Patents by Inventor Viyyoor M. Girijavallabhan

Viyyoor M. Girijavallabhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel farnesyl protein transferase inhibitors
    Publication number: 20020115679
    Abstract: The present invention describes compounds useful for the inhibition of Farnesyl Protein Transferase. This invention also discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with FPT.
    Type: Application
    Filed: November 27, 2001
    Publication date: August 22, 2002
    Inventors: F. George Njoroge, Bancha Vibulbhan, Viyyoor M. Girijavallabhan, Xiongwei Shi
  • Inhibitors of farnesyl-protein transferase
    Patent number: 6432959
    Abstract: Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: August 13, 2002
    Assignee: Schering Corporation
    Inventors: Alan B. Cooper, Ronald J. Doll, Johan A. Ferreira, Ashit Ganguly, Viyyoor M. Girijavallabhan, Arthur G. Taveras, Jianping Chao, John J. Baldwin, Chia-Yu Huang, Ge Li
  • Farnesyl protein transferase inhibitors
    Publication number: 20020103207
    Abstract: Disclosed are compounds of the formula: 1
    Type: Application
    Filed: December 20, 2001
    Publication date: August 1, 2002
    Inventors: Arthur G. Taveras, Ronald J. Doll, Alan B. Cooper, Johan A. Ferreira, Timothy Guzi, Alan K. Mallams, Dinanath F. Rane, Viyyoor M. Girijavallabhan, Adriano Afonso, Cynthia J. Aki, Jianping Chao, Carmen Alvarez, Joseph M. Kelly, Tarik Lalwani, Jagdish A. Desai, James J-S Wang, Jay Weinstein
  • Sulfonamide inhibitors of farnesyl-protein transferase
    Patent number: 6426352
    Abstract: Novel tricyclic sulfonamide compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel sulfonamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: July 30, 2002
    Assignee: Schering Corporation
    Inventors: F. George Njoroge, Bancha Vibulbhan, Arthur G. Taveras, Ronald J. Doll, Viyyoor M. Girijavallabhan
  • Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
    Patent number: 6403564
    Abstract: A method for treating a patient having chronic hepatitis C infection to eradicate detectable HCV-RNA involving a combination therapy using a therapeutically effective amount of ribavirin derivative of formula I and a therapeutically effective amount of interferon-alpha for a time period of from 20 up to 80 weeks.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: June 11, 2002
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Jinping McCormick, Raymond G. Lovey, Frank Bennett, Anil K. Saksena, Viyyoor M. Girijavallabhan
  • Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
    Publication number: 20020055473
    Abstract: Ribavirin derivatives represented by the formula II, pharmaceutical compositions containing them as well as methods of using the ribavirin derivatives represented by the formula II for the treatment of susceptible viral infections, for example, chronic hepatitis C infections administrating, the ribavirin derivatives being represented by formula II 1
    Type: Application
    Filed: April 18, 2001
    Publication date: May 9, 2002
    Inventors: Ashit K. Ganguly, Jinping McCormick, Raymond G. Lovey, Frank Bennett, Anil K. Saksena, Viyyoor M. Girijavallabhan
  • Farnesyl protein transferase inhibitors
    Patent number: 6372747
    Abstract: Disclosed are compounds of the formula: wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group; R8 represents H when the alkyl chain between the amide group and the R13 imidazole group is substituted, or R8 represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R8 is H, and the alkyl chain between the amide group and the R13 imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: April 16, 2002
    Assignee: Schering Corporation
    Inventors: Arthur G. Taveras, Ronald J. Doll, Alan B. Cooper, Johan A. Ferreira, Timothy Guzi, Dinanath F. Rane, Viyyoor M. Girijavallabhan, Cynthia J. Aki, Jianping Chao, Carmen Alvarez, Joseph M. Kelly, Tarik Lalwani, Jagdish A. Desai, James J-S Wang
  • Farnesyl protein transferase inhibitors
    Patent number: 6362188
    Abstract: Disclosed are compounds of the formula: wherein R8 represents a cyclic moiety to which is bound an imodazolylalkyl group; R9 represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: March 26, 2002
    Assignee: Schering Corporation
    Inventors: Timothy Guzi, Dinanath F. Rane, Alan K. Mallams, Alan B. Cooper, Ronald J. Doll, Viyyoor M. Girijavallabhan, Arthur G. Taveras, Corey Strickland, Joseph M. Kelly, Jianping Chao
  • Macrocyclic NS-3 serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties
    Publication number: 20020016294
    Abstract: The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: April 17, 2001
    Publication date: February 7, 2002
    Inventors: Srikanth Venkatraman, Kevin X. Chen, Ashok Arasappan, F. George Njoroge, Viyyoor M. Girijavallabhan, Tin-Yau Chan, Brian A. Mc Kittrick, Andrew J. Prongay, Vincent S. Madison
  • Methods for treating proliferative diseases
    Patent number: 6333333
    Abstract: Methods are provided for treating proliferative diseases, especially cancers, comprising administering (1) a farnesyl protein transferase inhibitor in conjunction with (2) an antineoplastic agent and/or radiation therapy.
