Patents by Inventor Werner Skuballa

Werner Skuballa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
    Publication number: 20060084652
    Abstract: The invention relates to alkylidene-tetrahydronaphthalene derivatives of general formula (I), process for their production, and their use as anti-inflammatory agents.
    Type: Application
    Filed: September 9, 2005
    Publication date: April 20, 2006
    Inventors: Stefan Baeurle, Markus Berger, Stefan Jaroch, Konrad Krolikiewicz, Duy Nguyen, Hartmut Rehwinkel, Heike Schaecke, Norbert Schmees, Werner Skuballa
  • 6-Alkenyl -, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
    Publication number: 20060046997
    Abstract: This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula (I) in which R1a, R1b, R2a, R3a, R3b, R4, R5, R6, R7, A, Y, D, E, G, Y and Z have the meanings that are indicated in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and thus find use in treating diseases or conditions associated with the need for cell growth, division and/or proliferation. Thus the compounds are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanoma, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (such as psoriasis, arthritis). Methods of use and preparation of the compounds are also described.
    Type: Application
    Filed: August 31, 2005
    Publication date: March 2, 2006
    Inventors: Ulrich Klar, Wolfgang Schwede, Werner Skuballa, Bernd Buchmann, Jens Hoffmann, Rosemarie Lichtner
  • Epothilone derivatives, process for their production, and their pharmaceutical use
    Publication number: 20060040990
    Abstract: Disclosed are epothilone compounds of formula I, which are useful as pharmaceutical compounds for treating, for example, malignant tumors and chronic inflammatory diseases and are useful in anti-angiogenesis therapy.
    Type: Application
    Filed: July 27, 2005
    Publication date: February 23, 2006
    Inventors: Ulrich Klar, Werner Skuballa, Bernd Buchmann, Wolfgang Schwede, Michael Schirner
  • Nonsteroidal antiinflammatory agents
    Publication number: 20060040933
    Abstract: are useful in the treatment of inflammation.
    Type: Application
    Filed: October 20, 2005
    Publication date: February 23, 2006
    Inventors: Stefan Jaroch, Manfred Lehmann, Norbert Schmees, Bernd Buchmann, Harmur Rehwinkel, Peter Droescher, Werner Skuballa, Konrad Krolikiewicz, Hartwig Hennekes, Heike Schaecke, Arndr Schottelius
  • Epothilon derivatives, method for the production and the use thereof as pharmaceuticals
    Patent number: 7001916
    Abstract: Disclosed are epothilone compounds of formula I, which are useful as pharmaceutical compounds for treating, for example, malignant tumors and chronic inflammatory diseases and are useful in anti-angiogenesis therapy.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: February 21, 2006
    Assignee: Schering, AG
    Inventors: Ulrich Klar, Werner Skuballa, Bernd Buchmann, Wolfgang Schwede, Michael Schirner
  • Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
    Publication number: 20050272823
    Abstract: The invention relates to multiply-substituted tetrahydronaphthalene derivatives of formula (I) process for their production and their use as antiinflammatory agents.
    Type: Application
    Filed: October 8, 2004
    Publication date: December 8, 2005
    Inventors: Hartmut Rehwinkel, Stefan Baeurle, Markus Berger, Norbert Schmees, Heike Schaecke, Konrad Krolikiewicz, Anne Mengel, Duy Nguyen, Stefan Jaroch, Werner Skuballa
  • Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
    Publication number: 20050222154
    Abstract: The invention relates to multiply-substituted tetrahydronaphthalene derivatives of formula (I) process for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: October 12, 2004
    Publication date: October 6, 2005
    Inventors: Hartmut Rehwinkel, Stefan Baeurle, Markus Berger, Norbert Schmees, Heike Schaecke, Konrad Krolikiewicz, Anne Mengel, Duy Nguyen, Stefan Jaroch, Werner Skuballa
  • Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
    Publication number: 20050209324
    Abstract: The invention relates to tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: October 12, 2004
    Publication date: September 22, 2005
    Inventors: Hartmut Rehwinkel, Stefan Baeurle, Markus Berger, Norbert Schmees, Heike Schaecke, Konrad Krolikiewicz, Anne Mengel, Duy Nguyen, Stefan Jaroch, Werner Skuballa
  • 16-Halogen-epothilone derivatives, method for producing them and their pharmaceutical use
    Publication number: 20050187270
    Abstract: A compound of formula C, BC and ABC.
