Patents by Inventor William A. Slusarchyk

William A. Slusarchyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ureido-substituted aniline compounds useful as serine protease inhibitors
    Patent number: 6846838
    Abstract: Compounds having the formula (I), or pharmaceutically-acceptable salts, hydrates or prodrugs thereof, are effective as inhibitors of Factor VIIa.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: January 25, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: William A. Slusarchyk, Scott A. Bolton, Timothy Herpin, Gregory S. Bisacchi, Zulan Pi, E. Scott Priestley
  • Beta lactam compounds and their use as inhibitors of tryptase
    Publication number: 20040147502
    Abstract: Beta lactam compounds are provided which have the structure 1
    Type: Application
    Filed: December 4, 2003
    Publication date: July 29, 2004
    Inventors: Gregory S. Bisacchi, James C. Sutton, William A. Slusarchyk, Uwe Treuner, Guohua Zhao
  • Ureido-substituted aniline compounds useful as serine protease inhibitors
    Publication number: 20040019085
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: June 17, 2003
    Publication date: January 29, 2004
    Inventors: William A. Slusarchyk, Scott A. Bolton, Timothy Herpin, Gregory S. Bisacchi, Zulan Pi, E. Scott Priestley
  • Acid derivatives useful as serine protease inhibitors
    Patent number: 6642252
    Abstract: Compounds having the formula (I), are useful as serine protease inhibitors, more particularly inhibitors of Factors VIIa, IXa, Xa, and/or XIa, wherein ring B is phenyl or pyridyl, W is preferably C(═O)NR4R5, L is a linker group, X2 comprises nitrogen or carbon, Z is an optionally-substituted monocyclic or bicyclic ring system, and R1, R2, R3, R4, R5 and R6 are as defined in the specification.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: November 4, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gregory S. Bisacchi, James C. Sutton, William A. Slusarchyk, Uwe D. Treuner, Guohua Zhao, Daniel L. Cheney, Yan Shi, Shung C. Wu
  • Acid derivatives useful as serine protease inhibitors
    Publication number: 20030166685
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: November 7, 2001
    Publication date: September 4, 2003
    Inventors: Gregory S. Bisacchi, James C. Sutton, William A. Slusarchyk, Uwe D. Treuner, Guohua Zhao, Daniel L. Cheney, Yan Shi, Shung C. Wu
  • Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
    Patent number: 6472414
    Abstract: Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2; Rx is H, alkyl, aryl or halogen; A is (1) a bond; (2) —O—; or (3) B is: and wherein L2, L1, R1, R2, R3, R3′, R3a, R3b, R4, R4′, R5, X,  are as defined herein.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: October 29, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Scott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Jeffrey A. Robl, William A. Slusarchyk, Richard B. Sulsky, Joseph A. Tino
  • Lactam compounds and their use as inhibitors of serine proteases and method
    Patent number: 6344450
    Abstract: Lactam inhibitors are provided which have the structure X is wherein Y is O or S and R4 is  R7O— or R8 and R1, R2, R3, R5, R6, R7, and R8, are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants, and are inhibitors of tryptase and thus are useful in treating asthma. Methods for treating cardiovascular diseases associated with thromboses and for treating asthma and related diseases are also provided.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: February 5, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gregory S. Bisacchi, Steven M. Seiler, R. Michael Lawrence, James C. Sutton, Jr., William A. Slusarchyk, Guohua Zhao
  • Beta lactam compounds and their use as inhibitors of tryptase
    Patent number: 6335324
    Abstract: Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: January 1, 2002
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Gregory S. Bisacchi, William A. Slusarchyk, Uwe Treuner, James C. Sutton, Robert Zahler, Steven Seiler, David R. Kronenthal, Michael E. Randazzo, Mark D. Schwinden, Zhongmin Xu, Zhongping Shi
  • Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
    Patent number: 5760246
    Abstract: Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2;R.sup.x is H, alkyl, aryl or halogen;A is(1) a bond;(2) --O--; or(3) ##STR2## B is: ##STR3## and wherein L.sup.2, L.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.3', R.sup.3a, R.sup.3b, R.sup.4, R.sup.4', R.sup.5, X, ##STR4## are as defined herein.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: June 2, 1998
    Inventors: Scott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Jeffrey A. Robl, William A. Slusarchyk, Richard B. Sulsky, Joseph A. Tino
  • Bis (hydroxymethyl) cyclobutyl purines
    Patent number: 5723609
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts wherein R.sub.1 is ##STR2## wherein R.sub.2 is hydrogen, methyl, fluoro, chloro, bromo, iodo, hydroxy or amino; or trifluoromethyl; R.sub.5 is alkyl; R.sub.6 is hydrogen, alkyl, substituted alkyl, or aryl; and R.sub.7 and R.sub.
