Abstract: Tissue-integrating biosensors, systems comprising these sensors and methods of using these sensors and systems for the detection of one or more analytes are provided.

Abstract: Disclosed are active engine compartment venting systems, methods for making and using such systems, and vehicles equipped with an active engine compartment vent and control logic for operating the vent. A method is disclosed for regulating operation of an active venting device fluidly coupled to a vent in an engine hood of a motor vehicle. The method includes a vehicle controller determining if a calibrated vehicle venting condition exists, and determining if a calibrated vehicle speed condition exists. Responsive to determining that the calibrated vehicle venting condition exists, the controller commands the active venting device to transition to an open state and thereby unobstruct the vent and allow venting fluid flow therethrough. Conversely, in response to determining that the calibrated vehicle speed condition exists, the controller commands the active venting device to transition to a closed state to thereby obstruct the vent and restrict venting fluid flow therethrough.

Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.

Abstract: A system includes implantable sensors and monitors and are operable to provide health-related feedback to users based on data received from the implantable sensors and monitors.

Abstract: An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.

Abstract: The present invention includes the complete genome sequence for the methanogen, Methanobrevibacter ruminantium, including polynucleotides which encode M. ruminantium polypeptides or peptides, as well as polynucleotides from non-coding regions. Also included are the encoded M. ruminantium polypeptides and peptides, and antibodies directed to these peptides or polypeptides, in addition to expression vectors and host cells for producing these peptides, polypeptides, polynucleotides, and antibodies. The invention further includes methods and compositions for detecting, targeting, and inhibiting microbial cells, especially methanogen cells such as M. ruminantium cells, using one or more of the disclosed peptides, polypeptides, polynucleotides, antibodies, expression vectors, and host cells.

Abstract: Some embodiments described herein relate to an apparatus including a light source configured to transmit an excitation optical signal to an implanted sensor and a detector configured to detect an analyte-dependent optical signal emitted from an implanted sensor. The apparatus can include a lens configured to focus at least a portion of the analyte-dependent optical signal onto the detector.

Abstract: Tissue-integrating electronic apparatuses, systems comprising such apparatuses and methods of using these apparatuses and systems for the detection of one or more signals are provided.

Abstract: Tissue-integrating biosensors, systems comprising these sensors and methods of using these sensors and systems for the detection of one or more analytes are provided.

Abstract: Some embodiments described herein relate to an apparatus, such as an inserter, having a housing and a needle at least partially disposed within the housing. An actuator can be coupled to the needle and configured to move the needle between an actuated configuration and a retracted configuration. A wire can be at least partially disposed within the needle. The wire can be fixedly and immovably coupled to the housing. In some embodiments a biosensor can be disposed within the needle and the apparatus can be configured to deliver or implant the biosensor to a patient, for example, under the patient's skin. The biosensor can constructed of a non-rigid material, such as hydrogel. In some embodiments, the apparatus can be configured to deliver or implant the biosensor without applying a force to the biosensor.

Abstract: An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.

Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.

Abstract: Tissue-integrating electronic apparatuses, systems comprising such apparatuses and methods of using these apparatuses and systems for the detection of one or more signals are provided.

Abstract: Some embodiments described herein relate to a sensor that includes an analyte-sensing dye and a reference dye. The analyte-sensing dye can be configured to emit an analyte-dependent optical signal in the presence of an analyte. Similarly stated, the intensity and/or duration of the analyte-dependent optical signal can be modulated by a quantity and/or concentration of the analyte in the environment of the sensor. The reference dye can be configured to emit an analyte-independent optical signal. The analyte-dependent optical signal and the analyte-independent optical signal have an analyte-dependent spectrum and an analyte-independent spectrum, respectfully. The analyte-dependent optical spectrum and the analyte-independent spectrum can be the same, substantially the same, and/or overlapping. The analyte-dependent optical signal can have a duration of lifetime that is shorter than a duration or lifetime of the analyte-independent optical signal.

Abstract: An armrest comprises a top surface; a first side surface and a second side surface being opposite to said first side surface; wherein said top surface incorporates a number of discrete regions; a first discrete region on which, in use, the elbow of a first user rests; said first discrete region extending diagonally towards said first side surface; and at least one further discrete region located in front of said first discrete region which extends diagonally towards said second side surface; whereby said second discrete region provides, in use, a resting surface for the elbow of a second user seating in an adjacent seat; wherein said first and said second regions are separated in the longitudinal direction by a line of separation which doesn't protrude higher than the majority of the top surface.