Abstract: A security device includes a transparent, coloured element in a first region of the device and in a surface of which a first optically variable effect generating relief structure is formed. A reflection enhancing layer extends over the first optically variable effect generating relief microstructure and follows the contour of the relief, the reflection enhancing layer also being provided in a second region of the device laterally offset from the first region.

Abstract: An optical device comprises a transparent substrate having: an array of micromirrors on one surface of the substrate; and a corresponding array of microimage elements, the micromirrors presenting convex surfaces to the microimage elements whereby each convex surface causes ambient light to pass through the microimage element array from a virtual focus, the arrangement of the microimage elements and micromirrors being such that they cooperate to generate a lenticular type or a moiré magnification effect.

Abstract: A moiré magnification device includes a transparent substrate carrying: a regular array of micro-focusing elements, that define a focal plane, on a first surface; a corresponding first array of microimage elements in a first colour located in a plane substantially coincident with the focal plane; and a corresponding second array of microimage elements, in a second colour, located in a plane substantially coincident with the focal plane. The pitches of the micro-focusing elements and first and second arrays and their relative locations are such that the array of micro-focusing elements cooperates with each of the first and second arrays to generate magnified versions of the microimage elements due to the moiré effect. The magnified version of the first array is viewed against a background defined by the magnified version of the second array, the first array exhibiting movement relative to the background when the device is tilted.

Abstract: A security device comprising at least first and second superposed optically variable effect generating structures (3-5, 31-51), each having a surface relief microstructure, the second optically variable effect generating structure being viewable through the first.

Abstract: A security device having a lenticular device that includes an array of lenticular focusing elements located over a corresponding array of sets of image strips such that at different viewing directions, a corresponding image strip from each set is viewed via respective ones of the lenticular focusing elements wherein the image strips are defined at least in part by a relief structure.

Abstract: A security device includes at least two lenticular devices, each lenticular device having an array of elongate lenticular focusing elements located above respective sets of image strips, wherein the elongate directions in which the lenticular focussing elements of the two lenticular devices extend are different.

Abstract: A lenticular device includes an array of lenticular focusing elements located over a corresponding array of pairs of image strips such that, in a first viewing direction, a first image strip from each pair is viewed by respective ones of the lenticular focusing elements and, in a second viewing direction, different from the first, a second image strip from eachpair is viewed by respective ones of the lenticular focusing elements, One of each pair of image strips has portions defining a first image in a first colour and a second image in a second colour respectively, and the other of each pair of image strips has portions defining the first image in the second colour and the second image in the first colour respectively, whereby on tilting the device, a colour switch is observed between the first and second images.

Abstract: The present invention provides a novel lactate difference imaging (LDI) technique, allowing assessment of the metabolic responses of tissue over a period of time. This approach utilises lactate change over a time period as an indicator of viable tissue, and offers benefits in the management and treatment of the effects of many common diseases, in particular stroke.

Abstract: A method of forming a security device comprises: a) providing an undeveloped photoresist layer on an electrically conductive layer; b) forming a first diffractive pattern in the undeveloped photoresist layer using optical-interferometry; c) forming a second diffractive pattern in the undeveloped photoresist layer using electron beam lithography; and d) thereafter developing the photoresist layer.

Abstract: The proposed invention is a human powered cycle/vehicle which utilizes a reciprocating arcuate linear handlebar motion to operate a double acting asynchronous propulsion mechanism which imparts constantly proportional input versus output motion to its' surface engaging propulsion wheel(s). The propulsion mechanism contains a complex mechanism which causes both backward and forward motions of a set of handlebars to propel the machine forward. A drive-train clutch (52) may be included which enables the propulsion mechanism to be disengaged thus allowing the cycle/vehicle to be reversed and or moved (pushed) in either direction via its' surface engaging wheel(s) in isolation to the propulsion mechanism. A steering mechanism may also be attached to the handlebars (1) which are rotated clockwise to steer the machine to the right and anti-clockwise to steer the machine to the left.

Abstract: Apparatus and methods are described for separate heating of substrate, catalyst and feedstock/transport gases for the controllable CVD synthesis of various carbon nanotubes and nanostructures, and particularly for CVD growth of oriented forests of multi-wall CNT forests, which are highly dry-spinnable into sheets and yarns.

