Patents by Inventor Vladimir Stoy

Vladimir Stoy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180344451
    Abstract: Artificial lenses and methods for optimizing vision in an eye of a patient comprising the steps of determining a target optical configuration including the optimum defocus and aberrations that the patients' eye should have in order to match or approximate the original optical configuration of the patient; determining the refractive change of the patient's eye required to achieve the optical configuration best corresponding to target optical configuration for the patient; and implementing the selected refractive change to achieve the target optical configuration.
    Type: Application
    Filed: May 2, 2016
    Publication date: December 6, 2018
    Applicant: Medicem Ophthalmic (CY) Limited
    Inventor: Vladimír Stoy
  • Patent number: 9474791
    Abstract: The subject of the invention is a sterile, dehydrated acellular implant, which during its rehydration by water or bodily fluids displays anisotropic expansion and can act as a substrate for adhesion, migration and growth of live cells. Collagen structures of the transplant are at least partially denatured through the action of heat or organic solvents, such as lower aliphatic alcohols and ketones, which simultaneously act as preservative and sterilization agents, especially for certain types of viruses. The implant is sterilized by radiation while in an substantially dehydrated state, preferably by accelerated electrons. The transplant can be derived from various animal tissues, especially mammalian tissues, such as human or porcine tissues. The tissues suitable for the invention can be, for example, skin, placenta, pericardium, peritoneum, intestinal wall, tendon, blood vessel, etc.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: October 25, 2016
    Assignee: MEDICEM TISSUE (CY) LIMITED
    Inventors: Tomas Drunecky, Eva Matouskova, Petr Stehlicek, Vladimir Stoy, Pavel Vesely
  • Publication number: 20160296662
    Abstract: A bioanalogic implantable ophthalmic lens (“BIOL”) capable of replacing the natural crystalline lens (NCL) in its various essential functions after the NCL having been removed and BIOL implanted into the posterior eye chamber and placed into the capsular bag vacated from the NCL. At least the posterior surface of the lens has a convex shape and is made from a transparent flexible hydrogel material. At least the anterior and posterior optical surfaces are defined by rotation of one or more conic sections along the main optical axis and the surfaces defined by the rotation will include a plane perpendicular to the axis and conical surface symmetrical by the axis. A hydrogel implantable ophthalmic lens whose optical parameters can be optimized and/or customized by a controlled absorption of electromagnetic radiation resulting in a change of the refractive index of the irradiated hydrogel.
    Type: Application
    Filed: June 23, 2016
    Publication date: October 13, 2016
    Applicant: Medicem Ophthalmic (CY) Limited
    Inventors: Vladimir Stoy, Václav Petrák, Miroslav Dudic
  • Publication number: 20150351901
    Abstract: A bioanalogic implantable ophthalmic lens (“BIOL”) capable of replacing the natural crystalline lens (NCL) in its various essential functions after the NCL having been removed and BIOL implanted into the posterior eye chamber and placed into the capsular bag vacated from the NCL. At least the posterior surface of the lens has a convex shape and is made from a transparent flexible hydrogel material. At least the anterior and posterior optical surfaces are defined by rotation of one or more conic sections along the main optical axis and the surfaces defined by the rotation will include a plane perpendicular to the axis and conical surface symmetrical by the axis.
    Type: Application
    Filed: December 12, 2013
    Publication date: December 10, 2015
    Applicant: MEDICEM OPHTHALMIC (CY) LIMITED
    Inventors: Vladimir Stoy, Eugen Chicevic
  • Publication number: 20110098758
    Abstract: There is disclosed a manipulation and storage tool for receiving and manipulating a partially dehydrated intervertebral disk. Manipulation and storage tool is configured to receive the disk and manipulate it into a smaller overall size and subsequently insert it into a temporary storage or sleeve device for later use. Manipulation and storage tool generally includes a manipulation assembly which is movably mounted with respect to a guide assembly. The guide assembly includes a throughbore and a slot for receiving the disk into the throughbore as well as a sleeve holder mounted at a distal end designed to retain a storage device or sleeve into which the manipulated disk is inserted. The manipulation assembly generally includes a drive member having an elongated shaft movably mounted within the bore of the guide assembly and at least one manipulation member for pin positioned adjacent the slot to manipulate the implant in response to movement of the drive member relative to the guide assembly.
