Patents by Inventor Wei-Li LEE

Wei-Li LEE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210069101
    Abstract: The present technology relates to depot assemblies for the controlled, sustained release of a therapeutic agent. The assembly can include a depot having a therapeutic region comprising a therapeutic agent, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for no less than 3 days.
    Type: Application
    Filed: April 11, 2019
    Publication date: March 11, 2021
    Inventors: Karun D. Naga, Hanson S. Gifford, III, Stephen W. Boyd, Patrick H. Ruane, Jackie Joe Hancock, Michael Feldstein, Koon Kiat Teu, Honglei Wang, Jingnan Luo, Daniel Boon Lim Seet, Wei Li Lee, Nassireddin Mokarram-Dorri
  • Publication number: 20200368398
    Abstract: The devices, systems, and methods disclosed herein may be directed to a delivery system including a therapeutic member configured for endoluminal placement via the delivery system into the esophagus of the patient, wherein the therapeutic member comprises a treatment portion comprising a film for controlled release of a chemotherapeutic agent. The film may comprise a control region, a therapeutic region, and a substantially impermeable base region. The film is configured to release the chemotherapeutic agent in a direction away from the substantially impermeable base region. The delivery system is configured to enable a treatment provider to position the treatment portion of the therapeutic member proximate to a treatment site associated with the esophagus of the patient, and the therapeutic member is configured to administer a therapeutically effective dose to the treatment site for a sustained period following endoluminal placement of the therapeutic member.
    Type: Application
    Filed: January 8, 2019
    Publication date: November 26, 2020
    Inventors: Karun D. Naga, Stephen W. Boyd, Hanson S. Gifford, III, Mark Deem, John Morriss, Martin Mayse, Honglei Wang, Jingnan Luo, Daniel Boon Lim Seet, Koon Kiat Teu, Wei Li Lee
  • Patent number: 9616031
    Abstract: The present invention relates to a method for encapsulating particles of a water-insoluble material within a capsule of a water-insoluble polymer, comprising (a) dispersing particles of the water-insoluble material or a solution containing the water-insoluble material in a first aqueous phase containing a first surfactant to obtain a first dispersion; (b) collecting the particles of the water-insoluble material coated with the first surfactant; (c) washing the collected particles; (d) adding the washed surfactant-coated water-insoluble material particles to a polymer solution containing the water-insoluble polymer of the capsule to obtain a polymer mixture; and (e) dispersing the polymer mixture in a second aqueous phase containing a second surfactant to obtain a second dispersion comprising the particles of the water-insoluble material encapsulated within the capsule of the water-insoluble polymer.
    Type: Grant
    Filed: November 24, 2011
    Date of Patent: April 11, 2017
    Assignee: Nanyang Technological University
    Inventors: Say Chye Joachim Loo, Yit Lung Khung, Wei Li Lee
  • Patent number: 9381163
    Abstract: The invention relates to capsules encapsulating particles loaded with one or more drugs, and in particular, to such capsules that are able to float. The capsules may be used for drug delivery in the gastrointestinal tract. Methods for forming the capsules are also disclosed, and in particular, double emulsion methods are used in forming the capsules.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: July 5, 2016
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Say Chye Joachim Loo, Wei Li Lee, Peixin Wee
  • Publication number: 20150164815
    Abstract: The invention relates to capsules encapsulating particles loaded with one or more drugs, and in particular, to such capsules that are able to float. The capsules may be used for drug delivery in the gastrointestinal tract. Methods for forming the capsules are also disclosed, and in particular, double emulsion methods are used in forming the capsules.
    Type: Application
    Filed: July 8, 2013
    Publication date: June 18, 2015
    Inventors: Say Chye Joachim Loo, Wei Li Lee, Peixin Wee
  • Publication number: 20130302429
    Abstract: The present invention relates to a method for encapsulating particles of a water-insoluble material within a capsule of a water-insoluble polymer, comprising (a) dispersing particles of the water-insoluble material or a solution containing the water-insoluble material in a first aqueous phase containing a first surfactant to obtain a first dispersion; (b) collecting the particles of the water-insoluble material coated with the first surfactant; (c) washing the collected particles; (d) adding the washed surfactant-coated water-insoluble material particles to a polymer solution containing the water-insoluble polymer of the capsule to obtain a polymer mixture; and (e) dispersing the polymer mixture in a second aqueous phase containing a second surfactant to obtain a second dispersion comprising the particles of the water-insoluble material encapsulated within the capsule of the water-insoluble polymer.
    Type: Application
    Filed: November 24, 2011
    Publication date: November 14, 2013
    Applicant: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Say Chye Joachim Loo, Yit Lung Khung, Wei Li Lee
  • Publication number: 20120128752
    Abstract: The invention relates to a method of manufacturing multi-phase microparticles. The method comprises dissolving at least three different polymers in a volatile organic solvent to obtain a first solution. The first solution comprises at least two cloud points, wherein the second cloud point is higher than the first cloud point. Viscosity of the first solution and the first and second cloud point are selected such that the at least three different polymers are immiscible with each other in the first solution. The first solution is dispersed into an aqueous continuous phase which comprises a surfactant to obtain an emulsion. The volatile organic solvent is evaporated from the emulsion. The total concentration of the at least three different polymers together in the emulsion before evaporation is below the first cloud point, or is above the first cloud point and below the second cloud point or is above the second cloud point.
    Type: Application
    Filed: June 7, 2010
    Publication date: May 24, 2012
    Applicant: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Say Chye Joachim Loo, Wei Li Lee
  • Publication number: 20120040164
    Abstract: The present invention provides a particle monolayer and a method for fabricating the same. The method comprises the following steps: providing a container; adding a solvent into said container; adding a mixture of a particle-suspension and a spreading agent into said solvent; and adding a solvent-soluble polymer to said mixture to form a particle-monolayer. By using a solvent-soluble polymer, the particle monolayer fabricated by the method is a large-area particle monolayer with ordered structure, and the method can be used for any kind of substrates.
    Type: Application
    Filed: August 2, 2011
    Publication date: February 16, 2012
    Applicant: Academia Sinica
    Inventors: Wei-Li LEE, Chi-Chih Ho, Keng-Hui Lin, Wen-Tau Juan