Patents by Inventor Wilhelmus Franciscus Johannes Verhaegh

Wilhelmus Franciscus Johannes Verhaegh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10373705
    Abstract: A sequencer device generates basic nucleotide sequence data 30 comprising probe data 34 of a capture probe in the sequencer device 10 and a determined sequence of identifiers 32 of a fragment of nucleic acids captured by the probe. The sequencer device outputs enriched nucleotide sequence data 36 that is enriched with data comprising a reference to a sequence 38 that is expected for the fragment of nucleic acids.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: August 6, 2019
    Assignee: Koninklijke Philips N.V.
    Inventors: Pieter Jan Van Der Zaag, Ronny Amberg, Peter Beyerlein, Wilhelmus Franciscus Johannes Verhaegh, Rene Boettcher
  • Publication number: 20190128899
    Abstract: The present invention relates to a method for inferring activity of a transcription factor of a signal transduction pathway in a subject. The method comprises performing (101) a first staining for detecting the transcription factor in cells of a sample of the subject and performing (102) a second staining for detecting a protein encoded by a target gene of the transcription factor in cells of the sample. The method further comprises quantifying (103) cells of the sample that show both a nuclear presence of the transcription factor and a presence of the target gene-encoded protein based on the first staining and the second staining, and inferring (104) the activity of the transcription factor in the subject based on the quantifying. This allows the presented method to more reliably infer the activity of the transcription factor in the subject.
    Type: Application
    Filed: June 7, 2017
    Publication date: May 2, 2019
    Inventors: Anja VAN DE STOLPE, Freek VAN HEMERT, Wilhelmus Franciscus Johannes VERHAEGH, Reinhold WIMBERGER-FRIEDL, John Cornelius Petrus VAN DER VEN
  • Publication number: 20190102510
    Abstract: A bioinformatics process which provides an improved means to detect a JAK-STAT3 cellular signaling pathway in a subject, such as a human, based on the expression levels of at least three unique target genes of the JAK-STAT3 cellular signaling pathway measured in a sample. The invention includes an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method. Kits are also provided for measuring expression levels of unique sets of JAK-STAT3 cellular signaling pathway target genes.
    Type: Application
    Filed: September 27, 2018
    Publication date: April 4, 2019
    Inventors: Meng DOU, Wilhelmus Franciscus Johannes VERHAEGH, Anja VAN DE STOLPE, Rick VELTER
  • Publication number: 20190100795
    Abstract: A bioinformatics process which provides an improved means to detect a JAK-STAT1/2 cellular signaling pathway in a subject, such as a human, based on the expression levels of at least three unique target genes of the JAK-STAT1/2 cellular signaling pathway measured in a sample. The invention includes an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method. Kits are also provided for measuring expression levels of unique sets of JAK-STAT1/2 cellular signaling pathway target genes.
    Type: Application
    Filed: September 27, 2018
    Publication date: April 4, 2019
    Inventors: Wilhelmus Franciscus Johannes VERHAEGH, Meng DOU, Anja VAN DE STOLPE, Rick VELTER
  • Publication number: 20190100790
    Abstract: A bioinformatics process which provides an improved means to detect a Notch cellular signaling pathway in a subject, such as a human, based on the expression levels of at least three unique target genes of the Notch cellular signaling pathway measured in a sample. The invention includes an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method. Kits are also provided for measuring expression levels of unique sets of Notch cellular signaling pathway target genes.
    Type: Application
    Filed: September 28, 2018
    Publication date: April 4, 2019
    Inventors: Anja Van De Stolpe, Laurentius Henricus Franciscus Maria Holtzer, Wilhelmus Franciscus Johannes Verhaegh
  • Publication number: 20170364633
    Abstract: A method of identifying co-expressed coding and noncoding genes is disclosed. The method may include receiving genetic sequences, mapping the genetic sequences to known coding and noncoding genes, correlating the mapped genes, and generating a co-expression network. A system for generating a co-expression network and providing the co-expression network to a user on a display is disclosed. The system may include a memory, one or more processors, one or more databases, and a display.
    Type: Application
    Filed: December 7, 2015
    Publication date: December 21, 2017
    Inventors: NILANJANA BANERJEE, NEVENKA DIMITROVA, SONIA CHOTHANI, WILHELMUS FRANCISCUS JOHANNES VERHAEGH, YEE HIM CHEUNG
  • Publication number: 20170249422
    Abstract: Data-driven generalized regression-based frameworks that support the transformation of measurements, applicable but not limited to gene expressions, from one platform to another over a wide dynamic range, with selected summary statistics/feature values as predictors for the model parameters. The framework consists of primary model training and transformation, and additional levels of categorical regression and transformation processes.
