Patents by Inventor Wende Lei

Wende Lei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160287689
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: January 4, 2016
    Publication date: October 6, 2016
    Inventors: William D. THOMAS, JR., Paul J. GIANNASCA, Zhenxi ZHANG, Wende LEI, Thomas P. MONATH
  • Patent number: 9226956
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: January 5, 2016
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: William D. Thomas, Jr., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Publication number: 20150030612
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 29, 2015
    Inventors: William D. THOMAS, JR., Paul J. GIANNASCA, Zhenxi ZHANG, Wende LEI, Thomas P. MONATH
  • Publication number: 20130177592
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: April 27, 2012
    Publication date: July 11, 2013
    Applicant: Sanofi Pasteur Biologics, LLC
    Inventors: William D. Thomas, JR., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Publication number: 20070231336
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: May 30, 2007
    Publication date: October 4, 2007
    Applicant: Acambis Inc.
    Inventors: William Thomas, Paul Giannasca, Zhenxi Zhang, Wende Lei, Thomas Monath
  • Publication number: 20060029608
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: September 26, 2005
    Publication date: February 9, 2006
    Inventors: William Thomas, Paul Giannasca, Zhenxi Zhang, Wende Lei, Thomas Monath
  • Patent number: 6969520
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: November 29, 2005
    Assignee: Acambis Inc.
    Inventors: William D. Thomas, Jr., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Publication number: 20040126383
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: December 16, 2003
    Publication date: July 1, 2004
    Inventors: William D. Thomas, Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Patent number: 6680168
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: January 20, 2004
    Assignee: Acambis, Inc.
    Inventors: William D. Thomas, Jr., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Publication number: 20010051153
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: March 22, 2001
    Publication date: December 13, 2001
    Inventors: William D. Thomas, Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Patent number: 6214341
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: April 10, 2001
    Assignee: OraVax
    Inventors: William D. Thomas, Jr., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Patent number: 5919463
    Abstract: The invention features methods and compositions for inducing protective and/or therapeutic immune responses to an antigen in a mammal. In these methods, an antigen is administered to the mammal with a toxin of a Clostridium (e.g., C. difficile), or a fragment or derivative thereof having adjuvant activity.
    Type: Grant
    Filed: October 16, 1995
    Date of Patent: July 6, 1999
    Assignee: OraVax, Inc.
    Inventors: William D. Thomas, Jr., Thomas P. Monath, Zhenxi Zhang, Francisco Javier Torres-Lopez, Wende Lei, David M. Lyerly, James S. Moncrief