Patents by Inventor William C. Shakespeare

William C. Shakespeare has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel quinolinones and uses thereof
    Publication number: 20040167101
    Abstract: The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): 1
    Type: Application
    Filed: November 17, 2003
    Publication date: August 26, 2004
    Inventors: Chester A. Metcalf, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek, Rajeswari Sundaramoorthi
  • Novel quinolines and uses thereof
    Publication number: 20040152671
    Abstract: This invention relates to compounds of the general formula: 1
    Type: Application
    Filed: November 17, 2003
    Publication date: August 5, 2004
    Applicant: ARIAD Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Chester A. Metcalf, William C. Shakespeare, Tomi K. Sawyer, Regine Bohacek, Rajeswari Sundaramoorthi
  • Quinolinones and uses thereof
    Patent number: 6713462
    Abstract: The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): in which RA, RB, RC, RD, R5, R7, R9, R9a, AK, p, q, r and X are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: March 30, 2004
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek, Rajeswari Sundaramoorthi
  • Quinolines and uses thereof
    Patent number: 6706699
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: March 16, 2004
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Regine Bohacek, Rajeswari Sundaramoorthi
  • Novel indolinones and uses thereof
    Publication number: 20030130234
    Abstract: This invention relates to compounds of the general formula: 1
    Type: Application
    Filed: June 21, 2002
    Publication date: July 10, 2003
    Inventors: William C. Shakespeare, Tomi K. Sawyer, Chester A. Metcalf, Yihan Wang, Regine Bohacek
  • Novel pyrazolo- and pyrrolo-pyrimidines and uses thereof
    Publication number: 20030114467
    Abstract: The invention relates to compounds of the general formula: 1
    Type: Application
    Filed: June 21, 2002
    Publication date: June 19, 2003
    Inventors: William C. Shakespeare, Tomi K. Sawyer, Chester A. Metcalf, Yihan Wang, Regine Bohacek, Rajeswari Sundaramoorthi
  • Novel quinolinones and uses thereof
    Publication number: 20030114486
    Abstract: The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): 1
    Type: Application
    Filed: June 21, 2002
    Publication date: June 19, 2003
    Inventors: Chester A. Metcalf, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek
  • Signal transduction inhibitors, compositions containing them
    Patent number: 6576766
    Abstract: This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutic compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of formula (1) as defined herein.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: June 10, 2003
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Manfred Weigele, Regine Bohacek, Virginia A. Jacobsen, Karina Macek, Michael G. Yang, Noriyuki H. Kawahata, Rajeswari Sundaramoorthi, Yihan Wang, Craig S. Takeuchi, George P. Luke, Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer
  • Novel quinolines and uses thereof
    Publication number: 20030105065
    Abstract: This invention relates to compounds of the general formula: 1
    Type: Application
    Filed: June 21, 2002
    Publication date: June 5, 2003
    Inventors: Yihan Wang, Chester A. Metcalf, William C. Shakespeare, Tomi K. Sawyer, Regine Bohacek
  • Novel pyridopyrimidines and uses thereof
    Publication number: 20030105115
    Abstract: This invention relates to compounds of the general formula: 1
    Type: Application
    Filed: June 21, 2002
    Publication date: June 5, 2003
    Inventors: Chester A. Metcalf, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek
  • Bicyclic signal transduction inhibitors, compositions containing them & uses thereof
    Patent number: 6573295
    Abstract: This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of the formula as defined herein.
    Type: Grant
    Filed: November 21, 2001
    Date of Patent: June 3, 2003
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: William C. Shakespeare, Michael G. Yang, Rajeswari Sundaramoorthi, Regine Bohacek, Charles Joseph Eyermann, Tomi K. Sawyer
  • Novel quinazolines and uses thereof
    Publication number: 20030100573
    Abstract: This invention relates to compounds of the general formula: 1
    Type: Application
    Filed: June 21, 2002
    Publication date: May 29, 2003
    Inventors: Yihan Wang, Chester A. Metcalf, William C. Shakespeare, Tomi K. Sawyer, Regine Bohacek
  • Novel pyridopyrimidones and uses thereof
    Publication number: 20030100572
    Abstract: This invention relates to compounds of the general formula: 1
    Type: Application
    Filed: June 21, 2002
    Publication date: May 29, 2003
    Applicant: ARIAD PHARMACEUTICALS,INC.