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: March 3, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William A. Slusarchyk, Robert Zahler
  • Hydroxymethyl cyclobutyl purines
    Patent number: 5369098
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and their pharmaceutically acceptable salts. R.sub.1 is ##STR2## R.sub.2 is hydrogen, --PO.sub.3 H.sub.2, ##STR3## wherein R.sub.3 is hydrogen, alkyl, substituted alkyl, or aryl, and R.sub.4 is alkyl.
    Type: Grant
    Filed: June 16, 1989
    Date of Patent: November 29, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: William A. Slusarchyk
  • Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
    Patent number: 5340816
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: August 23, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Robert Zahler, William A. Slusarchyk
  • Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
    Patent number: 5206244
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: September 20, 1991
    Date of Patent: April 27, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Robert Zahler, William A. Slusarchyk
  • Bis protected (hydroxymethyl)cyclobutanols
    Patent number: 5185459
    Abstract: Cyclobutanols of the formula ##STR1## wherein P is a hydroxy protecting group are useful intermediates in the preparation of antiviral compounds.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: February 9, 1993
    Assignee: E. R. Squibb & Sons Inc.
    Inventors: William A. Slusarchyk, Robert Zahler
  • Cyclobutane derivatives
    Patent number: 5130462
    Abstract: Cyclobutane derivatives of the formulas ##STR1## wherein P is a hydroxy protecting group and X is a leaving group are useful intermediates in the preparation of antiviral compounds.
    Type: Grant
    Filed: February 19, 1991
    Date of Patent: July 14, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William A. Slusarchyk, Robert Zahler
  • Bis (hydroxymethyl) cyclobutyl triazolopyrimidines
    Patent number: 5126345
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts wherein R.sub.1 is ##STR2## R.sub.6 is hydrogen, alkyl, substituted alkyl, or aryl; and R.sub.7 and R.sub.
    Type: Grant
    Filed: February 8, 1991
    Date of Patent: June 30, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William A. Slusarchyk, Robert Zahler
  • Process for preparing 4,4-dialkyl-2-azetidinones utilizing a pyridine (or substituted pyridine) sulfur trioxide complex
    Patent number: 4812564
    Abstract: Disclosed herein is a process for preparing a compound having the formula ##STR1## which comprises sulfonating a compound having the formula ##STR2## with a complex having the formula ##STR3## and cyclizing the resulting compound having the formula ##STR4## by treatment with a base.
    Type: Grant
    Filed: May 11, 1987
    Date of Patent: March 14, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William A. Slusarchyk, Tamara Dejneka
  • 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
    Patent number: 4777252
    Abstract: Antibacterial activity is exhibited by 3-acylamino-2-oxoazetidines having in the 1-position an activating group of the formula ##STR1## wherein R is ##STR2## and R.sub.
    Type: Grant
    Filed: August 13, 1987
    Date of Patent: October 11, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William A. Slusarchyk, Peter H. Ermann
  • 2-oxo-1-azetidinesulfonic acid salts
    Patent number: 4775670
    Abstract: Antibacterial activity is exhibited by .beta.-lactams having a sulfonic acid salt substituent in the 1-position and an amino or acylamino substituent in the 3-position.
    Type: Grant
    Filed: January 19, 1981
    Date of Patent: October 4, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Richard B. Sykes, William L. Parker, Christopher M. Cimarusti, William H. Koster, William A. Slusarchyk
  • Optically active cyclobutyl pyrimidine
    Patent number: H1142
    Abstract: The compound of the formula ##STR1## [1R-(1.alpha.(E),2.beta.,3.alpha.)]-1-[2,3-bis(hydroxymethyl)cyclobutyl]-5 - (2-bromoethenyl)-2,4(1H,3H)-pyrimidinedione, is an antiviral agent that is active against herpes simplex virus 1 and varicella-zoster virus.
    Type: Grant
    Filed: November 5, 1990
    Date of Patent: February 2, 1993
    Inventors: William A. Slusarchyk, Robert Zahler