Patents by Inventor William A. James

William A. James has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190345191
    Abstract: This disclosure features chemical entities (e.g., a compound that modulates (e.g., agonizes or partially agonizes) Stimulator of Interferon Genes (STING), or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that are useful, e.g., for treating a condition, disease or disorder in which a decrease or increase in STING activity (e.g., a decrease, e.g., a condition, disease or disorder associated with repressed or impaired STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.
    Type: Application
    Filed: August 31, 2017
    Publication date: November 14, 2019
    Inventors: Gary D. Glick, Shomir Ghosh, William R. Roush, Edward James Olhava, Roger Jones
  • Patent number: 10470701
    Abstract: Monitoring system configured to provide a health chart on an operator display. The health chart includes a plurality of indicators that identify patient parameters. The plurality of indicators form a column that extends parallel to a first axis. The health chart also includes linear projections that are aligned with respective indicators and extend parallel to a second axis that is perpendicular to the first axis. The linear projections represent values of the patient parameters that correspond to the respective indicators. The values are determined by the physiological data obtained from corresponding sensors. The patient monitoring system is configured to determine lengths of the linear projections based on the physiological data. The lengths extend from proximal ends of the linear projections to distal ends of the linear projections. The distal ends move parallel to the second axis toward or away from the respective indicators to change the length.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: November 12, 2019
    Assignee: General Electric Company
    Inventors: William James Balloni, Jamon Lewis
  • Patent number: 10476285
    Abstract: A tablet storage device includes a module on a cart frame that includes a wheeled base. A cart module defines a selectively accessible interior space having multiple storage slots within the interior space for holding tablets. In some cases a tablet storage device holds multiple tablets using two or more modules in a stacked arrangement on a wheeled base. Each module can hold a portion of the multiple tablets within storage slots within an interior space inside the module. The storage slots may have connectors for connecting to tablets, and the cart frame can have a network connection system that is adapted to provide a network connection for each tablet that is connected to one of the connectors. The cart frame may also have a power supply system for charging each tablet that is connected to one of the connectors.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: November 12, 2019
    Assignee: Ergotron, Inc.
    Inventors: Mustafa A. Ergun, Shaun Christopher Lindblad, Joseph Funk, William Dale Tischer, Peter Segar, David James Prince
  • Patent number: 10471218
    Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a dose selector (80) operable to set a dose by rotation relative to the housing (10), a number sleeve (60) arranged within the housing (10) such that at least a portion of the number sleeve (60) is visible through a first aperture (11b) in the housing (10), and a piston rod (30) coupled to the housing (10) and to a drive sleeve (40). Rotation of the drive sleeve (40) relative to the housing (10) causes the piston rod (30) to translate relative to the housing (10). The piston rod (30) is coupled to the housing (10) via a threaded interface (16, 31) with at least two different pitches.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: November 12, 2019
    Assignee: Sanofi
    Inventors: William Geoffrey Arthur Marsh, Anthony Paul Morris, Joseph Butler, Matthew Meredith Jones, Samuel Keir Steel, Richard James Vincent Avery
  • Patent number: 10472410
    Abstract: The present invention provides ICOSL specific antigen binding molecules which are isolated from immunized and synthetic Elasmobranchii derived libraries. In particular, the present invention relates to shark Variable New Antigen Receptor (VNAR) domains that specifically bind and neutralize the activity of human Induced Co-Stimulatory Ligand (ICOSL). The neutralizing VNAR domains are isolated from two independent sources; an immunized nurse shark library and a synthetic spiny dogfish framework fusion library. The molecules may be formulated as pharmaceutical compositions and used in medicine.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: November 12, 2019
    Inventors: Caroline Jane Barelle, William James Jonathan Finlay, Alfredo Darmanin-Sheehan
  • Patent number: 10463216
    Abstract: A wand and hose assembly for a vacuum cleaner includes a suction wand fluidly connected to the end of a suction hose by a duct and the duct incorporates an articulating joint for allowing articulated movement of the suction wand relative to the end of the suction hose. The wand and the duct are arranged for telescopic sliding movement relative to one another, and the articulating joint is moveable into a position in which the wand can slide telescopically through the duct for retraction into the suction hose.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: November 5, 2019
    Assignee: Dyson Technology Limited
    Inventors: David William Emmett, David Christopher James Newton, Stephen Robert Dimbylow
  • Publication number: 20190327884
    Abstract: A spreader includes a frame having wheels mounted on an axle. A gear assembly on the axle is coupled with a shaft. A hopper is mounted on the frame and holds particulate that empties through an opening within the bottom wall. An impeller is mounted on the shaft and receives the particulate emptied from the hopper. A controlled-release assembly is mounted about the shaft and includes a drive housing secured to the hopper. The drive housing has a funnel opening to dispense the particulate therethrough. A transfer wheel within the drive housing is rotatably coupled to the shaft. When the shaft is rotating, the transfer wheel rotates whereby the particulate is delivered to the funnel. When the shaft is stationary, the transfer wheel is stationary whereby particulate is not delivered to the funnel.