    Inventors: Chester A. Metcalf, William C. Shakespeare, Tomi K. Sawyer, Yihan Wang, Regine Bohacek
  • Bicyclic signal transduction inhibitors, compositions containing them & uses thereof
    Patent number: 6482852
    Abstract: This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of the formula as defined herein.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: November 19, 2002
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: William C. Shakespeare, Michael G. Yang, Rajeswari Sundaramoorthi, Regine Bohacek, Charles Joseph Eyermann, Tomi K. Sawyer
  • BICYCLIC SIGNAL TRANSDUCTION INHIBITORS, COMPOSITIONS CONTAINING THEM & USES THEREOF
    Publication number: 20020137941
    Abstract: This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds.
    Type: Application
    Filed: May 11, 2001
    Publication date: September 26, 2002
    Inventors: William C. Shakespeare, Michael G. Yang, Rajeswari Sundaramoorthi, Regine Bohacek, Charles Joseph Eyermann, Tomi K. Sawyer
  • Novel purinse
    Publication number: 20020132819
    Abstract: Novel purines and uses of these compounds for the treatment of bone related disorders and cancer is disclosed.
    Type: Application
    Filed: December 18, 2000
    Publication date: September 19, 2002
    Inventors: Chester A. Metcalf, Manfred Weigele, Tomi K. Sawyer, Regine Bohacek, William C. Shakespeare, Rajeswari Sundaramoorthi, Yihan Wang, David C. Dalgarno
  • Novel heterocycles
    Publication number: 20020103161
    Abstract: The present invention relates to bone-targeting compounds useful for treating a variety of disorders and conditions, e.g., of bone tissue.
    Type: Application
    Filed: December 18, 2000
    Publication date: August 1, 2002
    Inventors: Manfred Weigele, George P. Luke, Tomi K. Sawyer, Regine Bohacek, William C. Shakespeare, Rajeswari Sundaramoorthi, Yihan Wang, David C. Dalgarno, Chester A. Metcalf, Chi B. Vu, Noriyuki H. Kawahata
  • Purine derivatives
    Publication number: 20020068721
    Abstract: This invention relates to compounds of the general formula: 1
    Type: Application
    Filed: December 18, 2000
    Publication date: June 6, 2002
    Inventors: Manfred Weigele, Tomi K. Sawyer, Regine Bohacek, William C. Shakespeare, Rajeswari Sundaramoorthi, Yihan Wang, David C. Dalgarno, Chester A. Metcalf
  • Bicyclic signal transduction inhibitors, compositions containing them & uses thereof
    Publication number: 20020062031
    Abstract: This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds.
    Type: Application
    Filed: November 21, 2001
    Publication date: May 23, 2002
    Inventors: William C. Shakespeare, Michael G. Yang, Rajeswari Sundaramoorthi, Regine Bohacek, Charles Joseph Eyermann, Tomi K. Sawyer
  • Non-peptide peptidomimetics
    Patent number: 6197963
    Abstract: Compounds are provided which are crossreactive with peptides such as those which bind G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: wherein at least one of R1, R2, R3, R4, or R5 comprises a functional group which is chemically similar to that found in the peptide of interest.
    Type: Grant
    Filed: August 13, 1998
    Date of Patent: March 6, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ralph Hirschmann, John Hynes, Jr., Maria A. Cichy-Knight, Rachel D. van Rijn, Paul A. Sprengeler, P. Grant Spoors, William C. Shakespeare, Sherrie Pietranico-Cole, Amos B. Smith, III