    Type: Application
    Filed: September 12, 2003
    Publication date: April 28, 2011
    Inventors: Vladimir Stoy, Eugene A. Dickhudt, Robert Ziebol, Gerald Gontarz, Dan Baker, Jan Lovy
  • Publication number: 20080221501
    Abstract: The present invention provides systems and methods for reducing intraocular pressure, thereby to treat glaucoma and other disorders. The systems of the present invention include a shunt insertable across the clear cornea and a delivery device for inserting the shunt in the transcorneal position. The shunt has a body with a head at one end and a foot at the opposite end, and a channel therethrough permitting the passage of aqueous humor from the anterior chamber to the external surface of the cornea. A removable filter is positioned within the channel to regulate aqueous humor outflow and to resist the incursion of microorganisms.
    Type: Application
    Filed: May 13, 2008
    Publication date: September 11, 2008
    Applicant: Becton, Dickinson and Company
    Inventors: Dana Cote, Margaret Mulhem, Robert Pierce, Thaddeus Wandel, Vladimir Stoy
  • Patent number: 7204897
    Abstract: The present invention is a prosthetic for replacement of at least a part of the nucleus of a intravertebral disc. The prosthetic device is composed of at least two essentially parallel soft layers of an elastically deformable hydrogel and at least one rigid layer, the rigid layer having less compressibility than the soft layers, being adjacent to the soft layers, parallel to them, and firmly attached to them. In some embodiments, the soft layers have the same thickness and composition. Typically, the prosthesis has more than one rigid layer and these rigid layers have the same thickness and composition. The number of soft layers is usually one more than the number of rigid layers, with, e.g., at least three soft layers.
    Type: Grant
    Filed: April 23, 2004
    Date of Patent: April 17, 2007
    Assignee: Replication Medical, Inc.
    Inventors: Vladimir A. Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky
  • Publication number: 20050171611
    Abstract: The present invention is a prosthetic for replacement of at least a part of the nucleus of a intravertebral disc. The prosthetic device is composed of at least two essentially parallel soft layers of an elastically deformable hydrogel and at least one rigid layer, the rigid layer having less compressibility than the soft layers, being adjacent to the soft layers, parallel to them, and firmly attached to them. In some embodiments, the soft layers have the same thickness and composition. Typically, the prosthesis has more than one rigid layer and these rigid layers have the same thickness and composition. The number of soft layers is usually one more than the number of rigid layers, with, e.g., at least three soft layers.
    Type: Application
    Filed: April 23, 2004
    Publication date: August 4, 2005
    Inventors: Vladimir Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky
  • Patent number: 6726721
    Abstract: The present invention is a prosthetic for replacement of at least a part of the nucleus of a intravertebral disc. The prosthetic device is composed of at least two essentially parallel soft layers of an elastically deformable hydrogel and at least one rigid layer, the rigid layer having less compressibility than the soft layers, being adjacent to the soft layers, parallel to them, and firmly attached to them. In some embodiments, the soft layers have the same thickness and composition. Typically, the prosthesis has more than one rigid layer and these rigid layers have the same thickness and composition. The number of soft layers is usually one more than the number of rigid layers, with, e.g., at least three soft layers.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: April 27, 2004
    Assignee: Replication Medical Inc.
    Inventors: Vladimir A. Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky
  • Publication number: 20030212383
    Abstract: The present invention provides systems and methods for reducing intraocular pressure, thereby to treat glaucoma and other disorders. The systems of the present invention include a shunt insertable across the clear cornea and a delivery device for inserting the shunt in the transcorneal position. The shunt has a body with a head at one end and a foot at the opposite end, and a channel therethrough permitting the passage of aqueous humor from the anterior chamber to the external surface of the cornea. A removable filter is positioned within the channel to regulate aqueous humor outflow and to resist the incursion of microorganisms.
