Patents by Inventor Weston Blaine Griffin

Weston Blaine Griffin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190249130
    Abstract: A method includes introducing a suspension including cells suspended in a cell culture medium through a feed port or a drain port into a cavity of a cell culture vessel, the suspension being in an amount sufficient to cover a gas permeable, liquid impermeable membrane positioned at a bottom of the cell culture vessel, the feed port being disposed through a surface of the cell culture vessel and configured to permit additional cell culture medium into the cavity, and the drain port being disposed through the surface of the cell culture vessel and configured to permit removal of the cells, cell culture medium, and used cell culture medium from the cavity, allowing the cells to settle on the gas permeable, liquid impermeable membrane by gravity, removing the used cell culture medium through the drain port and introducing the additional cell culture medium through the feed port such that a constant volume is maintained in the cell culture vessel until the cells expand to a desired cell density, wherein the removi
    Type: Application
    Filed: February 9, 2018
    Publication date: August 15, 2019
    Inventors: Weston Blaine Griffin, Xiaohua Zhang, Reginald Donovan Smith, Vandana Keskar
  • Patent number: 10365190
    Abstract: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: July 30, 2019
    Assignee: Whatman International Limited
    Inventors: Philip Alexander Shoemaker, Weston Blaine Griffin, Erin Jean Finehout, Xuefeng Wang, Kashan Ali Shaikh, Greg Darryl Goddard
  • Patent number: 10335078
    Abstract: A method for separating and collecting cell-free plasma by finger stick that minimizes contamination with genomic DNA from a donor. The method comprising placing a tourniquet on one of the digits of the donor's finger to apply pressure, lancing the digit to create an incision in the digit, and collecting blood from the incision from the incision site. The collected blood is placed on a separation membrane wherein the separation membrane is in contact with a collection membrane and both the separation and collection membrane are inserted into a substrate configured to provide overlap between the membranes. A kit and instructions for carrying out the method is also provided.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: July 2, 2019
    Assignee: General Electric Company
    Inventors: Erik Leeming Kvam, Weston Blaine Griffin, Erin Jean Finehout, Ying Mao
  • Patent number: 10287548
    Abstract: The present approach relates to the design and use of a functionally closed bioreactor designed to immobilize, culture, and mature tissue on a loading platform. The bioreactor may be equipped with sensors for tissue monitoring which in conjunction with stiffness data can provide closed-loop control of tissue maturation. Based on a relationship between cartilage stiffness and tissue maturity, measurements of stiffness can be acquired and used as a surrogate for cartilage maturity without the need for destructive tests.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: May 14, 2019
    Assignee: General Electric Company
    Inventors: Vandana Keskar, Weston Blaine Griffin, Xiaohua Zhang
  • Publication number: 20190105609
    Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.
    Type: Application
    Filed: October 5, 2017
    Publication date: April 11, 2019
    Inventors: Chengkun Zhang, Kashan Ali Shaikh, Reginald Donovan Smith, Weston Blaine Griffin
  • Publication number: 20190105020
    Abstract: An assistive sample collection and storage assembly for collecting, transferring and storing a biological sample includes a sample collection device having a first portion and a second portion. The first portion is configured to receive a sample collection member. The assembly includes a sample storage device comprising a sample substrate to receive at least a portion of the biological sample from the sample collection member. The assembly is configured to exist in a first and second state. The sample collection member is disposed at a determined distance from the sample substrate in the first state. At least a portion of the sample collection member is in physical contact with at least a portion of the sample substrate in the second state. The sample collection member is configured to apply a determined amount of contact force between the collection member and the sample substrate in the second state of the assembly.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 11, 2019
    Inventors: Ying Mao, Weston Blaine Griffin, Erin Jean Finehout, Ian Hart
  • Patent number: 10190950
    Abstract: A semi-automated sampling assembly configured for aseptic sampling at one or more instances from a sample source having a biological inoculum is provided. The semi-automated sampling assembly includes a sampling conduit, a recovery conduit, one or more sampling kits, and a pumping device. The sampling conduit includes a first port and a second port, where the first port of the sampling conduit is configured to be operatively coupled to the sample source. Further, the recovery conduit includes a first port and a second port, where the first port of the recovery conduit is configured to be operatively coupled to the sample source. Also, the second port of the recovery conduit is operatively coupled to at least a portion of the sampling conduit. Moreover, the one or more sampling kits are operatively coupled to the sampling conduit, and the pumping device is operatively coupled to the sampling conduit.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: January 29, 2019
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Weston Blaine Griffin, Chengkun Zhang, Kenneth Roger Conway, Reginald Donovan Smith
  • Publication number: 20190017005
    Abstract: Disclosed herein is a cell harvesting instrument suitable for concentrating cells from a source suspension of cells and/or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump, at least one valve; and a processing kit removably insertable into the housing, said kit including a generally flat frame having or supporting plural sealed fluid paths arranged in a generally flat plane and such that fluids in the paths do not contact said mechanical elements, wherein at least portions of the fluid paths comprise flexible tubes, the outer surfaces of which are manipulateable by the or each fluid pump, to provide fluid flow in one or more of the paths and/or by the or each valve to restrict fluid flow in one or more of the paths. In an embodiment, the kit comprises also a fluid processing reservoir and a filter suitable for separating cells from fluid in said paths.
