Patents by Inventor Walter H. Moos

Walter H. Moos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5447916
    Abstract: Compounds of the formula: ##STR1## are useful for treating conditions modulated by .alpha..sub.1 -adrenergic receptors.
    Type: Grant
    Filed: July 30, 1993
    Date of Patent: September 5, 1995
    Assignee: Chiron Corporation
    Inventors: David C. Spellmeyer, Walter H. Moos, Eric J. Martin, Ronald N. Zuckermann, Gregory Stauber
  • Patent number: 5346911
    Abstract: Pharmaceutically useful nitrogen containing cyclic oxime and amine substituted compounds which are azabicyclo[2.2.1]oximes, azabicyclo[2.2.2]oximes, azabicyclo[2.2.1]amines, azabicyclo[2.2.2]amines, azabicyclo[3.2.1]oximes, and amine containing heterocyclic oximes wherein the heterocyclic ring contains from 3 to 7 carbon atoms are disclosed.
    Type: Grant
    Filed: August 24, 1993
    Date of Patent: September 13, 1994
    Assignee: Warner-Lambert Company
    Inventors: Corinne E. Augelli-Szafran, Stephen D. Barrett, Bradley W. Caprathe, Adam A. Galan, Juan C. Jaen, David J. Lauffer, Walter H. Moos, Michael R. Pavia, Kathryn B. Sanders, Haile Tecle, Anthony J. Thomas
  • Patent number: 5324483
    Abstract: An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold.
    Type: Grant
    Filed: February 2, 1993
    Date of Patent: June 28, 1994
    Assignee: Warner-Lambert Company
    Inventors: Donna R. Cody, Sheila H. H. DeWitt, John C. Hodges, John S. Kiely, Walter H. Moos, Michael R. Pavia, Bruce D. Roth, Mel C. Schroeder, Charles J. Stankovic
  • Patent number: 5306718
    Abstract: Pharmaceutically useful nitrogen containing cyclic oxime and amine substituted compounds of the following general Formulas I, II and III are disclosed: ##STR1## Specifically the compounds are azabicyclo [2.2.1] omimes, azabicyclo [2.2.2] oximes, azabicyclo [2.2.1] amines, azabicyclo [2.2.2] amines, azabicyclo [3.2.1] oximes and amine containing heterocyclic oximes wherein the heterocyclic ring contains from 4 to 5 [3 to 7] carbon atoms.
    Type: Grant
    Filed: October 16, 1991
    Date of Patent: April 26, 1994
    Assignee: Warner-Lambert Company
    Inventors: David J. Lauffer, Walter H. Moos, Michael R. Pavia, Haile Tecle, Anthony J. Thomas
  • Patent number: 5081304
    Abstract: A series of isotopically-labeled fluorenamine, dibenzofuranamine, and dibenzothiophenamine derivatives useful for diagnosing neurodegenerative disorders in mammals wherein a detectable amount of an isotope-labeled fluorenamine, dibenzofuranamine, or dibenzothiophenamine derivative is used.
    Type: Grant
    Filed: July 10, 1990
    Date of Patent: January 14, 1992
    Assignee: Warner-Lambert Company
    Inventor: Walter H. Moos
  • Patent number: 5073561
    Abstract: Certain N-substituted 1-(1,2,3,6-tetrahydro-3-pyridinyl)oximes and N-substituted 1-(1,2,3,6-tetrahydro-4-pyridinyl)oximes are useful as sigma binding agents for the treatment of depression, psychoses and/or inflammatory diseases.
    Type: Grant
    Filed: March 5, 1990
    Date of Patent: December 17, 1991
    Assignee: Warner-Lambert Company
    Inventors: Linda L. Coughenour, Robert E. Davis, David A. Downs, Thomas G. Heffner, Leonard T. Meltzer, Walter H. Moos, David W. Moreland, Haile Tecle
  • Patent number: 4999430
    Abstract: Novel prodrugs or depot derivatives of 1,2,3,4-tetrahydro-9-acridinamine are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as analgesic agents for the treatment of pain, as sleep aids and as agents for treating the symptoms of senile dementia, Alzheimer's disease, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, or similar conditions of cerebral insufficiency characterized by decreased cerebral acetylcholine production or release.