Abstract: The present invention provides improved methods for producing RPE cells from human embryonic stem cells or from other human pluripotent stem cells. The invention also relates to human retinal pigmented epithelial cells derived from human embryonic stem cells or other human multipotent or pluripotent stem cells. hRPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The hRPE cells described herein are useful for treating retinal degenerative diseases.

Abstract: A security device including a transparent base layer having a surface provided with an optically variable relief microstructure; a transparent high refractive index layer on the surface of the base layer, the high refractive index layer conforming to the surface relief microstructure; and a reflective metal layer printed on the transparent high refractive index layer. The metal layer is printed in the form of a pattern. The thickness of the transparent high refractive index layer is selected so as to achieve constructive interference of light with a wavelength ? in the range 450-650 nm reflected at each surface of the high refractive index layer.

Abstract: A security device comprises a substrate having an array of microlenses on one side and one or more corresponding arrays of microimages on the other side. The microimages are located at a distance from the microlenses substantially equal to the focal length of the microlenses. The substrate is sufficiently transparent to enable light to pass through the microlenses so as to reach the microimages. Each microimage is defined by an anti-reflection structure on the substrate formed by a periodic array of identical structural elements, light passing through a substrate and impinging on the microimages being reflected to a different extent than light which does not impinge on the microimages thereby rendering the microimages visible.

Abstract: A system for performing an end-to-side vascular anastomosis. including an anastomosis device, an application instrument and methods for performing a vascular anastomosis. The system is applicable for performing an anastomosis between a vascular graft and the ascending aorta in coronary artery bypass surgery, particularly in port-access CABG surgery. A first aspect of the invention includes a vascular anastomosis staple. A first configuration has two parts: an anchor member, forming the attachment with the target vessel wall and a coupling member, forming the attachment with the bypass graft vessel. The anastomosis is completed by inserting the coupling member, with the graft vessel attached, into the anchor member. A second configuration combines the functions of the anchor member and the coupling member into a one-piece anastomosis staple.

Abstract: A security device comprises a substrate having an array of microlenses on one side and one or more corresponding arrays of microimages on the other side. The microimages are located at a distance from the microlenses substantially equal to the focal length of the microlenses. The substrate is sufficiently transparent to enable light to pass through the microlenses so as to reach the microimages. Each microimage is defined by an anti-reflection structure on the substrate formed by a periodic array of identical structural elements, light passing through a substrate and impinging on the microimages being reflected to a different extent than light which does not impinge on the microimages thereby rendering the microimages visible.

Abstract: A device for engaging tissue having a preexisting opening includes a generally annular-shaped ring having a width disposed about a longitudinal axis, and at least two staple members extending from the ring. Each of the at least two staple members have a thickness and at least a distal portion formed of an elastic material. The distal portions of the staple members have a first configuration, where the distal portions are separated by a first distance and wherein the distal portions are substantially parallel to the longitudinal axis, and a second configuration, where the distal portions are separated by a second distance, the second distance being less than the first distance, and the at least two staple members engage tissue surrounding the preexisting opening. The annular-shaped ring has a width that is greater than the thickness of the at least two staple members.

Abstract: An optically variable magnetic stripe assembly includes a magnetic layer, an optically variable effect generating layer over the magnetic layer, and a reflective layer between the magnetic layer and the optically variable effect generating layer. The reflective layer includes at least one metal portion.

Abstract: An optically variable magnetic stripe assembly comprises a magnetic layer (5); an optically variable effect generating layer (1) over the magnetic layer; and a metallic reflecting layer (3) adjacent the optically variable effect generating layer and comprising an array of spaced metallic regions shaped as regular polygons.

Abstract: A security device including a surface relief microstructure which, in response to incident radiation, replays a hologram viewable within a viewing zone, the hologram including at least a first holographic image element in an image plane spaced from the surface of the microstructure. The device exhibits at least one further image in a plane spaced from the image plane of the first holographic element. On tilting the device, the first holographic image element exhibits apparent movement relative to the further image, which when expressed in radians, a rate of parallax movement per radian equals the spacing between phones and the product of the rate of movement and the included angle of the viewing zone defining a distance at least 20% of the dimension of the device in the direction of movement of the first holographic image element.