Patents by Inventor Vladimir M. Doroshenko
Vladimir M. Doroshenko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11360059Abstract: A system and method for sample analysis using a portable gas chromatography (GC)-mass spectrometry (MS) is provided. The GC-MS system includes an injector configured to accept a sample containing a mixture of chemicals and release at least part of the sample for a separation by GC, a MEMS GC column with an integrated heater configured to accept and at least partly separate the mixture of chemicals, and a mass analyzer in a vacuum chamber configured to accept and mass-analyze the released separated chemicals. The MEMS GC column with the integrated heater is located mostly inside the MS vacuum chamber.Type: GrantFiled: May 31, 2019Date of Patent: June 14, 2022Assignee: Mass Tech, Inc.Inventors: Vladimir M. Doroshenko, Victor V. Laiko
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Patent number: 11107669Abstract: A system and method for sample analysis using sub-atmospheric pressure (sub-AP) laser ionization. The sub-AP ion source includes a holder with a sample containing analyte molecules, a pulsed laser beam configured to generate ionized species from the sample, an ion extractor adjacent to the holder configured to extract analyte ions from the ionized species by an extraction electric field Es near the sample, an ion funnel structure composed of orifice electrodes located along an ion funnel pathway direction z. The ion funnel structure has an entrance and an exit, the exit being the electrode with the smallest aperture in the structure. This structure is configured for accepting the analyte ions from the ion extractor at the entrance and dragging them toward the exit using an axial electric field Ez along the direction z. The extraction electric field Es is at least partly electrically shielded from the axial electric field Ez.Type: GrantFiled: September 5, 2018Date of Patent: August 31, 2021Assignee: SCIENCE AND ENGINEERING SERVICES, LLCInventors: Vladimir M. Doroshenko, Victor V. Laiko, Eugene Moskovets
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Publication number: 20200378930Abstract: A system and method for sample analysis using a portable gas chromatography (GC)-mass spectrometry (MS) is provided. The GC-MS system includes an injector configured to accept a sample containing a mixture of chemicals and release at least part of the sample for a separation by GC, a MEMS GC column with an integrated heater configured to accept and at least partly separate the mixture of chemicals, and a mass analyzer in a vacuum chamber configured to accept and mass-analyze the released separated chemicals. The MEMS GC column with the integrated heater is located mostly inside the MS vacuum chamber.Type: ApplicationFiled: May 31, 2019Publication date: December 3, 2020Applicant: Mass Tech, Inc.Inventors: Vladimir M. DOROSHENKO, Victor V. LAIKO
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Publication number: 20190074170Abstract: A system and method for sample analysis using sub-atmospheric pressure (sub-AP) laser ionization. The sub-AP ion source includes a holder with a sample containing analyte molecules, a pulsed laser beam configured to generate ionized species from the sample, an ion extractor adjacent to the holder configured to extract analyte ions from the ionized species by an extraction electric field Es near the sample, an ion funnel structure composed of orifice electrodes located along an ion funnel pathway direction z. The ion funnel structure has an entrance and an exit, the exit being the electrode with the smallest aperture in the structure. This structure is configured for accepting the analyte ions from the ion extractor at the entrance and dragging them toward the exit using an axial electric field Ez along the direction z. The extraction electric field Es is at least partly electrically shielded from the axial electric field Ez.Type: ApplicationFiled: September 5, 2018Publication date: March 7, 2019Applicant: SCIENCE AND ENGINEERING SERVICES, LLCInventors: Vladimir M. Doroshenko, Victor V. Laiko, Eugene Moskovets
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Publication number: 20180076014Abstract: A system and method for sample analysis using sub-atmospheric pressure (sub-AP) laser ionization. The sub-AP ion source includes a holder with a sample containing analyte molecules, a pulsed laser beam configured to generate ionized species from the sample, an ion extractor adjacent to the holder configured to extract analyte ions from the ionized species by an extraction electric field Es near the sample, an ion funnel structure composed of orifice electrodes located along an ion funnel pathway direction z. The ion funnel structure has an entrance and an exit, the exit being the electrode with the smallest aperture in the structure. This structure is configured for accepting the analyte ions from the ion extractor at the entrance and dragging them toward the exit using an axial electric field Ez along the direction z. The extraction electric field Es is at least partly electrically shielded from the axial electric field Ez.Type: ApplicationFiled: September 9, 2016Publication date: March 15, 2018Applicant: SCIENCE AND ENGINEERING SERVICES, LLCInventors: Vladimir M. Doroshenko, Victor V. Laiko, Eugene Moskovets
