Abstract: The present invention covers 4-(3-amino-6-fluoro-1H-indazol-5-yl)-1,2,6-trimethyl-1,4-dihydropyridine-3,5-dicarbonitrile compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases.

Abstract: The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.

Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:7, 8, 9, 10, 11, or 12, the nucleotide sequence set forth in SEQ ID NO:4, 5, or 6, as well as variants and fragments thereof.

Abstract: Compositions and methods for conferring herbicide tolerance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include polynucleotides encoding herbicide tolerance polypeptides, vectors comprising those polynucleotides, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs or expression cassettes for transformation and expression in organisms, including microorganisms and plants. Compositions also include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated polynucleotides encoding HPPD inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.

Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. The toxin coding sequences can be used in DNA constructs or expression cassettes for expression in plants and bacteria. Compositions include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, polynucleotide sequences and the toxin proteins encoded thereby are provided. Also provided are antibodies specifically binding to those amino acid sequences. In particular, the invention encompasses nucleotide sequences encoding fusion proteins, as well as biologically active variants and fragments thereof, wherein the fusion protein contains the C-terminal portion of SEQ ID NO:43. The fusion protein may also contain the N-terminal portion of SEQ ID NO:45.

Abstract: A method of cleaning deposited material from a molding surface (10) of a mold (1) for forming ophthalmic lenses, including bringing a cleaning head (20) into contact with the molding surface (10), the rotational axis (22) of the cleaning head (20) being arranged normal to the molding surface (10), rotating (220) the cleaning head (20) around the rotational axis (22) while maintaining the contact between the cleaning head (20) and the molding surface (10), moving the cleaning head (20) to perform a precession motion (110) around a central normal (11) on the molding surface (10), while rotating (220) the cleaning head (20) around the rotational axis (22) and while maintaining the contact between the cleaning head (20) and the molding surface (10). During the precession motion (110) the rotational axis (22) includes an inclination angle (?1,?2) with the central normal (11) on the molding surface (10).

Abstract: A power-assisted hydraulic braking system includes a main brake line into which a setpoint brake pressure can be introduced via a brake valve actuated by a brake pedal, and from which a plurality of wheel brake lines branch off, each leading to an actuating unit of a wheel brake, and a valve arrangement of an ABS controller, comprising an inlet valve disposed between the main brake line and one of the wheel brake lines and an outlet valve disposed between the relevant wheel brake line and a pressureless return line. The inlet valve and the outlet valve are embodied as pressure-controlled 2/2-way switching valves with suitably sized switching cross-sections. At least one pilot control valve is associated with each of the inlet valve and the outlet valve, via which a control connection can be alternately subjected to a low or high control pressure to change over.

Abstract: A thermoelectric module may include a fluid-tight housing having at least one thermoelectrically active element arranged therein. The at least one thermoelectrically active element may have a coating. The housing may form an outer encapsulation and the coating may form an inner encapsulation for the at least one thermoelectrically active element.

Abstract: A method for estimating a probability distribution of the maximum coefficient of friction (?) at a current and/or future waypoint (s, s*) of a vehicle. According to the method, a first probability distribution (WV1) for the maximum coefficient of friction (?) at the waypoint (s) of the vehicle is determined by a Bayesian network from a first data set, which is, or was determined, for one, in particular current, waypoint (s) of the vehicle and which characterizes the maximum coefficient of friction (?) at the waypoint (s) of the vehicle.

Abstract: A method for determining a safe speed (v*) at a future waypoint (s*) of a vehicle moving along a route. In this step, at least one item of route data (in particular the curvature of the curve ?) characterizing the course of the route is determined. In addition, a first probability distribution (Pges) of a coefficient of friction (?) is provided at the current waypoint (s) and/or at the future waypoint (s*) of the vehicle. Subsequently a second probability distribution (Pv) of a vehicle speed (v) at the future waypoint (s*) is determined from the at least one item of route data (?) and from the first probability distribution (Pges). The safe speed (v*) is determined by statistical analysis from the second probability distribution (Pv).

Abstract: An external force-supported hydraulic braking system of a wheeled vehicle includes two brake circuits each having a main brake line configured to be connected to a pressure-carrying supply line or to a pressureless return line via a brake valve and further having a number of wheel brake lines branching from the main brake line and including a valve assembly of a TCS system. The valve assembly of the TCS system has a single TCS control valve formed as a 6/2-way magnetic switching valve configured to, in a non-actuated state, block a pressure-carrying main pressure line against two bypass lines each leading directly to a respective main brake line, and connect the two return lines to a pressureless collective line, and further configured to, in the actuated state, connect the main pressure line to the two bypass lines and block the two return lines against the collective line.

Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. The toxin coding sequences can be used in DNA constructs or expression cassettes for expression in plants and bacteria. Compositions include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, polynucleotide sequences and the toxin proteins encoded thereby are provided. Also provided are antibodies specifically binding to those amino acid sequences. In particular, the invention encompasses nucleotide sequences encoding fusion proteins, as well as biologically active variants and fragments thereof, wherein the fusion protein contains the C-terminal portion of SEQ ID NO:43. The fusion protein may also contain the N-terminal portion of SEQ ID NO:45.

Abstract: A power-assisted hydraulic braking system includes a main brake line into which a setpoint brake pressure can be introduced via a brake valve actuated by a brake pedal, and from which a plurality of wheel brake lines branch off, each leading to an actuating unit of a wheel brake, and a valve arrangement of an ABS controller, comprising an inlet valve disposed between the main brake line and one of the wheel brake lines and an outlet valve disposed between the relevant wheel brake line and a pressureless return line. The inlet valve and the outlet valve are embodied as pressure-controlled 2/2-way switching valves with suitably sized switching cross-sections. At least one pilot control valve is associated with each of the inlet valve and the outlet valve, via which a control connection can be alternately subjected to a low or high control pressure to change over.

Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. The toxin coding sequences can be used in DNA constructs or expression cassettes for expression in plants and bacteria. Compositions include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, polynucleotide sequences and the toxin proteins encoded thereby are provided. Also provided are antibodies specifically binding to those amino acid sequences. In particular, the invention encompasses nucleotide sequences encoding fusion proteins, as well as biologically active variants and fragments thereof, wherein the fusion protein contains the C-terminal portion of SEQ ID NO:43. The fusion protein may also contain the N-terminal portion of SEQ ID NO:45.

Abstract: A vehicle braking unit comprises an operating braking pressure inlet which receives an inlet braking pressure built up by a braking cylinder, and at least one operating brake pressure outlet at which an outlet braking pressure is provided for an operating brake modulator, which is upstream of the operating brake and provides anti-lock functionality. At least one connecting channel hydraulically connects the operating brake pressure inlet to the outlet. Brake fluid is supplied from a storage unit through the brake cylinder, the connecting channel and the operating brake modulator. The braking unit has a brake fluid inlet, through which the brake fluid is received from the storage unit, a brake fluid pump, by which the brake fluid is suctioned through the brake fluid inlet and a supply pressure is built up, and a valve unit that controls the outlet braking pressure and/or a parking brake release pressure by the supply pressure.

Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:7, 8, 9, 10, 11, or 12, the nucleotide sequence set forth in SEQ ID NO:4, 5, or 6, as well as variants and fragments thereof.

Abstract: A valve assembly for an antilock system of a brake system of a vehicle includes a cylindrical rotary valve rotatably mounted in a valve block and configured to be activated by a step motor, configured to occupy at least two shifting positions, and having one input and one output. In one of the shifting positions, at least one duct leading to a wheel brake cylinder can be acted upon with a pressurizing medium via the input. In another of the shifting positions, the pressurizing medium can be discharged via the output. The input and the output of the rotary valve are arranged in different axial planes and at an angle offset to one another.

Abstract: An external force-supported hydraulic braking system of a wheeled vehicle includes two brake circuits each having a main brake line configured to be connected to a pressure-carrying supply line or to a pressureless return line via a brake valve and further having a number of wheel brake lines branching from the main brake line and including a valve assembly of a TCS system. The valve assembly of the TCS system has a single TCS control valve formed as a 6/2-way magnetic switching valve configured to, in a non-actuated state, block a pressure-carrying main pressure line against two bypass lines each leading directly to a respective main brake line, and connect the two return lines to a pressureless collective line, and further configured to, in the actuated state, connect the main pressure line to the two bypass lines and block the two return lines against the collective line.

Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:7, 8, 9, 10, 11, or 12, the nucleotide sequence set forth in SEQ ID NO:4, 5, or 6, as well as variants and fragments thereof.

Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. The toxin coding sequences can be used in DNA constructs or expression cassettes for expression in plants and bacteria. Compositions include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, polynucleotide sequences and the toxin proteins encoded thereby are provided. Also provided are antibodies specifically binding to those amino acid sequences. In particular, the invention encompasses nucleotide sequences encoding fusion proteins, as well as biologically active variants and fragments thereof, wherein the fusion protein contains the C-terminal portion of SEQ ID NO:43. The fusion protein may also contain the N-terminal portion of SEQ ID NO:45.