    Type: Grant
    Filed: July 31, 1989
    Date of Patent: March 12, 1991
    Assignee: Warner-Lambert Company
    Inventors: Jeffrey A. Kester, Walter H. Moos, Anthony J. Thomas
  • Patent number: 4996201
    Abstract: 4-(N-Substituted amino)-2-butynyl-1-carbamates and thiocarbamates and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as centrally acting muscarinic agents and are useful as analgesic agents for the treatment of pain, as sleep aids and as agents for treating the symptoms of senile dementia, Alzheimer's disease, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, or similar conditions of cerebral insufficiency characterized by decreased cerebral acetylcholine production or release.
    Type: Grant
    Filed: August 2, 1989
    Date of Patent: February 26, 1991
    Assignee: Warner-Lambert Co.
    Inventors: Stephen C. Bergmeier, Jeffrey A. Kester, Walter H. Moos, Haile Tecle, Anthony J. Thomas
  • Patent number: 4988688
    Abstract: 4-(N-Substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as centrally acting muscarinic agents and are useful as analgesic agents for the treatment of pain, as sleep aids and as agents for treating the symptoms of senile dementia, Alzheimer's disease, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, or similar conditions of cerebral insufficiency characterized by decreased cerebral acetylcholine production or release.
    Type: Grant
    Filed: August 2, 1989
    Date of Patent: January 29, 1991
    Assignee: Warner-Lambert Company
    Inventors: Jeffrey A. Kester, Walter H. Moos, Anthony J. Thomas
  • Patent number: 4977172
    Abstract: (S)-3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)-methyl]-2-oxazolidinone or a pharmaceutically acceptable salt thereof is useful in the treatment of the symptoms of cognitive decline in an elderly patient suffering therefrom including the treatment of Alzheimer's disease.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: December 11, 1990
    Assignee: Warner-Lambert Company
    Inventors: Stephen J. Johnson, Walter H. Moos
  • Patent number: 4960815
    Type: Grant
    Filed: January 17, 1990
    Date of Patent: October 2, 1990
    Assignee: Warner-Lambert Company
    Inventor: Walter H. Moos
  • Patent number: 4937239
    Abstract: Novel 1-azabicycloalkane- and alkene-oximes (Ia) and 8-azabicyclo[3.2.1]octane- and octene-oximes (Ib) are provided, these compounds being useful as agents for treating pain or for treating the symptoms of senile cognitive decline. Also provided are pharmaceutical compositions containing the compounds and methods of treatment using the compounds in dosage form.
    Type: Grant
    Filed: February 13, 1989
    Date of Patent: June 26, 1990
    Assignee: Warner-Lambert Company
    Inventors: David J. Lauffer, Walter H. Moos, Hasile Tecle
  • Patent number: 4929734
    Abstract: Certain N-substituted 1-(1,2,3,6-tetrahydro-3-pyridinyl)oximes and N-substituted 1-(1,2,3,6-tetrahydro-4-pyridinyl)oximes are useful as sigma binding agents for the treatment of depression, psychoses and/or inflammatory diseases.
    Type: Grant
    Filed: October 18, 1988
    Date of Patent: May 29, 1990
    Assignee: Warner-Lambert Company
    Inventors: Linda L. Coughenour, Robert E. Davis, David A. Downs, Thomas G. Heffner, Leonard T. Meltzer, Walter H. Moos, David W. Moreland, Haile Tecle
  • Patent number: 4855308
    Abstract: A method is disclosed for the treatment or amelioration of the symptoms of cerebral insufficiency characterized by decreased central adrenergic and/or cholinergic function employing certain N-substituted aminopyridines.
    Type: Grant
    Filed: December 4, 1987
    Date of Patent: August 8, 1989
    Assignee: Warner-Lambert Company
    Inventors: Jeffrey A. Kester, Walter H. Moos, Anthony J. Thomas
  • Patent number: 4798841
    Abstract: Certain N-substituted 1-(1,2,3,6-tetrahydro-3-pyridinyl)oximes and N-substituted 1-(1,2,3,6-tetrahydro-4-pyridinyl)oximes are useful as analgesic agents or agents for the teatment or amelioration of the symptoms of cerebral insufficiency characterized by decreased central acetylcholine production or release.
