scores. Each such fitness score is computed by identifying neoantigens in the respective clone, computing a recognition potential for each neoantigen, and determining the corresponding clone fitness score of the respective clone as an aggregate of these recognition potentials. A total fitness, quantifying the likely responsiveness of the subject to the regimen, is computed by summing the clone fitness scores across the plurality of clones.
    Type: Application
    Filed: January 18, 2018
    Publication date: July 23, 2020
    Inventors: Marta Luksza, Vinod P. Balachandran, Arnold J. Levin, Jedd D. Wolchok, Taha Merghoub, Steven D. Leach, Timothy A. Chan, Benjamin D. Greenbaum, Michael Laessig