    Type: Application
    Filed: April 26, 2018
    Publication date: October 31, 2019
    Applicant: Chapin Manufacturing, Inc.
    Inventors: Ed Horeth, David Dubiel, William James Campbell
  • Publication number: 20190330725
    Abstract: Systems and methods of threading a metal substrate on a rolling mill include receiving a coil of the metal substrate. The method also includes uncoiling the metal substrate from the coil while the coil and guiding the metal substrate to a work stand of the rolling mill with a threading system.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 31, 2019
    Applicant: NOVELIS INC.
  • Patent number: 10456537
    Abstract: An apparatus includes a first member coupled to a second member. The first member defines a chamber containing a dry powder and includes a chamber wall that forms an outer boundary of the chamber. The second member includes a surface covering the chamber and defines an intake channel and an exit channel. The exit channel is fluidically coupled to the chamber via an exit opening. The intake channel is fluidically coupled to the chamber via an intake port. A center line of the intake channel is tangential to a portion of the chamber wall such that a portion of an inlet airflow conveyed into the chamber via the intake channel has a rotational motion. The intake port is defined at least in part by an intake ramp. The intake ramp includes a transition surface that forms an exit angle with respect to the surface of less than 105 degrees.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: October 29, 2019
    Inventors: Eric C. Richardson, Gilbert S. Mott, Jr., William James Alexander
  • Patent number: 10457674
    Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: October 29, 2019
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Niall Andrew Anderson, Nicholas Paul Barton, Sebastien Andre Campos, Edward Paul Cannons, Anthony William James Cooper, Kenneth David Down, Kevin James Doyle, Julie Nicole Hamblin, Graham George Adam Inglis, Armelle Le Gall, Vipulkumar Kantibhai Patel, Simon Peace, Andrew Sharpe, Gemma Victoria White
  • Patent number: 10459482
    Abstract: A method and apparatus for folding a case along a hinge where the hinge is designed to project the neutral bend access of the fold to a layer affixed to an outer surface of the case.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: October 29, 2019
    Inventor: William James McDermid
  • Patent number: 10456839
    Abstract: An on-car brake lathe is provided with a runout compensation system configured to monitor the rotational position of a pair of slant discs within an aligning joint of the on-car brake lathe. The system monitors the amount of runout present between the rotating components of the on-car brake lathe and the wheel hub to which the on-car brake lathe is secured. The system calculates the appropriate rotational position for each slant disc within the aligning joint required to impart a necessary adjustment in the wheel coupling rotational axis in order to align the on-car brake lathe with the rotational axis of the wheel hub. Finally, an adjustment mechanism is activated to rotationally drive each slant disc directly to the calculated rotational position with a minimum amount of rotational movement based on the current rotational position of each slant disc and the required calculated rotational positions.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: October 29, 2019
    Assignee: Hunter Engineering Company
    Inventors: William James Nelgner, Jeffrey P. Talbott, Joel A. Clasquin
  • Patent number: 10457918
    Abstract: The present disclosure provides a variant tyrosine hydroxylase that provides for increased production of L-DOPA in a host cell that expresses the tyrosine hydroxylase. The present disclosure provides nucleic acids encoding the variant tyrosine hydroxylase, and host cells genetically modified with the nucleic acids. The present disclosure provides methods of making L-DOPA in a host cell. The present disclosure provides methods of making a benzylisoquinoline alkaloid (BIA), or a BIA precursor. The present disclosure provides methods of detecting L-DOPA level in a cell. The present disclosure provides methods of identifying tyrosine hydroxylase variants that provide for increased L-DOPA production; and methods of identifying gene products that provide for increased tyrosine production.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: October 29, 2019
    Inventors: Vincent J. J. Martin, Lauren Narcross, John E. Dueber, William C. DeLoache, Zachary N. Russ, P. James Scrivens
  • Patent number: 10457736
    Abstract: The invention relates to antibody molecules and antigen-binding portions thereof which bind specifically to glucocorticoid-induced TNF receptor (GITR). In particular aspects of the invention, the antibody molecules specifically bind to human GITR and cynomolgus monkey GITR. The anti-GITR antibody molecules of the invention have been developed and optimized using CDR sequences derived from a murine anti-GITR antibody 6C8. Medical uses of the antibody molecules are disclosed.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: October 29, 2019
    Inventor: William James Jonathan Finlay
  • Patent number: 10458130
    Abstract: A demountable wall system includes a frame component. The frame component may include a front channel that receives a panel of the demountable wall system. In addition to the front channel, the frame component may include at least one of a front cover, a removable back cover, a leveling system, a supplemental channel, or a joining system. In some examples, the demountable wall system includes a door support system for movably supporting a door relative to the panel of the demountable wall system.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: October 29, 2019
    Assignee: Oldcastle BuildingEnvelope, Inc.