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Patent number: 9171708Abstract: An interchangeable ion source for a spectrometer. The ion source includes an interface which mounts the ion source relative to a gas inlet of the spectrometer, a sample holder, a laser which produces a laser beam capable of ionizing the sample at ambient pressure, and an optical system. The ion source includes an equipment chassis which supports the interface, the sample holder, the laser and the optical system as a rigid unit such that the interface, the sample holder, the laser and the optical system remain in alignment upon attachment and detachment of the ion source from the spectrometer and an enclosure which embraces an atmosphere around components of the ion source. In addition, the ion source includes a circulator which circulates at least part of the atmosphere within the enclosure.Type: GrantFiled: January 27, 2015Date of Patent: October 27, 2015Assignee: Science and Engineering Services, LLCInventors: Vladimir M. Doroshenko, Victor V. Laiko, Eugene Moskovets
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Patent number: 8825413Abstract: A method and system for deconvolution of a frequency spectrum obtained in an ICR mass spectrometer based on a detection of ion oscillation overtones of the M-th order (where the integer M>1). A plurality of frequency peaks is collected within the frequency spectrum corresponding respectively to oscillations of different groups of ions, and associates at least one of the frequency peaks having a frequency f and a measured amplitude A with a particular group of the ions. The method and system identify whether the frequency peak is related to one of an overtone frequency, a subharmonic frequency, a higher harmonic frequency, or a side-shifted frequency of the oscillations of the different group of ions.Type: GrantFiled: April 7, 2010Date of Patent: September 2, 2014Assignee: Science & Engineering Services, Inc.Inventors: Alexander Misharin, Konstantin Novoselov, Vladimir M. Doroshenko
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Patent number: 8796619Abstract: An orbital ion trap for electrostatic field ion trapping which includes an electrode structure defining an internal volume of the trap with at least some of electrode surfaces shaped to substantially follow equipotential lines of an ideal quadro-logarithmic electric potential around a longitudinal axis z. The ideal electric potential has an inner potential canyon, an outer potential canyon, and a low potential passage therebetween. The trap includes a trapping voltage supply which provides trapping voltages on the electrodes to generate a trapping electrostatic potential within the internal volume of the trap. The trapping electrostatic potential closely approximates at least a part of the ideal electric potential in at least a part of the internal volume of the trap.Type: GrantFiled: June 11, 2013Date of Patent: August 5, 2014Assignee: Science and Engineering Services, LLCInventors: Vladimir M. Doroshenko, Alexander Misharin
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Patent number: 8476586Abstract: A mass spectrometry (MS) method which includes generating in a vicinity of the quadrupole ion trap hydrogen molecules, directing at least part of the hydrogen molecules into the quadrupole ion trap cell, applying AC and DC voltages to quadrupole ion trap cell electrodes to create a combined AC/DC trapping field, placing sample ions inside the quadrupole ion trap cell, cooling at least part of said ions using said hydrogen molecules as a buffer gas, changing the combined AC/DC trapping field to eject the ions from the quadrupole ion trap cell, and detecting the ejected ions.Type: GrantFiled: June 24, 2011Date of Patent: July 2, 2013Assignee: Science & Engineering Services, Inc.Inventors: Alexander Misharin, Vladimir M. Doroshenko