    Type: Grant
    Filed: February 14, 2000
    Date of Patent: December 25, 2001
    Assignee: Schering Corporation
    Inventors: Walter R. Bishop, Joseph J. Catino, Ronald J. Doll, Ashit Ganguly, Viyyoor M. Girijavallabhan, Paul Kirschimeier, Ming Liu, Loretta L. Nielsen, David L. Cutler
  • Compounds useful for inhibition of farnesyl protein transferase
    Publication number: 20010039283
    Abstract: Novel compounds of the formula: 1
    Type: Application
    Filed: April 4, 2001
    Publication date: November 8, 2001
    Inventors: Alan B. Cooper, Ronald J. Doll, Anil K. Saksena, Viyyoor M. Girijavallabhan
  • 5?-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
    Patent number: 6277830
    Abstract: 5′-Amino acid esters of ribavirin represented by formula I: wherein R is CH3CH(NH2)—CO—, CH3CH2(CH3)CHCH(NH2)—CO—or H2N(CH2)4CH(NH2)—CO—; preferably R is or a pharmaceutically acceptable salt thereof, e.g., trifluoroacetate, tosylate, mesylate, and chloride, pharmaceutical compositions containing them as well as methods of treating patients having susceptible viral infections, e.g., chronic hepatitis C infections by administering a therapeutically effective amount of a ribavirin derivative, alone or in combination with a therapeutically effective amount of interferon-alpha are disclosed.
    Type: Grant
    Filed: July 7, 1999
    Date of Patent: August 21, 2001
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Jinping McCormick, Raymond G. Lovey, Frank Bennett, Anil K. Saksena, Viyyoor M. Girijavallabhan
  • Compounds useful for inhibition of farnesyl protein transferase
    Patent number: 6239140
    Abstract: Novel compounds of the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein: a represents N or NO−; R1 and R3 are the same or different and each represents halo; R2 and R4 are the same or different and each is selected from H and halo, provided that at least one of R2 and R4 is H; T is a substituent selected from SO2R or: Z is O or S; n is zero or an integer from 1 to 6; R is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, or N(R5)2; R5 is H, alkyl, aryl, heteroaryl or cycloalkyl. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: May 29, 2001
    Assignee: Schering Corporation
    Inventors: Alan B. Cooper, Ronald J. Doll, Anil K. Saksena, Viyyoor M. Girijavallabhan
  • Compounds useful for inhibition of farnesyl protein transferase
    Patent number: 6225322
    Abstract: Novel compounds of formula are disclosed. Also disclosed is a method of inhibiting farnesyl protein transferase function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Also disclosed is a method of effecting an anti-allergic response by administering the compounds.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: May 1, 2001
    Assignee: Schering Corporation
    Inventors: Alan B. Cooper, Jagdish A. Desai, Anil K. Saksena, Viyyoor M. Girijavallabhan, James J-S Wang
  • Method for treating proliferative diseases
    Patent number: 6096757
    Abstract: Methods are provided for treating proliferative diseases, especially cancers, comprising administering (1) a farnesyl protein transferase inhibitor in conjunction with (2) an antineoplastic agent and/or radiation therapy.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: August 1, 2000
    Assignee: Schering Corporation
    Inventors: Walter R. Bishop, Joseph J. Catino, Ronald J. Doll, Ashit Ganguly, Viyyoor M. Girijavallabhan, Paul Kirschimeier, Ming Liu, Loretta L. Nielsen, David L. Cutler
  • Tetrahydrofuran antifungal phosphate
    Patent number: 6043245
    Abstract: A compound of the formula I ##STR1## wherein G is H or PO.sub.3 H.sub.2 or a pharmaceutical acceptable salt thereof, pharmaceutical compositions containing such compounds and method of using such compounds or pharmaceutical compositions containing them to treat or prevent fungal infection are disclosed.