    Inventors: Conor McDonald, Joseph Schiavone, Jeffrey James Phillips, Nathan Creech, Gavin Brin, Kelley Douglass, William Lang, Jarett Gibson, James P. Clark
  • Publication number: 20190323007
    Abstract: The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.
    Type: Application
    Filed: May 29, 2019
    Publication date: October 24, 2019
    Applicants: Institut Gustave-Roussy, Institut National de la Sante et de la Rescherche Medicale (INSERM), Assistance Publique - Hopitaux de Paris, Universite de Versailles - St Quentin en Yvelines, Universite Paris-Sud
    Inventors: William VAINCHENKER, Valerie UGO, Chloe James, Jean-Pierre LE COUEDIC, Nicole CASADEVALL
  • Publication number: 20190324592
    Abstract: Pressure-sensing touch systems and methods are disclosed for sensing the occurrence of a touch event based on pressure applied at a touch location. The touch system includes a light-source system and a detector system operably adjacent respective input and output edges of a waveguide. Pressure at a touch location on the waveguide gives rise to a touch event causes the waveguide to bend or flex. The waveguide bending causes a change in the optical paths of light traveling by FTIR, causing the light distribution in the output light to change. The changes are detected and are used to determine whether a touch event occurred, as well as the time-evolution of the touch event. The changes in the output light can include polarization changes caused by birefringence induced in the waveguide by the applied pressure applied. Various detector configurations are disclosed for sensing the location and pressure of a touch event.
    Type: Application
    Filed: March 11, 2019
    Publication date: October 24, 2019
    Inventors: Minghan Chen, Jacques Gollier, Ming-Jun Li, Paul Francis Michaloski, William James Miller, Daniel Aloysius Nolan
  • Patent number: 10452447
    Abstract: A system and method for coordinating security components, including: determining, by an application executing on a client device, a need to perform a sharable functional task; identifying a first security component and a second security component installed on the client device and capable of performing variations of the sharable functional task, where variations of the sharable functional task are functionally overlapping and not identical; identifying a set of characteristics characterizing the first security component and the second security component; selecting the second security component as a primary security component for performing a variation of the sharable functional task based on the set of characteristics; delegating, by one or more processors, performance of the sharable functional task to the primary security component; and instructing the processors to cause functionality associated with the first security component to be at least partially suspended.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: October 22, 2019
    Inventors: Matthew John Joseph LaMantia, Brian James Buck, Stephen J. Edwards, William Neil Robinson
  • Patent number: 10450981
    Abstract: Methods and systems are provided for diagnosing an engine thermal encapsulation positioned around a powertrain of a vehicle. In one example, degradation of the thermal encapsulation may be determined by comparing a temperature sampled via a sensor during engine off condition with an expected temperature.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: October 22, 2019
    Assignee: Ford Global Technologies, LLC
    Inventors: Mark Anthony Tascillo, Thomas G. Leone, Kenneth James Miller, William Charles Ruona
  • Patent number: D864253
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: October 22, 2019
    Inventors: William James Thorne, Perry Liam Brown, Richard Leighton Barnes, Philip Warren, Mark Davies