Patents by Inventor Weston Blaine Griffin
Weston Blaine Griffin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240090869Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.Type: ApplicationFiled: November 27, 2023Publication date: March 21, 2024Inventors: David Andrew Shoudy, Craig Patrick Galligan, Weston Blaine Griffin, Jeffrey Michael Ashe, Warren Lee, James Enrico Sabatini
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Patent number: 11932842Abstract: An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.Type: GrantFiled: February 8, 2019Date of Patent: March 19, 2024Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Patent number: 11920119Abstract: A bioprocessing system includes a first module configured for enriching and isolating a population of cells, a second module configured for activating, genetically modifying, and expanding the population of cells, and a third module configured for harvesting the expanded population of cells.Type: GrantFiled: February 8, 2019Date of Patent: March 5, 2024Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20230414972Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, an alignment controller may be used to analyze images generated by an ultrasound transducer. The alignment controller may then send a communication to indicate the energy application device is positioned to provide therapy to the target region, or if the device needs to be repositioned. The alignment control of the energy application device provides guided repeatable targeting of the target anatomic region, even when in non-clinical settings.Type: ApplicationFiled: June 28, 2022Publication date: December 28, 2023Inventors: David Andrew Shoudy, Weston Blaine Griffin, Radhika Madhavan, Jeffrey Michael Ashe
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Patent number: 11826197Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.Type: GrantFiled: May 13, 2021Date of Patent: November 28, 2023Assignee: General Electric CompanyInventors: David Andrew Shoudy, Craig Patrick Galligan, Weston Blaine Griffin, Jeffrey Michael Ashe, Warren Lee, James Enrico Sabatini
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Patent number: 11807841Abstract: Disclosed herein is a cell harvesting instrument suitable for concentrating cells from a source suspension of cells and/or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump, at least one valve; and a processing kit removably insertable into the housing, said kit including a generally flat frame having or supporting plural sealed fluid paths arranged in a generally flat plane and such that fluids in the paths do not contact said mechanical elements, wherein at least portions of the fluid paths comprise flexible tubes, the outer surfaces of which are manipulatable by the or each fluid pump, to provide fluid flow in one or more of the paths and/or by the or each valve to restrict fluid flow in one or more of the paths. In an embodiment, the kit comprises also a fluid processing reservoir and a filter suitable for separating cells from fluid in said paths.Type: GrantFiled: December 22, 2016Date of Patent: November 7, 2023Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Weston Blaine Griffin, Dan Harris, Jim Dowling, Dan O'Sullivan
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Publication number: 20230242852Abstract: Disclosed herein is a cell harvesting instrument suitable for concentrating cells from a source suspension of cells and/or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump, at least one valve; and a processing kit removably insertable into the housing, said kit including a generally flat frame having or supporting plural sealed fluid paths arranged in a generally flat plane and such that fluids in the paths do not contact said mechanical elements, wherein at least portions of the fluid paths comprise flexible tubes, the outer surfaces of which are manipulatable by the or each fluid pump, to provide fluid flow in one or more of the paths and/or by the or each valve to restrict fluid flow in one or more of the paths. In an embodiment, the kit comprises also a fluid processing reservoir and a filter suitable for separating cells from fluid in said paths.Type: ApplicationFiled: April 6, 2023Publication date: August 3, 2023Inventors: Weston Blaine Griffin, Austin Lines, Dan Harris, David Schuelke, Krystal Burger
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Patent number: 11649423Abstract: Disclosed herein is a cell harvesting instrument suitable for concentrating cells from a source suspension of cells and/or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump, at least one valve; and a processing kit removably insertable into the housing, said kit including a generally flat frame having or supporting plural sealed fluid paths arranged in a generally flat plane and such that fluids in the paths do not contact said mechanical elements, wherein at least portions of the fluid paths comprise flexible tubes, the outer surfaces of which are manipulateable by the or each fluid pump, to provide fluid flow in one or more of the paths and/or by the or each valve to restrict fluid flow in one or more of the paths. In an embodiment, the kit comprises also a fluid processing reservoir and a filter suitable for separating cells from fluid in said paths.Type: GrantFiled: December 22, 2016Date of Patent: May 16, 2023Assignee: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Austin Lines, Dan Harris, David Schuelke, Krystal Burger
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Publication number: 20230060399Abstract: Disclosed herein is an instrument suitable for processing cells for example culturing, concentrating or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump; and a disposable processing kit complementary to the mechanical elements within the housing and comprising a fluid circuit including a fluid reservoir and plural fluid paths capable of carrying fluid flow caused by said pump(s), the instrument further including a mechanism for determining the quantity, or change in quantity of the fluid in the reservoir resulting from said fluid flow, the instrument yet further comprising a controller operable to control at least the pump and operable to perform a fault determination process, which includes the steps of determining the expected flow rate of said pump(s) calculated from the speed of the pump(s) and comparing that expected flow with the change in quantity of the fluid in the reservoir as determined by said mechanism.Type: ApplicationFiled: October 24, 2022Publication date: March 2, 2023Inventors: Weston Blaine Griffin, Mark Robert Timmins, Dan Harris, Spencer Lovette, Jim Dowling, Dan O'Sullivan, David Robinson