    Type: Application
    Filed: December 27, 2002
    Publication date: November 13, 2003
    Inventors: Dana Cote, Margaret Mulhern, Robert Pierce, Thaddeus Wandel, Vladimir Stoy
  • Publication number: 20030055506
    Abstract: The present invention is a prosthetic for replacement of at least a part of the nucleus of a intravertebral disc. The prosthetic device is composed of at least two essentially parallel soft layers of an elastically deformable hydrogel and at least one rigid layer, the rigid layer having less compressibility than the soft layers, being adjacent to the soft layers, parallel to them, and firmly attached to them. In some embodiments, the soft layers have the same thickness and composition. Typically, the prosthesis has more than one rigid layer and these rigid layers have the same thickness and composition. The number of soft layers is usually one more than the number of rigid layers, with, e.g., at least three soft layers.
    Type: Application
    Filed: May 10, 2001
    Publication date: March 20, 2003
    Inventors: Vladimir A. Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky
  • Publication number: 20020193531
    Abstract: The present invention involves a method of making a multiblock copolymer containing two or more types of sequences of derivatives of acrylic acid with at least one derivative being acrylic acid salt and at least one being acrylamide.
    Type: Application
    Filed: July 11, 2002
    Publication date: December 19, 2002
    Applicant: REPLICATION MEDICAL, INC.
    Inventors: Vladimir A. Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky
  • Publication number: 20010044502
    Abstract: The present invention involves a method of making a multiblock copolymer containing two or more types of sequences of derivatives of acrylic acid with at least one derivative being acrylic acid salt and at least one being acrylamide.
    Type: Application
    Filed: April 19, 2001
    Publication date: November 22, 2001
    Applicant: Replication Medical, Inc.
    Inventors: Vladimir A. Stoy, Petr Stehlicek, Zdena Kozlova, Tomas Drunecky
  • Patent number: 6264695
    Abstract: The present invention is a spinal nucleus implant for replacement of at least a portion of nucleus pulposus tissue removed from a spinal disc of a living vertebrate to restore function of the spinal disc and related vertebral joint. The implant is an anisotropically swellable, biomimetic xerogel plastic, having a two phase structure with a hydrophobic phase having high crystallinity and low water content and with hydrophilic phase having low crystallinity and high water content and having a negatively charged lubricious surface. The xerogel plastic is capable of rehydration and of osmotic movement of liquid therethrough in response to osmotic pressure change to thereby increase and decrease liquid content in its hydrated state. The present invention also relates to surgical implant procedures utilizing this spinal nucleus implant.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: July 24, 2001
    Assignee: Replication Medical, Inc.
    Inventor: Vladimir A. Stoy
  • Patent number: 6232406
    Abstract: The present invention is a method of making acrylonitrile copolymers having multi block structure comprising acrylic acid, acryl amids and acrylamidine hydrophilic groups in hydrophilic blocks and residual nitrile groups in hydrophobic blocks, by partial hydrolysis of polyacrylonitrile to a predetermined hydrolysis conversion at which the hydrolysis is self terminating by a process that improves quality and reduces product heterogeneity.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: May 15, 2001
    Assignee: Replication Medical Inc.
    Inventor: Vladimir A. Stoy
  • Patent number: 6040493
    Abstract: The present invention is a bioreactor wound dressing which includes a first layer, being a transport layer, in direct contact with a wound. It includes at least one layer of a permeable polymeric media containing, in equilibrium with body fluids, at least 40% by weight of liquid, and is impermeable for infectious agents of any kind and being permeable to water soluble substances having molecular weight up to at least 1000 Daltons. There is a second layer, being a fluid reservoir layer that is adjacent to the transport layer and is capable of containing between 40% and 100% of its volume of an aqueous liquid, wherein the transport layer and reservoir layer are permeably interconnected for aqueous solutions and are in a substantial osmotic equilibrium. The invention also includes a method of wound treatment utilizing the bioreactor wound dressing.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: March 21, 2000
    Assignee: Replication Medical, Inc.