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Patent number: 8471199Abstract: A portable mass spectrometer having an atmospheric pressure interface for introducing ions generated at ambient pressure gas conditions into a vacuum of the mass spectrometer. The mass spectrometer has a vacuum chamber having at least one vacuum section and at least one gas inlet for directing the ambient pressure gas including the ions into the at least one vacuum section. The at least one gas inlet has a gas passage channel of a length L and a limiting cross section S with a ratio of L/S being less than 20,000 cm?1. The mass spectrometer has a radio frequency (RF) ion guide in the at least one vacuum section positioned for collecting the ions from the at least one gas inlet and transmitting the ions further to a mass analyzer for analyzing the ions transmitted from the ion guide.Type: GrantFiled: April 6, 2012Date of Patent: June 25, 2013Assignee: Science and Engineering Services, Inc.Inventors: Vladimir M. Doroshenko, Victor V. Laiko, Alexander S. Misharin
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Patent number: 8440964Abstract: A device and method for transporting ions along a longitudinal direction in an elevated gas pressure region. The device includes a multipole ion guide having a set of rods positioned along the longitudinal direction on an inscribed diameter equal to or less than 3.5 mm, a voltage source which provides alternating voltages to at least a subset of the rods to create a trapping field in a transverse direction, and a conductance limit having an opening d and placed at the exit of the multipole ion guide. At the end of this configuration near the opening of the conductance limit, a converging continuum gas flow through the conductance limit is provided that transfers the ions collimating near a center of the ion guide into a low gas pressure region. The method injects ions into the elevated gas pressure region of the ion guide, and transports the ions in the converging continuum gas flow into the low gas pressure region.Type: GrantFiled: August 19, 2011Date of Patent: May 14, 2013Assignee: Science and Engineering Services, Inc.Inventors: Vadym D Berkout, Vladimir M. Doroshenko
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Publication number: 20130043382Abstract: A device and method for transporting ions along a longitudinal direction in an elevated gas pressure region. The device includes a multipole ion guide having a set of rods positioned along the longitudinal direction on an inscribed diameter equal to or less than 3.5 mm, a voltage source which provides alternating voltages to at least a subset of the rods to create a trapping field in a transverse direction, and a conductance limit having an opening d and placed at the exit of the multipole ion guide. At the end of this configuration near the opening of the conductance limit, a converging continuum gas flow through the conductance limit is provided that transfers the ions collimating near a center of the ion guide into a low gas pressure region. The method injects ions into the elevated gas pressure region of the ion guide, and transports the ions in the converging continuum gas flow into the low gas pressure region.Type: ApplicationFiled: August 19, 2011Publication date: February 21, 2013Applicant: Science & Engineering Services, Inc.Inventors: Vadym D. BERKOUT, Vladimir M. Doroshenko
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Publication number: 20120326026Abstract: A mass spectrometry (MS) method which includes generating in a vicinity of the quadrupole ion trap hydrogen molecules, directing at least part of the hydrogen molecules into the quadrupole ion trap cell, applying AC and DC voltages to quadrupole ion trap cell electrodes to create a combined AC/DC trapping field, placing sample ions inside the quadrupole ion trap cell, cooling at least part of said ions using said hydrogen molecules as a buffer gas, changing the combined AC/DC trapping field to eject the ions from the quadrupole ion trap cell, and detecting the ejected ionsType: ApplicationFiled: June 24, 2011Publication date: December 27, 2012Applicant: Science & Engineering Services, Inc.Inventors: Alexander MISHARIN, Vladimir M. Doroshenko
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Patent number: 8188423Abstract: A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase odd-electron containing species separately from the analyte ions, and mixes the gas-phase analyte ions and the odd-electron containing species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase odd-electron containing species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the odd-electron containing species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.Type: GrantFiled: May 21, 2010Date of Patent: May 29, 2012Assignee: Science & Engineering Services, Inc.Inventors: Vladimir M. Doroshenko, Vadym D. Berkout, Andrey Vilkov