    Type: Application
    Filed: October 16, 2015
    Publication date: August 31, 2017
    Inventors: YEE HIM CHEUNG, WILHELMUS FRANCISCUS JOHANNES VERHAEGH, NEVENKA DIMITROVA
  • Publication number: 20170147773
    Abstract: In certain implementations, health monitoring of an individual may be provided based on an individual-specific prediction model. In some implementations, a prediction model for health monitoring may be obtained. Health information associated with an individual may be obtained. The health information may indicate a co-occurrence of health conditions of the individual. An individual-specific prediction model associated with the individual may be generated based on the prediction model and the co-occurrence indication. Subsequent health information associated with the individual may be obtained. The subsequent health information may indicate one or more of: (i) subsequent measurements of the individual observed after the co-occurrence of the health conditions; or (ii) subsequent health conditions of the individual observed after the co-occurrence of the health conditions. A health status of the individual may be predicted based on the individual-specific prediction model and the subsequent health information.
    Type: Application
    Filed: November 8, 2016
    Publication date: May 25, 2017
    Inventors: Anja VAN DE STOLPE, Folke Charlotte NOERTEMANN, Wilhelmus Franciscus Johannes VERHAEGH
  • Publication number: 20160298196
    Abstract: The present invention relates to a method comprising inferring activity of a PI3K cellular signaling pathway in a tissue and/or cells and/or a body fluid of a medical subject based at least on expression levels of one or more target gene(s) of the PI3K cellular signaling pathway measured in an extracted sample of the tissue and/or the cells and/or the body fluid of the medical subject. The present invention further relates to an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method.
    Type: Application
    Filed: December 30, 2014
    Publication date: October 13, 2016
    Inventors: JAN HENDRIK VAN OOIJEN, WILHELMUS FRANCISCUS JOHANNES VERHAEGH, ANJA VAN DE STOLPE
  • Publication number: 20160117443
    Abstract: A bioinformatics method for determining a risk score that indicates a risk that a subject will experience a negative clinical event within a certain period of time. The risk score is based on a combination of activities of two or more cellular signaling pathways in a subject, such as a human, wherein the specific cellular signaling pathways are the PI3K pathway and one or more of a Wnt pathway, an ER pathway, and an HH pathway. The invention also includes an apparatus with a digital processor configured to perform such a method, to a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and to a computer program comprising program code means for causing a digital processing device to perform such a method. The invention achieves advanced prognosis of negative clinical events, for example, disease progression, recurrence, development of metastasis, or even death.
    Type: Application
    Filed: October 26, 2015
    Publication date: April 28, 2016
    Inventors: HENDRIK JAN VAN OOIJEN, WILHELMUS FRANCISCUS JOHANNES VERHAEGH, ANNE GODEFRIDA CATHARINA VAN BRUSSEL, JANNEKE WROBEL, ROBERT VAN GOG
  • Publication number: 20160110494
    Abstract: The present application relates to a method for determining a risk score that indicates a risk that a clinical event will occur within a certain period of time. The risk score is based at least in part on a combination of inferred activities of two or more cellular signaling pathways in a tissue and/or cells and/or a body fluid of a subject. The cellular signaling pathways comprise a Wnt pathway, an ER pathway, an HH pathway, and/or an AR pathway. The risk score is defined such that the indicated risk that the clinical event will occur within the certain period of time decreases with an increasing PER and increases with an increasing max(PWnt, PHH), wherein PER, Pwnt, and PHH denote the inferred activity of the ER pathway, the Wnt pathway, and the HH pathway, respectively.
    Type: Application
    Filed: April 24, 2014
    Publication date: April 21, 2016
    Inventors: WILHELMUS FRANCISCUS JOHANNES VERHAEGH, HENDRIK JAN VAN OOIJEN, ANJA VAN DE STOLPE, MARCIA ALVES DE INDA
  • Publication number: 20150347672
    Abstract: The present application mainly relates to specific methods for inferring activity of a cellular signaling pathway in tissue and/or cells of a medical subject based at least on expression levels of one or more target gene(s) of the cellular signaling pathway measured in an extracted sample of the tissue and/or cells of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.
    Type: Application
    Filed: December 18, 2013
    Publication date: December 3, 2015
    Inventors: Hendrik Jan VAN OOIJEN, Wilhelmus Franciscus Johannes VERHAEGH, Paul Arnold VAN DE WIEL
  • Publication number: 20140329690
    Abstract: A sequencer device generates basic nucleotide sequence data 30 comprising probe data 34 of a capture probe in the sequencer device 10 and a determined sequence of identifiers 32 of a fragment of nucleic acids captured by the probe. The sequencer device outputs enriched nucleotide sequence data 36 that is enriched with data comprising a reference to a sequence 38 that is expected for the fragment of nucleic acids.
    Type: Application
    Filed: April 17, 2012
    Publication date: November 6, 2014
    Inventors: Pieter Jan Van Der Zaag, Ronny Amberg, Wilhelmus Franciscus Johannes Verhaegh, Peter Beyerlein, Rene Boettcher
  • Publication number: 20140156200
    Abstract: The present application mainly relates to specific methods for inferring activity of one or more cellular signaling pathway(s) in tissue of a medical subject based at least on the expression level(s) of one or more target gene(s) of the cellular signaling pathway(s) measured in an extracted sample of the tissue of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.