    Type: Grant
    Filed: March 31, 1987
    Date of Patent: January 17, 1989
    Assignee: Warner-Lambert Company
    Inventors: David A. Downs, Walter H. Moos, David W. Moreland, Haile Tecle
  • Patent number: 4797419
    Abstract: Certain trisubstituted alkyl, aryl, pyridinyl, piperidinyl, and piperazinyl urea compounds stimulate the release of acetylcholine and are thus useful agents for the treatment of senile cognitive decline characterized by decreased cerebral acetylcholine production or release.A method for treating the symptoms of senile cognitive decline is disclosed.
    Type: Grant
    Filed: November 3, 1986
    Date of Patent: January 10, 1989
    Assignee: Warner-Lambert Company
    Inventors: Walter H. Moos, Anthony J. Thomas
  • Patent number: 4786648
    Abstract: Certain O-substituted-1,2,5,6-tetrahydro-3- or 1,2,3,6-tetrahydro-4-pyridine oximes are useful as agents for treating pain or for treating the symptoms of senile cognitive decline.
    Type: Grant
    Filed: September 4, 1987
    Date of Patent: November 22, 1988
    Assignee: Warner-Lambert Company
    Inventors: Stephen C. Bergmeier, David A. Downs, Walter H. Moos, David W. Moreland, Haile Tecle
  • Patent number: 4782071
    Abstract: Certain tetrasubstituted alkyl, aryl, pyridinyl, piperidinyl, and piperazinyl urea compounds stimulate the release of acetylcholine and are thus useful analgesic agents for alleviating pain or as cholinergic agents which are useful for the amelioration of the symptoms of cognitive decline in the elderly.These compounds have the general formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.4 are phenyl or substituted phenyl, and R.sub.3 is pyridinyl.Pharmaceutical compositions including these compounds as well as methods for the preparation of the compounds are also disclosed.
    Type: Grant
    Filed: November 3, 1986
    Date of Patent: November 1, 1988
    Assignee: Warner-Lambert Company
    Inventors: Donald E. Butler, David M. Lustgarten, Walter H. Moos, Anthony J. Thomas
  • Patent number: 4755594
    Abstract: The present inventions are novel N.sup.6 -substituted adenosines wherein the N substituent is ##STR1## wherein Ar is an unsubstituted or substituted (1) phenyl, (2) 1- or 2-naphthalenyl, (3) 2- or 3-thienyl, (4) 2- or 3-furanyl, (5) 2-, 4-, or 5-thiazyl, (6) 2-, 3-, or 4-pyridyl, or (7) 2-pyrimidyl wherein the substituents include at least one of lower alkyl, halo, trifluoromethyl, hydroxy, lower alkoxy, lower acyloxyamino, N-lower monoalkyl or N,N-lower dialkylamino, lower thioalkyl, lower alkylsulfonyl, or nitro and R' is hydrogen or alkyl, A is ##STR2## wherein q, q', or q" are one to four, n and m are independently zero to three provided if A is a bond then n and m is at least 2 and if A is other than a bond then n and m is at least one. These novel adenosines have highly desirable central nervous system and cardiovascular activities and therefore the present invention also includes pharmaceutical compositions and methods of use therefor.
    Type: Grant
    Filed: December 9, 1986
    Date of Patent: July 5, 1988
    Assignee: Warner-Lambert Company
    Inventors: Alexander J. Bridges, Harriet W. Hamilton, Walter H. Moos, Deedee L. Szotek
  • Patent number: 4745123
    Abstract: Certain substituted 1,2,3,6-tetrahydro- and 1,2,5,6-tetrahydropyridine-3-carboxylic acids, esters, and amides possessing muscarinic binding activity, having utility for the treatment of the symptoms of senile cognitive decline disclosed. Pharmaceutical compositions and a pharmaceutical method of treatment are also disclosed.
    Type: Grant
    Filed: February 18, 1986
    Date of Patent: May 17, 1988
    Assignee: Warner-Lambert Company
    Inventors: Donald E. Butler, John H. Dodd, Walter H. Moos, Haile Tecle