    Type: Application
    Filed: December 22, 2016
    Publication date: January 17, 2019
    Applicant: GE Healthcare Bio-Sciences Corp.
    Inventors: Weston Blaine Griffin, Austin Lines, Dan Harris, David Schuelke, Krystal Burger
  • Publication number: 20180371399
    Abstract: Disclosed herein is an instrument suitable for processing cells for example culturing, concentrating or washing said cells, the instrument comprising: a housing for accommodating mechanical elements including at least one fluid pump; and a disposable processing kit complementary to the mechanical elements within the housing and comprising a fluid circuit including a fluid reservoir and plural fluid paths capable of carrying fluid flow caused by said pump(s), the instrument further including a mechanism for determining the quantity, or change in quantity of the fluid in the reservoir resulting from said fluid flow, the instrument yet further comprising a controller operable to control at least the pump and operable to perform a fault determination process, which includes the steps of determining the expected flow rate of said pump(s) calculated from the speed of the pump(s) and comparing that expected flow with the change in quantity of the fluid in the reservoir as determined by said mechanism.
    Type: Application
    Filed: December 22, 2016
    Publication date: December 27, 2018
    Applicant: GE Healthcare Bio-Sciences Corp.
    Inventors: Weston Blaine Griffin, Mark Robert Timmins, Dan Harris, Spencer Lovette, Jim Dowling, Dan O'Sullivan
  • Patent number: 10131868
    Abstract: A bioreactor is provided. The bioreactor is a multi-scalable bioreactor, which comprises a culture vessel for seeding and culturing cells by adding a cell-culture media, wherein the culture vessel comprises at least a side wall and a bottom surface, a specific heat transfer area and a specific gas transfer area; wherein the culture vessel is configured to accommodate the cell-culture media volume up to 10 liters, and wherein the specific heat transfer area and the specific gas transfer area are independent of cell-culture media volume. A kit for culturing cells in a large scale is also provided which further comprises disposable tubings, culture bag or combinations thereof. A method for culturing cells is also provided.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: November 20, 2018
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Younkoo Jeong, Weston Blaine Griffin, Vandana Keskar, Zhipeng Zhang
  • Patent number: 10130258
    Abstract: An assistive sample collection and storage assembly for collecting, transferring and storing a biological sample includes a sample collection device having a first portion and a second portion. The first portion is configured to receive a sample collection member. The assembly includes a sample storage device comprising a sample substrate configured to receive at least a portion of the biological sample from the sample collection member. The assembly is configured to exist in a first state and a second state. The sample collection member is disposed at a determined distance from the sample substrate in the first state. At least a portion of the sample collection member is in physical contact with at least a portion of the sample substrate in the second state. The sample collection member is configured to apply a determined amount of contact force between the collection member and the sample substrate in the second state of the assembly.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: November 20, 2018
    Assignee: General Electric Company
    Inventors: Ying Mao, Weston Blaine Griffin, Erin Jean Finehout, Ian Hart
  • Publication number: 20180299354
    Abstract: An assistive sample collection and storage assembly for collecting, transferring and storing a biological sample includes a sample collection device having a first portion and a second portion. The first portion is configured to receive a sample collection member. The assembly includes a sample storage device comprising a sample substrate configured to receive at least a portion of the biological sample from the sample collection member. The assembly is configured to exist in a first state and a second state. The sample collection member is disposed at a determined distance from the sample substrate in the first state. At least a portion of the sample collection member is in physical contact with at least a portion of the sample substrate in the second state. The sample collection member is configured to apply a determined amount of contact force between the collection member and the sample substrate in the second state of the assembly.
