Abstract: Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analyzed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of the device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniatuized and/or disposable.

Abstract: Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analyzed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of the device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniaturized and/or disposable.

Abstract: A method and miniature analytical device with thermal regulation of reactant using a localized heat source capable of emitting electromagnetic radiation, such as light emitting diodes (“LED”s) and vertical cavity surface emitting lasers (“VCSEL”s), generating internal heat, such as resistive, inductive and Peltier heaters, or external heating. The miniature analytical device comprises of array of temperature-controlled zones to restrict the volume heated and localize the heating by having the localized heat source comprise an array of emitters or heaters.

Abstract: A liquid-filled microfluidics assembly and method of forming the same are disclosed. The assembly includes a non-metallic substrate having a liquid-filled microfluidics structure that includes a microchannel and a chamber in fluid communication therewith, and a metal tube embedded in the substrate, communicating with the chamber and sealed by crimping at a region along its length, thus to seal the structure adjacent the chamber. In forming the assembly, a polymer substrate having a microfluidics structure including a microchannel and a chamber in fluid communication therewith is molded around a metal tube communicating the chamber with a port at which liquid can be drawn or pumped into the structure. The structure is filled by drawing or pumping liquid into the structure through the port, and liquid in the structure, adjacent the chamber, is sealed by crimping the tube.

Abstract: A device and method to obtain a blood sample in a sealed configuration. The device includes a sampling assembly having a driver, a lancet, and a blood reservoir, and a pad having a proximal side and a distal side. The proximal side of the pad conforms to the shape of a skin area, and the distal side is attached to the sampling assembly. The pad and the sampling assembly are configured to provide a sealed configuration around the skin area for transferring blood from the skin area to the blood reservoir.

Abstract: Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analysed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of th device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniaturized and/or disposable.

Abstract: Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analysed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of the device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniatuized and/or disposable.

Abstract: A device and method to obtain a blood sample in a sealed configuration. The device includes a sampling assembly having a driver, a lancet, and a blood reservoir, and a pad having a proximal side and a distal side. The proximal side of the pad conforms to the shape of a skin area, and the distal side is attached to the sampling assembly. The pad and the sampling assembly are configured to provide a sealed configuration around the skin area for transferring blood from the skin area to the blood reservoir.

Abstract: A method and miniature analytical device with thermal regulation of reactants using a localized heat source capable of emitting electromagnetic radiation, such as light emitting diodes (“LED”s) and vertical cavity surface emitting lasers (“VCSEL”s), generating internal heat, such as resistive, inductive and Peltier heaters, or external heating. The miniature analytical device comprises of array of temperature-controlled zones to restrict the volume heated and localize the heating by having the localized heat source comprise an array of emitters or heaters.

Abstract: This invention encompasses a work station for conducting assays which comprises filtering assembly, a slide reading assembly, and a slide with a porous filter membrane wherein the slide has a means for aligning the slide within the filter assembly to filter reagents on predetermined portions of the porous filter membrane and also to position the slide in the slide reading assembly so that detection will occur in those same predetermined locations.

Abstract: This invention encompasses a slide reading assembly, and a slide with a porous filter membrane wherein the slide has a means for aligning the slide within a filter assembly to filter reagents on predetermined portions of the porous filter membrane and also to position the slide in a slide reading assembly so that detection will occur in those same predetermined locations.

Abstract: A clamping device for supporting a workpiece in a clamped condition. The device includes a split head fastener composed of a head having exterior and interior surfaces, and a threaded shaft attached to the head and extending substantially normally from the interior surface. The head is segmented by slots extending from the exterior surface toward the interior surface, and further defines a passageway extending inwardly along the axis from the exterior surface. To clamp a workpiece in the device, a tightening member carried on the shaft is rotated to bring it into contact with the interior surface of the head, in an outer surface region thereof only. This contact forces the segments surrounding the passageway to pivot toward the axis of the passageway, causing clamping of a workpiece received in the passageway.