Patents by Inventor Weiya Yun

Weiya Yun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS
    Publication number: 20100190979
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: January 26, 2010
    Publication date: July 29, 2010
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Shiming Li, Lee Apostle McDermott, Yimin Qian, Weiya Yun
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20100168419
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: March 11, 2010
    Publication date: July 1, 2010
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Shiming Li, Lee Apostle McDermott, Yimin Qian, Weiya Yun
  • INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE
    Publication number: 20100145047
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: November 18, 2009
    Publication date: June 10, 2010
    Inventors: David Robert Bolin, Stuart Hayden, Yimin Qian, Weiya Yun
  • Diacylglycerol acyltransferase inhibitors
    Patent number: 7714126
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: May 11, 2010
    Assignee: Via Pharmaceuticals, Inc.
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Shiming Li, Lee Apostle McDermott, Yimin Qian, Weiya Yun
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20090170864
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: May 1, 2008
    Publication date: July 2, 2009
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Lee Apostle McDermott, Yimin Qian, Jenny Tan, Weiya Yun
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20090105273
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: May 1, 2008
    Publication date: April 23, 2009
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Lee Aopstle McDermott, Yimin Qian, Jenny Tan, Weiya Yun
  • Quinazoline Protein Tyrosine Phosphatase Inhibitors
    Publication number: 20090105477
    Abstract: The present invention comprises aminoquinazoline compounds of the general formula I: wherein X is an unsubstituted or substituted phenyl, or is an unsubstituted or substituted 5 or 6 membered heteroaromatic ring. The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
    Type: Application
    Filed: October 30, 2008
    Publication date: April 23, 2009
    Inventors: Steven Joseph Berthel, Adrian Wai-Hing Cheung, Kshitij Chhabilbhai Thakkar, Weiya Yun
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20090099201
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: May 1, 2008
    Publication date: April 16, 2009
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Michael Hamilton, Lee Apostle McDermott, Yimin Qian, Jenny Tan, Weiya Yun
  • Diacylglycerol Acyltransferase Inhibitors
    Publication number: 20090093497
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: May 1, 2008
    Publication date: April 9, 2009
    Inventors: David Robert Bolin, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew Micheal Hamilton, Lee Apostle McDermott, Yimin Qian, Jenny Tan, Weiya Yun
  • DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS
    Publication number: 20090076275
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: September 10, 2008
    Publication date: March 19, 2009
    Inventors: David Robert Bolin, Jianping Cai, Adrian Wai-Hing Cheung, Robert Alan Goodnow, JR., Matthew Michael Hamilton, Shiming Li, Lee Apostle McDermott, Weiya Yun
  • PYRIDOPYRIMIDINE PROTEIN TYROSINE PHOSPHATASE INHIBITORS
    Publication number: 20090062276
    Abstract: The present invention comprises pyridopyrimidinediamine compounds of the general formula I: The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
    Type: Application
    Filed: October 28, 2008
    Publication date: March 5, 2009
    Inventors: Steven Joseph Berthel, Adrian Wai-Hing Cheung, Kyungjin Kim, Shiming Li, Kshitij Chhabilbhai Thakkar, Weiya Yun
  • Diaminopropionic acid derivatives
    Patent number: 7491741
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Grant
    Filed: February 8, 2007
    Date of Patent: February 17, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors
    Publication number: 20070270445
    Abstract: The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B, and are useful for lowering blood glucose concentrations in mammals.
    Type: Application
    Filed: June 27, 2007
    Publication date: November 22, 2007
    Inventors: Steven Berthel, Adrian Cheung, Kyungjin Kim, Kshitij Thakkar, Weiya Yun
  • Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors
    Patent number: 7262297
    Abstract: The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B, and are useful for lowering blood glucose concentrations in mammals.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: August 28, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Steven Joseph Berthel, Adrian Wai-Hing Cheung, Kyungjin Kim, Kshitij Chhabilbhai Thakkar, Weiya Yun
  • Diaminopropionic acid derivatives
    Publication number: 20070155671
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Application
    Filed: February 8, 2007
    Publication date: July 5, 2007
    Inventors: Nader Fotouhi, Paul Gillespie, Robert Guthrie, Sherrie Pietranico-Cole, Weiya Yun
  • Diacylglycerol acyltransferase inhibitors
    Publication number: 20070123504
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: November 17, 2006
    Publication date: May 31, 2007
    Inventors: David Bolin, Adrian Cheung, Fariborz Firooznia, Matthew Hamilton, Shiming Li, Lee McDermott, Yimin Qian, Weiya Yun
  • Diaminopropionic acid derivatives
    Patent number: 7217728
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Grant
    Filed: September 21, 2004
    Date of Patent: May 15, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Pyridopyrimidine protein tyrosine phosphatase inhibitors
    Publication number: 20070021445
    Abstract: The present invention comprises pyridopyrimidinediamine compounds of the general formula I: The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
    Type: Application
    Filed: July 18, 2006
    Publication date: January 25, 2007
    Inventors: Steven Berthel, Adrian Cheung, Kyungjin Kim, Shiming Li, Kshitij Thakkar, Weiya Yun
  • Sulfonamide substituted xanthine derivatives
    Patent number: 7148229
    Abstract: The present invention is a sulfonamide substituted xanthine derivative of formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is lower alkyl, lower alkyl substituted by phenyl, or lower alkyl substituted by halogen substituted phenyl; R2 is lower alkyl or lower alkyl substituted by lower cycloalkyl; and R3 is: Compounds of formula I and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: December 12, 2006
    Assignee: Hoffman-La Roche Inc.
    Inventors: Peter W. Dunten, Louise H. Foley, Nicholas J. S. Huby, Sherrie L. Pietranico-Cole, Weiya Yun
  • Amide substituted xanthine derivatives
    Patent number: 7135475
    Abstract: The present invention is a 1,3,8 substituted xanthine derivative of formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are as defined in the specification. Compounds of formula I and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: November 14, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Peter W. Dunten, Louise H. Foley, Nicholas J. S. Huby, Sherrie L. Pietranico-Cole, Weiya Yun