    Inventors: Randolph L. Cooke, Vladimir A. Stoy
  • Patent number: 5741828
    Abstract: The present invention is directed to a coating composition which includes a component A and component B. Component A is either an emulsion or dispersion having a hydrophobic elastomer stabilized with at lease one emulsifier. Component B is a dispersion or solution of a hydrophilic polymer which is insoluble in water, swellable in water and soluble in one or more water-miscible solvents. The hydrophobic elastomers may be polymers or copolymers of butadiene, isoprene, chloroprene, styrene, acrylonitrile, ethylene, propylene, isobutylene, alkylacrylates and alkylmethacrylates; polyrethanes, polyureas, polysiloxanes, elastomeric polyamides and polyesters. The hydrophilic polymers may be segmented polyurethanes, segmented polyures, segmented polyesters, partially hydrolyzed poly(vinyl acetate), partially hydrolyzed polyacrylonitrile, partially aminolyzed polyacrylonitrile, and ethylene glycol monomethacrylate.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: April 21, 1998
    Assignee: S.K.Y. Polymers, Inc.
    Inventors: Vladimir A. Stoy, Gerald A. Gontarz, Jr.
  • Patent number: 5736127
    Abstract: The present invention is directed to a composition comprising a nitrogen-containig drug-polymer salt and a method for making said composition. The drug-polymer salt is comprised of one or more drugs having basic groups as part of their chemical structure which are capable of forming salts with acids and one or more hydrophilic polymers containing carboxylate groups and amidine groups as pendant groups. Such polymeric salts of drugs have been found to have excellent bio-availability and advantageous release profiles in various forms (gels, ointments, pills, etc.). Particularly advantageous polymers contain pendant nitrile groups in addition to carboxyls and amidines which provide the polymer with hydrogel characteristics.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: April 7, 1998
    Assignee: Hymedix International, Inc.
    Inventors: Vladimir A. Stoy, Charles K. Kliment
  • Patent number: 5688855
    Abstract: A hydrophilic coating composition used to impart increased lubricity and wettability to the surface of a hydrophobic substrate which is comprised of three essential components:1) Hydrogel-forming polymer component A2) Water-soluble polymer component B3) Common solvent C for the components A and BThe water-insoluble, hydrogel-forming component A consists of a segmented copolymer with long, hydrophilic terminal blocks and the essentially hydrophobic central section. The two polymer components A and B have a limited miscibility in the absence of a common solvent C. Therefore, their blend tends to separate spontaneously into two polymer phases. The phase separation takes place during the solvent evaporation or extraction. A gradient of hydrophilicity and swelling within the coating layer is thus spontaneously created achieving a good adhesion to the substrate and high surface hydrophilicity at the same time.
    Type: Grant
    Filed: May 1, 1995
    Date of Patent: November 18, 1997
    Assignee: S.K.Y. Polymers, Inc.
    Inventors: Vladimir A. Stoy, Gerald A. Gontarz, Jr., Patrick Stoy
  • Patent number: RE42837
    Abstract: The present invention is a spinal nucleus implant for replacement of at least a portion of nucleus pulposus tissue removed from a spinal disc of a living vertebrate to restore function of the spinal disc and related vertebral joint. The implant is an anisotropically swellable, biomimetic xerogel plastic, having a two phase structure with a hydrophobic phase having high crystallinity and low water content and with hydrophilic phase having low crystallinity and high water content and having a negatively charged lubricious surface. The xerogel plastic is capable of rehydration and of osmotic movement of liquid therethrough in response to osmotic pressure change to thereby increase and decrease liquid content in its hydrated state. The present invention also relates to surgical implant procedures utilizing this spinal nucleus implant.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: October 11, 2011
    Assignee: Replication Medical, Inc.
    Inventors: Vladimir Stoy, Gerald Gontarz, Jr.