Patents by Inventor Warren Che Wor Chan
Warren Che Wor Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10345240Abstract: The invention combines recent advances in barcode technology with portable wireless communication devices to engineer a simple and low-cost chip-based multiplex wireless detection system. The system can analyze multiple targets of interest simultaneously in minutes and is applicable to detection of pathogens or contaminants in a wide range of fields including medicine, agriculture and the environment.Type: GrantFiled: December 11, 2013Date of Patent: July 9, 2019Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Warren Che Wor Chan, Kevin Ming
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Publication number: 20190195883Abstract: A solid diagnostic product comprising reagents necessary for a protein-based test or genetic test and method of using said solid diagnostic product in detecting targets of interest in a fluid sample.Type: ApplicationFiled: November 6, 2018Publication date: June 27, 2019Inventors: Warren Che Wor CHAN, Buddhisha Nayantara UDUGAMA, Pranav Karthike KADHIRESAN
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Patent number: 10036056Abstract: The present invention relates to catalytic nucleic acid molecule signal amplification combined with surface plasmon properties of gold nanoparticles to achieve simple and sensitive colorimetric detection of biological targets. The assays of the present invention have about 50 pM sensitivity without the need for purification steps, can detect multiple targets in parallel, and is easily adaptable to new targets. The methods of the present invention are capable of rapid detection of genetic targets for gonorrhea, syphilis, malaria, and hepatitis B infections.Type: GrantFiled: June 12, 2013Date of Patent: July 31, 2018Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Warren Che Wor Chan, Kyrylo Zagorovsky
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Patent number: 9695482Abstract: In a method and system for forming concentrated volumes of microbeads, a polymer solution and/or suspension includes a polymer dissolved and/or dispersed in a medium. Streams of a focusing fluid and of the polymer solution and/or suspension flow towards a fluid bath, and into intersection with one another, so as to focus the polymer solution and/or suspension. The polymer solution and/or suspension stream forms microbeads in the fluid bath Some of the focusing fluid is drawn from the fluid bath, so as to concentrate the microbeads in the fluid bath. The system includes a flow focusing apparatus and a liquid-containing cell. The focusing apparatus includes polymer and focusing nozzles. The cell contains the fluid bath and has an outlet port, through which the focusing fluid is drawn.Type: GrantFiled: October 7, 2013Date of Patent: July 4, 2017Assignee: Fio CoporationInventors: Sebastian Fournier-Bidoz, Warren Che Wor Chan
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Publication number: 20160299137Abstract: A method and system are provided for the simultaneous detection and identification of multiple pathogens in a patient sample. The sample is combined with microbeads, which have been injected with quantum dots or fluorescent dye and conjugated to pathogen-specific biorecognition molecules, such as antibodies and oligonucleotides. Treatment options may be determined based on the identities of the pathogens detected in the sample.Type: ApplicationFiled: June 16, 2016Publication date: October 13, 2016Inventors: Michael Mordinson GREENBERG, Kevin Charles KAIN, Warren Che Wor CHAN
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Patent number: 9360476Abstract: A system and method to test for the presence of target molecules in a biological test sample includes test molecules, a microfluidic chip, and irradiating and detection devices. The test molecules include bio-recognition molecules conjugable with the target molecules, and the corresponding conjugates. The microfluidic chip includes sample channels and flow focusing channels adjoining the sample channels. A buffer exiting from the focusing channels directs a single-file stream of the test molecules through one of the sample channels. The irradiating device delivers radiation for absorption by the test molecules in the single-file stream. After absorption, the test molecules emit fluorescence of a distinct fluorescent spectrum for each of the conjugates. The detection device monitors identifies the presence of the conjugates by monitoring for the distinct fluorescent spectrum. Thus, the test system and method identifies the presence of the target molecules in the test sample.Type: GrantFiled: December 19, 2007Date of Patent: June 7, 2016Assignee: FIO CORPORATIONInventors: Qing Xiang, Warren Che Wor Chan, Jesse M. Klostranec
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Publication number: 20160108465Abstract: The present invention relates to catalytic nucleic acid molecule signal amplification combined with surface plasmon properties of gold nanoparticles to achieve simple and sensitive colorimetric detection of biological targets. The assays of the present invention have about 50 pM sensitivity without the need for purification steps, can detect multiple targets in parallel, and is easily adaptable to new targets. The methods of the present invention are capable of rapid detection of genetic targets for gonorrhea, syphilis, malaria, and hepatitis B infections.Type: ApplicationFiled: June 12, 2013Publication date: April 21, 2016Inventors: Warren Che Wor CHAN, Kyrylo ZAGOROVSKY
