Patents by Inventor Walter Hepworth

Walter Hepworth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5182402
    Abstract: A method of killing or controlling unwanted plants by applying to the plant on to a locus thereof an effective amount of a compound of formula (I) ##STR1## or a salt thereof: wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are independently selected from hydrogen, hydroxy, alkyl, alkoxy, alkylcarbonyl, halogen, cyans, nitro, haloalkyl and haloalkoxy; R.sup.6 is hydrogen, hydroxy, amino, lower alkyl, halogen, cyano, haloalkyl, nitro, aryl, or a group C(O).sub.m R.sup.10, wherein R.sup.10 is hydrogen, alkyl, alkenyl, alkynyl or phenyl any of which may be optionally substituted and m is 1 or 2; R.sup.7 is hydrogen, lower alkyl, haloalkyl, C(O).sub.m R.sup.10 or halogen; or R.sup.6 and R.sup.7 together form an optionally substituted alkylene chain of 2 or 3 carbon atoms; R.sup.8 is hydrogen, lower alkyl or halogen or the group R.sup.7 or R.sup.8 together form an oxo group; and the group CZR.sup.9 is carboxy or an ester thereof, or R.sup.9 is a group SR.sup.10 or NR.sup.11 R.sup.12 wherein R.sup.
    Type: Grant
    Filed: September 19, 1991
    Date of Patent: January 26, 1993
    Assignee: Imperial Chemical Industries PLC
    Inventors: Terence Lewis, Harjinder S. Bansal, Raymond L. Sundley, Michael R. Bartley, Walter Hepworth, David J. Gilman, Ian T. Kay, David J. Collins
  • Patent number: 4187310
    Abstract: Novel 1,2-dihydro-2-oxoquinol-4-ylalkanoic acid derivatives bearing a variety of substituents on the quinoline nucleus but including, at position 1, an aromatic radical linked directly or through a C.sub.1-4 -alkylene or a C.sub.2-4 -alkenylene radical. Representative compounds of the invention are 1-(3,4-dichlorobenzyl)-3-methyl-1,2-dihydro-2-oxoquinol-4-ylacetic acid and .alpha.-(1-benzyl-1,2-dihydro-2-oxoquinol-4-yl)propionic acid. The compounds possess anti-inflammatory or analgesic properties, or are inhibitors of the enzyme aldose reductase.
    Type: Grant
    Filed: September 25, 1978
    Date of Patent: February 5, 1980
    Assignee: Imperial Chemical Industries Limited
    Inventors: David R. Brittain, Edward D. Brown, Walter Hepworth, Gilbert J. Stacey
  • Patent number: 4156002
    Abstract: The invention concerns pharmaceutical compositions having analgesic, and in some cases, in addition anti-inflammatory properties, for use in the treatment of painful inflammatory joint disease, which compositions contain as active ingredient a new or old 1-alkyl (or cycloalkyl)-4-(N-alkanoyl)substituted-amino-tetrahydro-1,3,5-triazine-2,6- dione of the formula: ##STR1## or a base-addition salt thereof. Many of the compounds of formula I are previously known as herbicides, and a representative example of such a compound which has now been surprisingly found to have useful analgesic properties is 1-isopropyl-4-(N-acetyl)isopropylamino-tetrahydro-1,3,5-triazine-2,6-dione . However certain of the compounds of formula I and the base-addition salts thereof are novel, a representative example being 1-isopropyl-4[(N-acetyl)pent-3-ylamino]-tetrahydro-1,3,5-triazine-2,6-dion e, and are provided as a further feature of the invention, together with analogy processes for their manufacture.
    Type: Grant
    Filed: February 13, 1978
    Date of Patent: May 22, 1979
    Assignee: Imperial Chemical Industries Limited
    Inventors: Edward D. Brown, Walter Hepworth, Ian T. Kay
  • Patent number: 4138490
    Abstract: Novel 1,2-dihydro-2-oxoquinol-4-ylalkanoic acid derivatives bearing a variety of substituents on the quinoline nucleus but including, at position 1, an aromatic radical linked directly or through a C.sub.1-4 -alkylene or a C.sub.2-4 -alkenylene radical. Representative compounds of the invention are 1-(3,4-dichlorobenzyl)-3-methyl-1,2-dihydro-2-oxoquinol-4-ylacetic acid and .alpha.-(1-benzyl-1,2-dihydro-2-oxoquinol-4-yl)propionic acid. The compounds possess anti-inflammatory or analgesic properties, or are inhibitors of the enzyme aldose reductase.
    Type: Grant
    Filed: September 12, 1977
    Date of Patent: February 6, 1979
    Assignee: Imperial Chemical Industries Limited
    Inventors: David R. Brittain, Edward D. Brown, Walter Hepworth, Gilbert J. Stacey
  • Patent number: 4066651
    Abstract: Novel 1,2-dihydro-2-oxoquinol-4-ylalkanoic acid derivatives bearing a variety of substituents on the quinoline nucleus but including, at position 1, an aromatic radical linked directly or through a C.sub.1-4 -alkylene or a C.sub.2-4 -alkenylene radical. Representative compounds of the invention are 1-(3,4-dichlorobenzyl)-3-methyl-1,2-dihydro-2-oxoquinol-4-ylacetic acid and .alpha.-(1-benzyl-1,2-dihydro-2-oxoquinol-4-yl)propionic acid. The compounds possess anti-inflammatory or analgesic properties, or are inhibitors of the enzyme aldose reductase.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: January 3, 1978
    Assignee: Imperial Chemical Industries Limited
    Inventors: David Robert Brittain, Edward Douglas Brown, Walter Hepworth, Gilbert Joseph Stacey
  • Patent number: 4012513
    Abstract: 1-(Heterocyclic)-indol-3-ylacetic acid derivatives, processes for their preparation, and pharmaceutical compositions comprising them. An illustrative compound of the invention is 1-(7-chloroquinazolin-4-yl)-5-methoxy-2-methylindol-3-ylacetic acid. The compounds have anti-inflammatory, analgesic and antipyretic activity. This application is a continuation-in-part of Ser. No. 296,202, filed Oct. 10, 1972, now U.S. Pat. No. 3,884,919.
    Type: Grant
    Filed: December 23, 1974
    Date of Patent: March 15, 1977
    Assignee: Imperial Chemical Industries Limited
    Inventors: George Richard Birchall, Walter Hepworth, Stephen Collyer Smith