Patents by Inventor William C. Shakespeare

William C. Shakespeare has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Unsaturated Heterocyclic Derivatives
    Publication number: 20120178716
    Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
    Type: Application
    Filed: December 5, 2011
    Publication date: July 12, 2012
    Applicant: ARIAD Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Wei-Sheng Huang, Rajeswari Sundaramoorthi, Xiaotian Zhu, R. Mathew Thomas, William C. Shakespeare, David C. Dalgarno, Tomi K. Sawyer
  • Bicyclic Heteroaryl Compounds
    Publication number: 20120135986
    Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
    Type: Application
    Filed: January 25, 2012
    Publication date: May 31, 2012
    Applicant: ARIAD Pharmaceuticals, Inc.
    Inventors: Dong Zou, Wei-Sheng Huang, R. Mathew Thomas, Jan Antionette C. Romero, Jiwei Qi, Yihan Wang, Xiaotian Zhu, William C. Shakespeare, Rajeswari Sundaramoorthi, Chester A. Metcalf, III, David C. Dalgarno, Tomi K. Sawyer
  • Arborist's climbing rope
    Patent number: 8136438
    Abstract: An arborist's climbing rope in which an eye splice having a splice tuck can be formed at one end includes in one embodiment a core of polypropylene, a first braided tubular sheath of nylon disposed about the core and a second braided tubular sheath of a polyester disposed about the first braided tubular sheath, the cross-sectional diameter of the fiber material of the core area being in the range of 1 to 10% of the total cross-sectional diameter of the arborist's climbing rope. In forming the eye splice a portion of the core is intentionally removed near the eye splice to form a space within the first tubular sheath where the core has been removed and the splice tuck is buried in and substantially completely fills the space within the first tubular sheath where the core has been intentionally removed.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: March 20, 2012
    Assignee: New England Ropes Corp.
    Inventor: William C. Shakespeare
  • Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors
    Patent number: 8114874
    Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use. In particular, the compounds include embodiments in which Ring T is an imidazo[1,2-b]pyridazine ring system, Rings A and B are each aryl and L1 is —C(O)NR1— or —NR1C(O)—. Uses for the compounds and for compositions containing them include treatment of cancer and other diseases mediated by protein kinases.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: February 14, 2012
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Dong Zou, Wei-Sheng Huang, R. Mathew Thomas, Jan Antionette C. Romero, Jiwei Qi, Yihan Wang, Xiaotian Zhu, William C. Shakespeare, Rajeswari Sundaramoorthi, Chester A. Metcalf, III, David C. Dalgarno, Tomi K. Sawyer
  • Unsaturated heterocyclic derivatives
    Patent number: 8071609
    Abstract: This invention relates to compounds of the general formula: in which Q is an ethynyl or ethenyl moiety; Ring A is an aryl, heteroaryl or heterocyclic ring or ring system; and the remaining variable groups are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: December 6, 2011
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Wei-Sheng Huang, Rajeswari Sundaramoorthi, Xiaotian Zhu, R. Mathew Thomas, William C. Shakespeare, David C. Dalgarno, Tomi K. Sawyer
  • AZAINDOLE DERIVATIVES AS KINASE INHIBITORS
    Publication number: 20110294806
    Abstract: This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
    Type: Application
    Filed: December 11, 2009
    Publication date: December 1, 2011
    Applicant: ARIAD Pharmaceuticals, Inc.
    Inventors: Jiwei Qi, Yihan Wang, Feng Li, William C. Shakespeare, Anna Kohlmann, David C. Dalgarno, Xiaotian Zhu
  • Arborist's climbing rope
    Publication number: 20100162882
    Abstract: An arborist's climbing rope in which an eye splice having a splice tuck can be formed at one end includes in one embodiment a core of polypropylene, a first braided tubular sheath of nylon disposed about the core and a second braided tubular sheath of a polyester disposed about the first braided tubular sheath, the core cross-sectional diameter being in the range of 1 to 10% of the total cross-sectional diameter of the arborist's climbing rope. In forming the eye splice a portion of the core is intentionally removed near the eye splice to form a space within the first tubular sheath where the core has been removed and the splice tuck is buried in and substantially completely fills the space within the first tubular sheath where the core has been intentionally removed.
    Type: Application
    Filed: March 4, 2010
    Publication date: July 1, 2010
    Inventor: William C. Shakespeare
  • Climbing rope
    Patent number: 7703372
    Abstract: A rope is disclosed that is firm for climbing purposes and in which the end of the rope can be spliced. The rope includes a core of a plurality of strands; a first braided tubular sheath disposed about the core; and a second braided tubular sheath disposed about the first braided tubular sheath. The plurality of strands fill at least a length of a center void formed in the first braided tubular sheath. The plurality of core strands are formed in an un-braided manner in at least one of twisted and non-twisted strands. At the splice the splice tucks fill the center void while the core strands fill only center void outside of the splice.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: April 27, 2010
    Assignee: New England Ropes Corp.
    Inventor: William C. Shakespeare
  • Acetylenic Heteroaryl Compounds
    Publication number: 20090176781
    Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
    Type: Application
    Filed: May 8, 2007
    Publication date: July 9, 2009
    Inventors: Yihan Wang, Xiaotian Zhu, Rajeswari Sundaramoorthi, Wei-Sheng Huang, Dong Zhu, R. Mathew Thomas, Jiwei Qi, Jan Antoinette C. Romero, David C. Dalgarno, William C. Shakespeare, Tomi K. Sawyer, Chester A. Metcalf, III
  • Unsaturated Heterocyclic Derivatives
    Publication number: 20090156596
    Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
    Type: Application
    Filed: August 11, 2006
    Publication date: June 18, 2009
    Inventors: Yihan Wang, Wei-Sheng Huang, Rajeswari Sundaramoorthi, Xiaotian Zhu, R. Mathew Thomas, William C. Shakespeare, David C. Dalgarno, Tomi K. Sawyer
  • Monocyclic Heterocyclic Compounds
    Publication number: 20090149471
    Abstract: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
    Type: Application
    Filed: May 8, 2007
    Publication date: June 11, 2009
    Inventors: William C. Shakespeare, Wei-Sheng Huang, David C. Dalgarno, Xiaotian Zhu, R. Matthew Thomas, Yihan Wang, Jiwei Qi, Rajeswari Sundaramoorthi, Dong Zou, Chester A. Metcalf, III, Tomi k. Sawyer, Jan Antoinette C. Romero
  • Heterocycles and uses thereof
    Patent number: 7238679
    Abstract: Compounds of the following formula are disclosed: wherein RB is a substituted or unsubstituted aryl or heteroaryl moiety; at least one of RU and RL is a phosphorus-containing moiety, J, and the other of RU and RL is independently chosen from H; halogen; —CN; —NO2; -J; —SO2R; —SO2NRR?; or —ZRJ, wherein each occurrence of Z is independently —O—, —S— or —NR— and each occurrence of RJ is independently —R, —COR, —COOR or —CONRR?.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: July 3, 2007
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Terence P. Keenan, William C. Shakespeare
  • Quinazolines and uses thereof
    Patent number: 7132427
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: November 7, 2006
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Regine Bohacek, Rajeswari Sundaramoorthi
  • Purine derivatives
    Patent number: 7115589
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use. In these compounds, RB is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety which comprises one or more phosphorus-containing moieties.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: October 3, 2006
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Manfred Weigele, Tomi K. Sawyer, Regine Bohacek, William C. Shakespeare, Rajeswari Sundaramoorthi, Yihan Wang, David C. Dalgarno, Chester A. Metcalf, III
  • Quinolinones and uses thereof
    Patent number: 7019139
    Abstract: The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): in which RA, RB, RC, RD, R5, R7, R9, R9a, AK, p, q, r and X are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: March 28, 2006
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek, Rajeswari Sundaramoorthi
  • Quinolines and uses thereof
    Patent number: 7009054
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: March 7, 2006
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Regine Bohacek, Rajeswari Sundaramoorthi
  • Indolinones and uses thereof
    Patent number: 6960572
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC, RD, RE, p, q and X are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: November 1, 2005
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: William C. Shakespeare, Tomi K. Sawyer, Chester A. Metcalf, III, Yihan Wang, Regine Bohacek
  • Phenylamino-pyrimidines and uses thereof
    Patent number: 6878697
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC, RD, w, x, y, and z are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: April 12, 2005
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek
  • NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF
    Publication number: 20040242611
    Abstract: This invention relates to compounds of the general formula: 1
    Type: Application
    Filed: June 21, 2002
    Publication date: December 2, 2004
    Inventors: Chester A. Metcalf, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek
  • Heterocycles and uses thereof
    Publication number: 20040171586
    Abstract: Compounds of the following formula are disclosed: 1
    Type: Application
    Filed: December 23, 2003
    Publication date: September 2, 2004
    Inventors: Terence P. Keenan, William C. Shakespeare