Patents by Inventor Wencai Ye

Wencai Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vinblastine derivatives, preparation method therefor and application thereof
    Patent number: 10377774
    Abstract: The present invention provides a new kind of vinca alkaloid derivatives, new applications thereof and preparation methods therefor. The vinca alkaloid derivatives comprise hydrazinolyzed vinca alkaloids and vinca alkaloid dipeptide derivative. The hydrazinolyzed vinca alkaloids are the compounds obtained from the reaction of vinca alkaloids or salts thereof with hydrazinolyzed hydrate; and the vinca alkaloid dipeptide derivatives are the compounds obtained from the condensation of hydrazinolyzed vinca alkaloids with N-benzyloxycarbonylglycyl proline. The present invention provides the uses of the vinca alkaloids derivatives or the pharmaceutical compositions thereof in anti-tumor, preventing or treating diabetic retinopathy, rheumatoid arthritis and serving as angiogenesis inhibitors or vascular disrupting agents.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: August 13, 2019
    Assignee: JINAN UNIVERSITY
    Inventors: Wencai Ye, Heru Chen, Dongmei Zhang, Minfeng Chen, Nanhui Xu
  • VINBLASTINE DERIVATIVES, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Publication number: 20160068552
    Abstract: The present invention provides a new kind of vinca alkaloid derivatives, new applications thereof and preparation methods therefor. The vinca alkaloid derivatives comprise hydrazinolyzed vinca alkaloids and vinca alkaloid dipeptide derivative. The hydrazinolyzed vinca alkaloids are the compounds obtained from the reaction of vinca alkaloids or salts thereof with hydrazinolyzed hydrate; and the vinca alkaloid dipeptide derivatives are the compounds obtained from the condensation of hydrazinolyzed vinca alkaloids with N-benzyloxycarbonylglycyl proline. The present invention provides the uses of the vinca alkaloids derivatives or the pharmaceutical compositions thereof in anti-tumor, preventing or treating diabetic retinopathy, rheumatoid arthritis and serving as angiogenesis inhibitors or vascular disrupting agents.
    Type: Application
    Filed: March 3, 2014
    Publication date: March 10, 2016
    Inventors: Wencai YE, Heru CHEN, Dongmei ZHANG, Minfeng CHEN, Nanhui XU
  • Gymnemic acid derivatives, process for the preparation thereof and use thereof as medicine
    Patent number: 6833443
    Abstract: This invention relates to new Gymnemic acid derivatives, their preparation, pharmaceutical composition or extract which contains them, and their medical use, especially the use in the prevention or treatment of the diseases associated with hyperglycemia, hyperlipidemia and platelets aggregation.
    Type: Grant
    Filed: January 15, 2002
    Date of Patent: December 21, 2004
    Assignee: Guilin Jiqi Pharmaceutical Co., Ltd.
    Inventors: Wencai Ye, Yue Dai, Xiaodong Cong, Xingxiang Zhu, Shouxun Zhao