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Patent number: 11512277Abstract: Disclosed herein is an instrument suitable for processing cells for example culturing, concentrating or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump; and a disposable processing kit complementary to the mechanical elements within the housing and comprising a fluid circuit including a fluid reservoir and plural fluid paths capable of carrying fluid flow caused by said pump(s), the instrument further including a mechanism for determining the quantity, or change in quantity of the fluid in the reservoir resulting from said fluid flow, the instrument yet further comprising a controller operable to control at least the pump and operable to perform a fault determination process, which includes the steps of determining the expected flow rate of said pump(s) calculated from the speed of the pump(s) and comparing that expected flow with the change in quantity of the fluid in the reservoir as determined by said mechanism.Type: GrantFiled: December 22, 2016Date of Patent: November 29, 2022Assignee: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Mark Robert Timmins, Dan Harris, Spencer Lovette, Jim Dowling, Dan O'Sullivan, David Robinson
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Publication number: 20220361844Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.Type: ApplicationFiled: May 13, 2021Publication date: November 17, 2022Inventors: David Andrew Shoudy, Craig Patrick Galligan, Weston Blaine Griffin, Jeffrey Michael Ashe, Warren Lee, James Enrico Sabatini
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Patent number: 11414639Abstract: A bioreactor vessel includes a bottom plate, a vessel body coupled to the bottom plate, the vessel body and the bottom plate defining an interior compartment therebetween, and a plurality of recesses formed in the bottom plate, each recess of the plurality of recesses being configured to receive a corresponding alignment pin on a bed plate for aligning the bioreactor vessel on the bed plate.Type: GrantFiled: February 8, 2019Date of Patent: August 16, 2022Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20220251496Abstract: A bioprocessing system includes a first fluid assembly having a first fluid assembly line connected to a first port of a first bioreactor vessel though a first bioreactor line of a first bioreactor vessel, a second fluid assembly having a second fluid assembly line connected to a second port of the first bioreactor vessel through a second bioreactor line of the first bioreactor vessel, and an interconnect line providing for fluid communication between the first fluid assembly and the second fluid assembly, and for fluid communication between the second bioreactor line of the first bioreactor vessel and the first bioreactor line of the first bioreactor vessel.Type: ApplicationFiled: May 2, 2022Publication date: August 11, 2022Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D. Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Patent number: 11371007Abstract: A bioprocessing system includes a first fluid assembly having a first fluid assembly line connected to a first port of a first bioreactor vessel though a first bioreactor line of a first bioreactor vessel, a second fluid assembly having a second fluid assembly line connected to a second port of the first bioreactor vessel through a second bioreactor line of the first bioreactor vessel, and an interconnect line providing for fluid communication between the first fluid assembly and the second fluid assembly, and for fluid communication between the second bioreactor line of the first bioreactor vessel and the first bioreactor line of the first bioreactor vessel.Type: GrantFiled: February 8, 2019Date of Patent: June 28, 2022Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20220062900Abstract: A fluid handling apparatus for a bioprocessing system includes a first plate having a first surface and a second surface, at least one fluid flow channel formed in the first surface, at least one valve recess formed in the first surface along the at least one fluid flow channel, and at least one fluid passageway extending through the first plate from the at least one fluid flow channel to the second surface, and a sealing layer disposed over the first surface and enclosing the at least one fluid flow channel. The at least one valve recess is configured to cooperate with an actuator and the sealing layer to prevent a flow of fluid through the at least one fluid flow channel.Type: ApplicationFiled: January 24, 2020Publication date: March 3, 2022Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: ANDREW ARTHUR PAUL BURNS, DENNIS CHEROK, MARK TIMMINS, PEI-HSIN KUO, WESTON BLAINE GRIFFIN
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Publication number: 20210291397Abstract: Apparatuses and methods for cutting a sample piece, having a shape and an outer dimension, out of a porous substrate, comprising: a puncher having an outermost dimension at a punch head; a stripping sleeve; a die having an innermost dimension that is larger than the outermost dimension of the punch head; and a fixture that holds the die in a fixed position relative to the puncher and stripping sleeve.Type: ApplicationFiled: June 8, 2021Publication date: September 23, 2021Inventor: Weston Blaine GRIFFIN
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Publication number: 20210222115Abstract: Disclosed herein is a cell harvesting instrument suitable for concentrating cells from a source suspension of cells and/or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump, at least one valve; and a processing kit removably insertable into the housing, said kit including a generally flat frame having or supporting plural sealed fluid paths arranged in a generally flat plane and such that fluids in the paths do not contact said mechanical elements, wherein at least portions of the fluid paths comprise flexible tubes, the outer surfaces of which are manipulateable by the or each fluid pump, to provide fluid flow in one or more of the paths and/or by the or each valve to restrict fluid flow in one or more of the paths. In an embodiment, the kit comprises also a fluid processing reservoir and a filter suitable for separating cells from fluid in said paths.Type: ApplicationFiled: December 22, 2016Publication date: July 22, 2021Applicant: GE Healthcare Bio-Sciences Corp.Inventors: Weston Blaine Griffin, Dan Harris, Jim Dowling, Dan O'Sullivan
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Patent number: 11027239Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.Type: GrantFiled: October 5, 2017Date of Patent: June 8, 2021Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Chengkun Zhang, Kashan Ali Shaikh, Reginald Donovan Smith, Weston Blaine Griffin
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Publication number: 20210102157Abstract: A bioreactor vessel includes a bottom plate, a vessel body coupled to the bottom plate, the vessel body and the bottom plate defining an interior compartment therebetween, and a plurality of recesses formed in the bottom plate, each recess of the plurality of recesses being configured to receive a corresponding alignment pin on a bed plate for aligning the bioreactor vessel on the bed plate.Type: ApplicationFiled: February 8, 2019Publication date: April 8, 2021Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20210102153Abstract: In an embodiment, a tubing module for a bioprocessing system includes a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with a peristaltic pump, a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of a pinch valve array, and wherein the first tubing holder block and the second tubing holder block are interconnected.Type: ApplicationFiled: February 8, 2019Publication date: April 8, 2021Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh