Patents by Inventor William Bunnelle

William Bunnelle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160376240
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, R3, R4, R5, R6, and X are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
    Type: Application
    Filed: January 16, 2015
    Publication date: December 29, 2016
    Applicant: ABBVIE INC.
    Inventors: William Bunnelle, Marlon Cowart, Irene Drizin, John Robert Koenig, Marina Pliushchev, Marc Scanio
  • Publication number: 20080234308
    Abstract: The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. Radiolabelled compounds useful for evaluating the binding affinity to ?7 nicotinic acetylcholine receptors also are described.
    Type: Application
    Filed: September 7, 2006
    Publication date: September 25, 2008
    Applicant: Abbott Laboratories
    Inventors: Michael Schrimpf, Kevin Sippy, David Anderson, William Bunnelle, Diana Nersesian
  • Publication number: 20080097094
    Abstract: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
    Type: Application
    Filed: December 15, 2007
    Publication date: April 24, 2008
    Applicant: Abbott Laboratories
    Inventors: Michael Schrimpf, Karin Tietje, Richard Toupence, Jianguo Ji, Anwer Basha, William Bunnelle, Jerome Daanen, Jennifer Frost, Kevin Sippy
  • Publication number: 20070184490
    Abstract: The invention relates to neuronal nicotinic receptor ligands, methods of identifying such ligands for neuronal nicotinic receptor modulation, particularly such ligands demonstrating beneficial side effect tolerability, and methods of using such neuronal nicotinic receptor ligands to provide pharmaceutical compositions and products.
    Type: Application
    Filed: January 16, 2007
    Publication date: August 9, 2007
    Inventors: Marleen Verlinden, Michael Meyer, Michael Decker, James Sullivan, William Bunnelle
  • Publication number: 20070135563
    Abstract: Disclosed are adhesives and processes for preparing the same, comprising at least one first homogeneous ethylene/?-olefin interpolymer, and optionally at least one tackifier, and optionally at least one plasticizer. The claimed adhesives are useful as adhesives such as are employed in various applications, such as in masking tape, clear office tape, labels, decals, bandages, decorative and protective sheets (such as shelf and drawer liners), floor tiles, sanitary napkin/incontinence device placement strips, sun control films, the joining of gaskets to automobile windows, packaging, bookbinding, construction of nonwoven articles, and insulation bonding.
    Type: Application
    Filed: February 5, 2007
    Publication date: June 14, 2007
    Applicant: The Dow Chemical Company
    Inventors: Eugene Simmons, William Bunnelle, David Malcolm, Keith Knutson, Thomas Harleysville, Mark Kroll, Michael Keehr, Deepak Parikh, Jimmy Allen, David Speth, Selim Yalvac, Malcolm Finlayson, Cyndi Rickey
  • Publication number: 20070083183
    Abstract: The invention relates to a disposable article and method relating to attachment tabs on a disposable article. The disposable article typically comprises a non-woven layer, an absorbent layer, and an outer film-wrapping layer associated with an attachment tab. The tabs are adhered to the polymer film and can be used to close the absorbent garment when in use. The invention also relates to a method of attaching the tabs to the polymer film using an adhesive having improved adhesive properties.
    Type: Application
    Filed: October 17, 2006
    Publication date: April 12, 2007
    Inventor: William Bunnelle
  • Publication number: 20070072892
    Abstract: The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. Radiolabelled compounds useful for evaluating the binding affinity to ?7 nicotinic acetylcholine receptors also are described.
    Type: Application
    Filed: September 7, 2006
    Publication date: March 29, 2007
    Inventors: Michael Schrimpf, Kevin Sippy, David Anderson, William Bunnelle, Diana Nersesian
  • Publication number: 20070060588
    Abstract: Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N+—O?; X is O, S, —NH—, and —N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by ?7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.