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Publication number: 20140038853Abstract: In a method and system for forming concentrated volumes of microbeads, a polymer solution and/or suspension includes a polymer dissolved and/or dispersed in a medium. Streams of a focusing fluid and of the polymer solution and/or suspension flow towards a fluid bath, and into intersection with one another, so as to focus the polymer solution and/or suspension. The polymer solution and/or suspension stream forms microbeads in the fluid bath Some of the focusing fluid is drawn from the fluid bath, so as to concentrate the microbeads in the fluid bath. The system includes a flow focusing apparatus and a liquid-containing cell. The focusing apparatus includes polymer and focusing nozzles. The cell contains the fluid bath and has an outlet port, through which the focusing fluid is drawn.Type: ApplicationFiled: October 7, 2013Publication date: February 6, 2014Applicant: FIO CORPORATIONInventors: Sebastian Fournier-Bidoz, Warren Che Wor Chan
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Patent number: 8597729Abstract: In a method and system for forming microbeads, a polymer solution includes particles and a polymer dissolved in a solvent. A stream of the polymer solution flows into a chamber. A focusing fluid contacts and focuses the polymer stream in the chamber. The focusing fluid and the focused polymer stream flow, as a single flow stream, out from the chamber. Pendant droplets detach from a leading end of the single flow stream to form the microbeads. The focusing fluid reacts with the polymer solution to form functional groups at a surface of the microbeads for binding with biorecognition molecules. In the system, a flow focusing apparatus includes a flow focusing body shaped to define the chamber. Microbeads formed according to the methods and systems are also disclosed.Type: GrantFiled: June 23, 2008Date of Patent: December 3, 2013Assignee: FIO CorporationInventors: Sebastien Fournier-Bidoz, Warren Che Wor Chan
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Patent number: 8551786Abstract: Systems and methods for enhancing fluorescent detection of target molecules in a test sample are for use with an irradiating device. First fluorophores are provided for absorption of EMF radiation, and emission of a first signal. Second fluorophores are provided for partial absorption of the first signal, and emission of a second signal distinguishable from the first signal. The fluorophores are combined with the test sample, and secured to the target molecules and relative to one another. After the first fluorophores receive the EMF radiation from the irradiating device, the first signal is detected, together with the second spectral signal if the target molecules are present in the test sample.Type: GrantFiled: July 9, 2008Date of Patent: October 8, 2013Assignee: FIO CorporationInventors: Warren Che Wor Chan, Travis Leon Jennings, Jesse M. Klostranec
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Patent number: 8551763Abstract: In a method and system for forming concentrated volumes of microbeads, a polymer solution and/or suspension includes a polymer dissolved and/or dispersed in a medium. Streams of a focusing fluid and of the polymer solution and/or suspension flow towards a fluid bath, and into intersection with one another, so &s to focus the polymer solution and/or suspension. The polymer solution and/or suspension stream forms microbeads in the fluid bath. Some of the focusing fluid is drawn from the fluid bath, so as to concentrate the microbeads in die fluid bath. The system includes a flow focusing apparatus and a liquid-containing cell. The focusing apparatus includes polymer and focusing nozzles. The cell contains the fluid bath and has an outlet port, through which the focusing fluid is drawn from the fluid bath.Type: GrantFiled: October 10, 2008Date of Patent: October 8, 2013Assignee: FIO CorporationInventors: Sebastien Fournier-Bidoz, Warren Che Wor Chan
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Patent number: 8360321Abstract: A method deconvolves a multiplexed fluorescence spectral signal into its component single-color fluorescence spectra emitted by contributing fluorophore types. A spectral database contains a parameter set for each of the component spectra. Optical codes are received as the multiplexed signals. A sliding window technique estimates a number and location of local peaks for the component spectra. Allowable variation ranges are assigned for the corresponding parameter sets. Each multiplexed signal is deconvolved into a sum of parametric values to generate a list of its component spectra. Encoded and received optical codes, in the form of multiplexed signals, are decoded and identified by their component spectra and contributing fluorophore types. A system for deconvolving the multiplexed signals includes a spectral database containing the parameter sets, a detection element receiving the optical codes, and a signal processor encoded to analyze and deconvolve the multiplexed signals.Type: GrantFiled: April 2, 2008Date of Patent: January 29, 2013Assignee: FIO CorporationInventors: Jeongjin Lee, Warren Che Wor Chan, Qing Xiang, Jesse Klostranec
