Abstract: The present invention provides method(s) for measuring gene copy number (CN) of a given locus of interest, comprising 1) obtaining the CN value of the locus of interest, 2) obtaining the CN value or values of one or more CN-invariant locus reference(s) (CNILR) in the biological sample, where the CNILR is a locus which is locally CN-invariant or a locus with a minimal coefficient of variation, 3) obtaining the CN value or values of one or more CN-invariant and survival insignificant locus reference reference(s) (CNISILR) determined based on survival prediction analysis for a specific subgroup; and 4) normalizing the CN value of the locus of interest by the CN values of one or more CNISILRs if defined, otherwise normalizing the CN value of the locus of interest by the CN values of said one or more CNILRs. In one embodiment, the CNILRs or CNISILRs is one or more loci from the group consisting of XRCC5, AUTS2, EIF5, PARN, YEATS2 and FHL2.

Abstract: Examples disclosed herein collect a cookie at a first device based on media accessed via a web page at the first device, obtain user information from a second device via communicative coupling between the first device and the second device, and in response to an instruction embedded in the media, send a hypertext transfer protocol (HTTP) request to a server, the HTTP request including the cookie, the user information, and information identifying exposure to the media.

Abstract: A method, comprising: —providing a process space atmosphere at a process space atmosphere pressure; —providing an exterior atmosphere at an exterior atmosphere pressure that is different from the process space atmosphere pressure; —providing a passage via which the exterior atmosphere is in open communication with the process space atmosphere, and via which substrates are exchangeable between the exterior atmosphere and the process space atmosphere; —injecting an exchange fluid into the passage at at least one exchange fluid injection point, so as to effect a flow of exchange fluid that extends through at least a part of the passage, wherein said flow is directed towards —the exterior in case the exterior atmosphere pressure is greater than the process space atmosphere pressure; or —the process space in case the exterior atmosphere pressure is smaller than the process space atmosphere pressure.

Abstract: Systems and methods are disclosed for identifying portable devices carried by the same person. An example method includes receiving media exposure data from one of a plurality of portable computing devices. Receiving segmented accelerometer data from the plurality of portable computing devices. Forming accelerometer classification data for the plurality of portable computing devices based on features extracted from the segmented accelerometer data. Comparing the accelerometer classification data for the first portable computing device to accelerometer classification data for the plurality of portable computing devices, to determine if the accelerometer classification data for the first portable computing device is sufficiently similar to a second portable computing devices.

Abstract: Methods, apparatus, systems and articles of manufacture (e.g., physical storage media) to implement power efficient detection of watermarks in media signals are disclosed. Example watermark detection methods disclosed herein include operating a watermark detector in a first operating mode to detect a first watermark in a media signal. Disclosed example watermark detection methods also include, in response to the first watermark being verified, operating the watermark detector in a second operating mode in which the watermark detector cycles between sleep intervals and active intervals to detect a second watermark at a second location in the media signal relative to a first location of the first watermark in the media signal.

Abstract: Systems and methods are disclosed for identifying users of portable user devices according to one or more accelerometer profiles created for a respective user. During a media session, the portable computing device collects media exposure data, while at the same time, collects data from the accelerometer and compares it to the user profile. The comparison authenticates the user and determines the physical activity the user is engaged in. Additional data may be collected from the portable computing device to determine one or more operational conditions of the device itself, including the detection of multiple devices being physically carried by one user. Gross motion strings may also be generated by devices and compared to see if strings match, thus suggesting multiple devices are being carried by one user.

Abstract: Methods, apparatus, systems and articles of manufacture (e.g., physical storage media) to implement power efficient detection of watermarks in media signals are disclosed. Example watermark detection methods disclosed herein include initiating a first search interval in which to attempt to detect watermarks in a media signal. Disclosed example watermark detection methods also initiating a sleep mode upon expiration of the first search interval in response to no valid watermarks being detected during the first search interval. Disclosed example watermark detection methods further include, upon expiration of a first sleep interval after initiation of the sleep mode, initiating a second search interval.

Abstract: Example systems and methods for configuring media devices utilizing audio codes and/or signatures are disclosed. Example methods disclosed herein include determining a characteristic of audio data received by a device, the characteristic including at least one of a code detected in the audio data or a signature generated from the audio data. Disclosed example methods also include determining whether the characteristic is mapped to at least one of a first command or a second command. Disclosed example methods further include, in response to determining the characteristic is mapped to the first command, executing the first command to cause the device to connect to a communication session to receive an upgrade to software executable on the device, and in response to determining the characteristic is mapped to the second command, executing the second command to cause a previously locked feature of the device to be unlocked.

Abstract: The present invention relates to markers for high-grade serous ovarian cancer (HG-SOC) and methods and uses thereof for diagnosing high-grade serous ovarian cancer (HG-SOC) and/or determining the prognosis of a subject suffering from high-grade serous ovarian cancer (HG-SOC) by determining the presence or absence of a mutation in a CHEK2 marker or mutations of markers from a 21-gene panel comprising ADAMTSL3, ATR, CHEK2, ENAH, ERN2, GLI2, GYPB, KIAA1324L, LRRN2, MAP3K6, MAPK15, MET, MLL4, NIPBL, PCDH15, PPP1CC, PTCH1, PTK2B, RPS6KA2, RSU1 and TNC. It also relates to the use of markers CHEK2, RPS6KA2 and MLL4 in predicting the risk of developing high-grade ovarian serous ovarian cancer by determining germline mutations in at least one of these three markers.

