Patents by Inventor Weicheng YUAN

Weicheng YUAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,4-sulfur-bridged polycyclic compounds containing dihydrobenzofuran structure, its preparation method and application thereof
    Patent number: 12162897
    Abstract: The present invention discloses a 1,4-sulfur-bridged polycyclic compound containing dihydrobenzofuran structure which has a structural formula (I). A preparation method is also disclosed which includes the steps of: dissolving 2-nitrobenzofuran (II) and 5H-thiazolone (III) in an organic solvent; then adding molecular sieve and chiral catalyst, stirring and allowing reaction at room temperature under argon protection until the reaction is completed; and carrying out separation and purification to obtain a 1,4-sulfur-bridged polycyclic compound (I) containing dihydrobenzofuran structure. The polycyclic compounds of the present invention have a substructure of dihydrobenzofuran and 1,4-thiopiperidinone. The application of the compound for the preparation of antitumor drugs is also disclosed, which has a good potential value in antitumor drug research. The preparation method has the advantages of novelty, simplicity, simple operation, mild reaction conditions, high yield and high stereoselectivity, and etc.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: December 10, 2024
    Inventors: Jianqiang Zhao, Shun Zhou, Weicheng Yuan, Yong You, Zhenhua Wang
  • 1,4-Sulfur-Bridged Polycyclic Compounds Containing Dihydrobenzofuran Structure, Its Preparation Method and Application Thereof
    Publication number: 20240287099
    Abstract: The present invention discloses a 1,4-sulfur-bridged polycyclic compound containing dihydrobenzofuran structure which has a structural formula (I). A preparation method is also disclosed which includes the steps of: dissolving 2-nitrobenzofuran (II) and 5H-thiazolone (III) in an organic solvent; then adding molecular sieve and chiral catalyst, stirring and allowing reaction at room temperature under argon protection until the reaction is completed; and carrying out separation and purification to obtain a 1,4-sulfur-bridged polycyclic compound (I) containing dihydrobenzofuran structure. The polycyclic compounds of the present invention have a substructure of dihydrobenzofuran and 1,4-thiopiperidinone. The application of the compound for the preparation of antitumor drugs is also disclosed, which has a good potential value in antitumor drug research. The preparation method has the advantages of novelty, simplicity, simple operation, mild reaction conditions, high yield and high stereoselectivity, and etc.
    Type: Application
    Filed: March 18, 2022
    Publication date: August 29, 2024
    Inventors: Jianqiang ZHAO, Shun ZHOU, Weicheng YUAN, Yong YOU, Zhenhua WANG