    Type: Grant
    Filed: September 25, 1998
    Date of Patent: March 28, 2000
    Assignee: Schering Corporation
    Inventors: Frank Bennett, Viyyoor M. Girijavallabhan, Naginbhai M. Patel, Anil K. Saksena, Ashit Ganguly
  • Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors
    Patent number: 6039683
    Abstract: Compounds of the following formula useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells are disclosed: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R and R.sup.2 are halo;R.sup.1 and R.sup.3 are H and halo, provided that at least one is H;W is N, CH or C when the double bond is present at the C-11 position;R.sup.4 is --(CH.sub.2).sub.n --R.sup.5 or ##STR2## R.sup.5 is ##STR3## R.sup.6 is R.sup.5 or ##STR4## Z.sup.1 and Z.sup.2 are independently selected from the group consisting of .dbd.O and .dbd.S;n is 1-6; andn.sub.1 is 0 or 1.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: March 21, 2000
    Assignee: Schering Corporation
    Inventors: F. George Njoroge, Bancha Vibulbhan, Patrick A. Pinto, Viyyoor M. Girijavallabhan
  • Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase
    Patent number: 5965570
    Abstract: Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: October 12, 1999
    Assignees: Schering Corporation, Pharmacopeia Inc.
    Inventors: Alan B. Cooper, Alan K. Mallams, Viyyoor M. Girijavallabhan, Ronald J. Doll, Arthur G. Taveras, F. George Njoroge, John J. Baldwin, John C. Reader
  • Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase
    Patent number: 5925648
    Abstract: Novel tricyclic N-cyanoimine compounds and pharmaceutical compositions of formula (1.0) ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein a, b, c, d, R.sup.1 -R.sup.8, X and Z are defined herein. Such compounds are inhibitors of the enzyme, farnesyl protein transferase. The compounds are useful for inhibiting Ras function and therefore inhibiting the abnormal growth of cells, in a mammals such as a human.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: July 20, 1999
    Assignee: Schering Corporation
    Inventors: Alan B. Cooper, James J-S Wang, Raymond G. Lovey, Jagdish A. Desai, Anil K. Saksena, Viyyoor M. Girijavallabhan, Ronald J. Doll
  • Soluble azole antifungal salt
    Patent number: 5883097
    Abstract: The lactic acid?CH.sub.3 CH(OH)CO.sub.2 H! addition salt of the compound of formula I ##STR1## wherein the molar ratio of lactic acid, preferably L-lactic acid, to the compound of formula I is preferably about 1:1, pharmaceutical compositions of the lactic acid addition salt in an aqueous lactic acid carrier suitable for intravenous administration, and methods of using either of them to treat and/or prevent susceptible fungal infections in a host such as a mammal are disclosed.
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: March 16, 1999
    Assignee: Schering Corporation
    Inventors: Raymond G. Lovey, Viyyoor M. Girijavallabhan, Anil K. Saksena, Bruce E. Reidenberg