Abstract: Methods, apparatus, systems and articles of manufacture (e.g., physical storage media) to implement power efficient detection of watermarks in media signals are disclosed. Example watermark detection methods disclosed herein include initiating a first search interval in which to attempt to detect watermarks in a media signal. Disclosed example watermark detection methods also initiating a sleep mode upon expiration of the first search interval in response to no valid watermarks being detected during the first search interval. Disclosed example watermark detection methods further include, upon expiration of a first sleep interval after initiation of the sleep mode, initiating a second search interval.

Abstract: Methods, apparatus, systems and articles of manufacture (e.g., physical storage media) to implement power efficient detection of watermarks in media signals are disclosed. Example watermark detection methods disclosed herein include operating a watermark detector in a first operating mode to search for a first watermark in a media signal. Such disclosed example methods also include, in response to detecting the first watermark, determining whether the first watermark satisfies a first condition. Such disclosed example methods further include, in response to determining the first watermark satisfies the first condition, operating the watermark detector in a second operating mode in which the watermark detector cycles between a sleep interval and an active interval to detect a second watermark at a second location in the media signal relative to a first location of the first watermark in the media signal.

Abstract: We describe a method of assigning a grade to a breast tumour, which grade is indicative of the aggressiveness of the tumour, the method comprising detecting the expression of a gene selected from the genes set out in Table D0 (6g-TAGs) or Table D1 (SWS Classifier 0). We also describe methods of treating patients having a high aggressiveness tumour or a low aggressiveness tumour, by identifying the aggressiveness tumour by obtaining, from a sample of a histological Grade 2 tumour isolated from the patient, gene expression data of BRRN1, AURKA, MELK, PRR11, CENPW and E2F1; assigning a grade to the tumour by applying a class prediction algorithm to the gene expression data, wherein a Grade 3 tumour is classified as a high aggressiveness tumour and a Grade 1 tumour is classified as a low aggressiveness tumour; and specifically treating the patient accordingly.

Abstract: Example systems and methods for configuring media devices utilizing audio codes and/or signatures are disclosed. Example methods disclosed herein include determining a characteristic of audio data received by a device, the characteristic including at least one of a code detected in the audio data or a signature generated from the audio data. Disclosed example methods also include determining whether the characteristic is mapped to at least one of a first command or a second command. Disclosed example methods further include, in response to determining the characteristic is mapped to the first command, executing the first command to cause the device to connect to a communication session to receive an upgrade to software executable on the device, and in response to determining the characteristic is mapped to the second command, executing the second command to cause a previously locked feature of the device to be unlocked.

Abstract: Disclosed examples involve collecting a cookie at a client device based on media accessed via a web page at the client device, and selecting a portable device identifier at the client device. The portable device identifier corresponds to a closest one of a plurality of portable devices in wireless communication with the client device. The portable device identifier is associated with a particular person. In response to instructions embedded in the media, a hypertext transfer protocol (HTTP) request is sent to a server. The HTTP request includes the cookie, the portable device identifier, and information identifying exposure to the media.

Abstract: Systems and methods are disclosed for securely transferring research data relating to media exposure data, such as radio, television, streaming media and the Internet. A plurality of portable computing devices seek and bond to a collector via Bluetooth in a specific area, such as a household. The collector authenticates itself with each of the portable computing devices and vice versa where the collector arranges a secure research data transfer session with each respective device using exchanged authentication files. As each secure session is made, each portable computing device transmits stored research data during the session.

Abstract: Examples disclosed herein collect a cookie at a first device based on media accessed via a web page at the first device, obtain user information from a second device via communicative coupling between the first device and the second device, and in response to an instruction embedded in the media, send a hypertext transfer protocol (HTTP) request to a server, the HTTP request including the cookie, the user information, and information identifying exposure to the media.

Abstract: Systems and methods are disclosed for providing portable device presence utilizing environmental ambient audio fingerprints. Portable devices provide media exposure data and environmental ambient fingerprints to a processing device, where the environmental ambient signatures provide at least one characteristic of the ambient audio surrounding each portable device. The environmental ambient signatures are then processed to determine if they match. Portable devices associated with matching signatures are identified. Ambient fingerprints may also be used to establish a logical location where media exposure took place. The ambient signatures are alternately combined with monitored data to provide more robust data sets for contextual processing.

Abstract: A computer-implemented method for establishing media data exposure for a computer processing device, where media data received in the computer processing device. The computer processing device pairs itself with a plurality of portable computing devices using a Bluetooth connection when media data is received. A signal strength characteristic of the Bluetooth connection is established in the computer processing device for each of the paired plurality of portable computing devices. Each signal strength characteristic with the received media data is then established to determine which signal strength characteristic is the strongest when the media data was received in the computer processing device.

Abstract: Example systems and methods for configuring media devices utilizing audio codes and/or signatures are disclosed. Example methods disclosed herein include, responsive to determining that an audio code is not present in audio data received by a device, generating a signature from the audio data. Such example methods also include determining whether the signature is associated with a first command to be executed by the device to modify operation of the device. Such example methods further include, when the signature is determined to be associated with the first command, executing the first command to modify the operation of the device.

Abstract: Examples disclosed herein collect research data relating to media received in a computer processing device. The research data includes a cookie associated with accessing the media. Examples disclosed herein present a message requesting communicative coupling of a portable computing device to the computer processing device when the portable computing device is not inductively coupled to the computer processing device. Examples disclosed herein receive information from the portable computing device via an inductive connection when it is detected that the portable computing device is coupled to the computer processing device. The information is indicative of a user of the portable computing device. The information is associated to the research data.