    Type: Application
    Filed: June 9, 2006
    Publication date: March 15, 2007
    Inventors: Jianguo Ji, Tao Li, Kathleen Mortell, Michael Schrimpf, Diana Nersesian, Liping Pan, William Bunnelle
  • Publication number: 20060089617
    Abstract: The invention relates to a disposable article and method relating to attachment tabs on a disposable article. The disposable article typically comprises a non-woven layer, an absorbent layer, and an outer film-wrapping layer associated with an attachment tab. The tabs are adhered to the polymer film and can be used to close the absorbent garment when in use. The invention also relates to a method of attaching the tabs to the polymer film using an adhesive having improved adhesive properties.
    Type: Application
    Filed: October 21, 2004
    Publication date: April 27, 2006
    Inventor: William Bunnelle
  • Publication number: 20050245531
    Abstract: Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N+—O—; X is O, S, —NH—, and —N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by ?7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.
    Type: Application
    Filed: June 15, 2005
    Publication date: November 3, 2005
    Inventors: Jianguo Ji, Tao Li, Kathleen Mortell, Michael Schrimpf, Diana Nersesian, Liping Pan, William Bunnelle
  • Publication number: 20050234031
    Abstract: Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by ?7nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.
    Type: Application
    Filed: February 4, 2005
    Publication date: October 20, 2005
    Inventors: Michael Schrimpf, Kevin Sippy, Jianguo Ji, Tao Li, Jennifer Frost, Clark Briggs, William Bunnelle
  • Publication number: 20050234168
    Abstract: A contact lens blocking composition with desirable melt properties can comprise a water soluble polymer such as a polyalkylpolyimine combined with an absorbent disintegrant or with a filler such as a highly soluble salt composition or both. The blocking composition can be readily removed from a shaped contact lens after machining and from the mandrel or other tool used in shaping the lens. The blocking composition is readily removed using an aqueous wash, aqueous washing solutions or ultrasonic cleaning procedures.
    Type: Application
    Filed: January 26, 2005
    Publication date: October 20, 2005
    Inventor: William Bunnelle
  • Publication number: 20050228094
    Abstract: A contact lens blocking composition with desirable melt properties can comprise a water soluble polymer such as a polyalkylpolyimine combined with a filler such as a highly soluble salt composition. The blocking composition can be readily removed from a shaped contact lens after machining and from the mandrel or other tool used in shaping the lens. The blocking composition is readily removed using an aqueous wash, aqueous washing solutions or ultrasonic cleaning procedures.
    Type: Application
    Filed: April 2, 2004
    Publication date: October 13, 2005
    Inventor: William Bunnelle
  • Publication number: 20050208108
    Abstract: A thermoplastic film that is configured to disperse in contact with a body fluid of a live human or other animal. The film includes a thermoplastic film former and a fatty alcohol. The film is produced by extruding or otherwise coating a coatable composition. For some applications, the film is edible, and disperses upon contacting the film to the eater's tongue. The edible film can include a breath freshening agent, a medicament or other substance. The film can also be used topically or in a mucous membrane to deliver a medicament.
    Type: Application
    Filed: March 19, 2004
    Publication date: September 22, 2005
    Inventors: Leonard Jannusch, William Bunnelle, Robert Hume
  • Publication number: 20050101602
    Abstract: Compounds of formula (I) Z-Ar1—Ar2??(I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by ?7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
    Type: Application
    Filed: September 16, 2004
    Publication date: May 12, 2005
    Inventors: Anwer Basha, William Bunnelle, Michael Dart, Megan Gallagher, Jianguo Ji, Tao Li, Jennifer Pace, Keith Ryther, Karin Tietje, Kathleen Mortell, Diana Nersesian, Michael Schrimpf
  • Publication number: 20050065178
    Abstract: Compounds of formula (I) Z-Ar1—Ar2??(I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from an unsubstituted or substituted 5-membered heteroaryl ring; an unsubstituted or substituted 6-membered heteroaryl ring; 3,4-(methylenedioxy)phenyl; and phenyl substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by ?7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
    Type: Application
    Filed: September 19, 2003
    Publication date: March 24, 2005
    Inventors: Anwer Basha, William Bunnelle, Michael Dart, Megan Gallagher, Jianguo Ji, Tao Li, Jennifer Pace, Keith Ryther, Karin Tietje