    Type: Application
    Filed: September 24, 2013
    Publication date: October 18, 2018
    Applicant: General Electric Company
    Inventors: Ying Mao, Weston Blaine Griffin, Erin Jean Finehout, Ian Hart
  • Patent number: 10088399
    Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: October 2, 2018
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters
  • Patent number: 9950321
    Abstract: A substrate for positioning a separation membrane and a collection membrane for separating and collecting plasma is disclosed. The substrate includes an inner flexure disposed proximate to a first peripheral portion of the substrate and an outer flexure disposed surrounding at least a portion of the inner flexure. The inner flexure is formed from a plurality of first slots in the substrate and the outer flexure is formed from a plurality of second slots in the substrate.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: April 24, 2018
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Weston Blaine Griffin, Erin Jean Finehout, Ying Mao
  • Patent number: 9949719
    Abstract: An ultrasound scan probe and support mechanism are provided for use in a multi-modality mammography imaging system, such as a combined tomosynthesis and ultrasound imaging system. In one embodiment, the ultrasound components may be positioned and configured so as not to interfere with the tomosynthesis imaging operation, such as to remain out of the X-ray beam path. Further, the ultrasound probe and associated components may be configured to as to move and scan the breast tissue under compression, such as under the compression provided by one or more paddles used in the tomosynthesis imaging operation.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: April 24, 2018
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Zhipeng Zhang, Cynthia Elizabeth Landberg Davis, Weston Blaine Griffin, Ying Mao
  • Publication number: 20180001336
    Abstract: The present invention is directed to a squeegee apparatus which includes a main housing including an inlet end and an outlet end, the outlet end including an extrusion face and a protruding lip member, the inlet end including an inlet opening and the extrusion face including at least one outlet opening, wherein the inlet opening and the at least one outlet opening are in fluid communication with each other within the main housing. The present invention is also directed to a method for repairing a thermal barrier coating with a squeegee apparatus including supplying a repair composition into the inlet opening of the squeegee apparatus and depositing the repair composition from the at least one outlet opening onto the damaged region and concurrently traversing the squeegee apparatus over the damaged region while contacting a thermal barrier coating adjacent to the damaged region with the lip member.
    Type: Application
    Filed: June 30, 2016
    Publication date: January 4, 2018
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Pei-Hsin KUO, Weston Blaine GRIFFIN, Venkat Subramaniam VENKATARAMANI, Hrishikesh KESHAVAN
  • Publication number: 20180002667
    Abstract: The present approach relates to the design and use of a functionally closed bioreactor designed to immobilize, culture, and mature tissue on a loading platform. The bioreactor may be equipped with sensors for tissue monitoring which in conjunction with stiffness data can provide closed-loop control of tissue maturation. Based on a relationship between cartilage stiffness and tissue maturity, measurements of stiffness can be acquired and used as a surrogate for cartilage maturity without the need for destructive tests.
    Type: Application
    Filed: June 29, 2016
    Publication date: January 4, 2018
    Inventors: Vandana Keskar, Weston Blaine Griffin, Xiaohua Zhang
  • Patent number: 9855014
    Abstract: The present disclosure relates to the manufacture and use of a non-rigid breast compression paddle, such as a compression paddle having a mesh material forming the primary interface with patient tissue. In certain implementations, an automatic feedback driven approach may be used in conjunction with such a compression paddle for compressing breast tissue.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: January 2, 2018
    Assignee: General Electric Company
    Inventors: Cynthia Elizabeth Landberg Davis, Zhipeng Zhang, Weston Blaine Griffin, Ying Mao
  • Publication number: 20170369832
    Abstract: A heating assembly for a bioreactor is disclosed. The heating assembly includes a holder having a plurality of segments coupled to each other to define a unitary structure and a heating component coupled to at least one segment of the plurality of segments. The unitary structure includes a top end, a bottom end, and a side wall. The side wall extends between the top end and the bottom end and along a circumferential direction of the heating assembly to define a cavity. At least a portion of the unitary structure has a gradually varied perimeter along a direction perpendicular to a plane which intersects the side wall and is parallel to the top end and the bottom end.
    Type: Application
    Filed: June 27, 2016
    Publication date: December 28, 2017
    Inventors: Ying Mao, Weston Blaine Griffin, Younkoo Jeong
  • Patent number: 9677975
    Abstract: A sampling assembly configured to be coupled to a sample source and facilitate aseptic sampling at one or more instances in time is provided. Further, the sampling assembly includes a first conduit having first and second ports, where the first port is configured to be coupled to the sample source. The sampling assembly also includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connector junctions. Also, each of the sub-ports is in fluidic communication with the first conduit. The sampling assembly also includes a plurality of sampling kits and one or more pumping devices. Further, each sampling kit is operatively coupled to a respective sub-port of a corresponding sub-conduit. Moreover, the one or more pumping devices are operatively and aseptically coupled to the second port of the first conduit.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: June 13, 2017
    Assignee: General Electric Company
    Inventors: Chengkun Zhang, Kenneth Roger Conway, Donald Joseph Buckley, Eugene Pauling Boden, Weston Blaine Griffin, Anshika Bajaj, Reginald Donovan Smith