    Type: Application
    Filed: July 19, 2012
    Publication date: June 5, 2014
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Wilhelmus Franciscus Johannes Verhaegh, Anja Van De Stolpe, Hendrik Jan Van Ooijen, Kalyana Chakravarth Dulla, Marcia Alves De Inda, Ralf Hoffmann
  • Patent number: 8682890
    Abstract: A method for generating a recommendation is provided. The method includes the steps of: receiving at least one of a negative and positive example from one or more other users; and determining a recommendation for a user based on at least one of the negative and positive examples. The method can further include the step of generating a user profile for the user based on previous behavior of the user, in which case the determining step can include determining the recommendation based on the negative example and the user profile. The determining step can also include the step of determining the recommendation based on both of the negative and positive examples.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: March 25, 2014
    Assignee: Pace Micro Technology PLC
    Inventors: Srinivas Gutta, Petrus Gerardus Meuleman, Wilhelmus Franciscus Johannes Verhaegh
  • Patent number: 8576173
    Abstract: The invention relates to a data processing device (100) enabling a user to input characters, the device comprising a touch-sensitive member (200) arranged to function as a virtual keyboard, said member including at least one touch sensor (160) for detecting touched zones on said member. The device further comprises key allocation means (110) for allocating at least two reference keys (220) of the virtual keyboard in response to said detection of the touched zones. The device comprises at least one pressure sensor (170) for sensing a finger (250) causing a force on the touch-sensitive member higher than other fingers when more than one finger touches said member. A recognition of a key stroke may be realized. The reference keys may be reallocated upon a user's request or detection of a predetermined condition. The invention also relates to a method of enabling a user to input characters.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: November 5, 2013
    Assignee: Koninklijke Philips N. V.
    Inventor: Wilhelmus Franciscus Johannes Verhaegh
  • Patent number: 8515681
    Abstract: A classification system (100) for classification of bio molecular data is provided. An input of the system receives a plurality of features (102) of a sample to be classified and a plurality of respective error estimates (104). A statistical module (106) associates probability density functions (108) with the features, wherein variances of the probability density functions depend on the error estimates. A replication module (110) produces a plurality of perturbed replicas (112) of the sample, wherein the features are randomly perturbed according to the corresponding respective probability density functions. A classifier (114) classifies the perturbed replicas based on the perturbed features. An analyzer (118) classifies the sample to be classified based on a statistical analysis of the classified replicas (116) to obtain a sample classification (120).
    Type: Grant
    Filed: April 21, 2009
    Date of Patent: August 20, 2013
    Assignee: Koninklijke Philips N.V.
    Inventors: Herman Sontrop, Wilhelmus Franciscus Johannes Verhaegh, Rene Van Den Ham
  • Patent number: 8490123
    Abstract: In a method and device for generating a user profile on the basis of playlists, the user profile is generated on the basis of the user's own playlists and properties derived from them. In this way, more playlists are considered in the generation of a user profile, thereby generating a more reliable user profile. Aspects taken into account includes frequency of occurrence, creation date of the playlist, and relation between content items (songs, video, etc.) in one or more playlists.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: July 16, 2013
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Maarten Peter Bodlaender, Wilhelmus Franciscus Johannes Verhaegh, Arnout Michiel De Mooij
  • Patent number: 8321895
    Abstract: The invention relates to an apparatus for selecting at least one program item to be stored on the basis of user preferences. The apparatus comprises a receiver (110) for obtaining program schedule data related to at least one program item, and a timer (150) arranged to ascertain a period of time in which at least one program item is to be stored, a user preference module (130) arranged to obtain user preferences for at least one program item to be stored in the ascertained period of time, and a selection unit (140) arranged to select, using the program schedule data and the user preferences, at least one program item to be stored over a long period of time which is substantially longer than regular periods of nonusage of the apparatus. The invention takes into consideration that the user preferences for storing the program items may depend on the period of time in which the program items are to be selected.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: November 27, 2012
    Assignee: Pace Micro Technology PLC
    Inventors: Wilhelmus Franciscus Johannes Verhaegh, Petrus Gerardus Meuleman
  • Patent number: 8122469
    Abstract: A method and arrangement for modifying settings of a television program recommender displays the rating (recommended or not recommended) for a selected television program, and also displays icons for selection by the user to indicate whether the user agrees or disagrees with the recommendation. The television program recommender then updates its settings based on the user's icon selection. In addition, if the user indicates that he/she disagrees with the recommendation, the television program recommender determines and displays the number of times that the user needs to indicate his/her desires with respect to the selected television program in order for the recommendation to agree with the user's desires.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: February 21, 2012
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Wilhelmus Franciscus Johannes Verhaegh, Srinivas Gutta, Serverius Petrus Paulus Pronk