    Type: Application
    Filed: March 25, 2005
    Publication date: August 25, 2005
    Inventors: Ulrich Klar, Werner Skuballa, Bernd Buchmann, Wolfgang Schwede, Michael Schirner
  • 16-halogen-epothilone derivatives, process for their production, and their pharmaceutical use
    Patent number: 6930102
    Abstract: A compund of formula I, an epothilone derivative, its method of preparation, and use as a pharmaceutical agent in treating malignant tumors
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: August 16, 2005
    Assignee: Schering AG
    Inventors: Ulrich Klar, Werner Skuballa, Bernd Buchmann, Wolfgang Schwede, Michael Schirner
  • Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
    Publication number: 20050171109
    Abstract: The invention relates to tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: October 12, 2004
    Publication date: August 4, 2005
    Inventors: Hartmut Rehwinkel, Stefan Baeurle, Markus Berger, Norbert Schmees, Heike Schaecke, Konrad Krolikiewicz, Anne Mengel, Duy Nguyen, Stefan Jaroch, Werner Skuballa
  • Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
    Publication number: 20050165050
    Abstract: The invention relates to quinoline and isoquinoline derivatives of general formula I and a process for their production, and their use as inflammation inhibitors.
    Type: Application
    Filed: February 17, 2005
    Publication date: July 28, 2005
    Inventors: Stefan Jaroch, Manfred Lehmann, Norbert Schmees, Markus Berger, Hartmut Rehwinkel, Konrad Krolikiewicz, Werner Skuballa, Heike Schaecke, Arndt. Schottelius
  • Substituted pentanols, a process for their production and their use as anti-inflammatory agents
    Publication number: 20050143415
    Abstract: The invention relates to substituted pentanols, a process for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: October 5, 2004
    Publication date: June 30, 2005
    Inventors: Stefan Jaroch, Stefan Baeurle, Markus Berger, Konrad Krolikiewicz, Duy Nguyen, Hartmut Rehwinkel, Norbert Schmees, Werner Skuballa, Heike Schaecke
  • Rearranged pentanols, a process for their production and their use as anti-inflammatory agents
    Publication number: 20050131226
    Abstract: The invention relates to the compounds of formula I, a process for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: October 8, 2004
    Publication date: June 16, 2005
    Inventors: Hartmut Rehwinkel, Stefan Baeurle, Markus Berger, Norbert Schmees, Heike Schaecke, Konrad Krolikiewicz, Anne Mengel, Duy Nguyen, Stefan Jaroch, Werner Skuballa
  • 6-Alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
    Publication number: 20050113429
    Abstract: This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula (I) in which R1a, R1b, R2b, R3a, R3b, R4, R5, R6, R7, A, Y, D, E, G, Y and Z have the meanings that are indicated in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and thus find use in treating diseases or conditions associated with the need for cell growth, division and/or proliferation. Thus the compounds are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanoma, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (such as psoriasis, arthritis). Methods of use and preparation of the compounds are also described.
    Type: Application
    Filed: October 18, 2004
    Publication date: May 26, 2005
    Inventors: Ulrich Klar, Wolfgang Schwede, Werner Skuballa, Bernd Buchmann, Jens Hoffmann, Rosemarie Lichtner
  • Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
    Patent number: 6897224
    Abstract: The invention relates to quinoline and isoquinoline derivatives of general formula I a process for their production and their use as inflammation inhibitors.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: May 24, 2005
    Assignee: Schering AG
    Inventors: Stefan Jaroch, Manfred Lehmann, Norbert Schmees, Markus Berger, Hartmut Rehwinkel, Konrad Krolikiewicz, Werner Skuballa, Heike Schäecke, Arndt. J. G. Schottelius
  • Nonsteroidal antiinflammatory agents
    Publication number: 20040254249
    Abstract: Compounds of Formula 1 1
    Type: Application
    Filed: June 24, 2004
    Publication date: December 16, 2004
    Inventors: Stefan Jaroch, Manfred Lehmann, Norbert Schmees, Bernd Buchmann, Harmur Rehwinkel, Peter Droescher, Werner Skuballa, Konrad Krolikiewicz, Hartwig Hennekes, Heike Schaecke, Arndr Schottelius
  • Lipoxin A4 analogs
    Patent number: 6831186
    Abstract: This invention is directed to lipoxin A4 analogs of the following formula (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: December 14, 2004
    Assignee: Schering Aktiengesellschft
    Inventors: John G Bauman, William J Guilford, John F Parkinson, Werner Skuballa, Babu Subramanyam
  • Lipoxin A4 analogs
    Publication number: 20040162433
    Abstract: This invention is directed to lipoxin A4 analogs of the following formula (I) and (II): 1
    Type: Application
    Filed: February 18, 2004
    Publication date: August 19, 2004
    Applicant: Schering Aktiengesellschaft
    Inventors: John G. Bauman, William J. Guilford, John F. Parkinson, Werner Skuballa, Babu Subramanyam
  • Nonsteroidal antiinflammatory agents
    Patent number: 6777409
    Abstract: The compound of formula 1 useful in the treatment of inflammation.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: August 17, 2004
    Assignee: Schering Aktiengesellschaft Patents
    Inventors: Stefan Jaroch, Manfred Lehmann, Norbert Schmees, Bernd Buchmann, Harmur Rehwinkel, Peter Droescher, Werner Skuballa, Konrad Krolikiewicz, Hartwig Hennekes, Heike Schaecke, Arndt Schottelius