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Publication number: 20110251801Abstract: A method and system for deconvolution of a frequency spectrum obtained in an ICR mass spectrometer based on a detection of ion oscillation overtones of the M-th order (where the integer M>1). A plurality of frequency peaks is collected within the frequency spectrum corresponding respectively to oscillations of different groups of ions, and associates at least one of the frequency peaks having a frequency f and a measured amplitude A with a particular group of the ions. The method and system identify whether the frequency peak is related to one of an overtone frequency, a subharmonic frequency, a higher harmonic frequency, or a side-shifted frequency of the oscillations of the different group of ions.Type: ApplicationFiled: April 7, 2010Publication date: October 13, 2011Applicant: Science & Engineering Services, Inc.Inventors: Alexander MISHARIN, Konstantin Novoselov, Vladimir M. Doroshenko
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Publication number: 20110224104Abstract: A method and system for identification of microorganisms in a sample. The method includes processing the sample to produce at least one group of biomarker molecules from at least one microorganism in the sample, tandem mass-analyzing biomarker fragment ions from the at least one group of biomarker molecules to obtain a sample biomarker tandem mass spectrum of the biomarker, and identifying the microorganism in the sample based on a comparison of the sample biomarker tandem mass spectrum to an experimentally-derived reference tandem mass spectrum (stored in the reference library) from a known microorganism. The system includes a sample processing unit configured to process the sample and produce at least one group of biomarker molecules from at least one microorganism in the sample. The system includes a mass-analyzer for tandem mass analysis biomarker fragment ions.Type: ApplicationFiled: June 1, 2007Publication date: September 15, 2011Applicant: Science & Engineering Services, Inc.Inventors: Evgenia Razumovski, Berk Oktem, Appavu K. Sundaram, Vsevolod S. Rakov, Sudeepta Shanbhag, Sergey Kurnosenko, Vladimir M. Doroshenko
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Patent number: 7858392Abstract: A system and corresponding method for processing of biological samples prior to spectroscopy analysis. The system includes a support for an organic sample, a solution applicator configured to apply a solution for extraction of at least one biomarker protein from the organic sample. The system includes a digester-medium applicator configured to apply to the organic sample a digesting medium capable of at least partial digestion of the biomarker proteins into peptides. The system includes a heating device configured to heat at least one of the organic sample, the solution, the digesting medium, and the biomarker proteins to a temperature above room temperature.Type: GrantFiled: May 26, 2006Date of Patent: December 28, 2010Assignee: Science and Engineering Services, Inc.Inventors: Nelli I. Taranenko, Berk Oktem, Appavu K. Sundaram, Vladimir M. Doroshenko
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Publication number: 20100288920Abstract: A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase odd-electron containing species separately from the analyte ions, and mixes the gas-phase analyte ions and the odd-electron containing species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase odd-electron containing species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the odd-electron containing species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.Type: ApplicationFiled: May 21, 2010Publication date: November 18, 2010Applicant: Science & Engineering Services, Inc.Inventors: Vladimir M. Doroshenko, Vadym D. Berkout, Andrey Vilkov
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Patent number: 7723676Abstract: A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase radical species separately from the analyte ions, and mixes the gas-phase analyte ions and the radical species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase radical species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the radical species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.Type: GrantFiled: December 18, 2007Date of Patent: May 25, 2010Assignee: Science & Engineering Services, Inc.Inventors: Andrey Vilkov, Vladimir M. Doroshenko
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Publication number: 20090152458Abstract: A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase radical species separately from the analyte ions, and mixes the gas-phase analyte ions and the radical species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase radical species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the radical species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.Type: ApplicationFiled: December 18, 2007Publication date: June 18, 2009Applicant: Science & Engineering Services, Inc.Inventors: Andrey Vilkov, Vladimir M. Doroshenko