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Publication number: 20120156490Abstract: In a method and system for forming microbeads, a polymer solution includes particles and a polymer dissolved in a solvent. A stream of the polymer solution flows into a chamber. A focusing fluid contacts and focuses the polymer stream in the chamber. The focusing fluid and the focused polymer stream flow, as a single flow stream, out from the chamber. Pendant droplets detach from a leading end of the single flow stream to form the microbeads. The focusing fluid reacts with the polymer solution to form functional groups at a surface of the microbeads for binding with biorecognition molecules. In the system, a flow focusing apparatus includes a flow focusing body shaped to define the chamber. Microbeads formed according to the methods and systems are also disclosed.Type: ApplicationFiled: June 23, 2008Publication date: June 21, 2012Applicant: FIO CorporationInventors: Sebastien Fournier-Bidoz, Warren Che Wor Chan
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Publication number: 20110284639Abstract: A method deconvolves a multiplexed fluorescence spectral signal into its component single-color fluorescence spectra emitted by contributing fluorophore types. A spectral database contains a parameter set for each of the component spectra. Optical codes are received as the multiplexed signals. A sliding window technique estimates a number and location of local peaks for the component spectra. Allowable variation ranges are assigned for the corresponding parameter sets. Each multiplexed signal is deconvolved into a sum of parametric values to generate a list of its component spectra. Encoded and received optical codes, in the form of multiplexed signals, are decoded and identified by their component spectra and contributing fluorophore types. A system for deconvolving the multiplexed signals includes a spectral database containing the parameter sets, a detection element receiving the optical codes, and a signal processor encoded to analyze and deconvolve the multiplexed signals.Type: ApplicationFiled: April 2, 2008Publication date: November 24, 2011Applicant: FIO CorporationInventors: Jeongjin Lee, Warren Che Wor Chan
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Publication number: 20110081643Abstract: In a method and system for forming concentrated volumes of microbeads, a polymer solution and/or suspension includes a polymer dissolved and/or dispersed in a medium. Streams of a focusing fluid and of the polymer solution and/or suspension flow towards a fluid bath, and into intersection with one another, so &s to focus the polymer solution and/or suspension. The polymer solution and/or suspension stream forms microbeads in the fluid bath. Some of the focusing fluid is drawn from the fluid bath, so as to concentrate the microbeads in die fluid bath. The system includes a flow focusing apparatus and a liquid-containing cell. The focusing apparatus includes polymer and focusing nozzles. The cell contains the fluid bath and has an outlet port, through which the focusing fluid is drawn from the fluid bath.Type: ApplicationFiled: October 10, 2008Publication date: April 7, 2011Inventors: Sebastian Fournier-Bidoz, Warren Che Wor Chan
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Publication number: 20110053278Abstract: Systems and methods for enhancing fluorescent detection of target molecules in a test sample are for use with an irradiating device. First fluorophores are provided for absorption of EMF radiation, and emission of a first signal. Second fluorophores are provided for partial absorption of the first signal, and emission of a second signal distinguishable from the first signal. The fluorophores are combined with the test sample, and secured to the target molecules and relative to one another. After the first fluorophores receive the EMF radiation from the irradiating device, the first signal is detected, together with the second spectral signal if the target molecules are present in the test sample.Type: ApplicationFiled: July 9, 2008Publication date: March 3, 2011Applicant: FIO CorporationInventors: Warren Che Wor Chan, Travis Leon Jennings, Jesse M. Klostranec
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Publication number: 20100151443Abstract: A system and method to test for the presence of target molecules in a biological test sample includes test molecules, a microfluidic chip, and irradiating and detection devices. The test molecules include bio-recognition molecules conjugable with the target molecules, and the corresponding conjugates. The microfluidic chip includes sample channels and flow focusing channels adjoining the sample channels. A buffer exiting from the focusing channels directs a single-file stream of the test molecules through one of the sample channels. The irradiating device delivers radiation for absorption by the test molecules in the single-file stream. After absorption, the test molecules emit fluorescence of a distinct fluorescent spectrum for each of the conjugates. The detection device monitors identifies the presence of the conjugates by monitoring for the distinct fluorescent spectrum. Thus, the test system and method identifies the presence of the target molecules in the test sample.Type: ApplicationFiled: December 19, 2007Publication date: June 17, 2010Applicant: FIO CorporationInventors: Qing Xiang, Warren Che Wor Chan, Jesse M. Klostranec
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Publication number: 20100021937Abstract: A method and system are provided for the simultaneous detection and identification of multiple pathogens in a patient sample. The sample is combined with microbeads, which have been injected with quantum dots or fluorescent dye and conjugated to pathogen-specific biorecognition molecules, such as antibodies and oligonucleotides. Treatment options may be determined based on the identities of the pathogens detected in the sample.Type: ApplicationFiled: February 13, 2007Publication date: January 28, 2010Applicant: FIO CORPORATIONInventors: Michael Mordinson Greenberg, Kevin Charles Kain, Warren Che Wor Chan